LOCUS       sequence-273594-        1403 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  expresses PTPN11 E76G.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 1403)
  AUTHORS   Cremer A, Ellegast JM, Alexe G, Frank ES, Ross L, Chu SH, Pikman Y, 
            Robichaud A, Goodale A, Haupl B, Mohr S, Rao AV, Walker AR, Blachly 
            JS, Piccioni F, Armstrong SA, Byrd JC, Oellerich T, Stegmaier K
  TITLE     Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia.
  JOURNAL   Cancer Discov. 2020 Feb;10(2):214-231. doi: 
            10.1158/2159-8290.CD-19-0209. Epub 2019 Nov 26.
  PUBMED    31771968
REFERENCE   2  (bases 1 to 1403)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: 
            "10.1158/2159-8290.CD-19-0209"; journalName: "Cancer Discov"; date: 
            "2020-02"; volume: "10"; issue: "2"; pages: "214-231"
COMMENT     Sequence Label: pLX307/PTPN11 E76G
FEATURES             Location/Qualifiers
     source          1..1403
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     intron          154..357
                     /label=EF-1-alpha intron A
                     /note="truncated intron upstream of the start codon of 
                     human EF-1-alpha"
     primer_bind     314..334
                     /label=EF1a-F
                     /note="Human elongation factor-1a promoter, forward primer"
     protein_bind    386..410
                     /gene="mutant version of attB"
                     /label=attB1
                     /bound_moiety="BP Clonase(TM)"
                     /note="recombination site for the Gateway(R) BP reaction"
ORIGIN
        1 cctgctgcag ggagctcaaa atggaggacg cggcgctcgg gagagcgggc gggtgagtca
       61 cccacacaaa ggaaaagggc ctttccgtcc tcagccgtcg cttcatgtga ctccacggag
      121 taccgggcgc cgtccaggca cctcgattag ttctcgagct tttggagtac gtcgtcttta
      181 ggttgggggg aggggtttta tgcgatggag tttccccaca ctgagtgggt ggagactgaa
      241 gttaggccag cttggcactt gatgtaattc tccttggaat ttgccctttt tgagtttgga
      301 tcttggttca ttctcaagcc tcagacagtg gttcaaagtt tttttcttcc atttcaggtg
      361 tcgtgaggct agcatcgatt gatcaacaag tttgtacaaa aaagcaggct ccgcggccgc
      421 ccccttcacc atggcatcgc ggagatggtt tcacccaaat atcactggtg tggaggcaga
      481 aaacctactg ttgacaagag gagttgatgg cagttttttg gcaaggccta gtaaaagtaa
      541 ccctggagac ttcacacttt ccgttagaag aaatggagct gtcacccaca tcaagattca
      601 gaacactggt gattactatg acctgtatgg aggggagaaa tttgccactt tggctgggtt
      661 ggtccagtat tacatggaac atcacgggca attaaaagag aagaatggag atgtcattga
      721 gcttaaatat cctctgaact gtgcagatcc tacctctgaa aggtggtttc atggacatct
      781 ctctgggaaa gaagcagaga aattattaac ngaaaaagga aaacatggta gttttcttgt
      841 acgagagagc cagagccacc ctggagattt tgttctttct gtgcgcactg gtgatgacaa
      901 aggggagagc aatgacggca agtctaaagt gacccatgtt atgattcgct gtcaggaact
      961 gaaatacgac gttggtggag gagaacggtt tgattctttg acagatcttg tggaacatta
     1021 taagaagaat cctatggtgg aaacattggg tacagtacta caactcaagc agccccttaa
     1081 cacgactcgt ataaatgctg ctgaaataga aagcagagtt cgagaactaa gcaaattagc
     1141 tgagaccaca gataaagtca aacaaggctt ttgggaagaa tttgagacac tacaacaaca
     1201 ggagtgcaaa cttctctaca gccgaaaaga gggtcaaagg naagaaacaa aaacaaaaat
     1261 agatataaaa acatcctgcc ctttgatcat accagggttg tcctacacga tggtgatccc
     1321 aatgagcctg tttcnnatta catcaatgca antatcatca tgcctgaatt tgaaacnagt
     1381 gcaacaattc aagcccaaaa aga
//
