LOCUS       sequence-243798-       34702 bp    DNA     circular UNA 15-DEC-2025
DEFINITION  To generate E1/E3-deleted human adenovirus 5 (HAdV-5) bearing a 
            chimeric fiber and an EF1a promoter-controlled transgene..
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 34702)
  AUTHORS   Liu H, Lu Z, Zhang X, Guo X, Mei L, Zou X, Zhong Y, Wang M, Hung T
  TITLE     Single plasmid-based, upgradable and backward compatible adenoviral 
            vector systems.
  JOURNAL   Hum Gene Ther. 2019 Feb 22. doi: 10.1089/hum.2018.258.
  PUBMED    30793964
REFERENCE   2  (bases 1 to 34702)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Hum Gene 
            Ther. 2019 Feb 22. doi: 10.1089/hum.2018.258."
COMMENT     Sequence Label: pKAd5f11p-EPG
FEATURES             Location/Qualifiers
     source          1..34702
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     primer_bind     125..142
                     /label=L4440
                     /note="L4440 vector, forward primer"
     primer_bind     complement(223..242)
                     /label=pRS-marker
                     /note="pRS vectors, use to sequence yeast selectable 
                     marker"
     repeat_region   276..378
                     /label=ITR
                     /note="inverted terminal repeat of human adenovirus 
                     serotype 5"
     regulatory      11086..11095
                     /label=Kozak sequence
                     /note="vertebrate consensus sequence for strong initiation 
                     of translation (Kozak, 1987)"
                     /regulatory_class="other"
     CDS             18561..18572
                     /codon_start=1
                     /product="Factor Xa recognition and cleavage site"
                     /label=Factor Xa site
                     /translation="IEGR"
     misc_feature    join(25665..25702,25703..25768)
                     /label=Ad SA
                     /note="adenovirus major late transcript splice acceptor 
                     (Friedrich and Soriano, 1991)"
     polyA_signal    29298..29419
                     /label=SV40 poly(A) signal
                     /note="SV40 polyadenylation signal"
     primer_bind     complement(29309..29328)
                     /label=EBV-rev
                     /note="SV40 polyA terminator, reverse primer"
     primer_bind     29363..29382
                     /label=SV40pA-R
                     /note="SV40 polyA, reverse primer"
     CDS             complement(join(29577..30287,30288..30290,30291..30293))
                     /codon_start=1
                     /product="enhanced GFP"
                     /label=EGFP
                     /translation="MVSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTL
                     KFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFFKDD
                     GNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIK
                     VNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLL
                     EFVTAAGITLGMDELYK"
     CDS             complement(join(29577..30287,30288..30290,30291..30293))
                     /codon_start=1
                     /product="the original enhanced GFP (Yang et al., 1996)"
                     /label=EGFP
                     /note="mammalian codon-optimized"
                     /translation="MVSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTL
                     KFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFFKDD
                     GNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIK
                     VNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLL
                     EFVTAAGITLGMDELYK"
     primer_bind     complement(29619..29640)
                     /label=EGFP-C
                     /note="EGFP, forward primer"
     primer_bind     29968..29987
                     /label=EXFP-R
                     /note="For distinguishing EGFP variants, reverse primer"
     primer_bind     30227..30248
                     /label=EGFP-N
                     /note="EGFP, reverse primer"
     promoter        complement(30309..31491)
                     /label=EF-1-alpha promoter
                     /note="strong constitutive promoter for human elongation 
                     factor EF-1-alpha"
     intron          30318..31260
                     /label=EF-1-alpha intron A
                     /note="intron upstream of the start codon of human 
                     EF-1-alpha"
     primer_bind     complement(30341..30361)
                     /label=EF1a-F
                     /note="Human elongation factor-1a promoter, forward primer"
     misc_signal     31653..31803
                     /label=Ad5 Psi
                     /note="packaging signal for adenovirus serotype 5"
     repeat_region   31891..31993
                     /label=ITR
                     /note="inverted terminal repeat of human adenovirus 
                     serotype 5"
     rep_origin      32031..32411
                     /direction=RIGHT
                     /label=M13 ori
                     /note="M13 bacteriophage origin of replication; arrow 
                     indicates direction of (+) strand synthesis"
     primer_bind     complement(32118..32137)
                     /label=F1ori-R
                     /note="F1 origin, reverse primer"
     primer_bind     32328..32349
                     /label=F1ori-F
                     /note="F1 origin, forward primer"
     CDS             complement(32459..33253)
                     /codon_start=1
                     /product="aminoglycoside phosphotransferase"
                     /label=NeoR/KanR
                     /note="confers resistance to neomycin, kanamycin, and G418 
                     (Geneticin(R))"
                     /translation="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRP
                     VLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLS
                     SHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQ
                     GLAPAELFARLKASMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIA
                     LATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF"
     CDS             complement(32459..33253)
                     /codon_start=1
                     /gene="aph(3')-II (or nptII)"
                     /product="aminoglycoside phosphotransferase from Tn5"
                     /label=NeoR/KanR
                     /note="confers resistance to neomycin, kanamycin, and G418 
                     (Geneticin(R))"
                     /translation="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRP
                     VLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLS
                     SHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQ
                     GLAPAELFARLKASMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIA
                     LATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF"
     primer_bind     complement(32570..32589)
                     /label=Neo-F
                     /note="Neomycin resistance gene, forward primer"
     primer_bind     33180..33199
                     /label=Neo-R
                     /note="Neomycin resistance gene, reverse primer"
     rep_origin      34085..34673
                     /direction=RIGHT
                     /label=ori
                     /note="high-copy-number ColE1/pMB1/pBR322/pUC origin of 
                     replication"
     primer_bind     34574..34593
                     /label=pBR322ori-F
                     /note="pBR322 origin, forward primer"
ORIGIN
        1 cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt
       61 ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga
      121 gcgcagcgag tcagtgagcg aggaagcgga agagcgcctg atgcggtatt ttctccttac
      181 gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct gctctgatgc
      241 cgcatagtta agccagtata cggatcctta attaacatca tcaataatat accttatttt
      301 gggttgaagc caatatgata atgagggggt ggagtttgtg acgtggcgcg gggcgtggga
      361 acggggcggg tgacgtaggt tttagggcgg agtaacttgt atgtgttggg aattgtagtt
      421 ttcttaaaat gggaagtgac gtaacgtggg aaaacggaag tgacgatttg aggaagttgt
      481 gggttttttg gctttcgttt ctgggcgtag gttcgcgtgc ggttttctgg gtgttttttg
      541 tggactttaa ccgttacgtc attttttagt cctatatata ctcgctctgc acttggccct
      601 tttttacact gtgactgatt gagctggtgc cgtgtcgagt ggtgtttttt taataggttt
      661 tcttttttac tggtaaggct gactgttatg gctgccgctg tggaagcgct gtatgttgtt
      721 ctggagcggg agggtgctat tttgcctagg caggagggtt tttcaggtgt ttatgtgttt
      781 ttctctccta ttaattttgt tatacctcct atgggggctg taatgttgtc tctacgcctg
      841 cgggtatgta ttcccccggg ctatttcggt cgctttttag cactgaccga tgtgaatcaa
      901 cctgatgtgt ttaccgagtc ttacattatg actccggaca tgaccgagga gctgtcggtg
      961 gtgcttttta atcacggtga ccagtttttt tacggtcacg ccggcatggc cgtagtccgt
     1021 cttatgctta taagggttgt ttttcctgtt gtaagacagg cttctaatgt ttaaatgttt
     1081 ttttgttatt ttattttgtg tttatgcaga aacccgcaga catgtttgag agaaaaatgg
     1141 tgtctttttc tgtggtggtt ccggagctta cctgccttta tctgcatgag catgactacg
     1201 atgtgctttc ttttttgcgc gaggctttgc ctgatttttt gagcagcacc ttgcatttta
     1261 tatcgccgcc catgcaacaa gcttacatcg gggctacgct ggttagcata gctccgagta
     1321 tgcgtgtcat aatcagtgtg ggttcttttg tcatggttcc tggcggggaa gtggccgcgc
     1381 tggtccgtgc agacctgcac gattatgttc agctggccct gcgaagggac ctacgggatc
     1441 gcggtatttt tgttaatgtt ccgcttttga atcttataca ggtctgtgag gaacctgaat
     1501 ttttgcaatc atgattcgct gcttgaggct gaaggtggag ggcgctctgg agcagatttt
     1561 tacaatggcc ggacttaata ttcgggattt gcttagagat atattgagaa ggtggcgaga
     1621 tgagaattat ttgggcatgg ttgaaggtgc tggaatgttt atagaggaga ttcaccctga
     1681 agggtttagc ctttacgtcc acttggacgt gagggccgtt tgccttttgg aagccattgt
     1741 gcaacatctt acaaatgcca ttatctgttc tttggctgta gagtttgacc acgccaccgg
     1801 aggggagcgc gttcacttaa tagatcttca ttttgaggtt ttggataatc ttttggaata
     1861 aaaaaaaaaa catggttctt ccagctcttc ccgctcctcc cgtgtgtgac tcgcagaacg
     1921 aatgtgtagg ttggctgggt gtggcttatt ctgcggtggt ggatgttatc agggcagcgg
     1981 cgcatgaagg agtttacata gaacccgaag ccagggggcg cctggatgct ttgagagagt
     2041 ggatatacta caactactac acagagcgat ctaagcggcg agaccggaga cgcagatctg
     2101 tttgtcacgc ccgcacctgg ttttgcttca ggaaatatga ctacgtccgg cgttccattt
     2161 ggcatgacac tacgaccaac acgatctcgg ttgtctcggc gcactccgta cagtagggat
     2221 cgtctacctc cttttgagac agaaacccgc gctaccatac tggaggatca tccgctgctg
     2281 cccgaatgta acactttgac aatgcacaac gtgagttacg tgcgaggtct tccctgcagt
     2341 gtgggattta cgctgattca ggaatgggtt gttccctggg atatggttct aacgcgggag
     2401 gagcttgtaa tcctgaggaa gtgtatgcac gtgtgcctgt gttgtgccaa cattgatatc
     2461 atgacgagca tgatgatcca tggttacgag tcctgggctc tccactgtca ttgttccagt
     2521 cccggttccc tgcagtgtat agccggcggg caggttttgg ccagctggtt taggatggtg
     2581 gtggatggcg ccatgtttaa tcagaggttt atatggtacc gggaggtggt gaattacaac
     2641 atgccaaaag aggtaatgtt tatgtccagc gtgtttatga ggggtcgcca cttaatctac
     2701 ctgcgcttgt ggtatgatgg ccacgtgggt tctgtggtcc ccgccatgag ctttggatac
     2761 agcgccttgc actgtgggat tttgaacaat attgtggtgc tgtgctgcag ttactgtgct
     2821 gatttaagtg agatcagggt gcgctgctgt gcccggagga caaggcgcct tatgctgcgg
     2881 gcggtgcgaa tcatcgctga ggagaccact gccatgttgt attcctgcag gacggagcgg
     2941 cggcggcagc agtttattcg cgcgctgctg cagcaccacc gccctatcct gatgcacgat
     3001 tatgactcta cccccatgta ggcgtggact tctccttcgc cgcccgttaa gcaaccgcaa
     3061 gttggacagc agcctgtggc tcagcagctg gacagcgaca tgaacttaag tgagctgccc
     3121 ggggagttta ttaatatcac tgatgagcgt ttggctcgac aggaaaccgt gtggaatata
     3181 acacctaaga atatgtctgt tacccatgat atgatgcttt ttaaggccag ccggggagaa
     3241 aggactgtgt actctgtgtg ttgggaggga ggtggcaggt tgaatactag ggttctgtga
     3301 gtttgattaa ggtacggtga tctgtataag ctatgtggtg gtggggctat actactgaat
     3361 gaaaaatgac ttgaaatttt ctgcaattga aaaataaaca cgttgaaaca taacacaaac
     3421 gattctttat tcttgggctc agtcgtcttc tctgatgtag taaaaggtaa atggggaggt
     3481 gactagggtt gtagcagagg tttgcacctc tggggcatct cctgtgttcc aggaccaagt
     3541 tatacgaata caatatgatg tctcgtcatt tattgctctt cggttaagca tgacagatat
     3601 gtcaatggga aaagcagtgc gatcactagc tgtgtagtaa caagttccgt aaatgtagtt
     3661 ttctttttct ctagaattat cattgaaagg ataggcagtc gtgctgggca tgaaaccttt
     3721 agcattagta atggcaccag tagccatgtt ttgtcctgat ttatgattaa gtggagtttt
     3781 gagggatgag agtctagtta gtaaattacc agtagaatcg aaaaacagct ctgcagtaaa
     3841 atttatattt ctgtgtgtag ttagcatatt aaaattgtta gatactccta taacataaac
     3901 aaatgcagtg actagtgctc cagttttaac tagtgttaga attaatttgc aatcattaga
     3961 ttcactggag ttcatgattt gacagttggc ttcggtgggg ttgactcctg tccataaggt
     4021 gttaatattg tcatcaatgc aaatgttgtt tgaattgaat gtaagtcctt gtcctaattt
     4081 gatacaaagt ttattttcat tcgttcccaa tccggctcct agtggtaaac ctatagagtg
     4141 accagtctta acgagtggtg tggtggcact tatgttttct ttcaaaaaac cgttggtgtc
     4201 atccactgta agtccccctc ccacttttag ctgtagagat ccgcctgtgg ttgttagtgg
     4261 ggttaaacat tttaaagtaa gaactccagg gggactctct tgaaacccat tgggggatac
     4321 aaagggagga gtaagaaaag gcacagttgg aggaccggtt tccgtgtcat atggatacac
     4381 ggggttgaag gtatcttcag acggtcttgc gcgcttcatc tgcaacaaca tgaagatagt
     4441 gggtgcggat ggacaggaac aggaggaaac tgacattcca tttagattgt ggagaaagtt
     4501 tgcagccagg aggaagctgc aataccagag ctgggaggag ggcaaggagg tgctgctgaa
     4561 taaactggac agaaatttgc taactgattt taagtaagtg atgctttatt attttttttt
     4621 attagttaaa gggaataaga tccccgggta ctctagttaa tcgacttagg cgacctgaca
     4681 ttaactagag gatcttgatg taatccaggg ttaggacagt tgcaaatcac agtgagaaca
     4741 cagggtcccc tgtcccgctc aactagcagg gggcgctggg taaactcccg aatcaggcta
     4801 cgggcaagct ctccctgggc ggtaagccgg acgccgtgcg ccgggccctc gatatgatcc
     4861 tcgggcaatt caaagtagca aaactcaccg gagtcgcggg caaagcactt gtggcggcga
     4921 cagtggacca ggtgtttcag gcgcagttgc tctgcctctc cacttaacat tcagtcgtag
     4981 ccgtccgccg agtcctttac cgcgtcaaag ttaggaataa attgatccgg atagtggccg
     5041 ggaggtcccg agaaggggtt aaagtagacc gatggcacaa attcctcaat aaattgcaga
     5101 gttccaatgc ctccagagcg cggctcagag gacgaggtct gcagagttag gattgcctga
     5161 cgaggcgtga atgaagagcg gccggcgccg ccgatctgaa atgtcccgtc cggacggaga
     5221 ccaagcgagg agctcaccga ctcgtcgttg agctgaatac ctcgccctct gattgtcagg
     5281 tgagttatac cctgcccggg cgaccgcacc ctgtgacgaa agccgcccgc aagctgcgcc
     5341 cctgagttag tcatctgaac ttcggcctgg gcgtctctgg gaagtaccac agtggtggga
     5401 gcgggacttt cctggtacac cagggcagcg ggccaactac ggggattaag gttattacga
     5461 ggtgtggtgg taatagccgc ctgttccagg agaattcggt ttcggtgggc gcgtattccg
     5521 ttgacccggg atatcatgtg gggtcccgcg ctcatgtagt ttattcgggt tgagtagtct
     5581 tgggcagctc cagccgcaag tcccatttgt ggctggtaac tccacatgta gggcgtggga
     5641 atttccttgc tcataatggc gctgacaaca ggtgctggcg ccgggtgtgg ccgctggaga
     5701 tgacgtagtt ttcgcgctta aatttgagaa agggcgcgaa actagtcctt aagagtcagc
     5761 gcgcagtatt tactgaagag agcctccgcg tcttccagcg tgcgccgaag ctgatcttcg
     5821 cttttgtgat acaggcagct gcgggtgagg gatcgcagag acctgttttt tattttcagc
     5881 tcttgttctt ggcccctgct ctgttgaaat atagcataca gagtgggaaa aatcctgttt
     5941 ctaagctcgc gggtcgatac gggttcgttg ggcgccagac gcagcgctcc tcctcctgct
     6001 gctgccgccg ctgtggattt cttgggcttt gtcagagtct tgctatccgg tcgcctttgc
     6061 ttctgtgtgg ccgctgctgt tgctgccgct gccgccggtg cagtatgggc tgtagagatg
     6121 acggtagtaa tgcaggatgt tacgggggaa ggccacgccg tgatggtaga gaagaaagcg
     6181 gcgggcgaag gagatgttgc ccccacagtc ttgcaagcaa gcaactatgg cgttcttgtg
     6241 cccgcgccat gagcggtagc cttggcgctg ttgttgctct tgggctaacg gcggcggctg
     6301 cttggactta ccggccctgg ttccagtggt gtcccatcta cggttgggtc ggcgaacggg
     6361 cagtgccggc ggcgcctgag gagcggaggt tgtagccatg ctggaaccgg ttgccgattt
     6421 ctggggcgcc ggcgagggga atgcgaccga gggtgacggt gtttcgtctg acacctcttc
     6481 gacctcggaa gcttcctcgt ctaggctctc ccagtcttcc atcatgtcct cctcctcctc
     6541 gtccaaaacc tcctctgcct gactgtccca gtattcctcc tcgtccgtgg gtggcggcgg
     6601 cagctgcagc ttctttttgg gtgccatcct gggaagcaag ggcccgcggc tgctgctgat
     6661 agggctgcgg cggcgggggg attgggttga gctcctcgcc ggactggggg tccaagtaaa
     6721 ccccccgtcc ctttcgtagc agaaactctt ggcgggcttt gttgatggct tgcaattggc
     6781 caagaatgtg gccctgggta atgacgcagg cggtaagctc cgcattaggc gggcgggatt
     6841 ggtcttcgta gaacctaatc tcgtgggcgt ggtagtcctc aggtacaaat ttgcgaaggt
     6901 aagccgacgt ccacagcccc ggagtgagtt tcaaccccgg agccgcggac ttttcgtcag
     6961 gcgagggacc ctgcagctca aaggtaccga taatttgact ttcgttaagc agctgcgaat
     7021 tgcaaaccag ggagcggtgc ggggtgcata ggttgcagcg acagtgacac tccagtagac
     7081 cgtcaccgct cacgtcttcc attatgtcag agtggtaggc aaggtagttg gctagctgca
     7141 gaaggtagca gtggccccaa agcggcggag ggcattcgcg gtacttaatg ggcacaaagt
     7201 cgctaggaag tgcacagcag gtggcgggca agattcctga gcgctctagg ataaagttcc
     7261 taaagttctg caacatgctt tgactggtga agtctggcag accctgttgc agggttttaa
     7321 gcaggcgttc ggggaaaatg atgtccgcca ggtgcgcggc cacggagcgc tcgttgaagg
     7381 ccgtccatag gtccttcaag ttttgcttta gcagtttctg cagctccttg aggttgcact
     7441 cctccaagca ctgctgccaa acgcccatgg ccgtctgcca ggtgtagcat agaaataagt
     7501 aaacgcagtc gcggacgtag tcgcggcgcg cctcgccctt gagcgtggaa tgaagcacgt
     7561 tttgcccaag gcggttttcg tgcaaaattc caaggtagga gaccaggttg cagagctcca
     7621 cgttggagat cttgcaggcc tggcgtacgt agccctgtcg aaaggtgtag tgcaatgttt
     7681 cctctagctt gcgctgcatc tccgggtcag caaagaaccg ctgcatgcac tcaagctcca
     7741 cggtaacgag cactgcggcc atcattagtt tgcgtcgctc ctccaagtcg gcaggctcgc
     7801 gcgtttgaag ccagcgcgct agctgctcgt cgccaactgc gggtaggccc tcctctgttt
     7861 gttcttgcaa atttgcatcc ctctccaggg gctgcgcacg gcgcacgatc agctcactca
     7921 tgactgtgct catgaccttg gggggtaggt taagtgccgg gtaggcaaag tgggtgacct
     7981 cgatgctgcg ttttagtacg gctaggcgcg cgttgtcacc ctcgagttcc accaacactc
     8041 cagagtgact ttcattttcg ctgttttcct gttgcagagc gtttgccgcg cgcttctcgt
     8101 cgcgtccaag accctcaaag atttttggca cttcgttgag cgaggcgata tcaggtatga
     8161 cagcgccctg ccgcaaggcc agctgcttgt ccgctcggct gcggttggca cggcaggata
     8221 ggggtatctt gcagttttgg aaaaagatgt gataggtggc aagcacctct ggcacggcaa
     8281 atacggggta gaagttgagg cgcgggttgg gctcgcatgt gccgttttct tggcgtttgg
     8341 ggggtacgcg cggtgagaat aggtggcgtt cgtaggcaag gctgacatcc gctatggcga
     8401 ggggcacatc gctgcgctct tgcaacgcgt cgcagataat ggcgcactgg cgctgcagat
     8461 gcttcaacag cacgtcgtct cccacatcta ggtagtcgcc atgcctttcg tccccccgcc
     8521 cgacttgttc ctcgtttgcc tctgcgttgt cctggtcttg ctttttatcc tctgttggta
     8581 ctgagcggtc ctcgtcgtct tcgcttacaa aacctgggtc ctgctcgata atcacttcct
     8641 cctcctcaag cgggggtgcc tcgacgggga aggtggtagg cgcgttggcg gcatcggtgg
     8701 aggcggtggt ggcgaactca gagggggcgg ttaggctgtc cttcttctcg actgactcca
     8761 tgatcttttt ctgcctatag gagaaggaaa tggccagtcg ggaagaggag cagcgcgaaa
     8821 ccacccccga gcgcggacgc ggtgcggcgc gacgtccccc aaccatggag gacgtgtcgt
     8881 ccccgtcccc gtcgccgccg cctccccggg cgcccccaaa aaagcggatg aggcggcgta
     8941 tcgagtccga ggacgaggaa gactcatcac aagacgcgct ggtgccgcgc acacccagcc
     9001 cgcggccatc gacctcggcg gcggatttgg ccattgcgcc caagaagaaa aagaagcgcc
     9061 cttctcccaa gcccgagcgc ccgccatcac cagaggtaat cgtggacagc gaggaagaaa
     9121 gagaagatgt ggcgctacaa atggtgggtt tcagcaaccc accggtgcta atcaagcatg
     9181 gcaaaggagg taagcgcaca gtgcggcggc tgaatgaaga cgacccagtg gcgcgtggta
     9241 tgcggacgca agaggaagag gaagagccca gcgaagcgga aagtgaaatt acggtgatga
     9301 acccgctgag tgtgccgatc gtgtctgcgt gggagaaggg catggaggct gcgcgcgcgc
     9361 tgatggacaa gtaccacgtg gataacgatc taaaggcgaa cttcaaacta ctgcctgacc
     9421 aagtggaagc tctggcggcc gtatgcaaga cctggctgaa cgaggagcac cgcgggttgc
     9481 agctgacctt caccagcaac aagacctttg tgacgatgat ggggcgattc ctgcaggcgt
     9541 acctgcagtc gtttgcagag gtgacctaca agcatcacga gcccacgggc tgcgcgttgt
     9601 ggctgcaccg ctgcgctgag atcgaaggcg agcttaagtg tctacacgga agcattatga
     9661 taaataagga gcacgtgatt gaaatggatg tgacgagcga aaacgggcag cgcgcgctga
     9721 aggagcagtc tagcaaggcc aagatcgtga agaaccggtg gggccgaaat gtggtgcaga
     9781 tctccaacac cgacgcaagg tgctgcgtgc acgacgcggc ctgtccggcc aatcagtttt
     9841 ccggcaagtc ttgcggcatg ttcttctctg aaggcgcaaa ggctcaggtg gcttttaagc
     9901 agatcaaggc ttttatgcag gcgctgtatc ctaacgccca gaccgggcac ggtcaccttt
     9961 tgatgccact acggtgcgag tgcaactcaa agcctgggca cgcgcccttt ttgggaaggc
    10021 agctaccaaa gttgactccg ttcgccctga gcaacgcgga ggacctggac gcggatctga
    10081 tctccgacaa gagcgtgctg gccagcgtgc accacccggc gctgatagtg ttccagtgct
    10141 gcaaccctgt gtatcgcaac tcgcgcgcgc agggcggagg ccccaactgc gacttcaaga
    10201 tatcggcgcc cgacctgcta aacgcgttgg tgatggtgcg cagcctgtgg agtgaaaact
    10261 tcaccgagct gccgcggatg gttgtgcctg agtttaagtg gagcactaaa caccagtatc
    10321 gcaacgtgtc cctgccagtg gcgcatagcg atgcgcggca gaaccccttt gatttttaaa
    10381 cggcgcagac ggcaagggtg ggggtaaata atcacccgag agtgtacaaa taaaagcatt
    10441 tgcctttatt gaaagtgtct ctagtacatt atttttacat gtttttcaag tgacaaaaag
    10501 aagtggcgct cctaatctgc gcactgtggc tgcggaagta gggcgagtgg cgctccagga
    10561 agctgtagag ctgttcctgg ttgcgacgca gggtgggctg tacctgggga ctgttgagca
    10621 tggagttggg taccccggta ataaggttca tggtggggtt gtgatccatg ggagtttggg
    10681 gccagttggc aaaggcgtgg agaaacatgc agcagaatag tccacaggcg gccgagttgg
    10741 gcccctgtac gctttgggtg gacttttcca gcgttataca gcggtcgggg gaagaagcaa
    10801 tggcgctacg gcgcaggagt gactcgtact caaactggta aacctgcttg agtcgctggt
    10861 cagaaaagcc aaagggctca aagaggtagc atgtttttga gtgcgggttc caggcaaagg
    10921 ccatccagtg tacgccccca gtctcgcgac cggccgtatt gactatggcg caggcgagct
    10981 tgtgtggaga aacaaagcct ggaaagcgct tgtcataggt gcccaaaaaa tatggcccac
    11041 aaccaagatc tttgacaatg gctttcagtt cctgctcact ggagcccatg gcggcagctg
    11101 ttgttgatgt tgcttgcttc tttatgttgt ggcgttgccg gccgagaagg gcgtgcgcag
    11161 gtacacggtt tcgatgacgc cgcggtgcgg ctggtgcaca cggaccacgt caaagacttc
    11221 aaacaaaaca taaagaaggg tgggctcgtc catgggatcc acctcaaaag tcatgtctag
    11281 cgcgtgggcg gagttggcgt agagaaggtt ttggcccagg tctgtgagtg cgcccatgga
    11341 cataaagtta ctggagaatg ggatgcgcca aagggtgcga tcgcaaagaa actttttctg
    11401 ggtaatgctg tcaactgcgg tcttgcctat aagcggatag gggaagttag cagggtaggc
    11461 ctgtccttcg cgcatggtgg gggcaaggta gccaacaaat ccagagttgt tgtgttggtg
    11521 taggatgccc acctgttggt agtccttgta tttagtatca tccaccacct gacggctcat
    11581 gggctggaag tttctaaaga aggagtacat gcggtccttg tagctctctg ggatatagaa
    11641 gccctggtag ccaatgttat agttagctag catttgtacc aggaaccagt ctttggtcat
    11701 gttacactgg gcaacgttgt aaccctcccc gtcaactgag cgcttaattt caaactcgtt
    11761 gggggtaagc aggcggtcat tgccaggcca gctgacagaa gagtcaaagg taatggccac
    11821 cttcttaaag gtgtggttga ggtaaaaggt tccatctagg tagggtatag agccagagta
    11881 ggtgtaataa gggtcgtagc ccgagcccag tgatggggtt tccttagtct taaggcgcgt
    11941 gaaggcccag ccgcggaaag ccgcccagtt gcgggagggg atggatatgg gcacgttggt
    12001 agcgttggcg ggtatagggt agagcatgtt ggcggcggag agatagtcgt taaaggactg
    12061 gtcgttggtg tcgtttctaa gcatggcctc aagcgtggag gcggtgttgt gggccatggg
    12121 gaagaaggtg gcgtaaaggc aaatgctatc aaacttaatg ctggctccgt caacccttag
    12181 gtcatttcct agggagctct gcagaaccat gttaacatcc ttcctgaagt tccactcgta
    12241 ggtgtatgag cccggcagga gaaggaggtt tttaatggca aagaacttct gaggcacctg
    12301 gatgtggaag ggcacatagc gaccattgcc cagcaacatt gagcggtagc gcaggccagc
    12361 attgcggtgg tggttaaatg ggttgacgtt gtccatatag tcaagggacc agcgtgctcc
    12421 aaggttaatg tagcagtcca ctagcccggg agccaccact cgcttgttca tgtagtcgta
    12481 ggtgtttggg ttatcagaaa tttttacgtt ggaaggactg tactttagct tgtcgggcaa
    12541 atacagcgct atgttggagt acaggaaatt tctccacagg ttggcattta gattgatttc
    12601 catggcaaaa ttatttccaa ctcttatttc atttttatct gaaaattctg tagcatcttt
    12661 ttcccatcca ttttcctgac ctgttttagg ttttaccttg gtaagagtct ctgtattaat
    12721 cacacctccc agtggaaagc agtaatttgg aagttcatct tcagttccat gattttcaat
    12781 aattctaaca tctggatcat agctgtcaac agcctgattc cacatagaaa agtacctggt
    12841 tctatcacca atggaatcaa gcaaaagctg gtatgaaagc tctgtgtttc tgtcttgcaa
    12901 atctacaaca gcattcaact gcgatgcttg gcccgccaga acacccatat tacccgtgct
    12961 gttgtaatac attagaccaa taaaattgtc cctaaaagca atgtaattag gcctgttggg
    13021 catagattgt tggcccatta gttctcgtga gttaccttcc ttaatagtgg gcatgtaaga
    13081 aatatgagtg tctggggttt ctatatctac atcttcactg tacaatacca ctttaggagt
    13141 caagttatca ccattgcctg cggctgcctc agtagttgag aaaaattgca tttccacttg
    13201 actttctagc tttccatttt gttgctttac aagaatgcct tgccctccat tttcatttgt
    13261 gggttttgca tatgaaccgt aacatggttt cattggggta gtctttttta ggactctccc
    13321 agctgcatga ttaatttctg tttcgtacca ctgagattct cctatttgag gttcaggttg
    13381 aaatgtttta tcggcatatt taggtgtttg accttcgaca cctatttgaa taccctcctt
    13441 tgtaatattt ataccagaat aaggcgcctg cccaaatacg tgagtttttt gctgctcagc
    13501 ttgctcgtct acttcgtctt cgttgtcatc gtcctcttct tctaggttta tttcaagagc
    13561 agtagcagct tcatcccatt cgcaaggatt tggggcaccc ttgggagcca gggcgttgta
    13621 ggcagtgcca gagtagggct taaaagtagg gcccctgtcc agcacgccgc ggatgtcaaa
    13681 gtacgtggaa gccatgtcca gcacacggtt atcacccaca gctagggtga accgcgcctt
    13741 gtacgagtac gcagtatcct cacggtccac agggatgaac cgcagcgtca aacgctggga
    13801 ccggtctgtg gtcacgtcgt gcgtaggcgc caccgtgggg tttctaaact tgttattcag
    13861 gctgaagtac gtctcggtgg cgcgggcaaa ctgcaccagc ccggggctca ggtactccga
    13921 ggcgtcctgg cccgagatgt gcatgtaaga ccactgcggc atcatcgaag gggtagccat
    13981 cttggaaagc gggcgcgcgg cggctcagca gctcctctgg cggcgacatg gacgcataca
    14041 tgacacacat acgacacgtt agctatcaga agcatcgtcg gcgcttcagg gattgcaccc
    14101 ccagacccac gatgctgttc agtgtgcttt gccagttgcc actggctacg ggccgcaacg
    14161 atcgcggacc gctggcggcg cggcgcaggg acgcgcggct aggacgggtt acaacaacgg
    14221 cggtcgggcc tggcagcaca ggtttctgct gggtgtcggc ggggggaggc aggtccagcg
    14281 ttacgggtgt gtgctggccc agcactccgg tagccatggg cgcgatggga cgggtggtgg
    14341 gcaggccttg ctttagtgcc tcctcgtacg agggaggctc gtctatttgc gtcaccagag
    14401 tttcttccct gtcggggcgc ggacgctttt cgccacgccc ctctggagac actgtctcca
    14461 cggccggtgg aggctcctct acgggagggc ggggatcaag cttactgtta atcttatttt
    14521 gcactgcctg gttggccagg tccaccaccc cgctaatgcc agaggccagg ccatctacca
    14581 ccttttgttg gaaattttgc tctttcaact tatccctcag catctggcct gtgctgctgt
    14641 tccaggcctt gctgccatag ttcttaacgg tggaaccgaa atttttaatg ccgctccaca
    14701 gcgagcccca gctgaaggcg ccaccgctca tattgctggt gccgatatct tgccagtttc
    14761 ccatgaacgg gcgcgagccg tgtcgcgggg ccagagacgc aaagttgatg tcttccattc
    14821 tacaaaatag ttacaggacc aagcgagcgt gagagtccag actttttatt ttgatttttc
    14881 cacatgcaac ttgtttttaa tcagtgtctc tgcgcctgca aggccacgga tgcaattccg
    14941 ggcacggcgc caatcgccgc ggcgatcagt ggaataagga ggggcaggat accgccgcgc
    15001 atgcgacggt gcgacgcgcg ccgccgccgg tggtgcgcac gacgcatgcc gcccgtcagg
    15061 ccgtggccgg ccatgcccct cctacggtgc attcttcctc ggaatcccgg caccgggaaa
    15121 cggaggcggc aggtgagggc catatctgca agaaccacaa agaccggctt ttaaacgatg
    15181 ctggggtggt agcgcgctgt tggcagcacc agggtcctgc ctccttcgcg agccaccctg
    15241 cgcacggaaa tcggggccag cacgggctgg cgacggcggc ggcgggttcc agtggtggtt
    15301 cggcgtcggg tagttgctcg tcttctgggg cggtaggtgt agccacgata gccgggggta
    15361 ggcgcaatgg aaggatgtag ggcatattcg ggcagtagcg cgctggcggc gccgtacttc
    15421 ctcgaacggc gcgggcgccg gggggctgaa acgcgaaaca tccacgggtc cgtttgcacc
    15481 tccgtagagg tcttggacgc ggccgcagcg accgcctgca ccgcggcatc cgccaccgct
    15541 gaggcaaccg gggacgtttg tgtctccatg ccctctgtgg cggtggcaat actggtgcta
    15601 ctggtagtgg gtatctgaac gtccacggtc tgcacgccca gtcccggcgc cacctgcttg
    15661 attggccgca cgcggacctc gggctccagc ccaggttcca cggtcatttt ttccaagaca
    15721 tcttccagtc gctggcgctt gggtaccatc agctgcacgg tgggtgccaa gtcaccagac
    15781 tcgcgcttta ggccgcgctt ttcttcggac ggtgcaagcg cgggcagcac ctgctgcagt
    15841 gttacgggct ttaggctagg tgttgggttg ccctcgtcca gcggcaacgc cagcatgtcc
    15901 ttatgccgct ttccgtaggc aaactccccg aggcgctcgt tggcctgctc aagcaggtcc
    15961 tcgtcgccgt acacctcatc atacacgcgc ttgtaggtgc gggtggagcg ctcaccgggc
    16021 gtaaagacta cggtggtgcc gggtcgcaaa acacgtttta cgcgtcgacc tttccactgt
    16081 acccgtcgcc tgggcgcggt agcgtgcagc agttccacct cgtcgtcaag ttcatcatca
    16141 tcatctttct ttttcttttt gacccgcttt agctttcggg gcttgtaatc ctgctcttcc
    16201 ttcttcgggg ggccatagat ctccggcgcg atgacctgga gcatctcttc tttgattttg
    16261 cgcttggaca tagcttcgtt gcgcgccgcc gccgctggat acatacaaca gtacgagtct
    16321 aagtagtttt ttcttgcaat ctagttgcgc ggggggcggg tgcgcacggg cacgcgcagg
    16381 ccgctaaccg agtcgcgcac ccaatacacg ttgcccctgc gaccctgagt catagcacta
    16441 atggccgcgg ctgctgcggc ggccgctcgt cgcctggacc tggggggcac agtgacaata
    16501 cccgcggcca gccttcgagc ggcccgcatg gccgcccgtc ggccggtgcg acgtgcgcgg
    16561 ttaagcaggg ccgccgccgc gcgttgggcg gcagtgccgg gtcggcggcg gtggcgacgt
    16621 gctacgcgcc tccgccgtct cttcatttta gcatagcgcc gggctccgcg caccacggtc
    16681 tgaatggccg cgtccactgt ggacactggt ggcggcgtgg gcgtgtagtt gcgcgcctcc
    16741 tccaccaccg cgtcgatggc gtcatcgacg gtggtgcgcc cagtgcggcc gcgtttgtgc
    16801 gcgccccagg gcgcgcggta gtgcccgcgc acgcgcactg ggtgttggtc ggagcgcttc
    16861 ttggccccgc caaacatctt gcttgggaag cgcaggcccc agcctgtgtt attgctgggc
    16921 gatataagga tggacatgct tgctcaaaaa gtgcggctcg ataggacgcg cggcgagact
    16981 atgcccaggg ccttgtaaac gtaggggcag gtgcggcgtc tggcgtcagt aatggtcact
    17041 cgctggactc ctccgatgct gttgcgcagc ggtagcgtcc cgtgatctgt gagagcagga
    17101 acgttttcac tgacggtggt gatggtgggg gctggcgggc gcgccaaaat ctggttctcg
    17161 ggaaagcgat tgaacacgtg ggtcagagag gtaaactggc ggatgagttg ggagtagacg
    17221 gcctggtcgt tgtagaagct cttggagtgc acgggcaaca gctcggcgcc caccaccgga
    17281 aagttgctga tctggcgcgt ggagcggaag gtcacggggt cttgcatcat gtctggcaac
    17341 gaccagtaga cctgctccga gccgcaggtt acgtcaggag tgcaaagcag ggtccatgag
    17401 cggattccgg tctgagggtc gccgtagttg tatgcaaggt accagctgcg gtactgggtg
    17461 aaggtgctgt cattgcttat taggttgtaa ctgcgtttct tgctgtcctc tgtcaggggt
    17521 ttgatcaccg gtttcttctg aggcttctcg acctcgggtt gcgcagcggg ggcggcagct
    17581 tcggccgctg cttcggcctc agcgcgcttc tcctcagccc gtgtggcaaa ggtgtcgccg
    17641 cgaatggcat gatcgttcat gtcctccacc ggctgcattg ccgcggctgc cgcgttggag
    17701 ttctcttccg cgccgctgcc actgctgttg ctgccgcctg cgccaccccc gccctgttcg
    17761 gtgtcatctt tcaagctcgc ctggtaggcg tccacatcca acagtgcggg aatgttacca
    17821 ccctccagat catcgtaggt gatcctaaag ccctcctgga agggttgccg cttgcggatg
    17881 cccaacaagt tgctcaggcg gctgtgggtg aagtccaccc cgcatcctgg cagcaaaatg
    17941 atgtctggat ggaaggcttc gtttgtatat accccaggca tgacaagacc agtgacgggg
    18001 tcaaacccca gtctgaagtt gcgggtgtca aactttaccc cgatgtcgct ttccagaacc
    18061 ccgttctgtc tgcccacttt caagtagtgc tccacgatcg cgttgttcat aaggtctatg
    18121 gtcatggtct cggagtagtt gccctcgggc agcgtgaact ccacccactc gtatttcagc
    18181 tccacctgat tgtccttagt aggcaagcgc gacaccatca cccgcgcctt aaacttattg
    18241 gtaaacatga actcgttcac atttggcatg ttggtatgca ggatggtttt caggtcgccg
    18301 ccccagtgcg accggtcgtc aagattgatg gtctgtgtgc ttgcctcccc cgggctgtag
    18361 tcattgtttt gaatgaccgt ggtcagaaag ttgctgtggt cgttctggta gttcagggat
    18421 gccacatccg ttgacttgtt gtccaccagg tacacacggg tggtgtcgaa taggggtgcc
    18481 aactcagagt aacggatgct gtttctcccc ccggtaggcc gcaggtaccg cggaggcaca
    18541 aacggcgggt ccaggggagc atcgaaggga gaacccagcg ccgccgccac tggcgccgcg
    18601 ctcaccacac tctcgtagga gggaggagga ccttcctcat acatcgccgc gcgccgcata
    18661 ctaaggggaa tacaagaaaa ccaacgctcg gtgccatggc cttggtgagt tttttatttt
    18721 gcatcatgct tttttttttt taaaacattc tccccagcct ggggcgaagg tgcgcaaacg
    18781 ggttgccact ccctcccaaa tccaggacgc tgctgtcgtc tgccgagtca tcgtcctccc
    18841 acaccagacc ccgctgacgg tcgtgccttt gacgacgggt gggcgggcgc gggcctggca
    18901 cgtccctgtg ctcctgcgcg tacgtcttcc atctactcat cttgtccact aggctctcta
    18961 tcccgttgtt gggaaatgcc ggaggcaggt ttttttcgcg ctgcggctgc agcagcgagt
    19021 tgtttaggta ctcctcctcg cccagcaggc gcgggcgggt ggtgcgagtg ctggtaagag
    19081 accctatcaa gcttggaaat gggctactag catctgaccg cggggccgca gcgcctagat
    19141 cggacaagct gcttggcctg cggaagcttt cctttcgcag cgccgcctct gcctgctcgc
    19201 gctgttgcaa ctctagcagg gtctgcggtt gcggggaaaa cacgctgtcg tctatgtcgt
    19261 cccagaggaa tccatcgtta ccctcgggca cctcgaatcc cccggtgtag aaaccagggg
    19321 gcggtagcca gtgcgggttc aagatggcat tggtgaaata ctcggggttc acggcggccg
    19381 cgcgatgcaa gtagtccatt aggcggttga taaacggccg gtttgaggca tacatgcccg
    19441 gttccatgtt gcgcgcggtc atgtccagcg ccacgctggg cgttaccccg tcgcgcatca
    19501 ggttaaggct cacgctctgc tgcacgtagc gcaaaatgcg ctcctcctcg ctatttaaac
    19561 tgtgcaacga ggggatcttc tgccgccggt tggtcagcag gtagtttagg gttgcctcca
    19621 ggctgcccgt gtcctcctgc cccagcgcgc ggctgacact tgtaatctcc tggaaagtat
    19681 gctcgtccac atgcgcctga cctatggcct cgcggtacag tgtcagcaag tgacctaggt
    19741 atgtgtcccg ggacacgctg ccactgtccg tgaagggcgc tattagcagc agcaacaggc
    19801 gcgagttggg cgtcagcaag ctagacacgg tcgcgcggtc gcctgtggga gcccgcaccc
    19861 cccacagccc ctgcaagttt ttgaaagcct ggctcaggtt tacggtctgc aggccttgtc
    19921 tactggtctg gaaaaaatag tctggcccag actggtacac ctcactttgc ggtgtctcag
    19981 tcaccattag ccgcagtgcg ctcacaaagt tggtgtagtc ctcctgtccc cgcggcacgt
    20041 tggcgggctg tgtactcagg aaggcgttta gtgcaaccat ggagcccagg ttgccctgct
    20101 gctgcgcgcg ctcacgctgc gccacggcct cgcgcacatc ccccaccagc cggtccaggt
    20161 tggtctgcac gttgccgctg ttgtaacgag ccacgcgctg aagcagcgcg tcgtagacca
    20221 ggccggcctc gtcgggccgg atggccctgt tttcggccag cgcgtttacg atcgccagca
    20281 ccttctcgtg cgtggggttt gcgcgcgccg ggaccaccgc ttccagaatt gcggagagcc
    20341 ggttggcctg cggctgctgc cggaacgcgt caggattgcg cgcagtcagc gacatgatgc
    20401 ggtccatgac ctggcgccag tcgtccgtgg agttaaggcc ggacggctgg ctctgcagcg
    20461 ccgcccgcac cgccgggtcc gttgcgtctt gcatcatctg atcagaaaca tcaccgctta
    20521 gtactcgccg tcctctggct cgtactcatc gtcctcgtca tattcctcca cgccgccgac
    20581 gttgccagcg cgcgcgggtg ccaccgccag cccaggtccg gccccagctg cctccagggc
    20641 gcgtcggctt ggggcccagc gcaggtcagc gcccgcgtca aagtaggact cggcctctct
    20701 atcgccgctg cccgtgccag ccagggccct ttgcaggctg tgcatcagct cgcggtcgct
    20761 gagctcgcgc cgccggctca cgctcacggc cttgtggatg cgctcgttgc gataaacgcc
    20821 caggtcgtcg ctcaaggtaa gcaccttcag cgccatgcgc atgtagaacc cctcgatctt
    20881 tacctccttg tctatgggaa cgtaaggggt atggtatatc ttgcgggcgt aaaacttgcc
    20941 caggctaagc atggaatagt tgatggcggc caccttgtca gccaggctca agctgcgctc
    21001 ctgcaccact atgctctgca ggatgtttat caaatcgagc agccagcggc cctcgggctc
    21061 tactatgttt agcagcgcat ccctgaatgc ctcgttgtcc ctgctgtgct gcactataag
    21121 gaacagctgc gccatgagcg gcttgctatt tgggttttgc tccagcgcgc ttacaaagtc
    21181 ccacagatgc atcagtccta tagccacctc ctcgcgcgcc acaagcgtac gcacgtggtt
    21241 gttaaagctt ttttgaaagt taatctcctg gttcaccgtc tgctcgtatg cggttaccag
    21301 gtcggcggcc gccacgtgtg cgcgcgcggg actaatcccg gttcgcgcgt cgggctcaaa
    21361 gtcctcctcg cgcagcaacc gctcgcgatt caggccatgc cgcagctcgc gccctgcgtg
    21421 gaactttcga tcccgcatct cctcgggctc ctctccctcg cggtcgcgaa acaggttctg
    21481 ccgcggcacg tacgcctcac gcgtatcacg cttcagctgc acccttgggt gccgctcagg
    21541 agagggcgct cctagccgcg ccaggccctc gccctcctcc aagtccaggt agtgccgggc
    21601 ccggcgccgc gggggttcgt aatcaccatc tgctgccgcg tcaaccgcgg atgtcgcccc
    21661 tcctgacgcg gtaggaggag gggagggtgc cctgcatgtc tgccgctgct cttgctcttg
    21721 ccgctgctga ggaggggggc gcatctgccg cagcaccgga tgcatctggg aaaagcaaaa
    21781 aaggggctcg tccctgtttc cggaggaatt tgcaagcggg gtcttgcatg acggggaggc
    21841 aaacccccgt tcgccgcagt ccggccggtc cgagactcga accgggggtc ccgcgactca
    21901 acccttggaa aataaccctc cggctacagg gagcgagcca cttaatgctt tcgctttcca
    21961 gcctaaccgc ttacgctgcg cgcggccagt ggccaaaaaa gctagcgcag cagccgccgc
    22021 gcctggaagg aagccaaaag gagcactccc ccgttgtctg acgtcgcaca cctgggttcg
    22081 acacgcgggc ggtaaccgca tggatcacgg cggacggccg gatacggggc tcgaaccccg
    22141 gtcgtccgcc atgataccct tgcgaattta tccaccagac cacggaagag tgcccgctta
    22201 caggctctcc ttttgcacgc tagagcgtca acgattgcgc gcgcctgacc ggccagagcg
    22261 tcccgaccat ggagcacttt ttgccgctgc gcaacatctg gaaccgcgtc cgcgactttc
    22321 cgcgcgcctc caccaccgcc gccggcatca cctggatgtc caggtacatc tacggatatc
    22381 atcgccttat gttggaagat ctcgcccccg gagccccggc caccctacgc tggcccctct
    22441 accgccagcc gccgccgcac tttttggtgg gataccagta cctggtgcgg acttgcaacg
    22501 actacgtatt tgactcgagg gcttactcgc gtctcaggta caccgagctc tcgcagccgg
    22561 gtcaccagac cgttaactgg tccgttatgg ccaactgcac ttacaccatc aacacgggcg
    22621 cataccaccg ctttgtggac atggatgact tccagtctac cctcacgcag gtgcagcagg
    22681 ccatattagc cgagcgcgtt gtcgccgacc tagccctgct tcagccgatg aggggcttcg
    22741 gggtcacacg catgggagga agagggcgcc acctacggcc aaactccgcc gccgccgcag
    22801 cgatagatgc aagagatgca ggacaagagg aaggagaaga agaagtgccg gtagaaaggc
    22861 tcatgcaaga ctactacaaa gacctgcgcc gatgtcaaaa cgaagcctgg ggcatggccg
    22921 accgcctgcg cattcagcag gccggaccca aggacatggt gcttctgtcg accatccgcc
    22981 gtctcaagac cgcctacttt aattacatca tcagcagcac ctccgccaga aacaaccccg
    23041 accgccgccc gctgccgccc gccacggtgc tcagcctacc ttgcgactgt gactggttag
    23101 acgcctttct cgagaggttt tccgatccgg tcgatgcgga ctcgctcagg tccctcggcg
    23161 gcggagtacc tacacaacaa ttgttgagat gcatcgttag cgccgtatcc ctgccgcatg
    23221 gcagcccccc gccaacccat aaccgggaca tgacgggcgg cgtcttccaa ctgcgccccc
    23281 gcgagaacgg ccgcgccgtc accgagacca tgcgccgtcg ccgcggggag atgatcgagc
    23341 gctttgtcga ccgcctcccg gtgcgccgtc gtcgccgccg tgtcccccct cccccaccgc
    23401 cgccagaaga agaagaaggg gaggccctta tggaagagga gattgaagaa gaagaagagg
    23461 cccctgtagc ctttgagcgc gaggtgcgcg acactgtcgc cgagctcatc cgtcttctgg
    23521 aggaggagtt aaccgtgtcg gcgcgcaact cccagttttt caacttcgcc gtggacttct
    23581 acgaggccat ggagcgcctt gaggccttgg gggatatcaa cgaatccacg ttgcgacgct
    23641 gggttatgta cttcttcgtg gcagaacaca ccgccaccac cctcaactac ctctttcagc
    23701 gcctgcgaaa ctacgccgtc ttcgcccggc acgtggagct caatctcgcg caggtggtca
    23761 tgcgcgcccg cgatgccgaa gggggcgtgg tctacagccg cgtctggaac gagggaggcc
    23821 tcaacgcctt ctcgcagctc atggcccgca tttccaacga cctcgccgcc accgtggagc
    23881 gagccggacg cggagatctc caggaggaag agatcgagca gttcatggcc gagatcgcct
    23941 atcaagacaa ctcaggagac gtgcaggaga ttttgcgcca ggccgccgtc aacgacaccg
    24001 aaattgattc tgtcgaactc tctttcaggt tcaagctcac cgggcccgtc gtcttcacgc
    24061 agaggcgcca gattcaggag atcaaccgcc gcgtcgtcgc gttcgccagc aacctacgcg
    24121 cgcagcacca gctcctgccc gcgcgcggcg ccgacgtgcc cctgccccct ctcccggcgg
    24181 gtccggagcc ccccctacct ccgggggctc gcccgcgtca ccgcttttag atgcatcatc
    24241 caaggacacc cccgcggccc accgcccgcc gcgcggtacc gtagtcgcgc cgcggggatg
    24301 cggcctcttg caagccatcg acgccgccac caaccagccc ctggaaatta ggtatcacct
    24361 ggatctagcc cgcgccctga cccgtctatg cgaggtaaac ctgcaggagc tcccgcctga
    24421 cctgacgccg cgggagctcc agaccatgga cagctcccat ctgcgcgatg ttgtcatcaa
    24481 gctccgaccg ccgcgcgcgg acatctggac tttgggctcg cgcggcgtgg tggtccgatc
    24541 caccgtaact cccctcgagc agccagacgg tcaaggacaa gcagccgaag tagaagacca
    24601 ccagccaaac ccgccaggcg aggggctcaa attcccactc tgcttccttg tgcgcggtcg
    24661 tcaggtcaac ctcgtgcagg atgtacagcc cgtgcaccgc tgccagtact gcgcacgttt
    24721 ttacaaaagc cagcacgagt gttcggcccg tcgcagggac ttctactttc accacatcaa
    24781 tagccactcc tccaattggt ggcgggagat ccagttcttc ccgatcggct cgcatcctcg
    24841 caccgagcgt ctctttgtca cctacgatgt agagacctat acttggatgg gggcctttgg
    24901 gaagcagctc gtgcccttca tgctggtcat gaagttcggc ggagatgagc ctctagtgac
    24961 tgccgcgcga gacctagccg cgaaccttgg atgggaccgc tgggaacaag acccgcttac
    25021 cttctactgc atcaccccag aaaaaatggc cataggtcgc cagtttagga cctttcgcga
    25081 ccacctgcaa atgctaatgg cccgtgacct gtggagctca ttcgtcgctt ccaaccctca
    25141 tcttgcagac tgggcccttt cagagcacgg gctcagctcc cctgaagagc tcacctacga
    25201 ggaacttaaa aaattgcctt ccatcaaggg catcccgcgc ttcttggaac tttacattgt
    25261 gggccacaac atcaacggct ttgacgagat cgtgctcgcc gcccaggtaa ttaacaaccg
    25321 ttccgaggtg ccgggaccct tccgcatcac acgcaacttt atgcctcgcg cgggaaagat
    25381 actcttcaac gatgtcacct tcgccctgcc aaatccgcgt tccaaaaagc gcacggactt
    25441 tttgctctgg gagcagggcg gatgcgacga cactgacttc aaataccagt acctcaaagt
    25501 catggtcagg gacacctttg cgctcaccca cacctcgctc cggaaggccg cgcaggcata
    25561 cgcgctaccc gtagaaaagg gatgctgcgc ctaccaggcc gtcaaccagt tctacatgct
    25621 aggctcttac cgttcggagg ccgacgggtt tccgatccaa gagtactgga aagaccgcga
    25681 agagtttgtc ctcaaccgcg agctgtggaa aaaaaaggga caggataagt atgacatcat
    25741 caaggaaacc ctggactact gcgccctaga cgtgcaggtc accgccgagc tggtcaacaa
    25801 gctgcgcgac tcctacgcct ccttcgtgcg tgacgcggta ggtctcacag acgccagctt
    25861 caacgtcttc cagcgtccaa ccatatcatc caactcacat gccatcttca ggcagatagt
    25921 cttccgagca gagcagcccg cccgtagcaa cctcggtccc gacctcctcg ctccctcgca
    25981 cgaactatac gattacgtgc gcgccagcat ccgcggtgga agatgctacc ctacatatct
    26041 tggaatactc agagagcccc tctacgttta cgacatttgc ggcatgtacg cctccgcgct
    26101 cacccacccc atgccatggg gtcccccact caacccatac gagcgcgcgc ttgccgcccg
    26161 cgcatggcag caggcgctag acttgcaagg atgcaagata gactacttcg acgcgcgcct
    26221 gctgcccggg gtctttaccg tggacgcaga ccccccggac gagacgcagc tagaccccct
    26281 accgccattc tgctcgcgca agggcggccg cctctgctgg accaacgagc gcctacgcgg
    26341 agaggtagcc accagcgttg accttgtcac cctgcacaac cgcggttggc gcgtgcacct
    26401 ggtgcccgac gagcgcacca ccgtctttcc cgaatggcgg tgcgttgcgc gcgaatacgt
    26461 gcagctaaac atcgcggcca aggagcgcgc cgatcgcgac aaaaaccaaa ccctgcgctc
    26521 catcgccaag ttgctgtcca acgccctcta cgggtcgttt gccaccaagc ttgacaacaa
    26581 aaagattgtc ttttctgacc agatggatgc ggccaccctc aaaggcatca ccgcgggcca
    26641 ggtgaatatc aaatcctcct cgtttttgga aactgacaat cttagcgcag aagtcatgcc
    26701 cgcttttcag agggagtact caccccaaca gctggccctc gcagacagcg atgcggaaga
    26761 gagtgaggac gaacgcgccc ccaccccctt ttatagcccc ccttcaggaa cacccggtca
    26821 cgtggcctac acctacaaac caatcacctt ccttgatgcc gaagagggcg acatgtgtct
    26881 tcacaccctg gagcgagtgg accccctagt ggacaacgac cgctacccct cccacttagc
    26941 ctccttcgtg ctggcctgga cgcgagcctt tgtctcagag tggtccgagt ttctatacga
    27001 ggaggaccgc ggaacaccgc tcgaggacag gcctctcaag tctgtatacg gggacacgga
    27061 cagccttttc gtcaccgagc gtggacaccg gctcatggaa accagaggta agaaacgcat
    27121 caaaaagcat gggggaaacc tggtttttga ccccgaacgg ccagagctca cctggctcgt
    27181 ggaatgcgag accgtctgcg gggcctgcgg cgcggatgcc tactccccgg aatcggtatt
    27241 tctcgcgccc aagctctacg ccctcaaaag tctgcactgc ccctcgtgcg gcgcctcctc
    27301 caagggcaag ctgcgcgcca agggccacgc cgcggagggg ctggactatg acaccatggt
    27361 caaatgctac ctggccgacg cgcagggcga agaccggcag cgcttcagca ccagcaggac
    27421 cagcctcaag cgcaccctgg ccagcgcgca gcccggagcg caccccttca ccgtgaccca
    27481 gactacgctg acgaggaccc tgcgcccgtg gaaagacatg accctggccc gtctggacga
    27541 gcaccgacta ctgccgtaca gcgaaagccg ccccaacccg cgaaacgagg agatatgctg
    27601 gatcgagatg ccgtagagca ggtgaccgag ctgtgggacc gcctggaact gcttggtcaa
    27661 acgctcaaaa gcatgcctac ggcggacggt ctcaaaccgt tgaaaaactt tgcttccttg
    27721 caagaactgc tatcgctggg cggcgagcgc cttctggcgg atttggtcag ggaaaacatg
    27781 cgagtcaggg acatgcttaa cgaagtggcc cccctgctca gggatgacgg cagctgcagc
    27841 tctcttaact accagttgca gccggtaata ggtgtgattt acgggcccac cggctgcggt
    27901 aagtcgcagc tgctcaggaa cctgctttct tcccagctga tctcccctac cccggaaacc
    27961 gttttcttca tcgccccgca ggtagacatg atccccccat ctgaactcaa agcgtgggaa
    28021 atgcaaatct gtgagggtaa ctacgcccct gggccggatg gaaccattat accgcagtct
    28081 ggcaccctcc gcccgcgctt tgtaaaaatg gcctatgacg atctcatcct ggaacacaac
    28141 tatgacgtta gtgatcccag aaatatcttc gcccaggccg ccgcccgtgg gcccattgcc
    28201 atcattatgg acgaatgcat ggaaaatctt ggaggtcaca agggcgtctc caagttcttc
    28261 cacgcatttc cttctaagct acatgacaaa tttcccaagt gcaccggata cactgtgctg
    28321 gtggttctgc acaacatgaa tccccggagg gatatggctg ggaacatagc caacctaaaa
    28381 atacagtcca agatgcatct catatcccca cgtatgcacc catcccagct taaccgcttt
    28441 gtaaacactt acaccaaggg cctgcccctg gcaatcagct tgctactgaa agacattttt
    28501 aggcaccacg cccagcgctc ctgctacgac tggatcatct acaacaccac cccgcagcat
    28561 gaagctctgc agtggtgcta cctccacccc agagacgggc ttatgcccat gtatctgaac
    28621 atccagagtc acctttacca cgtcctggaa aaaatacaca ggaccctcaa cgaccgagac
    28681 cgctggtccc gggcctaccg cgcgcgcaaa acccctaaat aaagacagca agacacttgc
    28741 ttgatccaaa tccaaacaga gtctggtttt ttatttatgt tttaaaccgc attgggaggg
    28801 gaggaagcct tcagggcaga aacctgctgg cgcagatcca acagctgctg agaaacgaca
    28861 ttaagttccc gggtcaaaga atccaattgt gccaaaagag ccgtcaactt gtcatcgcgg
    28921 gcggatgaac gggaagctgc actgcttgca agcgggctca ggaaagcaaa gtcagtcaca
    28981 atcccgcggg cggtggctgc agcggctgaa gcggcggcgg aggctgcagt ctccaacggc
    29041 gttccagaca cggtctcgta ggtcaaggta gtagagtttg cgggcaggac ggggcgacca
    29101 tcaatgctgg agcccatcac attctgacgc accccggccc atgggggcat gcgcgttgtc
    29161 aaatatgagc tcacaatgct tccatcaaac gagttggtgc tcatggcggc ggcggctgct
    29221 gcaaaacaga tacaaaacta cataagaccc ccaccttata tattctttcc cacccttaac
    29281 cacgcccaga tccgcgttaa gatacattga tgagtttgga caaaccacaa ctagaatgca
    29341 gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat
    29401 aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg
    29461 ggaggtgtgg gaggtttttt aaagcaagta aaacctctac aaatgtggta tggctgatta
    29521 tgatcagtta tctagatccg gtggatcgga tgtttaaaca agctttagag tccggacttg
    29581 tacagctcgt ccatgccgag agtgatcccg gcggcggtca cgaactccag caggaccatg
    29641 tgatcgcgct tctcgttggg gtctttgctc agggcggact gggtgctcag gtagtggttg
    29701 tcgggcagca gcacggggcc gtcgccgatg ggggtgttct gctggtagtg gtcggcgagc
    29761 tgcacgctgc cgtcctcgat gttgtggcgg atcttgaagt tcaccttgat gccgttcttc
    29821 tgcttgtcgg ccatgatata gacgttgtgg ctgttgtagt tgtactccag cttgtgcccc
    29881 aggatgttgc cgtcctcctt gaagtcgatg cccttcagct cgatgcggtt caccagggtg
    29941 tcgccctcga acttcacctc ggcgcgggtc ttgtagttgc cgtcgtcctt gaagaagatg
    30001 gtgcgctcct ggacgtagcc ttcgggcatg gcggacttga agaagtcgtg ctgcttcatg
    30061 tggtcggggt agcggctgaa gcactgcacg ccgtaggtca gggtggtcac gagggtgggc
    30121 cagggcacgg gcagcttgcc ggtggtgcag atgaacttca gggtcagctt gccgtaggtg
    30181 gcatcgccct cgccctcgcc ggacacgctg aacttgtggc cgtttacgtc gccgtccagc
    30241 tcgaccagga tgggcaccac cccggtgaac agctcctcgc ccttgctcac catggtttaa
    30301 acggtacctc acgacacctg aaatggaaga aaaaaacttt gaaccactgt ctgaggcttg
    30361 agaatgaacc aagatccaaa ctcaaaaagg gcaaattcca aggagaatta catcaagtgc
    30421 caagctggcc taacttcagt ctccacccac tcagtgtggg gaaactccat cgcataaaac
    30481 ccctcccccc aacctaaaga cgacgtactc caaaagctcg agaactaatc gaggtgcctg
    30541 gacggcgccc ggtactccgt ggagtcacat gaagcgacgg ctgaggacgg aaaggccctt
    30601 ttcctttgtg tgggtgactc acccgcccgc tctcccgagc gccgcgtcct ccattttgag
    30661 ctccctgcag cagggccggg aagcggccat ctttccgctc acgcaactgg tgccgaccgg
    30721 gccagccttg ccgcccaggg cggggcgata cacggcggcg cgaggccagg caccagagca
    30781 ggccggccag cttgagacta cccccgtccg attctcggtg gccgcgctcg caggcccctc
    30841 ctcgccgaac atgtgcgctg ggacgcacgg gccccgtcgc cgcccgcggc cccaaaaacc
    30901 gaaataccag tgtgcagatc ttggcccgca tttacaagac tatcttgcca gaaaaaaagc
    30961 gtcgcagcag gtcatcaaaa attttaaatg gctagagact tatcgaaagc agcgagacag
    31021 gcgcgaaggt gccaccagat tcgcacgcgg cggccccagc gcccaagcca ggcctcaact
    31081 caagcacgag gcgaaggggc tccttaagcg caaggcctcg aactctccca cccacttcca
    31141 acccgaagct cgggatcaag aatcacgtac tgcagccagg ggcgtggaag taattcaagg
    31201 cacgcaaggg ccataacccg taaagaggcc aggcccgcgg gaaccacaca cggcacttac
    31261 ctgtgttctg gcggcaaacc cgttgcgaaa aagaacgttc acggcgacta ctgcacttat
    31321 atacggttct cccccaccct cgggaaaaag gcggagccag tacacgacat cactttccca
    31381 gtttaccccg cgccaccttc tctaggcacc ggttcaattg ccgacccctc cccccaactt
    31441 ctcggggact gtgggcgatg tgcgctctgc ccactgacgg gcaccggagc ctcacgcatg
    31501 ctcttctcca cctcagtgat gacgagagcg ggcgggtgag ggggcgggaa cgcagcgatc
    31561 tctgggttct acgttagtgg gagtttaacg acggtccctg ggattcccca aggcaggggc
    31621 gagtcctttt gtatgaatta ctcgacgtca gtattacgcg ctatgagtaa cacaaaatta
    31681 ttcagatttc acttcctctt attcagtttt cccgcgaaaa tggccaaatc ttactcggtt
    31741 acgcccaaat ttactacaac atccgcctaa aaccgcgcga aaattgtcac ttcctgtgta
    31801 caccggcgca caccaaaaac gtcacttttg ccacatccgt cgcttacatg tgttccgcca
    31861 cacttgcaac atcacacttc cgccacacta ctacgtcacc cgccccgttc ccacgccccg
    31921 cgccacgtca caaactccac cccctcatta tcatattggc ttcaatccaa aataaggtat
    31981 attattgatg atgttaatta agaattaatt cgatcctgaa tggcgaatgg acgcgccctg
    32041 tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc
    32101 cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg
    32161 ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta gtgctttacg
    32221 gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc catcgccctg
    32281 atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg gactcttgtt
    32341 ccaaactgga acaacactca accctatctc ggtctattct tttgatttat aagggatttt
    32401 gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaatttt aacaaaattc
    32461 agaagaactc gtcaagaagg cgatagaagg cgatgcgctg cgaatcggga gcggcgatac
    32521 cgtaaagcac gaggaagcgg tcagcccatt cgccgccaag ctcttcagca atatcacggg
    32581 tagccaacgc tatgtcctga tagcggtccg ccacacccag ccggccacag tcgatgaatc
    32641 cagaaaagcg gccattttcc accatgatat tcggcaagca ggcatcgcca tgggtcacga
    32701 cgagatcctc gccgtcgggc atgctcgcct tgagcctggc gaacagttcg gctggcgcga
    32761 gcccctgatg ctcttcgtcc agatcatcct gatcgacaag accggcttcc atccgagtac
    32821 gtgctcgctc gatgcgatgt ttcgcttggt ggtcgaatgg gcaggtagcc ggatcaagcg
    32881 tatgcagccg ccgcattgca tcagccatga tggatacttt ctcggcagga gcaaggtgag
    32941 atgacaggag atcctgcccc ggcacttcgc ccaatagcag ccagtccctt cccgcttcag
    33001 tgacaacgtc gagcacagct gcgcaaggaa cgcccgtcgt ggccagccac gatagccgcg
    33061 ctgcctcgtc ttgcagttca ttcagggcac cggacaggtc ggtcttgaca aaaagaaccg
    33121 ggcgcccctg cgctgacagc cggaacacgg cggcatcaga gcagccgatt gtctgttgtg
    33181 cccagtcata gccgaatagc ctctccaccc aagcggccgg agaacctgcg tgcaatccat
    33241 cttgttcaat catgcgaaac gatcctcatc ctgtctcttg atcagagctt gatcccctgc
    33301 gccatcagat ccttggcggc aagaaagcca tccagtttac tttgcagggc ttcccaacct
    33361 taccagaggg cgccccagct ggcaattccg gttcgcttgc tgtccataaa accgcccagt
    33421 ctagctatcg ccatgtaagc ccactgcaag ctacctgctt tctctttgcg cttgcgtttt
    33481 cccttgtcca gatagcccag tagctgacat tcatccgggg tcagcaccgt ttctgcggac
    33541 tggctttcta cgtgaaaagg atctaggtga agatcctttt tgataatctc atggctgcag
    33601 caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc
    33661 aacaattaat agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc
    33721 ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta
    33781 tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg
    33841 ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga
    33901 ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac
    33961 ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa
    34021 tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat
    34081 cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc
    34141 taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg
    34201 gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc
    34261 acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg
    34321 ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg
    34381 ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa
    34441 cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg
    34501 aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga
    34561 gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct
    34621 gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca
    34681 gcaacgcggc ctttttacgg tt
//
