LOCUS       sequence-165945-         987 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  luciferase reporter for mutant TERT promoter.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 987)
  AUTHORS   Bell RJ, Rube HT, Kreig A, Mancini A, Fouse SD, Nagarajan RP, Choi 
            S, Hong C, He D, Pekmezci M, Wiencke JK, Wrensch MR, Chang SM, Walsh
            KM, Myong S, Song JS, Costello JF
  TITLE     Cancer. The transcription factor GABP selectively binds and 
            activates the mutant TERT promoter in cancer.
  JOURNAL   Science. 2015 May 29;348(6238):1036-9. doi: 10.1126/science.aab0015.
            Epub 2015 May 14.
  PUBMED    25977370
REFERENCE   2  (bases 1 to 987)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: 
            "10.1126/science.aab0015"; journalName: "Science"; date: 
            "2015-05-29- 29"; volume: "348"; issue: "6238"; pages: "1036-9"
COMMENT     Sequence Label: pGL4.0-TERT G250A
FEATURES             Location/Qualifiers
     source          1..987
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     misc_feature    241..332
                     /label=pause site
                     /note="RNA polymerase II transcriptional pause signal from 
                     the human alpha-2 globin gene"
     primer_bind     complement(273..292)
                     /label=RVprimer3
                     /note="pGL3 vector, forward primer"
     polyA_signal    346..394
                     /note="synthetic polyadenylation signal"
ORIGIN
        1 acagtaccgg attgccaagc ttggccgccg aggccagatc cagcgctgcc tgaaactcgc
       61 gccgcgagga gagggcgggg ccgcggaaag gaaggggagg ggctgggagg gcccggaggg
      121 ggctgggccg gggacccgga aggggtcggg acggggcggg gtccgcgcgg aggaggcgga
      181 gctggaaggt gaaggggcag gactcgaggc tagcgagctc aggtaccggc cagttaggcc
      241 agagaaatgt tctggcacct gcacttgcac tggggacagc ctattttgct agtttgtttt
      301 gtttcgtttt gttttgatgg agagcgtatg ttagtactat cgattcacac aaaaaaccaa
      361 cacacagatg taatgaaaat aaagatattt tattgcggcc tgtccaatac ctcccgtacc
      421 ttaatattac ttacttatcc ttgagagacg tactagtaac cctgataaat gcttcaataa
      481 tattgaaaaa ggacgagtat gagcatccaa cattttcgtg tcgcactcat tcccttcttt
      541 gcggcatttt gcttgcctgt ttttgcacac cccgaaacgc tggtgaaagt aaaagatgct
      601 gaagatcaac tgggtgcaag agtgggctat atcgaactgg atctcaatag cggcaagatc
      661 cttgagtctt tccgccccga agaacgattc ccgatgatga gcactttcaa agtactgcta
      721 tgtggcgcgg tgttgtcccg tatagacgcc gggcaagagc agcttggtcg ccgtatacac
      781 tactcacaaa acgacttggt tgagtactcg ccggtcacgg aaaagcatct tacggatggc
      841 atgacggtaa gagaattgtg tagtgctgcc attaccatga gcgacaacac cgcggccaac
      901 ttacttctga caacgatcgg aggccctaag gagctgactg catttcttca taatatgggt
      961 gatcatgtga cccggcttga ccgctgg
//
