LOCUS       sequence-194989-       20437 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  Second generation Rosa26 gene targeting vector to induce a 
            Cre-dependent mosaic of cells expressing different chromatin 
            localized fluorescent proteins and Notch signalling genes.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 20437)
  AUTHORS   Pontes-Quero S, Heredia L, Casquero-Garcia V, Fernandez-Chacon M, 
            Luo W, Hermoso A, Bansal M, Garcia-Gonzalez I, Sanchez-Munoz MS, 
            Perea JR, Galiana-Simal A, Rodriguez-Arabaolaza I, Del Olmo-Cabrera 
            S, Rocha SF, Criado-Rodriguez LM, Giovinazzo G, Benedito R
  TITLE     Dual ifgMosaic: A Versatile Method for Multispectral and 
            Combinatorial Mosaic Gene-Function Analysis.
  JOURNAL   Cell. 2017 Aug 10;170(4):800-814.e18. doi: 
            10.1016/j.cell.2017.07.031.
  PUBMED    28802047
REFERENCE   2  (bases 1 to 20437)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: 
            "10.1016/j.cell.2017.07"; journalName: "Cell"; date: "2017-08-10- 
            10"; volume: "170"; issue: "4"; pages: "800-814.e18"
COMMENT     Sequence Label: iChr2-Notch Mosaic (SO250)
FEATURES             Location/Qualifiers
     source          1..20437
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     primer_bind     326..348
                     /label=pCAGGS-5
                     /note="Chimeric intron in CAG promoter, forward primer"
     primer_bind     410..429
                     /label=pCAG-F
                     /note="Rabbit beta-globin intron, for pCAG plasmids, 
                     forward primer"
     protein_bind    complement(463..496)
                     /label=loxN
                     /bound_moiety="Cre recombinase"
                     /note="Cre-mediated recombination occurs in the 8-bp core 
                     sequence (AGGTATAC) (Shaw et al., 2021). loxN sites are 
                     compatible with each other, but incompatible with loxP or 
                     lox2272 sites."
     protein_bind    complement(504..537)
                     /label=lox2272
                     /bound_moiety="Cre recombinase"
                     /note="Cre-mediated recombination occurs in the 8-bp core 
                     sequence (AAGTATCC) (Shaw et al., 2021). lox2272 sites are 
                     compatible with each other, but incompatible with loxP or 
                     loxN sites (Lee and Saito, 1988)."
     protein_bind    complement(546..579)
                     /label=loxP
                     /bound_moiety="Cre recombinase"
                     /note="Cre-mediated recombination occurs in the 8-bp core 
                     sequence (ATGTATGC) (Shaw et al., 2021)."
     regulatory      593..602
                     /label=Kozak sequence
                     /note="vertebrate consensus sequence for strong initiation 
                     of translation (Kozak, 1987)"
                     /regulatory_class="other"
     CDS             638..658
                     /codon_start=1
                     /product="nuclear localization signal of SV40 (simian virus
                     40) large T antigen"
                     /label=SV40 NLS
                     /translation="PKKKRKV"
     CDS             659..1363
                     /codon_start=1
                     /product="Phialidium yellow fluorescent proteim"
                     /label=PhiYFP
                     /note="mammalian codon-optimized"
                     /translation="MSSGALLFHGKIPYVVEMEGNVDGHTFSIRGKGYGDASVGKVDAQ
                     FICTTGDVPVPWSTLVTTLTAGAQCFAKYGPELKDFYKSCMPDGYVQERTITFEGDGNF
                     KTRAEVTFENGSVYNRVKLNGQGFKKDGHVLGKNLEFNFTPHCLYIWGDQANHGLKSAF
                     KICHEITGSKGDFIVADHTQMNTPIGGGPVHVPEYHHMSYHVKLSKDVTDHRDNMSLKE
                     TVRAVDCRKTYL"
     polyA_signal    1546..1667
                     /label=SV40 poly(A) signal
                     /note="SV40 polyadenylation signal"
     protein_bind    complement(1679..1712)
                     /label=loxN
                     /bound_moiety="Cre recombinase"
                     /note="Cre-mediated recombination occurs in the 8-bp core 
                     sequence (AGGTATAC) (Shaw et al., 2021). loxN sites are 
                     compatible with each other, but incompatible with loxP or 
                     lox2272 sites."
     regulatory      1719..1728
                     /label=Kozak sequence
                     /note="vertebrate consensus sequence for strong initiation 
                     of translation (Kozak, 1987)"
                     /regulatory_class="other"
     CDS             1731..1748
                     /codon_start=1
                     /product="6xHis affinity tag"
                     /label=6xHis
                     /translation="HHHHHH"
     CDS             1749..2123
                     /codon_start=1
                     /gene="HIST1H2BJ"
                     /product="human histone H2B"
                     /label=H2B
                     /translation="PEPAKSAPAPKKGSKKAVTKAQKKGGKKRKRSRKESYSIYVYKVL
                     KQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPG
                     ELAKHAVSEGTKAITKYTSAK"
     CDS             2145..2855
                     /codon_start=1
                     /product="monomeric derivative of DsRed fluorescent protein
                     (Shaner et al., 2004)"
                     /label=mCherry
                     /note="mammalian codon-optimized"
                     /translation="MVSKGEEDNMAIIKEFMRFKVHMEGSVNGHEFEIEGEGEGRPYEG
                     TQTAKLKVTKGGPLPFAWDILSPQFMYGSKAYVKHPADIPDYLKLSFPEGFKWERVMNF
                     EDGGVVTVTQDSSLQDGEFIYKVKLRGTNFPSDGPVMQKKTMGWEASSERMYPEDGALK
                     GEIKQRLKLKDGGHYDAEVKTTYKAKKPVQLPGAYNVNIKLDITSHNEDYTIVEQYERA
                     EGRHSTGGMDELYK"
     primer_bind     complement(2290..2308)
                     /label=mCherry-R
                     /note="mCherry, reverse primer"
     primer_bind     2558..2577
                     /label=mCherry-F
                     /note="mCherry, forward primer"
     misc_feature    2869..3457
                     /label=WPRE
                     /note="woodchuck hepatitis virus posttranscriptional 
                     regulatory element"
     CDS             complement(3340..3351)
                     /codon_start=1
                     /product="Factor Xa recognition and cleavage site"
                     /label=Factor Xa site
                     /translation="IEGR"
     polyA_signal    3591..3712
                     /label=SV40 poly(A) signal
                     /note="SV40 polyadenylation signal"
     protein_bind    complement(3727..3760)
                     /label=lox2272
                     /bound_moiety="Cre recombinase"
                     /note="Cre-mediated recombination occurs in the 8-bp core 
                     sequence (AAGTATCC) (Shaw et al., 2021). lox2272 sites are 
                     compatible with each other, but incompatible with loxP or 
                     loxN sites (Lee and Saito, 1988)."
     regulatory      3768..3777
                     /label=Kozak sequence
                     /note="vertebrate consensus sequence for strong initiation 
                     of translation (Kozak, 1987)"
                     /regulatory_class="other"
     CDS             3774..4154
                     /codon_start=1
                     /gene="HIST1H2BJ"
                     /product="human histone H2B"
                     /label=H2B
                     /translation="MAPEPAKSAPAPKKGSKKAVTKAQKKGGKKRKRSRKESYSIYVYK
                     VLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLL
                     PGELAKHAVSEGTKAITKYTSAK"
     regulatory      4173..4182
                     /label=Kozak sequence
                     /note="vertebrate consensus sequence for strong initiation 
                     of translation (Kozak, 1987)"
                     /regulatory_class="other"
     CDS             join(4179..4181,4182..4184,4185..4892)
                     /codon_start=1
                     /product="enhanced GFP"
                     /label=EGFP
                     /translation="MVSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTL
                     KFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFFKDD
                     GNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIK
                     VNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLL
                     EFVTAAGITLGMDELY"
     CDS             join(4179..4181,4182..4184,4185..4892)
                     /codon_start=1
                     /product="the original enhanced GFP (Yang et al., 1996)"
                     /label=EGFP
                     /note="mammalian codon-optimized"
                     /translation="MVSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTL
                     KFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFFKDD
                     GNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIK
                     VNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLL
                     EFVTAAGITLGMDELY"
     CDS             4896..4937
                     /codon_start=1
                     /product="epitope tag from simian virus 5"
                     /label=V5 tag
                     /translation="GKPIPNPLLGLDST"
     CDS             4947..5000
                     /codon_start=1
                     /product="2A peptide from Thosea asigna virus capsid 
                     protein"
                     /label=T2A
                     /note="Eukaryotic ribosomes fail to insert a peptide bond 
                     between the Gly and Pro residues, yielding separate 
                     polypeptides."
                     /translation="EGRGSLLTCGDVEENPGP"
     misc_feature    5245..5833
                     /label=WPRE
                     /note="woodchuck hepatitis virus posttranscriptional 
                     regulatory element"
     CDS             complement(5716..5727)
                     /codon_start=1
                     /product="Factor Xa recognition and cleavage site"
                     /label=Factor Xa site
                     /translation="IEGR"
     polyA_signal    5967..6088
                     /label=SV40 poly(A) signal
                     /note="SV40 polyadenylation signal"
     protein_bind    complement(6103..6136)
                     /label=loxP
                     /bound_moiety="Cre recombinase"
                     /note="Cre-mediated recombination occurs in the 8-bp core 
                     sequence (ATGTATGC) (Shaw et al., 2021)."
     regulatory      6143..6152
                     /label=Kozak sequence
                     /note="vertebrate consensus sequence for strong initiation 
                     of translation (Kozak, 1987)"
                     /regulatory_class="other"
     CDS             6155..6181
                     /codon_start=1
                     /product="HA (human influenza hemagglutinin) epitope tag"
                     /label=HA
                     /translation="YPYDVPDYA"
     CDS             6182..6556
                     /codon_start=1
                     /gene="HIST1H2BJ"
                     /product="human histone H2B"
                     /label=H2B
                     /translation="PEPAKSAPAPKKGSKKAVTKAQKKGGKKRKRSRKESYSIYVYKVL
                     KQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPG
                     ELAKHAVSEGTKAITKYTSAK"
     regulatory      6575..6584
                     /label=Kozak sequence
                     /note="vertebrate consensus sequence for strong initiation 
                     of translation (Kozak, 1987)"
                     /regulatory_class="other"
     CDS             join(6581..6583,6584..6586,6587..7297)
                     /codon_start=1
                     /product="enhanced monomeric variant of CFP (Rizzo et al., 
                     2004)"
                     /label=mCerulean
                     /note=" mammalian codon-optimized"
                     /translation="MVSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTL
                     KFICTTGKLPVPWPTLVTTLTWGVQCFARYPDHMKQHDFFKSAMPEGYVQERTIFFKDD
                     GNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNAISDNVYITADKQKNGIK
                     ANFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSKLSKDPNEKRDHMVLL
                     EFVTAAGITLGMDELYK"
     CDS             7307..7360
                     /codon_start=1
                     /product="2A peptide from Thosea asigna virus capsid 
                     protein"
                     /label=T2A
                     /note="Eukaryotic ribosomes fail to insert a peptide bond 
                     between the Gly and Pro residues, yielding separate 
                     polypeptides."
                     /translation="EGRGSLLTCGDVEENPGP"
     CDS             9725..9748
                     /codon_start=1
                     /product="FLAG(R) epitope tag, followed by an enterokinase 
                     cleavage site"
                     /label=FLAG
                     /translation="DYKDDDDK"
     misc_feature    9765..10353
                     /label=WPRE
                     /note="woodchuck hepatitis virus posttranscriptional 
                     regulatory element"
     CDS             complement(10236..10247)
                     /codon_start=1
                     /product="Factor Xa recognition and cleavage site"
                     /label=Factor Xa site
                     /translation="IEGR"
     polyA_signal    10487..10608
                     /label=SV40 poly(A) signal
                     /note="SV40 polyadenylation signal"
     protein_bind    10646..10679
                     /label=FRT (minimal)
                     /bound_moiety="FLP recombinase from the Saccharomyces 
                     cerevisiae 2u plasmid"
                     /note="supports FLP-mediated excision but not integration 
                     (Turan and Bode, 2011)"
     promoter        10743..11242
                     /label=PGK promoter
                     /note="mouse phosphoglycerate kinase 1 promoter"
     primer_bind     complement(10778..10801)
                     /label=MSCV-rev
                     /note="Murine stem cell virus, reverse primer"
     primer_bind     11175..11194
                     /label=mPGK-F
                     /note="Mouse PGK promoter, forward primer"
     promoter        11254..11301
                     /label=EM7 promoter
                     /note="synthetic bacterial promoter "
     CDS             11320..12123
                     /codon_start=1
                     /gene="aph(3')-II (or nptII)"
                     /product="aminoglycoside phosphotransferase from Tn5"
                     /label=NeoR/KanR
                     /note="confers resistance to neomycin, kanamycin, and G418 
                     (Geneticin(R))"
                     /translation="MGSAIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQ
                     GRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQD
                     LLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDE
                     EHQGLAPAELFARLKARMPDGDDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQ
                     DIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF"
     primer_bind     complement(11383..11402)
                     /label=Neo-R
                     /note="Neomycin resistance gene, reverse primer"
     primer_bind     11993..12012
                     /label=Neo-F
                     /note="Neomycin resistance gene, forward primer"
     primer_bind     complement(12155..12172)
                     /label=BGH-rev
                     /note="Bovine growth hormone terminator, reverse primer. 
                     Also called BGH reverse"
     polyA_signal    12161..12385
                     /label=bGH poly(A) signal
                     /note="bovine growth hormone polyadenylation signal"
     protein_bind    12443..12476
                     /label=FRT (minimal)
                     /bound_moiety="FLP recombinase from the Saccharomyces 
                     cerevisiae 2u plasmid"
                     /note="supports FLP-mediated excision but not integration 
                     (Turan and Bode, 2011)"
     misc_feature    15117..19457
                     /label=Rosa26 right arm
                     /note="right homology arm from intron 1 of the mouse Rosa26
                     gene (Soriano, 1999)"
     primer_bind     complement(19508..19524)
                     /label=SK primer
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     promoter        complement(19557..19575)
                     /label=T7 promoter
                     /note="promoter for bacteriophage T7 RNA polymerase"
     primer_bind     complement(19585..19601)
                     /label=M13 fwd
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     rep_origin      19743..20198
                     /direction=RIGHT
                     /label=f1 ori
                     /note="f1 bacteriophage origin of replication; arrow 
                     indicates direction of (+) strand synthesis"
     primer_bind     complement(19830..19849)
                     /label=F1ori-R
                     /note="F1 origin, reverse primer"
     primer_bind     20040..20061
                     /label=F1ori-F
                     /note="F1 origin, forward primer"
     primer_bind     20339..20355
                     /label=M13 fwd
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     promoter        20365..20383
                     /label=T7 promoter
                     /note="promoter for bacteriophage T7 RNA polymerase"
     primer_bind     20416..20432
                     /label=SK primer
                     /note="common sequencing primer, one of multiple similar 
                     variants"
ORIGIN
        1 ggggagggct cgggggaggg gcgcggcggc ccccggagcg ccggcggctg tcgaggcgcg
       61 gcgagccgca gccattgcct tttatggtaa tcgtgcgaga gggcgcaggg acttcctttg
      121 tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc gcaccccctc tagcgggcgc
      181 ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg gggagggcct tcgtgcgtcg
      241 ccgcgccgcc gtccccttct ccctctccag cctcggggct gtccgcgggg ggacggctgc
      301 cttcgggggg gacggggcag ggcggggttc ggcttctggc gtgtgaccgg cggctctaga
      361 gcctctgcta accatgttca tgccttcttc tttttcctac agctcctggg caacgtgctg
      421 gttattgtgc tgtctcatca ttttggcaaa gaattcctcg agataacttc gtatagtata
      481 ccttatacga agttatcgag ctcataactt cgtataggat actttatacg aagttataac
      541 tcgagataac ttcgtatagc atacattata cgaagttata ccggcagatc tcgccaccat
      601 ggtgagtgtg attacagagg ctagcttcac catggctcct aagaagaaga ggaaggtgat
      661 gagcagcggc gccctgctgt tccacggcaa gatcccctac gtggtggaga tggagggcaa
      721 tgtggatggc cacaccttca gcatccgcgg caagggctac ggcgatgcca gcgtgggcaa
      781 ggtggatgcc cagttcatct gcaccacagg cgatgtgccc gtgccctgga gcaccctggt
      841 gaccaccctg accgcaggcg cccagtgctt cgccaagtac ggccccgagc tgaaggattt
      901 ctacaagagc tgcatgcccg atggctacgt gcaggagcgc accatcacct tcgagggtga
      961 tggcaatttc aagacccgcg ccgaggtgac cttcgagaat ggcagcgtgt acaatcgcgt
     1021 gaagctgaat ggccagggct tcaagaagga tggccacgtg ctgggcaaga atctggagtt
     1081 caatttcacc ccccactgcc tgtacatctg gggcgatcag gccaatcacg gcctgaagag
     1141 cgccttcaag atctgccacg agatcaccgg cagcaagggc gatttcatcg tggccgatca
     1201 cacccagatg aataccccca tcggcggcgg ccccgtgcac gtgcccgagt accaccacat
     1261 gagctaccac gtgaagctga gcaaggatgt gaccgatcac cgcgataata tgagcctgaa
     1321 ggagaccgtg cgcgccgtgg attgccgcaa gacctacctg tgacgcttaa ttagctgagc
     1381 ttggactcct gttgatagat ccagtaatga cctcagaact ccatctggcc gcgactctag
     1441 atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac
     1501 ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca
     1561 gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt
     1621 tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttaagg cgaagcttat
     1681 aacttcgtat agtatacctt atacgaagtt atcggcgcgc caccatggcg catcatcatc
     1741 atcatcatcc agagccagcg aagtctgctc ccgccccgaa aaagggctcc aagaaggcgg
     1801 tgactaaggc gcagaagaaa ggcggcaaga agcgcaagcg cagccgcaag gagagctatt
     1861 ccatctatgt ctacaaggtt ctgaagcagg tccaccctga caccggcatt tcgtccaagg
     1921 ccatgggcat catgaattcg tttgtgaacg acattttcga gcgcatcgca ggtgaggctt
     1981 cccgcctggc gcattacaac aagcgctcga ccatcacctc cagggagatc cagacggccg
     2041 tgcgcctgct gctgcctggg gagttggcca agcacgccgt gtccgagggt actaaggcca
     2101 tcaccaagta caccagcgct aaggatcccc gggtaccggt aaccatggtg agcaagggcg
     2161 aggaggataa catggccatc atcaaggagt tcatgcgctt caaggtgcac atggagggct
     2221 ccgtgaacgg ccacgagttc gagatcgagg gcgagggcga gggccgcccc tacgagggca
     2281 cccagaccgc caagctgaag gtgaccaagg gtggccccct gcccttcgcc tgggacatcc
     2341 tgtcccctca gttcatgtac ggctccaagg cctacgtgaa gcaccccgcc gacatccccg
     2401 actacttgaa gctgtccttc cccgagggct tcaagtggga gcgcgtgatg aacttcgagg
     2461 acggcggcgt ggtgaccgtg acccaggact cctccctgca ggacggcgag ttcatctaca
     2521 aggtgaagct gcgcggcacc aacttcccct ccgacggccc cgtaatgcag aagaagacca
     2581 tgggctggga ggcctcctcc gagagaatgt accccgagga cggcgccctg aagggcgaga
     2641 tcaagcagag gctgaagctg aaggacggcg gccactacga cgctgaggtc aagaccacct
     2701 acaaggccaa gaagcccgtg cagctgcccg gcgcctacaa cgtcaacatc aagttggaca
     2761 tcacctccca caacgaggac tacaccatcg tggaacagta cgaacgcgcc gagggccgcc
     2821 actccactgg cggcatggac gagctgtaca agtgaggcgc gccccgctaa tcaacctctg
     2881 gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta
     2941 tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt
     3001 ttctcctcct tgtataaatc ctggttgctg tctctttatg aggagttgtg gcccgttgtc
     3061 aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg ttggggcatt
     3121 gccaccacct gtcagctcct ttccgggact ttcgctttcc ccctccctat tgccacggcg
     3181 gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac
     3241 aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc ctgtgttgcc
     3301 acctggattc tgcgcgggac gtccttctgc tacgtccctt cggccctcaa tccagcggac
     3361 cttccttccc gcggcctgct gccggctctg cggcctcttc cgcgtcttcg ccttcgccct
     3421 cagacgagtc ggatctccct ttgggccgcc tccccgcatc gataccgtcg agactgctgc
     3481 accagatcat aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc
     3541 cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta
     3601 ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat
     3661 ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct taaggcgtgg
     3721 agatctataa cttcgtatag gatactttat acgaagttat cggtaccgcc accatggcgc
     3781 cagagccagc gaagtctgct cccgccccga aaaagggctc caagaaggcg gtgactaagg
     3841 cgcagaagaa aggcggcaag aagcgcaagc gcagccgcaa ggagagctat tccatctatg
     3901 tctacaaggt tctgaagcag gtccaccctg acaccggcat ttcgtccaag gccatgggca
     3961 tcatgaactc gtttgtgaac gacattttcg agcgcatcgc aggtgaggct tcccgcctgg
     4021 cgcattacaa caagcgctcg accatcacct ccagggagat ccagacggcc gtgcgcctgc
     4081 tgctgcctgg ggagttggcc aagcacgccg tgtccgaggg tactaaggcc atcaccaagt
     4141 acaccagcgc taaggatccc cgggtaccgg tcgccaccat ggtgagcaag ggcgaggagc
     4201 tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac ggccacaagt
     4261 tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc ctgaagttca
     4321 tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc ctgacctacg
     4381 gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc ttcaagtccg
     4441 ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac ggcaactaca
     4501 agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc gagctgaagg
     4561 gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac aactacaaca
     4621 gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg aacttcaaga
     4681 tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag cagaacaccc
     4741 ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc cagtccgccc
     4801 tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc gtgaccgccg
     4861 ccgggatcac tctcggcatg gacgagctgt acattggtaa gcctatccct aaccctctcc
     4921 tcggtctcga ttctacgggc agtggagagg gcagaggaag tctgctaaca tgcggtgacg
     4981 tcgaggagaa tcctggccca gaattcctac ccacctgccc catggcggag ttcgcgctgc
     5041 cgcggcacag cgcggtcatg gagcgcctcc gccgccgcat cgaactgtgc cggcgccacc
     5101 acagcacctg tgaggcccgc tacgaggctg tgtctcccga gcgcctggag ctggagcgcc
     5161 agcacacctt tgccctgcac cagcgctgca tccaggccaa ggccaagcgc gccggcaagc
     5221 actaactcga gggcgcgccc cgctaatcaa cctctggatt acaaaatttg tgaaagattg
     5281 actggtattc ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct
     5341 ttgtatcatg ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg
     5401 ttgctgtctc tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact
     5461 gtgtttgctg acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc
     5521 gggactttcg ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc
     5581 cgctgctgga caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa
     5641 tcatcgtcct ttccttggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc
     5701 ttctgctacg tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg
     5761 gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg
     5821 gccgcctccc cgcatcgata ccgtcgagac tgctgcacca gatcataatc agccatacca
     5881 catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac
     5941 ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat
     6001 aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg
     6061 gtttgtccaa actcatcaat gtatcttaag gcgtggacta gtataacttc gtatagcata
     6121 cattatacga agttatcggc gcgccaccat ggcgtatcca tatgacgtcc cagactatgc
     6181 cccagagcca gcgaagtctg ctcccgcccc gaaaaagggc tccaagaagg cggtgactaa
     6241 ggcgcagaag aaaggcggca agaagcgcaa gcgcagccgc aaggagagct attccatcta
     6301 tgtctacaag gttctgaagc aggtccaccc tgacaccggc atttcgtcca aggccatggg
     6361 catcatgaac tcgtttgtga acgacatttt cgagcgcatc gcaggtgagg cttcccgcct
     6421 ggcgcattac aacaagcgct cgaccatcac ctccagggag atccagacgg ccgtgcgcct
     6481 gctgctgcct ggggagttgg ccaagcacgc cgtgtccgag ggtactaagg ccatcaccaa
     6541 gtacaccagc gctaaggatc cccgggtacc ggtcgccacc atggtgagca agggcgagga
     6601 gctgttcacc ggggtggtgc ccatcctggt cgagctggac ggcgacgtaa acggccacaa
     6661 gttcagcgtg tccggcgagg gcgagggcga tgccacctac ggcaagctga ccctgaagtt
     6721 catctgcacc accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca ccctgacctg
     6781 gggcgtgcag tgcttcgccc gctaccccga ccacatgaag cagcacgact tcttcaagtc
     6841 cgccatgccc gaaggctacg tccaggagcg caccatcttc ttcaaggacg acggcaacta
     6901 caagacccgc gccgaggtga agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa
     6961 gggcatcgac ttcaaggagg acggcaacat cctggggcac aagctggagt acaacgccat
     7021 cagcgacaac gtctatatca ccgccgacaa gcagaagaac ggcatcaagg ccaacttcaa
     7081 gatccgccac aacatcgagg acggcagcgt gcagctcgcc gaccactacc agcagaacac
     7141 ccccatcggc gacggccccg tgctgctgcc cgacaaccac tacctgagca cccagtccaa
     7201 gctgagcaaa gaccccaacg agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc
     7261 cgccgggatc actctcggca tggacgagct gtacaagggc agtggagagg gcagaggaag
     7321 tctgctaaca tgcggtgacg tcgaggagaa tcctggccca gaattccctg agggcttcaa
     7381 agtgtctgag gccagcaaga agaagcggcg ggagcccctc ggcgaggact ccgtgggcct
     7441 caagcccctg aagaacgctt cagacggtgc cctcatggac gacaaccaga atgagtgggg
     7501 ggacgaggac ctggagacca agaagttccg gttcgaggag cccgtggttc tgcctgacct
     7561 ggacgaccag acagaccacc ggcagtggac tcagcagcac ctggatgccg ctgacctgcg
     7621 catgtctgcc atggccccca caccgcccca gggtgaggtt gacgccgact gcatggacgt
     7681 caatgtccgc gggcctgatg gcttcacccc gctcatgatc gcctcctgca gcgggggcgg
     7741 cctggagacg ggcaacagcg aggaagagga ggacgcgccg gccgtcatct ccgacttcat
     7801 ctaccagggc gccagcctgc acaaccagac agaccgcacg ggcgagaccg ccttgcacct
     7861 ggccgcccgc tactcacgct ctgatgccgc caagcgcctg ctggaggcca gcgcagatgc
     7921 caacatccag gacaacatgg gccgcacccc gctgcatgcg gctgtgtctg ccgacgcaca
     7981 aggtgtcttc cagatcctga tccggaaccg agccacagac ctggatgccc gcatgcatga
     8041 tggcacgacg ccactgatcc tggctgcccg cctggccgtg gagggcatgc tggaggacct
     8101 catcaactca cacgccgacg tcaacgccgt agatgacctg ggcaagtccg ccctgcactg
     8161 ggccgccgcc gtgaacaatg tggatgccgc agttgtgctc ctgaagaacg gggctaacaa
     8221 agatatgcag aacaacaggg aggagacacc cctgtttctg gccgcccggg agggcagcta
     8281 cgagaccgcc aaggtgctgc tggaccactt tgccaaccgg gacatcacgg atcatatgga
     8341 ccgcctgccg cgcgacatcg cacaggagcg catgcatcac gacatcgtga ggctgctgga
     8401 cgagtacaac ctggtgcgca gcccgcagct gcacggagcc ccgctggggg gcacgcccac
     8461 cctgtcgccc ccgctctgct cgcccaacgg ctacctgggc agcctcaagc ccggcgtgca
     8521 gggcaagaag gtccgcaagc ccagcagcaa aggcctggcc tgtggaagca aggaggccaa
     8581 ggacctcaag gcacggagga agaagtccca ggatggcaag ggctgcctgc tggacagctc
     8641 cggcatgctc tcgcccgtgg actccctgga gtcaccccat ggctacctgt cagacgtggc
     8701 ctcgccgcca ctgctgccct ccccgttcca gcagtctccg tccgtgcccc tcaaccacct
     8761 gcctgggatg cccgacaccc acctgggcat cgggcacctg aacgtggcgg ccaagcccga
     8821 gatggcggcg ctgggtgggg gcggccggct ggcctttgag actggcccac ctcgtctctc
     8881 ccacctgcct gtggcctctg gcaccagcac cgtcctgggc tccagcagcg gaggggccct
     8941 gaatttcact gtgggcgggt ccaccagttt gaatggtcaa tgcgagtggc tgtcccggct
     9001 gcagagcggc atggtgccga accaatacaa ccctctgcgg gggagtgtgg caccaggccc
     9061 cctgagcaca caggccccct ccctgcagca tggcatggta ggcccgctgc acagtagcct
     9121 tgctgccagc gccctgtccc agatgatgag ctaccagggc ctgcccagca cccggctggc
     9181 cacccagcct cacctggtgc agacccagca ggtgcagcca caaaacttac agatgcagca
     9241 gcagaacctg cagccagcaa acatccagca gcagcaaagc ctgcagccgc caccaccacc
     9301 accacagccg caccttggcg tgagctcagc agccagcggc cacctgggcc ggagcttcct
     9361 gagtggagag ccgagccagg cagacgtgca gccactgggc cccagcagcc tggcggtgca
     9421 cactattctg ccccaggaga gccccgccct gcccacgtcg ctgccatcct cgctggtccc
     9481 acccgtgacc gcagcccagt tcctgacgcc cccctcgcag cacagctact cctcgcctgt
     9541 ggacaacacc cccagccacc agctacaggt gcctgagcac cccttcctga ccccttcgcc
     9601 ggagtcgccc gaccaatggt cgtcctcgtc gccgcactct aatgtgtctg actggtctga
     9661 gggcgtgtcg tcgcccccgc cctccatgca gtcccagatc gcgcgcatcc cggaggcctt
     9721 caaggactac aaggatgacg atgacaaata aggcgcgccc cgctaatcaa cctctggatt
     9781 acaaaatttg tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg
     9841 gatacgctgc tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct
     9901 cctccttgta taaatcctgg ttgctgtctc tttatgagga gttgtggccc gttgtcaggc
     9961 aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc cactggttgg ggcattgcca
    10021 ccacctgtca gctcctttcc gggactttcg ctttccccct ccctattgcc acggcggaac
    10081 tcatcgccgc ctgccttgcc cgctgctgga caggggctcg gctgttgggc actgacaatt
    10141 ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct gctcgcctgt gttgccacct
    10201 ggattctgcg cgggacgtcc ttctgctacg tcccttcggc cctcaatcca gcggaccttc
    10261 cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga
    10321 cgagtcggat ctccctttgg gccgcctccc cgcatcgata ccgtcgagac tgctgcacca
    10381 gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca
    10441 cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc
    10501 agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt
    10561 ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttaag gcgtggcggc
    10621 cgcagcatag ggatccccga attccgaagt tcctattctc tagaaagtat aggaacttca
    10681 ggtctgaaga ggagtttacg tccagccaag ctagcttggc tgcaggtcgt cgaaattcta
    10741 ccgggtaggg gaggcgcttt tcccaaggca gtctggagca tgcgctttag cagccccgct
    10801 gggcacttgg cgctacacaa gtggcctctg gcctcgcaca cattccacat ccaccggtag
    10861 gcgccaaccg gctccgttct ttggtggccc cttcgcgcca ccttctactc ctcccctagt
    10921 caggaagttc ccccccgccc cgcagctcgc gtcgtgcagg acgtgacaaa tggaagtagc
    10981 acgtctcact agtctcgtgc agatggacag caccgctgag caatggaagc gggtaggcct
    11041 ttggggcagc ggccaatagc agctttgctc cttcgctttc tgggctcaga ggctgggaag
    11101 gggtgggtcc gggggcgggc tcaggggcgg gctcaggggc ggggcgggcg cccgaaggtc
    11161 ctccggaggc ccggcattct gcacgcttca aaagcgcacg tctgccgcgc tgttctcctc
    11221 ttcctcatct ccgggccttt cgacctgcag cctgttgaca attaatcatc ggcatagtat
    11281 atcggcatag tataatacga caaggtgagg aactaaacca tgggatcggc cattgaacaa
    11341 gatggattgc acgcaggttc tccggccgct tgggtggaga ggctattcgg ctatgactgg
    11401 gcacaacaga caatcggctg ctctgatgcc gccgtgttcc ggctgtcagc gcaggggcgc
    11461 ccggttcttt ttgtcaagac cgacctgtcc ggtgccctga atgaactgca ggacgaggca
    11521 gcgcggctat cgtggctggc cacgacgggc gttccttgcg cagctgtgct cgacgttgtc
    11581 actgaagcgg gaagggactg gctgctattg ggcgaagtgc cggggcagga tctcctgtca
    11641 tctcaccttg ctcctgccga gaaagtatcc atcatggctg atgcaatgcg gcggctgcat
    11701 acgcttgatc cggctacctg cccattcgac caccaagcga aacatcgcat cgagcgagca
    11761 cgtactcgga tggaagccgg tcttgtcgat caggatgatc tggacgaaga gcatcagggg
    11821 ctcgcgccag ccgaactgtt cgccaggctc aaggcgcgca tgcccgacgg cgatgatctc
    11881 gtcgtgaccc atggcgatgc ctgcttgccg aatatcatgg tggaaaatgg ccgcttttct
    11941 ggattcatcg actgtggccg gctgggtgtg gcggaccgct atcaggacat agcgttggct
    12001 acccgtgata ttgctgaaga gcttggcggc gaatgggctg accgcttcct cgtgctttac
    12061 ggtatcgccg ctcccgattc gcagcgcatc gccttctatc gccttcttga cgagttcttc
    12121 tgaggggatc aattctctag agctcgctga tcagcctcga ctgtgccttc tagttgccag
    12181 ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact
    12241 gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt
    12301 ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat
    12361 gctggggatg cggtgggctc tatggcttct gaggcggaaa gaaccagctg gggctcgact
    12421 agagcttgcg gaacccttcg ttgaagttcc tattctctag aaagtatagg aacttcagtc
    12481 gacgtgctcc aaggagagtt tgctggcaag atcttcgggg tcgatgctaa cacagggaat
    12541 gtgcttgcct atgagaggct agaccgggag aaagtctctg agtatcgtcg acaattcgag
    12601 ctcgctagag ccccatcctc actggatgag agataatggc cttacgttgt gccaggggag
    12661 ggtcgggctg gatttagcaa gatttacctt ctccaaagag cggtgctgca gtggcacagc
    12721 tgcccacgga ggtggggggg tcaccgtccc tggaggtgat gaagaactgt ggggatgtgg
    12781 cactgaggga catggccagt gggcacggtg ggtgggttgg ggttggtctt ggggatcttg
    12841 gagggctttt ccagccttca tgatttgacg attgtatgaa catctacatg gcaattctcc
    12901 agctgcctgt cccagtccta ctgacccagc tgtatctctc caggcaagct cttccacccc
    12961 ttctgcttgc atccagacac catcaaacat gcaggctcag acacagggac cagcagtgtc
    13021 tgtggccttt ttgtgctcct ctccatgctg ggttttaact tgctctttgt ccttctatcc
    13081 tatcttctta tccttaaggc tgttctgaac gctgtgactt ggagagtgtc ccagagccct
    13141 caacacctgc atgtcccacg tccatgctgt cctgcacttc cttatcccca agatctgcct
    13201 ctccgtgatg cactgaattg gcaaacatgt gtcaccccag accaacaatg tcacagcaaa
    13261 ctcccccttg ataggacaag ggggaatggc tttacactga gacaggggag gtttgggttg
    13321 gatatgagga ggcagttttt cccccagagg gtggtgacgc actgaacagg ttgcccaagg
    13381 aggctgtgga tgccccatcc ctgcaggcat tcaaggccag gctggatgtg gctctgggca
    13441 gcctgggctg ctggttgatg accctgcaca tagcaggggg ttggatctgg atgagcactg
    13501 tgctcctttg caacccaggc cgttctatga ttctgtcatt ctaaatctct ctttcagcct
    13561 aaagcttttt ccccgtatcc ccccaggtgt ctgcaggctc aaagagcagc gagaagcgtt
    13621 cagaggaaag cgatcccgtg ccaccttccc cgtgcccggg ctgtccccgc acgctgccgg
    13681 ctcggggatg cggggggagc gccggaccgg agcggagccc cgggcggctc gctgctgccc
    13741 cctagcgggg gcggggcgga gccccgggcg gctcgctgct gccccctagc gggggaggga
    13801 cgtaattaca tccctggggg ctttgggggg gggctgtccc tctagcgagc tcggtaccca
    13861 gagccccatc ctcactgact ccgtcctgga gttggatgag agataatggc cttacgttgt
    13921 gccaggggag ggtcgggctg gatttagcaa gatttacctt ctccaaagag cggtgctgca
    13981 gtggcacagc tgcccacgga ggtggggggg tcaccgtccc tggaggtgat gaagaactgt
    14041 ggggatgtgg cactgaggga catggccagt gggcacggtg ggtgggttgg ggttggtctt
    14101 ggggatcttg gagggctttt ccagccttca tgatttgacg attgtatgaa catctacatg
    14161 gcaattctcc agctgcctgt cccagtccta ctgacccagc tgtatctctc caggcaagct
    14221 cttccacccc ttctgcttgc atccagacac catcaaacat gcaggctcag acacagggac
    14281 cagcagtgtc tgtggccttt ttgtgctcct ctccatgctg ggttttaact tgctctttgt
    14341 ccttctatcc tatcttctta tccttaaggc tgttctgaac gctgtgactt ggagagtgtc
    14401 ccagagccct caacacctgc atgtcccacg tccatgctgt cctgcacttc cttatcccca
    14461 agatctgcct ctccgtgatg cactgaattg gcaaacatgt gtcaccccag accaacaatg
    14521 tcacagcaaa ctcccccttg ataggacaag ggggaatggc tttacactga gacaggggag
    14581 gtttgggttg gatatgagga ggcagttttt cccccagagg gtggtgacgc actgaacagg
    14641 ttgcccaagg aggctgtgga tgccccatcc ctgcaggcat tcaaggccag gctggatgtg
    14701 gctctgggca gcctgggctg ctggttgatg accctgcaca tagcaggggg ttggatctgg
    14761 atgagcactg tgctcctttg caacccaggc cgttctatga ttctgtcatt ctaaatctct
    14821 ctttcagcct aaagcttttt ccccgtatcc ccccaggtgt ctgcaggctc aaagagcagc
    14881 gagaagcgtt cagaggaaag cgatcccgtg ccaccttccc cgtgcccggg ctgtccccgc
    14941 acgctgccgg ctcggggatg cggggggagc gccggaccgg agcggagccc cgggcggctc
    15001 gctgctgccc cctagcgggg gagggacgta attacatccc tgggggcttt gggggggggc
    15061 tgtccctcta ggggtacccg gggatcttaa ttaacggcgg cggagtatcg aattcgctag
    15121 aagatgggcg ggagtcttct gggcaggctt aaaggctaac ctggtgtgtg ggcgttgtcc
    15181 tgcaggggaa ttgaacaggt gtaaaattgg agggacaaga cttcccacag attttcggtt
    15241 ttgtcgggaa gttttttaat aggggcaaat aaggaaaatg ggaggatagg tagtcatctg
    15301 gggttttatg cagcaaaact acaggttatt attgcttgtg atccgcctcg gagtattttc
    15361 catcgaggta gattaaagac atgctcaccc gagttttata ctctcctgct tgagatcctt
    15421 actacagtat gaaattacag tgtcgcgagt tagactatgt aagcagaatt ttaatcattt
    15481 ttaaagagcc cagtacttca tatccatttc tcccgctcct tctgcagcct tatcaaaagg
    15541 tattttagaa cactcatttt agccccattt tcatttatta tactggctta tccaacccct
    15601 agacagagca ttggcatttt ccctttcctg atcttagaag tctgatgact catgaaacca
    15661 gacagattag ttacatacac cacaaatcga ggctgtagct ggggcctcaa cactgcagtt
    15721 cttttataac tccttagtac actttttgtt gatcctttgc cttgatcctt aattttcagt
    15781 gtctatcacc tctcccgtca ggtggtgttc cacatttggg cctattctca gtccagggag
    15841 ttttacaaca atagatgtat tgagaatcca acctaaagct taactttcca ctcccatgaa
    15901 tgcctctctc ctttttctcc atttataaac tgagctatta accattaatg gtttccaggt
    15961 ggatgtctcc tcccccaata ttacctgatg tatcttacat attgccaggc tgatatttta
    16021 agacattaaa aggtatattt cattattgag ccacatggta ttgattactg cttactaaaa
    16081 ttttgtcatt gtacacatct gtaaaaggtg gttccttttg gaatgcaaag ttcaggtgtt
    16141 tgttgtcttt cctgacctaa ggtcttgtga gcttgtattt tttctattta agcagtgctt
    16201 tctcttggac tggcttgact catggcattc tacacgttat tgctggtcta aatgtgattt
    16261 tgccaagctt cttcaggacc tataattttg cttgacttgt agccaaacac aagtaaaatg
    16321 attaagcaac aaatgtattt gtgaagcttg gtttttaggt tgttgtgttg tgtgtgcttg
    16381 tgctctataa taatactatc caggggctgg agaggtggct cggagttcaa gagcacagac
    16441 tgctcttcca gaagtcctga gttcaattcc cagcaaccac atggtggctc acaaccatct
    16501 gtaatgggat ctgatgccct cttctggtgt gtctgaagac cacaagtgta ttcacattaa
    16561 ataaataaat cctccttctt cttctttttt ttttttttaa agagaatact gtctccagta
    16621 gaatttactg aagtaatgaa atactttgtg tttgttccaa tatggtagcc aataatcaaa
    16681 ttactcttta agcactggaa atgttaccaa ggaactaatt tttatttgaa gtgtaactgt
    16741 ggacagagga gccataactg cagacttgtg ggatacagaa gaccaatgca gactttaatg
    16801 tcttttctct tacactaagc aataaagaaa taaaaattga acttctagta tcctatttgt
    16861 ttaaactgct agctttactt aacttttgtg cttcatctat acaaagctga aagctaagtc
    16921 tgcagccatt actaaacatg aaagcaagta atgataattt tggatttcaa aaatgtaggg
    16981 ccagagttta gccagccagt ggtggtgctt gcctttatgc ctttaatccc agcactctgg
    17041 aggcagagac aggcagatct ctgagtttga gcccagcctg gtctacacat caagttctat
    17101 ctaggatagc caggaataca cacagaaacc ctgttgggga ggggggctct gagatttcat
    17161 aaaattataa ttgaagcatt ccctaatgag ccactatgga tgtggctaaa tccgtctacc
    17221 tttctgatga gatttgggta ttattttttc tgtctctgct gttggttggg tcttttgaca
    17281 ctgtgggctt tctttaaagc ctccttcctg ccatgtggtc tcttgtttgc tactaacttc
    17341 ccatggctta aatggcatgg ctttttgcct tctaagggca gctgctgaga tttgcagcct
    17401 gatttccagg gtggggttgg gaaatctttc aaacactaaa attgtccttt aatttttttt
    17461 ttaaaaaatg ggttatataa taaacctcat aaaatagtta tgaggagtga ggtggactaa
    17521 tattaaatga gtccctcccc tataaaagag ctattaaggc tttttgtctt atacttaact
    17581 ttttttttaa atgtggtatc tttagaacca agggtcttag agttttagta tacagaaact
    17641 gttgcatcgc ttaatcagat tttctagttt caaatccaga gaatccaaat tcttcacagc
    17701 caaagtcaaa ttaagaattt ctgactttta atgttaattt gcttactgtg aatataaaaa
    17761 tgatagcttt tcctgaggca gggtctcact atgtatctct gcctgatctg caacaagata
    17821 tgtagactaa agttctgcct gcttttgtct cctgaatact aaggttaaaa tgtagtaata
    17881 cttttggaac ttgcaggtca gattctttta taggggacac actaagggag cttgggtgat
    17941 agttggtaaa atgtgtttca agtgatgaaa acttgaatta ttatcaccgc aacctacttt
    18001 ttaaaaaaaa aagccaggcc tgttagagca tgcttaaggg atccctagga cttgctgagc
    18061 acacaagagt agttacttgg caggctcctg gtgagagcat atttcaaaaa acaaggcaga
    18121 caaccaagaa actacagtta aggttacctg tctttaaacc atctgcatat acacagggat
    18181 attaaaatat tccaaataat atttcattca agttttcccc catcaaattg ggacatggat
    18241 ttctccggtg aataggcaga gttggaaact aaacaaatgt tggttttgtg atttgtgaaa
    18301 ttgttttcaa gtgatagtta aagcccatga gatacagaac aaagctgcta tttcgaggtc
    18361 tcttggttta tactcagaag cacttctttg ggtttccctg cactatcctg atcatgtgct
    18421 aggcctacct taggctgatt gttgttcaaa taaacttaag tttcctgtca ggtgatgtca
    18481 tatgatttca tatatcaagg caaaacatgt tatatatgtt aaacatttgt acttaatgtg
    18541 aaagttaggt ctttgtgggt ttgattttta attttcaaaa cctgagctaa ataagtcatt
    18601 tttacatgtc ttacatttgg tggaattgta taattgtggt ttgcaggcaa gactctctga
    18661 cctagtaacc ctacctatag agcactttgc tgggtcacaa gtctaggagt caagcatttc
    18721 accttgaagt tgagacgttt tgttagtgta tactagttta tatgttggag gacatgttta
    18781 tccagaagat attcaggact atttttgact gggctaagga attgattctg attagcactg
    18841 ttagtgagca ttgagtggcc tttaggcttg aattggagtc acttgtatat ctcaaataat
    18901 gctggccttt tttaaaaagc ccttgttctt tatcaccctg ttttctacat aatttttgtt
    18961 caaagaaata cttgtttgga tctccttttg acaacaatag catgttttca agccatattt
    19021 tttttccttt tttttttttt ttttggtttt tcgagacagg gtttctctgt atagccctgg
    19081 ctgtcctgga actcactttg tagaccaggc tggcctcgaa ctcagaaatc cgcctgcctc
    19141 tgcctcctga gtgccgggat taaaggcgtg caccaccacg cctggctaag ttggatattt
    19201 tgttatataa ctataaccaa tactaactcc actgggtgga tttttaattc agtcagtagt
    19261 cttaagtggt ctttattggc ccttcattaa aatctactgt tcactctaac agaggctgtt
    19321 ggtactagtg gcacttaagc aacttcctac ggatatacta gcagattaag ggtcagggat
    19381 agaaactagt ctagcgtttt gtatacctac cagctttata ctaccttgtt ctgatagaaa
    19441 tatttcagga catctagctt atcgataccg tcgacgttcg aacacgtgga attcctgcag
    19501 cccgggggat ccactagttc tagagcggcc gccaccgcgg tggagctcca attcgcccta
    19561 tagtgagtcg tattacgcgc gctcactggc cgtcgtttta caacgtcgtg actgggaaaa
    19621 ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca gctggcgtaa
    19681 tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga atggcgaatg
    19741 ggacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac
    19801 cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc
    19861 cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt
    19921 tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt cacgtagtgg
    19981 gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag
    20041 tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt cttttgattt
    20101 ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt
    20161 taacgcgaat tttaacaaaa tattaacgct tacaatttcc attcgccatt caggctgcgc
    20221 aactgttggg aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg
    20281 ggatgtgctg caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt
    20341 aaaacgacgg ccagtgagcg cgcgtaatac gactcactat agggcgaatt ggagctccac
    20401 cgcggtggcg gccgctctag aactagtgga tcccccg
//
