LOCUS       sequence-180691-       18956 bp    DNA     circular SYN 15-DEC-2025
DEFINITION  Dicot Target-AID vector expressing dicot-optimized nCas9-PmCDA1 with
            sgRNA targeting SlDella.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      synthetic DNA construct
  ORGANISM  synthetic DNA construct
REFERENCE   1  (bases 1 to 18956)
  AUTHORS   Shimatani Z, Kashojiya S, Takayama M, Terada R, Arazoe T, Ishii H, 
            Teramura H, Yamamoto T, Komatsu H, Miura K, Ezura H, Nishida K, 
            Ariizumi T, Kondo A
  TITLE     Targeted base editing in rice and tomato using a CRISPR-Cas9 
            cytidine deaminase fusion.
  JOURNAL   Nat Biotechnol. 2017 Mar 27. doi: 10.1038/nbt.3833.
  PUBMED    28346401
REFERENCE   2  (bases 1 to 18956)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Nat 
            Biotechnol. 2017 Mar 27. doi: 10.1038/nbt.3833."
COMMENT     Sequence Label: pDicAID_nCas9-PmCDA_NptII_Della
FEATURES             Location/Qualifiers
     source          1..18956
                     /mol_type="other DNA"
                     /organism="synthetic DNA construct"
     misc_feature    113..137
                     /label=RB T-DNA repeat
                     /note="right border repeat from nopaline C58 T-DNA"
     protein_bind    295..316
                     /label=CAP binding site
                     /bound_moiety="E. coli catabolite activator protein"
                     /note="CAP binding activates transcription in the presence 
                     of cAMP."
     promoter        join(331..336,337..354,355..361)
                     /label=lac promoter
                     /note="promoter for the E. coli lac operon"
     protein_bind    369..385
                     /label=lac operator
                     /bound_moiety="lac repressor encoded by lacI"
                     /note="The lac repressor binds to the lac operator to 
                     inhibit transcription in E. coli. This inhibition can be 
                     relieved by adding lactose or 
                     isopropyl-beta-D-thiogalactopyranoside (IPTG)."
     primer_bind     374..396
                     /label=M13/pUC Reverse
                     /note="In lacZ gene"
     primer_bind     393..409
                     /label=M13 rev
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     primer_bind     393..409
                     /label=M13 Reverse
                     /note="In lacZ gene. Also called M13-rev"
     protein_bind    485..509
                     /gene="mutant version of attB"
                     /label=attB1
                     /bound_moiety="BP Clonase(TM)"
                     /note="recombination site for the Gateway(R) BP reaction"
     protein_bind    578..677
                     /gene="mutant version of attL"
                     /label=attL2
                     /bound_moiety="LR Clonase(TM)"
                     /note="recombination site for the Gateway(R) LR reaction"
     protein_bind    683..707
                     /gene="mutant version of attB"
                     /label=attB2
                     /bound_moiety="BP Clonase(TM)"
                     /note="recombination site for the Gateway(R) BP reaction"
     misc_RNA        complement(719..794)
                     /label=gRNA scaffold
                     /note="guide RNA scaffold for the Streptococcus pyogenes 
                     CRISPR/Cas9 system"
     protein_bind    complement(1203..1302)
                     /gene="mutant version of attL"
                     /label=attL1
                     /bound_moiety="LR Clonase(TM)"
                     /note="recombination site for the Gateway(R) LR reaction"
     primer_bind     1322..1338
                     /label=pBluescriptKS
                     /note="For pBluescript vector"
     primer_bind     1323..1339
                     /label=KS primer
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     protein_bind    complement(1443..1566)
                     /gene="mutant version of attR"
                     /label=attR4
                     /bound_moiety="LR Clonase(TM)"
                     /note="recombination site for the Gateway(R) LR reaction"
     CDS             join(2507..2533,2534..2536,2537..6610)
                     /codon_start=1
                     /product="nickase mutant of the Cas9 endonuclease from the 
                     Streptococcus pyogenes Type II CRISPR/Cas system"
                     /label=Cas9(D10A)
                     /note="generates RNA-guided single strand nicks in DNA due 
                     to the D10A mutation in the RuvC catalytic domain"
                     /translation="MDKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKK
                     NLIGALLFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEES
                     FLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIK
                     FRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRL
                     ENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQ
                     IGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVR
                     QQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLL
                     RKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARG
                     NSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEY
                     FTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFD
                     SVEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEER
                     LKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFM
                     QLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGR
                     HKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLY
                     LYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVP
                     SEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKH
                     VAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYL
                     NAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKT
                     EITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQTGGFSK
                     ESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGI
                     TIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNE
                     LALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILAD
                     ANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVL
                     DATLIHQSITGLYETRIDLSQLGGD"
     CDS             6623..6643
                     /codon_start=1
                     /product="nuclear localization signal of SV40 (simian virus
                     40) large T antigen"
                     /label=SV40 NLS
                     /translation="PKKKRKV"
     CDS             6836..6901
                     /codon_start=1
                     /product="three tandem FLAG(R) epitope tags, followed by an
                     enterokinase cleavage site"
                     /label=3xFLAG
                     /translation="DYKDHDGDYKDHDIDYKDDDDK"
     CDS             6908..7531
                     /codon_start=1
                     /product="cytidine deaminase from the sea lamprey 
                     Petromyzon marinus (Rogozin et al., 2007)"
                     /label=PmCDA1
                     /translation="MTDAEYVRIHEKLDIYTFKKQFFNNKKSVSHRCYVLFELKRRGER
                     RACFWGYAVNKPQSGTERGIHAEIFSIRKVEEYLRDNPGQFTINWYSSWSPCADCAEKI
                     LEWYNQELRGNGHTLKIWACKLYYEKNARNQIGLWNLRDNGVGLNVMVSEHYQCCRKIF
                     IQSSHNQLNENRWLEKTLKRAEKRRSELSIMIQVKILHTTKSPAV"
     CDS             7535..7555
                     /codon_start=1
                     /product="nuclear localization signal of SV40 (simian virus
                     40) large T antigen"
                     /label=SV40 NLS
                     /translation="PKKKRKV"
     promoter        9833..10178
                     /label=CaMV 35S promoter
                     /note="strong constitutive promoter from cauliflower mosaic
                     virus"
     primer_bind     10121..10141
                     /label=35S promoter
                     /note="CaMV 35S promoter, forward primer"
     CDS             10193..10990
                     /codon_start=1
                     /gene="aph(3')-II (or nptII)"
                     /product="aminoglycoside phosphotransferase from Tn5"
                     /label=NeoR/KanR
                     /note="confers resistance to neomycin, kanamycin, and G418 
                     (Geneticin(R))"
                     /translation="MGIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGR
                     PVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLL
                     SSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEH
                     QGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDI
                     ALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF"
     primer_bind     complement(10250..10269)
                     /label=Neo-R
                     /note="Neomycin resistance gene, reverse primer"
     primer_bind     10860..10879
                     /label=Neo-F
                     /note="Neomycin resistance gene, forward primer"
     protein_bind    complement(12142..12266)
                     /gene="mutant version of attR"
                     /label=attR2
                     /bound_moiety="LR Clonase(TM)"
                     /note="recombination site for the Gateway(R) LR reaction"
     primer_bind     complement(12306..12323)
                     /label=M13 Forward
                     /note="In lacZ gene. Also called M13-F20 or M13 (-21) 
                     Forward"
     primer_bind     complement(12306..12322)
                     /label=M13 fwd
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     primer_bind     complement(12315..12337)
                     /label=M13/pUC Forward
                     /note="In lacZ gene"
     misc_feature    12537..12561
                     /label=LB T-DNA repeat
                     /note="left border repeat from nopaline C58 T-DNA"
     CDS             13082..13873
                     /codon_start=1
                     /gene="aadA"
                     /product="aminoglycoside adenylyltransferase (Murphy, 
                     1985)"
                     /label=SmR
                     /note="confers resistance to spectinomycin and 
                     streptomycin"
                     /translation="MGEAVIAEVSTQLSEVVGVIERHLEPTLLAVHLYGSAVDGGLKPH
                     SDIDLLVTVTVRLDETTRRALINDLLETSASPGESEILRAVEVTIVVHDDIIPWRYPAK
                     RELQFGEWQRNDILAGIFEPATIDIDLAILLTKAREHSVALVGPAAEELFDPVPEQDLF
                     EALNETLTLWNSPPDWAGDERNVVLTLSRIWYSAVTGKIAPKDVAADWAMERLPAQYQP
                     VILEARQAYLGQEEDRLASRADQLEEFVHYVKGEITKVVGK"
     rep_origin      14119..14707
                     /direction=RIGHT
                     /label=ori
                     /note="high-copy-number ColE1/pMB1/pBR322/pUC origin of 
                     replication"
     primer_bind     14608..14627
                     /label=pBR322ori-F
                     /note="pBR322 origin, forward primer"
     primer_bind     14861..14878
                     /label=L4440
                     /note="L4440 vector, forward primer"
     misc_feature    14893..15033
                     /label=bom
                     /note="basis of mobility region from pBR322"
     primer_bind     complement(14959..14978)
                     /label=pRS-marker
                     /note="pRS vectors, use to sequence yeast selectable 
                     marker"
     primer_bind     15119..15141
                     /label=pGEX 3'
                     /note="pGEX vectors, reverse primer"
     rep_origin      15377..15571
                     /label=pVS1 oriV
                     /note="origin of replication for the Pseudomonas plasmid 
                     pVS1 (Heeb et al., 2000)"
     CDS             complement(15637..16710)
                     /codon_start=1
                     /product="replication protein from the Pseudomonas plasmid 
                     pVS1 (Heeb et al., 2000)"
                     /label=pVS1 RepA
                     /translation="MSGRKPSGPVQIGAALGDDLVEKLKAAQAAQRQRIEAEARPGESW
                     QAAADRIRKESRQPPAAGAPSIRKPPKGDEQPDFFVPMLYDVGTRDSRSIMDVAVFRLS
                     KRDRRAGEVIRYELPDGHVEVSAGPAGMASVWDYDLVLMAVSHLTESMNRYREGKGDKP
                     GRVFRPHVADVLKFCRRADGGKQKDDLVETCIRLNTTHVAMQRTKKAKNGRLVTVSEGE
                     ALISRYKIVKSETGRPEYIEIELADWMYREITEGKNPDVLTVHPDYFLIDPGIGRFLYR
                     LARRAAGKAEARWLFKTIYERSGSAGEFKKFCFTVRKLIGSNDLPEYDLKEEAGQAGPI
                     LVMRYRNLIEGEASAGS"
     CDS             complement(17139..17768)
                     /codon_start=1
                     /product="stability protein from the Pseudomonas plasmid 
                     pVS1 (Heeb et al., 2000)"
                     /label=pVS1 StaA
                     /translation="MKVIAVLNQKGGSGKTTIATHLARALQLAGADVLLVDSDPQGSAR
                     DWAAVREDQPLTVVGIDRPTIDRDVKAIGRRDFVVIDGAPQAADLAVSAIKAADFVLIP
                     VQPSPYDIWATADLVELVKQRIEVTDGRLQAAFVVSRAIKGTRIGGEVAEALAGYELPI
                     LESRITQRVSYPGTAAAGTTVLESEPEGDAAREVQALAAEIKSKLI"
ORIGIN
        1 gatcccgagg ggaaccctgt ggttggcatg cacatacaaa tggacgaacg gataaacctt
       61 ttcacgccct tttaaatatc cgattattct aataaacgct cttttctctt aggtttaccc
      121 gccaatatat cctgtcaaac actgatagtt taaactgaag gcgggaaacg acaatctgat
      181 ccaagctcaa gctccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg
      241 cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt
      301 gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt
      361 gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgaca tgattacgaa
      421 tttcaggtga ctgatagtga cctgttcgtt gcaacaaatt gatgagcaat gcttttttat
      481 aatgccaact ttgtacaaaa aagcaggcgg cgcgtcctgc aggataggga taacagggta
      541 atttaattaa ggtaccgagc tcggatccac tagtgatcaa ataatgattt tattttgact
      601 gatagtgacc tgttcgttgc aacaaattga tgagcaatta ttttttataa tgccaacttt
      661 gtacaagaaa gctgggttaa tgccaacttt gtacaagaaa gctgggtcta gaaaaaaagc
      721 accgactcgg tgccactttt tcaagttgat aacggactag ccttatttta acttgctatt
      781 tctagctcta aaacggcgga ggtagctata agtgcaatca ctacttcgac tctagctgta
      841 tataaactca gcttcgtttt cttatctaag cgatgtggga cttttgaaga ttgttttcaa
      901 cttaaatggg cctatataag aaatactatt gttctttccc atataaatgg gcctgcttct
      961 cttctttcag attcccaggg gccttttgaa gattatcttc atatcttaag aatgaagatg
     1021 ttttattcaa tcaaattctt gaaggttcga tgcctaatca ttctaatcct gggacaaact
     1081 atgaaacaag atacaaaaac tccgaatgga aagttaaaaa gaagaaaacg aaagctacgg
     1141 ttcaagaaaa tgtaagctga taaacaaaaa aaaactgtat gaacgaagaa gaagaaaaaa
     1201 agagcctgct tttttgtaca aagttggcat tataaaaaag cattgctcat caatttgttg
     1261 caacgaacag gtcactatca gtcaaaataa aatcattatt tgatcgaatt cccgcggccg
     1321 ctcgaggtcg acggtatcga taagcttggc gcgccattac cctgttatcc ctatcctgca
     1381 ggattaacac ccaacttttc tatggcccct acaggtcact aataccatct aagtagttga
     1441 ttcatagtga ctggatatgt tgtgttttac agtattatgt agtctgtttt ttatgcaaaa
     1501 tctaatttaa tatattgata tttatatcat tttacgtttc tcgttcaact tttctataca
     1561 aagttgaaga tctgactagc aacgattgta caattgcttc tttaaaaaag gaagaaagaa
     1621 agaaagaaaa gaatcaacat cagcgttaac aaacggcccc gttacggccc aaacggtcat
     1681 atagagtaac ggcgttaagc gttgaaagac tcctatcgaa atacgtaacc gcaaacgtgt
     1741 catagtcaga tcccctcttc cttcaccgcc tcaaacacaa aaataatctt ctacagccta
     1801 tatatacaac ccccccttct atctctcctt tctcacaatt catcatcttt ctttctctac
     1861 ccccaatttt aagaaatcct ctcttctcct cttcattttc aaggtaaatc tctctctctc
     1921 tctctctctc tgttattcct tgttttaatt aggtatgtat tattgctagt ttgttaatct
     1981 gcttatctta tgtatgcctt atgtgaatat ctttatcttg ttcatctcat ccgtttagaa
     2041 gctataaatt tgttgatttg actgtgtatc tacacgtggt tatgtttata tctaatcaga
     2101 tatgaatttc ttcatattgt tgcgtttgtg tgtaccaatc cgaaatcgtt gatttttttc
     2161 atttaatcgt gtagctaatt gtacgtatac atatggatct acgtatcaat tgttcatctg
     2221 tttgtgtttg tatgtataca gatctgaaaa catcacttct ctcatctgat tgtgttgtta
     2281 catacataga tatagatctg ttatatcatt ttttttatta attgtgtata tatatatgtg
     2341 catagatctg gattacatga ttgtgattat ttacatgatt ttgttattta cgtatgtata
     2401 tatgtagatc tggacttttt ggagttgttg acttgattgt atttgtgtgt gtatatgtgt
     2461 gttctgatct tgatatgtta tgtatgtgca gcgaattcgg cgcgcaatgg ataagaagta
     2521 ctctatcgga ctcgctatcg gaactaactc tgtgggatgg gctgtgatca ccgatgagta
     2581 caaggtgcca tctaagaagt tcaaggttct cggaaacacc gataggcact ctatcaagaa
     2641 aaaccttatc ggtgctctcc tcttcgattc tggtgaaact gctgaggcta ccagactcaa
     2701 gagaaccgct agaagaaggt acaccagaag aaagaacagg atctgctacc tccaagagat
     2761 cttctctaac gagatggcta aagtggatga ttcattcttc cacaggctcg aagagtcatt
     2821 cctcgtggaa gaagataaga agcacgagag gcaccctatc ttcggaaaca tcgttgatga
     2881 ggtggcatac cacgagaagt accctactat ctaccacctc agaaagaagc tcgttgattc
     2941 tactgataag gctgatctca ggctcatcta cctcgctctc gctcacatga tcaagttcag
     3001 aggacacttc ctcatcgagg gtgatctcaa ccctgataac tctgatgtgg ataagttgtt
     3061 catccagctc gtgcagacct acaaccagct tttcgaagag aaccctatca acgcttcagg
     3121 tgtggatgct aaggctatcc tctctgctag gctctctaag tcaagaaggc ttgagaacct
     3181 cattgctcag ctccctggtg agaagaagaa cggacttttc ggaaacttga tcgctctctc
     3241 tctcggactc acccctaact tcaagtctaa cttcgatctc gctgaggatg caaagctcca
     3301 gctctcaaag gatacctacg atgatgatct cgataacctc ctcgctcaga tcggagatca
     3361 gtacgctgat ttgttcctcg ctgctaagaa cctctctgat gctatcctcc tcagtgatat
     3421 cctcagagtg aacaccgaga tcaccaaggc tccactctca gcttctatga tcaagagata
     3481 cgatgagcac caccaggatc tcacacttct caaggctctt gttagacagc agctcccaga
     3541 gaagtacaaa gagattttct tcgatcagtc taagaacgga tacgctggtt acatcgatgg
     3601 tggtgcatct caagaagagt tctacaagtt catcaagcct atcctcgaga agatggatgg
     3661 aaccgaggaa ctcctcgtga agctcaatag agaggatctt ctcagaaagc agaggacctt
     3721 cgataacgga tctatccctc atcagatcca cctcggagag ttgcacgcta tccttagaag
     3781 gcaagaggat ttctacccat tcctcaagga taacagggaa aagattgaga agattctcac
     3841 cttcagaatc ccttactacg tgggacctct cgctagagga aactcaagat tcgcttggat
     3901 gaccagaaag tctgaggaaa ccatcacccc ttggaacttc gaagaggtgg tggataaggg
     3961 tgctagtgct cagtctttca tcgagaggat gaccaacttc gataagaacc ttccaaacga
     4021 gaaggtgctc cctaagcact ctttgctcta cgagtacttc accgtgtaca acgagttgac
     4081 caaggttaag tacgtgaccg agggaatgag gaagcctgct tttttgtcag gtgagcaaaa
     4141 gaaggctatc gttgatctct tgttcaagac caacagaaag gtgaccgtga agcagctcaa
     4201 agaggattac ttcaagaaaa tcgagtgctt cgattcagtt gagatttctg gtgttgagga
     4261 taggttcaac gcatctctcg gaacctacca cgatctcctc aagatcatta aggataagga
     4321 tttcttggat aacgaggaaa acgaggatat cttggaggat atcgttctta ccctcaccct
     4381 ctttgaagat agagagatga ttgaagaaag gctcaagacc tacgctcatc tcttcgatga
     4441 taaggtgatg aagcagttga agagaagaag atacactggt tggggaaggc tctcaagaaa
     4501 gctcattaac ggaatcaggg ataagcagtc tggaaagaca atccttgatt tcctcaagtc
     4561 tgatggattc gctaacagaa acttcatgca gctcatccac gatgattctc tcacctttaa
     4621 agaggatatc cagaaggctc aggtttcagg acagggtgat agtctccatg agcatatcgc
     4681 taacctcgct ggatctcctg caatcaagaa gggaatcctc cagactgtga aggttgtgga
     4741 tgagttggtg aaggtgatgg gaaggcataa gcctgagaac atcgtgatcg aaatggctag
     4801 agagaaccag accactcaga agggacagaa gaactctagg gaaaggatga agaggatcga
     4861 ggaaggtatc aaagagcttg gatctcagat cctcaaagag caccctgttg agaacactca
     4921 gctccagaat gagaagctct acctctacta cctccagaac ggaagggata tgtatgtgga
     4981 tcaagagttg gatatcaaca ggctctctga ttacgatgtt gatcatatcg tgccacagtc
     5041 attcttgaag gatgattcta tcgataacaa ggtgctcacc aggtctgata agaacagggg
     5101 taagagtgat aacgtgccaa gtgaagaggt tgtgaagaaa atgaagaact attggaggca
     5161 gctcctcaac gctaagctca tcactcagag aaagttcgat aacttgacta aggctgagag
     5221 gggaggactc tctgaattgg ataaggcagg attcatcaag aggcagcttg tggaaaccag
     5281 gcagatcact aagcacgttg cacagatcct cgattctagg atgaacacca agtacgatga
     5341 gaacgataag ttgatcaggg aagtgaaggt tatcaccctc aagtcaaagc tcgtgtctga
     5401 tttcagaaag gatttccaat tctacaaggt gagggaaatc aacaactacc accacgctca
     5461 cgatgcttac cttaacgctg ttgttggaac cgctctcatc aagaagtatc ctaagctcga
     5521 gtcagagttc gtgtacggtg attacaaggt gtacgatgtg aggaagatga tcgctaagtc
     5581 tgagcaagag atcggaaagg ctaccgctaa gtatttcttc tactctaaca tcatgaattt
     5641 cttcaagacc gagattaccc tcgctaacgg tgagatcaga aagaggccac tcatcgagac
     5701 aaacggtgaa acaggtgaga tcgtgtggga taagggaagg gatttcgcta ccgttagaaa
     5761 ggtgctctct atgccacagg tgaacatcgt taagaaaacc gaggtgcaga ccggtggatt
     5821 ctctaaagag tctatcctcc ctaagaggaa ctctgataag ctcattgcta ggaagaagga
     5881 ttgggaccct aagaaatacg gtggtttcga ttctcctacc gtggcttact ctgttctcgt
     5941 tgtggctaag gttgagaagg gaaagagtaa gaagctcaag tctgttaagg aacttctcgg
     6001 aatcactatc atggaaaggt catctttcga gaagaaccca atcgatttcc tcgaggctaa
     6061 gggatacaaa gaggttaaga aggatctcat catcaagctc ccaaagtact cactcttcga
     6121 actcgagaac ggtagaaaga ggatgctcgc ttctgctggt gagcttcaaa agggaaacga
     6181 gcttgctctc ccatctaagt acgttaactt tctttacctc gcttctcact acgagaagtt
     6241 gaagggatct ccagaagata acgagcagaa gcaacttttc gttgagcagc acaagcacta
     6301 cttggatgag atcatcgagc agatctctga gttctctaaa agggtgatcc tcgctgatgc
     6361 aaacctcgat aaggtgttgt ctgcttacaa caagcacaga gataagccta tcagggaaca
     6421 ggcagagaac atcatccatc tcttcaccct taccaacctc ggtgctcctg ctgctttcaa
     6481 gtacttcgat acaaccatcg ataggaagag atacacctct accaaagaag tgctcgatgc
     6541 taccctcatc catcagtcta tcactggact ctacgagact aggatcgatc tctcacagct
     6601 cggtggtgat tcaagggctg atcctaagaa gaagaggaag gttggaggag ggccaggagc
     6661 agagtatgtt agagcgttgt ttgattttaa cggtaacgat gaagaggatt taccctttaa
     6721 gaaaggcgac attctcagga ttagggataa acctgaagag caatggtgga atgctgagga
     6781 tagtgaaggc aaacgaggaa tgattttagt gccgtatgtg gagaaatatt cgggtgacta
     6841 caaagatcat gatggtgatt acaaagacca tgacatcgac tacaaggatg atgatgataa
     6901 gtcagggatg acagatgctg aatatgtcag aatccacgaa aagttggaca tttacacgtt
     6961 taagaagcag ttcttcaaca acaagaaatc tgtttcgcat aggtgctatg tgcttttcga
     7021 actaaaacgt cgtggagaaa gacgggcttg cttttggggt tacgcggtta acaaaccaca
     7081 atcaggtact gaacgaggaa tacacgctga aatcttttct atccgaaagg ttgaggaata
     7141 tctacgtgac aatcctggac agttcactat caattggtat tctagctggt caccatgtgc
     7201 agattgtgct gagaagattc tcgaatggta caatcaagag cttagaggca atggacatac
     7261 attgaaaata tgggcatgca agctctacta cgaaaagaat gccagaaacc aaattgggct
     7321 ttggaacttg agggataatg gagttgggct taatgtcatg gtttctgagc actatcaatg
     7381 ttgtcggaag atcttcatac aaagttccca taaccagttg aatgagaaca gatggttaga
     7441 gaaaaccctt aaaagagccg agaagagaag atccgaactg agcattatga tacaggtcaa
     7501 aattctgcat accactaaga gtccagctgt aggtcctaag aagaaacgta aagtagggcc
     7561 ctgatccagg cctcccagct ttcgtccgta tcatcggttt cgacaacgtt cgtcaagttc
     7621 aatgcatcag tttcattgcc cacacaccag aatcctacta agtttgagta ttatggcatt
     7681 ggaaaagctg ttttcttcta tcatttgttc tgcttgtaat ttactgtgtt ctttcagttt
     7741 ttgttttcgg acatcaaaat gcaaatggat ggataagagt taataaatga tatggtcctt
     7801 ttgttcattc tcaaattatt attatctgtt gtttttactt taatgggttg aatttaagta
     7861 agaaaggaac taacagtgtg atattaaggt gcaatgttag acatataaaa cagtctttca
     7921 cctctctttg gttatgtctt gaattggttt gtttcttcac ttatctgtgt aatcaagttt
     7981 actatgagtc tatgatcaag taattatgca atcaagttaa gtacagtata ggcttgagct
     8041 ccctaggccc ctaggtaatt cttcggaccc aagaatgcta agccaagagg agctgttatc
     8101 gccgtcctcc tgcttgtttc tctctttttg ttgctgtttc ttcattagcg tggacaaagt
     8161 tttcaaccgg cctatctgtt atcattttct tctattcaaa gactgtaata cctattgcta
     8221 cctgtggttc tcacttgtga ttttggacac atatgttcgg tttattcaaa tttaatcaga
     8281 tgcctgatga gggtaccaga aaaaatacgt gttctggttg tttttgagtt gcgattattc
     8341 tatgaaatga ataacatcga agttatcatc ccagtatttt cgcatgaatg ttcttttctt
     8401 ctgtcttgtg catcagtgat ctagtgcatg ggagtttgta ttgtgatgtt cgacatcacg
     8461 taacttccac tttgcctttg ctgttcgata ttttaatgac atgtcacaca cacttctgat
     8521 acttttcttt cttggctatt gtgccagcat gatgcaagat gcatcacagc atcagatata
     8581 ttctcatcgt caggctttag cagcacacga gcacgctttg ccgcttaaaa gttgtacggc
     8641 gcagcttaga catcccctgt agaagtgata atcttttcac ttttccttaa acaaattgag
     8701 aggggaaatg gaaccatgtg gatcagagaa gcttttgttt ctttacacaa gaatatttgg
     8761 tacagtgggg gtcctatgtt cgtgggttcg tggcttggct gcctgtcttc aaccaagtgt
     8821 tttcagttca acatgttagc gtgtagaaag agcacaattc tgtttatctc caaggtaaaa
     8881 tgtggcattc tgttaaagaa catgatcctg ccaatttttt aagtttcaat ggaagaggaa
     8941 tgtaaagctt tctatggttt gtgtacacaa cacagtggaa gaggagtgca agctttctat
     9001 ggtttgtgtg cgcgttgtgt gtcagcactt caattttgtt agaaaatgaa agaaaaaaaa
     9061 ggatgatcat gcttatagta aatcactctt tttcctcgcc ttctgtacgt tttgacttga
     9121 caagatttta aaatctgtac atgacctttg ttttaaaatt actttatgta tttccatctt
     9181 tcaagttatg cagatgtcat cacaaattgt tacaccaatc accaggctgg ctgtttatat
     9241 attatcagac caggctatat agagtatact atactaactg ttcatattat ctggaaatct
     9301 tgcttgctac ttgagcggta aaagggtata gatatgaggg tccccagatt agccttttca
     9361 atttcagaaa gaatgctaac ccacagatgg ttagagaggc ttacgcagca ggtctcatca
     9421 agacgatcta cccgagcaat aatctccagg aaatcaaata ccttcccaag aaggttaaag
     9481 atgcagtcaa aagattcagg actaactgca tcaagaacac agagaaagat atatttctca
     9541 agatcagaag tactattcca gtatggacga ttcaaggctt gcttcacaaa ccaaggcaag
     9601 taatagagat tggagtctct aaaaaggtag ttcccactga atcaaaggcc atggagtcaa
     9661 agattcaaat agaggaccta acagaactcg ccgtaaagac tggcgaacag ttcatacaga
     9721 gtctcttacg actcaatgac aagaagaaaa tcttcgtcaa catggtggag cacgacacac
     9781 ttgtctactc caaaaatatc aaagatacag tctcagaaga ccaaagggca attgagactt
     9841 ttcaacaaag ggtaatatcc ggaaacctcc tcggattcca ttgcccagct atctgtcact
     9901 ttattgtgaa gatagtggaa aaggaaggtg gctcctacaa atgccatcat tgcgataaag
     9961 gaaaggccat cgttgaagat gcctctgccg acagtggtcc caaagatgga cccccaccca
    10021 cgaggagcat cgtggaaaaa gaagacgttc caaccacgtc ttcaaagcaa gtggattgat
    10081 gtgatatctc cactgacgta agggatgacg cacaatccca ctatccttcg caagaccctt
    10141 cctctatata aggaagttca tttcatttgg agagaacacg ggggactcta gaatggggat
    10201 tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc tattcggcta
    10261 tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgtttcggc tgtcagcgca
    10321 ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg aactccagga
    10381 cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga
    10441 cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg ggcaggatct
    10501 cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg caatgcggcg
    10561 gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac atcgcatcga
    10621 gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg acgaagagca
    10681 tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgcgcatgc ccgacggcga
    10741 ggatctcgtc gtgacacatg gcgatgcctg cttgccgaat atcatggtgg aaaatggccg
    10801 cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc aggacatagc
    10861 gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt
    10921 gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc ttctcgacga
    10981 gttcttctga gagctctggg ctaatctaaa acgatttatc tgtggcttca agtgtatcga
    11041 tcacttatgt gaggtgtaat tactggtgtt tttggtgtgc tctggttcct ttcaagtgtg
    11101 ttgttgccgc tcgaactact ccgctatgta aaacggtaaa acctgttgtc tcattatgaa
    11161 agtgaactat attatgttct actactactc tacttagtca attttcttca ccttgattag
    11221 tgtaaatatg aatcttatat tcttatgtct taagaaatta gcacatgtga agcctccaag
    11281 tgcatatttt ctcgatcgcg agacgcacaa tgcgtgagaa attcagctgg ttatactcaa
    11341 atatattaat atatctagca gcagctcatg gagattcagg aaacttggca tccctaatcc
    11401 ctaccatttc cattcttccg agattgacag ttcaatacaa gtacagtaat ctcctggtaa
    11461 gtttcttatt aacttgacat gtagtagtaa taatttgtac gtagcataga tacatagaca
    11521 caaaaatgtc ctccccattg agctagccga ttggagccga acaccgcagg aatgaattta
    11581 cataatctgc aaagaataaa tggaatgtgc ctccacagga aaaccagcgg cagtgtggcg
    11641 ttttcaagag cagccgtaag tcgaagccta ttctgaatcg tagaaatcac tggggcatgg
    11701 tgtaattaca tccgactcca acatctgtac caccctgtgc attgtaggcc gctcctctgg
    11761 caaagaactt acacattgtt tagcaagaga aagtagagca tccaaggtct caatctgcac
    11821 tccctcacaa tatggatcga caatttccct ctcccgattc tcaccgacca ggaaattcaa
    11881 ctgccacaga gcaagtagat tatttcaaga atacattaaa tcaattgaag gcatacgtaa
    11941 ttcatatcag aaaactgtgg atatgaaatg gaaggacata aaggtcatac atacccatcc
    12001 aacaatgttc aatccctttt caataaatga tgcatcagta ggtcgttttc cgcttagtat
    12061 ttcaagtagc aaaactccaa aactgtagac gtcagtcttt tcggtggctc tgccactttg
    12121 catatactcc tgcaggtcga ccatagtgac tggatatgtt gtgttttaca gtattatgta
    12181 gtctgttttt tatgcaaaat ctaatttaat atattgatat ttatatcatt ttacgtttct
    12241 cgttcagctt tcttgtacaa agtggtgata tcccgcggaa atacgtagaa ttcgggaagc
    12301 ttggcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt
    12361 aatcgccttg cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc
    12421 gatcgccctt cccaacagtt gcgcagcctg aatggcgaat gctagagcaa ttcggcgtta
    12481 attcagtaca ttaaaaacgt ccgcaatgtg ttattaagtt gtctaagcgt caatttgttt
    12541 acaccacaat atatcctgcc accagccagc caacagctcc ccgaccggca gctcggcaca
    12601 aaatcaccac tcgatacagg cagcccatca gtccgggacg gcgtcagcgg gagagccgtt
    12661 gtaaggcggc agactttgct catgttaccg atgctattcg gaagaacggc aactaagctg
    12721 ccgggtttga aacacggatg atctcgcgga gggtagcatg ttgattgtaa cgatgacaga
    12781 gcgttgctgc ctgtgatcaa ttcgggcacg aacccagtgg acataagcct gttcggttcg
    12841 taagctgtaa tgcaagtagc gtatgcgctc acgcaactgg tccagaacct tgaccgaacg
    12901 cagcggtggt aacggcgcag tggcggtttt catggcttgt tatgactgtt tttttggggt
    12961 acagtctatg cctcgggcat ccaagcagca agcgcgttac gccgtgggtc gatgtttgat
    13021 gttatggagc agcaacgatg ttacgcagca gggcagtcgc cctaaaacaa agttaaacat
    13081 catgggggaa gcggtgatcg ccgaagtatc gactcaacta tcagaggtag ttggcgtcat
    13141 cgagcgccat ctcgaaccga cgttgctggc cgtacatttg tacggctccg cagtggatgg
    13201 cggcctgaag ccacacagtg atattgattt gctggttacg gtgaccgtaa ggcttgatga
    13261 aacaacgcgg cgagctttga tcaacgacct tttggaaact tcggcttccc ctggagagag
    13321 cgagattctc cgcgctgtag aagtcaccat tgttgtgcac gacgacatca ttccgtggcg
    13381 ttatccagct aagcgcgaac tgcaatttgg agaatggcag cgcaatgaca ttcttgcagg
    13441 tatcttcgag ccagccacga tcgacattga tctggctatc ttgctgacaa aagcaagaga
    13501 acatagcgtt gccttggtag gtccagcggc ggaggaactc tttgatccgg ttcctgaaca
    13561 ggatctattt gaggcgctaa atgaaacctt aacgctatgg aactcgccgc ccgactgggc
    13621 tggcgatgag cgaaatgtag tgcttacgtt gtcccgcatt tggtacagcg cagtaaccgg
    13681 caaaatcgcg ccgaaggatg tcgctgccga ctgggcaatg gagcgcctgc cggcccagta
    13741 tcagcccgtc atacttgaag ctagacaggc ttatcttgga caagaagaag atcgcttggc
    13801 ctcgcgcgca gatcagttgg aagaatttgt ccactacgtg aaaggcgaga tcaccaaggt
    13861 agtcggcaaa taatgtctag ctagaaattc gttcaagccg acgccgcttc gcggcgcggc
    13921 ttaactcaag cgttagatgc actaagcaca taattgctca cagccaaact atcaggtcaa
    13981 gtctgctttt attattttta agcgtgcata ataagcccta cacaaattgg gagatatatc
    14041 atgcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga
    14101 aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac
    14161 aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt
    14221 tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc
    14281 gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat
    14341 cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag
    14401 acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc
    14461 cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag
    14521 cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac
    14581 aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg
    14641 gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct
    14701 atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc
    14761 tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga
    14821 gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga
    14881 agcggaagag cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg
    14941 catatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc agtatacact
    15001 ccgctatcgc tacgtgactg ggtcatggct gcgccccgac acccgccaac acccgctgac
    15061 gcgccctgac gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc
    15121 gggagctgca tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag gcagggtgcc
    15181 ttgatgtggg cgccggcggt cgagtggcga cggcgcggct tgtccgcgcc ctggtagatt
    15241 gcctggccgt aggccagcca tttttgagcg gccagcggcc gcgataggcc gacgcgaagc
    15301 ggcggggcgt agggagcgca gcgaccgaag ggtaggcgct ttttgcagct cttcggctgt
    15361 gcgctggcca gacagttatg cacaggccag gcgggtttta agagttttaa taagttttaa
    15421 agagttttag gcggaaaaat cgcctttttt ctcttttata tcagtcactt acatgtgtga
    15481 ccggttccca atgtacggct ttgggttccc aatgtacggg ttccggttcc caatgtacgg
    15541 ctttgggttc ccaatgtacg tgctatccac aggaaagaga ccttttcgac ctttttcccc
    15601 tgctagggca atttgcccta gcatctgctc cgtacattag gaaccggcgg atgcttcgcc
    15661 ctcgatcagg ttgcggtagc gcatgactag gatcgggcca gcctgccccg cctcctcctt
    15721 caaatcgtac tccggcaggt catttgaccc gatcagcttg cgcacggtga aacagaactt
    15781 cttgaactct ccggcgctgc cactgcgttc gtagatcgtc ttgaacaacc atctggcttc
    15841 tgccttgcct gcggcgcggc gtgccaggcg gtagagaaaa cggccgatgc cgggatcgat
    15901 caaaaagtaa tcggggtgaa ccgtcagcac gtccgggttc ttgccttctg tgatctcgcg
    15961 gtacatccaa tcagctagct cgatctcgat gtactccggc cgcccggttt cgctctttac
    16021 gatcttgtag cggctaatca aggcttcacc ctcggatacc gtcaccaggc ggccgttctt
    16081 ggccttcttc gtacgctgca tggcaacgtg cgtggtgttt aaccgaatgc aggtttctac
    16141 caggtcgtct ttctgctttc cgccatcggc tcgccggcag aacttgagta cgtccgcaac
    16201 gtgtggacgg aacacgcggc cgggcttgtc tcccttccct tcccggtatc ggttcatgga
    16261 ttcggttaga tgggaaaccg ccatcagtac caggtcgtaa tcccacacac tggccatgcc
    16321 ggccggccct gcggaaacct ctacgtgccc gtctggaagc tcgtagcgga tcacctcgcc
    16381 agctcgtcgg tcacgcttcg acagacggaa aacggccacg tccatgatgc tgcgactatc
    16441 gcgggtgccc acgtcataga gcatcggaac gaaaaaatct ggttgctcgt cgcccttggg
    16501 cggcttccta atcgacggcg caccggctgc cggcggttgc cgggattctt tgcggattcg
    16561 atcagcggcc gcttgccacg attcaccggg gcgtgcttct gcctcgatgc gttgccgctg
    16621 ggcggcctgc gcggccttca acttctccac caggtcatca cccagcgccg cgccgatttg
    16681 taccgggccg gatggtttgc gaccgctcac gccgattcct cgggcttggg ggttccagtg
    16741 ccattgcagg gccggcagac aacccagccg cttacgcctg gccaaccgcc cgttcctcca
    16801 cacatggggc attccacggc gtcggtgcct ggttgttctt gattttccat gccgcctcct
    16861 ttagccgcta aaattcatct actcatttat tcatttgctc atttactctg gtagctgcgc
    16921 gatgtattca gatagcagct cggtaatggt cttgccttgg cgtaccgcgt acatcttcag
    16981 cttggtgtga tcctccgccg gcaactgaaa gttgacccgc ttcatggctg gcgtgtctgc
    17041 caggctggcc aacgttgcag ccttgctgct gcgtgcgctc ggacggccgg cacttagcgt
    17101 gtttgtgctt ttgctcattt tctctttacc tcattaactc aaatgagttt tgatttaatt
    17161 tcagcggcca gcgcctggac ctcgcgggca gcgtcgccct cgggttctga ttcaagaacg
    17221 gttgtgccgg cggcggcagt gcctgggtag ctcacgcgct gcgtgatacg ggactcaaga
    17281 atgggcagct cgtacccggc cagcgcctcg gcaacctcac cgccgatgcg cgtgcctttg
    17341 atcgcccgcg acacgacaaa ggccgcttgt agccttccat ccgtgacctc aatgcgctgc
    17401 ttaaccagct ccaccaggtc ggcggtggcc catatgtcgt aagggcttgg ctgcaccgga
    17461 atcagcacga agtcggctgc cttgatcgcg gacacagcca agtccgccgc ctggggcgct
    17521 ccgtcgatca ctacgaagtc gcgccggccg atggccttca cgtcgcggtc aatcgtcggg
    17581 cggtcgatgc cgacaacggt tagcggttga tcttcccgca cggccgccca atcgcgggca
    17641 ctgccctggg gatcggaatc gactaacaga acatcggccc cggcgagttg cagggcgcgg
    17701 gctagatggg ttgcgatggt cgtcttgcct gacccgcctt tctggttaag tacagcgata
    17761 accttcatgc gttccccttg cgtatttgtt tatttactca tcgcatcata tacgcagcga
    17821 ccgcatgacg caagctgttt tactcaaata cacatcacct ttttagacgg cggcgctcgg
    17881 tttcttcagc ggccaagctg gccggccagg ccgccagctt ggcatcagac aaaccggcca
    17941 ggatttcatg cagccgcacg gttgagacgt gcgcgggcgg ctcgaacacg tacccggccg
    18001 cgatcatctc cgcctcgatc tcttcggtaa tgaaaaacgg ttcgtcctgg ccgtcctggt
    18061 gcggtttcat gcttgttcct cttggcgttc attctcggcg gccgccaggg cgtcggcctc
    18121 ggtcaatgcg tcctcacgga aggcaccgcg ccgcctggcc tcggtgggcg tcacttcctc
    18181 gctgcgctca agtgcgcggt acagggtcga gcgatgcacg ccaagcagtg cagccgcctc
    18241 tttcacggtg cggccttcct ggtcgatcag ctcgcgggcg tgcgcgatct gtgccggggt
    18301 gagggtaggg cgggggccaa acttcacgcc tcgggccttg gcggcctcgc gcccgctccg
    18361 ggtgcggtcg atgattaggg aacgctcgaa ctcggcaatg ccggcgaaca cggtcaacac
    18421 catgcggccg gccggcgtgg tggtgtcggc ccacggctct gccaggctac gcaggcccgc
    18481 gccggcctcc tggatgcgct cggcaatgtc cagtaggtcg cgggtgctgc gggccaggcg
    18541 gtctagcctg gtcactgtca caacgtcgcc agggcgtagg tggtcaagca tcctggccag
    18601 ctccgggcgg tcgcgcctgg tgccggtgat cttctcggaa aacagcttgg tgcagccggc
    18661 cgcgtgcagt tcggcccgtt ggttggtcaa gtcctggtcg tcggtgctga cgcgggcata
    18721 gcccagcagg ccagcggcgg cgctcttgtt catggcgtaa tgtctccggt tctagtcgca
    18781 agtattctac tttatgcgac taaaacacgc gacaagaaaa cgccaggaaa agggcagggc
    18841 ggcagcctgt cgcgtaactt aggacttgtg cgacatgtcg ttttcagaag acggctgcac
    18901 tgaacgtcag aagccgactg cactatagca gcggaggggt tggatcaaag tacttt
//
