LOCUS       sequence-165941-         993 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  luciferase reporter for TERT promoter.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 993)
  AUTHORS   Bell RJ, Rube HT, Kreig A, Mancini A, Fouse SD, Nagarajan RP, Choi 
            S, Hong C, He D, Pekmezci M, Wiencke JK, Wrensch MR, Chang SM, Walsh
            KM, Myong S, Song JS, Costello JF
  TITLE     Cancer. The transcription factor GABP selectively binds and 
            activates the mutant TERT promoter in cancer.
  JOURNAL   Science. 2015 May 29;348(6238):1036-9. doi: 10.1126/science.aab0015.
            Epub 2015 May 14.
  PUBMED    25977370
REFERENCE   2  (bases 1 to 993)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: 
            "10.1126/science.aab0015"; journalName: "Science"; date: 
            "2015-05-29- 29"; volume: "348"; issue: "6238"; pages: "1036-9"
COMMENT     Sequence Label: pGL4.0-TERT WT
FEATURES             Location/Qualifiers
     source          1..993
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     misc_feature    242..333
                     /label=pause site
                     /note="RNA polymerase II transcriptional pause signal from 
                     the human alpha-2 globin gene"
     primer_bind     complement(274..293)
                     /label=RVprimer3
                     /note="pGL3 vector, forward primer"
     polyA_signal    347..395
                     /note="synthetic polyadenylation signal"
ORIGIN
        1 aacagtaccg gattgccaag cttggccgcc gaggccagat ccagcgctgc ctgaaactcg
       61 cgccgcgagg agagggcggg gccgcggaaa ggaaggggag gggctgggag ggcccggagg
      121 gggctgggcc ggggacccgg gaggggtcgg gacggggcgg ggtccgcgcg gaggaggcgg
      181 agctggaagg tgaaggggca ggactcgagg ctagcgagct caggtaccgg ccagttaggc
      241 cagagaaatg ttctggcacc tgcacttgca ctggggacag cctattttgc tagtttgttt
      301 tgtttcgttt tgttttgatg gagagcgtat gttagtacta tcgattcaca caaaaaacca
      361 acacacagat gtaatgaaaa taaagatatt ttattgcggc ctgtccaata cctcccgtac
      421 cttaatatta cttacttatc cttgagagac gtactagtaa ccctgataaa tgcttcaata
      481 atattgaaaa aggacgagta tgagcatcca acattttcgt gtcgcactca ttcccttctt
      541 tgcggcattt tgcttgcctg tttttgcaca ccccgaaacg ctggtgaaag taaaagatgc
      601 tgaagatcaa ctgggtgcaa gagtgggcta tatcgaactg gatctcaata gcggcaagat
      661 ccttgagtct ttccgccccg aagaacgatt cccgatgatg agcactttca aagtactgct
      721 atgtggcgcg gtgttgtccc gtatagacgc cgggcaagag cagcttggtc gccgtataca
      781 ctactcacaa aacgacttgg ttgagtactc gccggtcacg gaaaagcatc ttacggatgg
      841 catgacggta agagaattgt gtagtgctgc cattaccatg agcgacaaca ccgcggccaa
      901 cttacttctg acaacgatcg gaggccctaa ggagctgact gcatttcttc ataatatggg
      961 tgatcatgtg acccggcttg accgctggga acc
//
