LOCUS       sequence-145594-         550 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  vector encoding both shRNA against CDK4(1) and shRNA against 
            CDK6(1).
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 550)
  AUTHORS   Acevedo M, Vernier M, Mignacca L, Lessard F, Huot G, Moiseeva O, 
            Bourdeau V, Ferbeyre G
  TITLE     A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from 
            PML-induced Senescence.
  JOURNAL   Cancer Res. 2016 Jun 1;76(11):3252-64. doi: 
            10.1158/0008-5472.CAN-15-2347. Epub 2016 Mar 29.
  PUBMED    27206849
REFERENCE   2  (bases 1 to 550)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: 
            "10.1158/0008-5472.CAN-15-2347"; journalName: "Cancer Res"; date: 
            "2016-06-1- 1"; volume: "76"; issue: "11"; pages: "3252-64"
COMMENT     Sequence Label: shCDK4/6(1)
FEATURES             Location/Qualifiers
     source          1..550
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     ncRNA           62..183
                     /label=5' miR-30a
                     /note="sequence upstream of the 71-nt precursor of the 
                     human miR-30a microRNA (Zeng et al., 2002)"
                     /ncRNA_class="miRNA"
     ncRNA           211..225
                     /label=miR-30a loop
                     /note="loop from the the 71-nt precursor of the human 
                     miR-30a microRNA (Zeng et al., 2002)"
                     /ncRNA_class="miRNA"
     ncRNA           253..379
                     /label=3' miR-30a
                     /note="sequence downstream of the 71-nt precursor of the 
                     human miR-30a microRNA (Zeng et al., 2002)"
                     /ncRNA_class="miRNA"
     ncRNA           416..537
                     /label=5' miR-30a
                     /note="sequence upstream of the 71-nt precursor of the 
                     human miR-30a microRNA (Zeng et al., 2002)"
                     /ncRNA_class="miRNA"
ORIGIN
        1 cctcactcct tctctaggcg ccggaattag atctctcgac tagggataac agggtaattg
       61 tttgaatgag gcttcagtac tttacagaat cgttgcctgc acatcttgga aacacttgct
      121 gggattactt cttcaggtta acccaacaga aggctcgaga aggtatattg ctgttgacag
      181 tgagcgtagt cttgctccag tccagctata gtgaagccac agatgtatag ctggactgga
      241 gcaagacttt gcctactgcc tcggaattca aggggctact ttaggagcaa ttatcttgtt
      301 tactaaaact gaataccttg ctatctcttt gatacatttt tacaaagctg aattaaaatg
      361 gtataaatta aatcactttt ttggatctct cgactaggga taacagggta attgtttgaa
      421 tgaggcttca gtactttaca gaatcgttgc ctgcacatct tggaaacact tgctgggatt
      481 acttcttcag gttaacccaa cagaaggctc gagaaggtat attgctgttg acagtgagcg
      541 cctgagaatg
//
