LOCUS       sequence-165964-        1017 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  luciferase reporter for mutant TERT promoter.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 1017)
  AUTHORS   Bell RJ, Rube HT, Kreig A, Mancini A, Fouse SD, Nagarajan RP, Choi 
            S, Hong C, He D, Pekmezci M, Wiencke JK, Wrensch MR, Chang SM, Walsh
            KM, Myong S, Song JS, Costello JF
  TITLE     Cancer. The transcription factor GABP selectively binds and 
            activates the mutant TERT promoter in cancer.
  JOURNAL   Science. 2015 May 29;348(6238):1036-9. doi: 10.1126/science.aab0015.
            Epub 2015 May 14.
  PUBMED    25977370
REFERENCE   2  (bases 1 to 1017)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: 
            "10.1126/science.aab0015"; journalName: "Science"; date: 
            "2015-05-29- 29"; volume: "348"; issue: "6238"; pages: "1036-9"
COMMENT     Sequence Label: pGL4.0-TERT G228A
FEATURES             Location/Qualifiers
     source          1..1017
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     misc_feature    243..334
                     /label=pause site
                     /note="RNA polymerase II transcriptional pause signal from 
                     the human alpha-2 globin gene"
     primer_bind     complement(275..294)
                     /label=RVprimer3
                     /note="pGL3 vector, forward primer"
     polyA_signal    348..396
                     /note="synthetic polyadenylation signal"
ORIGIN
        1 caacagtacc ggattgccaa gcttggccgc cgaggccaga tccagcgctg cctgaaactc
       61 gcgccgcgag gagagggcgg ggccgcggaa aggaagggga ggggctggga gggcccggaa
      121 ggggctgggc cggggacccg ggaggggtcg ggacggggcg gggtccgcgc ggaggaggcg
      181 gagctggaag gtgaaggggc aggactcgag gctagcgagc tcaggtaccg gccagttagg
      241 ccagagaaat gttctggcac ctgcacttgc actggggaca gcctattttg ctagtttgtt
      301 ttgtttcgtt ttgttttgat ggagagcgta tgttagtact atcgattcac acaaaaaacc
      361 aacacacaga tgtaatgaaa ataaagatat tttattgcgg cctgtccaat acctcccgta
      421 ccttaatatt acttacttat ccttgagaga cgtactagta accctgataa atgcttcaat
      481 aatattgaaa aaggacgagt atgagcatcc aacattttcg tgtcgcactc attcccttct
      541 ttgcggcatt ttgcttgcct gtttttgcac accccgaaac gctggtgaaa gtaaaagatg
      601 ctgaagatca actgggtgca agagtgggct atatcgaact ggatctcaat agcggcaaga
      661 tccttgagtc tttccgcccc gaagaacgat tcccgatgat gagcactttc aaagtactgc
      721 tatgtggcgc ggtgttgtcc cgtatagacg ccgggcaaga gcagcttggt cgccgtatac
      781 actactcaca aaacgacttg gttgagtact cgccggtcac ggaaaagcat cttacggatg
      841 gcatgacggt aagagaattg tgtagtgctg ccattaccat gagcgacaac accgcggcca
      901 acttacttct gacaacgatc ggaggcccta aggagctgac tgcatttctt cataatatgg
      961 gtgatcatgt gacccggctt gaccgctggg aaccagagtt gaacgaagcc ataccga
//
