LOCUS       sequence-207180-        2463 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  expresses FGFR2 with a single amino acid change in mammalian cells.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 2463)
  AUTHORS   Egan JB, Marks DL, Hogenson TL, Vrabel AM, Sigafoos AN, Tolosa EJ, 
            Carr RM, Safgren SL, Hesles EE, Almada LL, Romecin-Duran PA, Iguchi 
            E, Ala'Aldeen A, Kocher JA, Oliver GR, Prodduturi N, Mead DW, 
            Hossain A, Huneke NE, Tagtow CM, Ailawadhi S, Ansell SM, Banck MS, 
            Bryce AH, Carballido EM, Chanan-Khan AA, Curtis KK, Resnik E, 
            Gawryletz CD, Go RS, Halfdanarson TR, Ho TH, Joseph RW, Kapoor P, 
            Mansfield AS, Meurice N, Nageswara Rao AA, Nowakowski GS, Pardanani 
            A, Parikh SA, Cheville JC, Feldman AL, Ramanathan RK, Robinson SI, 
            Tibes R, Finnes HD, McCormick JB, McWilliams RR, Jatoi A, Patnaik 
            MM, Silva AC, Wieben ED, McAllister TM, Rumilla KM, Kerr SE, 
            Lazaridis KN, Farrugia G, Stewart AK, Clark KJ, Kennedy EJ, Klee EW,
            Borad MJ, Fernandez-Zapico ME
  TITLE     Molecular Modeling and Functional Analysis of Exome 
            Sequencing-Derived Variants of Unknown Significance Identify a 
            Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma.
  JOURNAL   JCO Precis Oncol. 2017;2017:PO.17.00018. doi: 10.1200/PO.17.00018. 
            Epub 2017 Aug 1.
  PUBMED    30761385
REFERENCE   2  (bases 1 to 2463)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "JCO Precis 
            Oncol."; date: "2017"; volume: "2017:PO.17.00018. doi"; pages: " 
            10.1200/PO.17.00018. Epub 2017 Aug 1"
COMMENT     Sequence Label: FGFR2 K41E 3xFlag
FEATURES             Location/Qualifiers
     source          1..2463
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     protein_bind    397..408
                     /label=ZF binding site
                     /bound_moiety="CCR5TC zinc-finger domain"
                     /note="target sequence for the CCR5TC zinc-finger domain 
                     from the CCR5-224 (+) zinc-finger nuclease (Perez et al., 
                     2008; Gross et al., 2013)"
ORIGIN
        1 atggtcagct ggggtcgttt catctgcctg gtcgtggtca ccatggcaac cttgtccctg
       61 gcccggccct ccttcagttt agttgaggat accacattag agccagaaga gccaccaacc
      121 gagtaccaaa tctctcaacc agaagtgtac gtggctgcgc caggggagtc gctagaggtg
      181 cgctgcctgt tgaaagatgc cgccgtgatc agttggacta aggatggggt gcacttgggg
      241 cccaacaata ggacagtgct tattggggag tacttgcaga taaagggcgc cacgcctaga
      301 gactccggcc tctatgcttg tactgccagt aggactgtag acagtgaaac ttggtacttc
      361 atggtgaatg tcacagatgc catctcatcc ggagatgatg aggatgacac cgacggtgcg
      421 gaagattttg tcagtgagaa cagtaacaac aagagagcac catactggac caacacagaa
      481 aagatggaaa agcggctcca tgctgtgcct gcggccaaca ctgtcaagtt tcgctgccca
      541 gccgggggga acccaatgcc aaccatgcgg tggctgaaaa acgggaagga gtttaagcag
      601 gagcatcgca ttggaggcta caaggtacga aaccagcact ggagcctcat tatggaaagt
      661 gtggtcccat ctgacaaggg aaattatacc tgtgtggtgg agaatgaata cgggtccatc
      721 aatcacacgt accacctgga tgttgtggag cgatcgcctc accggcccat cctccaagcc
      781 ggactgccgg caaatgcctc cacagtggtt ggaggagacg tagagtttgt ctgcaaggtt
      841 tacagtgatg cccagcccca catccagtgg atcaagcacg tggaaaagaa cggcagtaaa
      901 tacgggcccg acgggctgcc ctacctcaag gttctcaagg ccgccggtgt taacaccacg
      961 gacaaagaga ttgaggttct ctatattcgg aatgtaactt ttgaggacgc tggggaatat
     1021 acgtgcttgg cgggtaattc tattgggata tcctttcact ctgcatggtt gacagttctg
     1081 ccagcgcctg gaagagaaaa ggagattaca gcttccccag actacctgga gatagccatt
     1141 tactgcatag gggtcttctt aatcgcctgt atggtggtaa cagtcatcct gtgccgaatg
     1201 aagaacacga ccaagaagcc agacttcagc agccagccgg ctgtgcacaa gctgaccaaa
     1261 cgtatccccc tgcggagaca agtaacagtt tcggctgagt ccagctcctc catgaactcc
     1321 aacaccccgc tggtgaggat aacaacacgc ctctcttcaa cggcagacac ccccatgctg
     1381 gcaggggtct ccgagtatga acttccagag gacccaaaat gggagtttcc aagagataag
     1441 ctgacactgg gcaagcccct gggagaaggt tgctttgggc aagtggtcat ggcggaagca
     1501 gtgggaattg acaaagacaa gcccaaggag gcggtcaccg tggccgtgaa gatgttgaaa
     1561 gatgatgcca cagagaaaga cctttctgat ctggtgtcag agatggagat gatgaagatg
     1621 attgggaaac acaagaatat cataaatctt cttggagcct gcacacagga tgggcctctc
     1681 tatgtcatag ttgagtatgc ctctaaaggc aacctccgag aatacctccg agcccggagg
     1741 ccacccggga tggagtactc ctatgacatt aaccgtgttc ctgaggagca gatgaccttc
     1801 aaggacttgg tgtcatgcac ctaccagctg gccagaggca tggagtactt ggcttcccaa
     1861 aaatgtattc atcgagattt agcagccaga aatgttttgg taacagaaaa caatgtgatg
     1921 aaaatagcag actttggact cgccagagat atcaacaata tagactatta caaaaagacc
     1981 accaatgggc ggcttccagt caagtggatg gctccagaag ccctgtttga tagagtatac
     2041 actcatcaga gtgatgtctg gtccttcggg gtgttaatgt gggagatctt cactttaggg
     2101 ggctcgccct acccagggat tcccgtggag gaacttttta agctgctgaa ggaaggacac
     2161 agaatggata agccagccaa ctgcaccaac gaactgtaca tgatgatgag ggactgttgg
     2221 catgcagtgc cctcccagag accaacgttc aagcagttgg tagaagactt ggatcgaatt
     2281 ctcactctca caaccaatga ggaatacttg gacctcagcc aacctctcga acagtattca
     2341 cctagttacc ctgacacaag aagttcttgt tcttcaggag atgattctgt tttttctcca
     2401 gaccccatgc cttacgaacc atgccttcct cagtatccac acataaacgg cagtgttaaa
     2461 aca
//
