LOCUS       sequence-167434-        4098 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  express NSD2 E1099K mutant  in mammalian cells.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 4098)
  AUTHORS   Jaffe JD, Wang Y, Chan HM, Zhang J, Huether R, Kryukov GV, Bhang HE,
            Taylor JE, Hu M, Englund NP, Yan F, Wang Z, Robert McDonald E 3rd, 
            Wei L, Ma J, Easton J, Yu Z, deBeaumount R, Gibaja V, Venkatesan K, 
            Schlegel R, Sellers WR, Keen N, Liu J, Caponigro G, Barretina J, 
            Cooke VG, Mullighan C, Carr SA, Downing JR, Garraway LA, Stegmeier F
  TITLE     Global chromatin profiling reveals NSD2 mutations in pediatric acute
            lymphoblastic leukemia.
  JOURNAL   Nat Genet. 2013 Nov;45(11):1386-91. doi: 10.1038/ng.2777. Epub 2013 
            Sep 29.
  PUBMED    24076604
REFERENCE   2  (bases 1 to 4098)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: "10.1038/ng.2777"; 
            journalName: "Nat Genet"; date: "2013-11"; volume: "45"; issue: 
            "11"; pages: "1386-91"
COMMENT     Sequence Label: LVXN-Neo-NSD2-E1099K
FEATURES             Location/Qualifiers
     source          1..4098
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     CDS             2664..2675
                     /codon_start=1
                     /product="WELQut protease recognition and cleavage site"
                     /label=WELQut site
                     /translation="WELQ"
ORIGIN
        1 atggaattta gcatcaagca gagtcccctt tctgttcaga gtgttgtaaa gtgcataaag
       61 atgaagcagg caccagaaat cctcggcagt gccaacggga agactccgag ctgcgaggtg
      121 aaccgcgagt gttctgtgtt cctcagcaaa gcccagctct ccagtagcct gcaggagggg
      181 gtcatgcaga agtttaacgg ccacgacgcc ctgcccttta ttccagccga caagctgaaa
      241 gatcttactt cccgggtgtt taatggagaa cccggcgcac acgatgccaa actgcgtttt
      301 gagtcccagg aaatgaaagg gattgggaca ccccctaaca ctacccctat caaaaatggc
      361 tctccagaaa ttaagctgaa aatcaccaaa acatacatga atgggaagcc tctctttgaa
      421 tcttccattt gtggtgacag tgctgctgat gtgtctcagt cagaagaaaa tggacaaaaa
      481 ccagaaaaca aggcgagaag gaacaggaag aggagcataa aatatgactc cttgctggag
      541 cagggccttg tcgaagcagc tcttgtgtct aagatctcaa gtccttcaga taaaaagatt
      601 ccagctaaga aagagtcttg tccaaacact ggaagagaca aagaccacct gttgaaatac
      661 aacgttggtg atttggtgtg gtccaaagtg tcgggttacc cttggtggcc ttgcatggtt
      721 tctgcagatc cactccttca cagctatacc aaacttaaag gtcagaaaaa gagtgcacgc
      781 cagtatcacg tacagttctt tggtgacgcc ccagaaagag cttggatatt tgagaagagc
      841 ctcgtagctt ttgaaggaga aggacagttt gaaaaattat gccaggaaag tgccaagcag
      901 gcacccacga aagctgagaa aattaagcta ttgaaaccaa tttcagggaa attgagggcc
      961 cagtgggaaa tgggcattgt tcaagcagaa gaagctgcaa gcatgtcagt ggaggagcgg
     1021 aaagccaagt tcacctttct ctatgtgggg gaccagcttc atctcaaccc tcaagtagcc
     1081 aaggaggctg gcattgctgc agagtctttg ggagaaatgg cagaatcctc aggagtcagt
     1141 gaagaagctg ctgaaaaccc caagtctgtg agagaagagt gcattcccat gaagagaagg
     1201 cggagggcca aactgtgtag ctctgcagag accctggaga gtcaccccga catagggaag
     1261 agtactcctc aaaagacggc agaggctgac cccagaagag gagtagggtc tcctcctggg
     1321 aggaagaaga ccacagtctc catgccacga agcaggaagg gagatgcagc atcccagttt
     1381 ttggtcttct gtcaaaaaca cagggatgag gtggtagctg agcacccaga tgcttcaggt
     1441 gaggagattg aagagctgct caggtcacag tggagtctgc tgagtgagaa gcagagagca
     1501 cgctacaaca ccaagtttgc cctggtggcc cctgtccagg ctgaagaaga ctctggtaat
     1561 gtaaatggga aaaaaagaaa ccacacaaag aggatacagg accctacaga agatgctgaa
     1621 gctgaggaca cacccaggaa aagactcagg acggacaagc acagtcttcg gaagagagac
     1681 acaatcactg acaaaacggc cagaacaagc tcttacaagg ccatggaggc agcctcctcg
     1741 ctcaagagcc aggcagcaac gaaaaatctg tctgatgcat gtaaaccact gaagaagcga
     1801 aatcgggctt ccacggcagc atcttcagct cttgggttta gcaaaagttc atctccttct
     1861 gcatccttaa ctgagaatga ggtctcggac agcccgggag acgagccctc ggagtcccca
     1921 tacgaaagtg cagacgaaac acaaactgaa gtatctgtct catccaaaaa gtctgagcga
     1981 ggagtgactg ccaaaaagga gtatgtgtgc cagctgtgtg agaagccggg cagcctcctg
     2041 ctctgtgaag gaccctgctg cggagctttc cacctcgcct gccttgggct ttcccggagg
     2101 ccagaaggga ggttcacctg cagcgagtgt gcctcaggga ttcactcatg tttcgtgtgt
     2161 aaagagagca agacagatgt taagcgctgt gtggtaactc agtgtggaaa attttaccat
     2221 gaggcttgtg tgaaaaaata ccctctgact gtatttgaga gccgaggttt ccgctgcccc
     2281 ctccacagct gtgtgagctg ccatgcttcc aacccttcaa acccaaggcc gtcaaaaggt
     2341 aaaatgatgc ggtgtgtccg ctgccccgtt gcctatcaca gcggggatgc ttgtctggca
     2401 gcaggatgct cagtgatcgc ctccaacagc atcatctgca ctgcccactt cactgctcgg
     2461 aaggggaagc gacaccacgc ccacgtcaac gtgagctggt gcttcgtgtg ctccaaaggg
     2521 gggagccttc tgtgctgtga gtcctgccca gcggccttcc accctgactg cctgaacatc
     2581 gagatgcctg acggcagctg gttctgcaat gactgcaggg ctgggaagaa gctgcacttc
     2641 caggatatca tttgggtgaa acttgggaac tacagatggt ggccggcaga agtttgccat
     2701 cccaaaaatg ttcccccaaa tattcagaaa atgaagcacg agattggaga attccctgtg
     2761 tttttctttg ggtctaaaga ttattactgg acgcatcagg cgcgagtgtt cccgtacatg
     2821 gagggggacc ggggcagccg ctaccagggg gtcagaggga tcggaagagt cttcaaaaac
     2881 gcactgcaag aagctgaagc tcgttttcgt gaaattaagc ttcagaggga agcccgagaa
     2941 acacaggaga gcgagcgcaa gcccccacca tacaagcaca tcaaggtgaa taagccttac
     3001 gggaaagtcc agatctacac agcggatatt tcagaaatcc ctaagtgcaa ctgcaagccc
     3061 acagatgaga atccttgtgg ctttgattcg gagtgtctga acaggatgct gatgtttgag
     3121 tgccacccgc aggtgtgtcc cgcgggcgag ttctgccaga accagtgctt caccaagcgc
     3181 cagtacccag agaccaagat catcaagaca gatggcaaag ggtggggcct ggtcgccaag
     3241 agggacatca gaaagggaga atttgttaac gagtacgttg gggagctgat cgacgaggag
     3301 gagtgcatgg cgagaatcaa gcacgcacac gagaacgaca tcacccactt ctacatgctc
     3361 actatagaca aggaccgtat aatagacgct ggccccaaag gaaactactc tcgatttatg
     3421 aatcacagct gccagcccaa ctgtgagacc ctcaagtgga cagtgaatgg ggacactcgt
     3481 gtgggcctgt ttgccgtctg tgacattcct gcagggacgg agctgacttt taactacaac
     3541 ctcgattgtc tgggcaatga aaaaacggtc tgccggtgtg gagcctccaa ttgcagtgga
     3601 ttcctcgggg atagaccaaa gacctcgacg accctttcat cagaggaaaa gggcaaaaag
     3661 accaagaaga aaacgaggcg gcgcagagca aaaggggaag ggaagaggca gtcagaggac
     3721 gagtgcttcc gctgcggtga tggcgggcag ctggtgctgt gtgaccgcaa gttctgcacc
     3781 aaggcctacc acctgtcctg cctgggcctt ggcaagcggc ccttcgggaa gtgggaatgt
     3841 ccttggcatc attgtgacgt gtgtggcaaa ccttcgactt cattttgcca cctctgcccc
     3901 aattcgttct gtaaggagca ccaggacggg acagccttca gctgcacccc ggacgggcgg
     3961 tcctactgct gtgagcatga cttaggggcg gcatcggtca gaagcaccaa gactgagaag
     4021 ccccccccag agccagggaa gccgaagggg aagaggcggc ggcggagggg ctggcggaga
     4081 gtcacagagg gcaaatag
//
