LOCUS       sequence-389110-       17384 bp    DNA     circular SYN 15-DEC-2025
DEFINITION  Entry clone for wt BIRC6.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      synthetic DNA construct
  ORGANISM  synthetic DNA construct
REFERENCE   1  (bases 1 to 17384)
  AUTHORS   Hunkeler M, Jin CY, Fischer ES
  TITLE     Structures of BIRC6-client complexes provide a mechanism of 
            SMAC-mediated release of caspases.
  JOURNAL   Science. 2023 Mar 17;379(6637):1105-1111. doi: 
            10.1126/science.ade5750. Epub 2023 Feb 9.
  PUBMED    36758104
REFERENCE   2  (bases 1 to 17384)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: 
            "10.1126/science.ade5750"; journalName: "Science"; date: 
            "2023-03-17- 17"; volume: "379"; issue: "6637"; pages: "1105-1111"
COMMENT     Sequence Label: pDONR223_BIRC6
FEATURES             Location/Qualifiers
     source          1..17384
                     /mol_type="other DNA"
                     /organism="synthetic DNA construct"
     primer_bind     92..109
                     /label=L4440
                     /note="L4440 vector, forward primer"
     terminator      complement(268..295)
                     /label=rrnB T2 terminator
                     /note="transcription terminator T2 from the E. coli rrnB 
                     gene"
     terminator      complement(387..473)
                     /gene="Escherichia coli rrnB"
                     /label=rrnB T1 terminator
                     /note="transcription terminator T1 from the E. coli rrnB 
                     gene"
     primer_bind     522..544
                     /label=M13/pUC Forward
                     /note="In lacZ gene"
     primer_bind     536..553
                     /label=M13 Forward
                     /note="In lacZ gene. Also called M13-F20 or M13 (-21) 
                     Forward"
     primer_bind     537..553
                     /label=M13 fwd
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     protein_bind    569..668
                     /gene="mutant version of attL"
                     /label=attL1
                     /bound_moiety="LR Clonase(TM)"
                     /note="recombination site for the Gateway(R) LR reaction"
     protein_bind    complement(15263..15362)
                     /gene="mutant version of attL"
                     /label=attL2
                     /bound_moiety="LR Clonase(TM)"
                     /note="recombination site for the Gateway(R) LR reaction"
     primer_bind     complement(15379..15398)
                     /label=T7
                     /note="T7 promoter, forward primer"
     promoter        complement(15380..15398)
                     /label=T7 promoter
                     /note="promoter for bacteriophage T7 RNA polymerase"
     primer_bind     complement(15403..15419)
                     /label=M13 rev
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     primer_bind     complement(15403..15419)
                     /label=M13 Reverse
                     /note="In lacZ gene. Also called M13-rev"
     CDS             15850..16641
                     /codon_start=1
                     /gene="aadA"
                     /product="aminoglycoside adenylyltransferase (Murphy, 
                     1985)"
                     /label=SmR
                     /note="confers resistance to spectinomycin and 
                     streptomycin"
                     /translation="MREAVIAEVSTQLSEVVGVIERHLEPTLLAVHLYGSAVDGGLKPH
                     SDIDLLVTVTVRLDETTRRALINDLLETSASPGESEILRAVEVTIVVHDDIIPWRYPAK
                     RELQFGEWQRNDILAGIFEPATIDIDLAILLTKAREHSVALVGPAAEELFDPVPEQDLF
                     EALNETLTLWNSPPDWAGDERNVVLTLSRIWYSAVTGKIAPKDVAADWAMERLPAQYQP
                     VILEARQAYLGQEEDRLASRADQLEEFVHYVKGEITKVVGK"
     rep_origin      16734..17322
                     /direction=RIGHT
                     /label=ori
                     /note="high-copy-number ColE1/pMB1/pBR322/pUC origin of 
                     replication"
     primer_bind     17223..17242
                     /label=pBR322ori-F
                     /note="pBR322 origin, forward primer"
ORIGIN
        1 ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga
       61 taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga
      121 gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca
      181 cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaata cgcgtaccgc
      241 tagccaggaa gagtttgtag aaacgcaaaa aggccatccg tcaggatggc cttctgctta
      301 gtttgatgcc tggcagttta tggcgggcgt cctgcccgcc accctccggg ccgttgcttc
      361 acaacgttca aatccgctcc cggcggattt gtcctactca ggagagcgtt caccgacaaa
      421 caacagataa aacgaaaggc ccagtcttcc gactgagcct ttcgttttat ttgatgcctg
      481 gcagttccct actctcgcgt taacgctagc atggatgttt tcccagtcac gacgttgtaa
      541 aacgacggcc agtcttaagc tcgggcccca aataatgatt ttattttgac tgatagtgac
      601 ctgttcgttg caacaaattg atgagcaatg cttttttata atgccaactt tgtacaaaaa
      661 agcaggctta tcgcgaacca tggtaacggg tgggggtgcg gcaccacccg gcacggtcac
      721 tgagccgctg ccatccgtga tagtgctttc tgccggtcga aagatggccg cagctgctgc
      781 cgccgcctcc ggacctggtt gttcctctgc cgcaggagct ggggctgcgg gggttagcga
      841 atggctggta ctgcgagatg gctgcatgca ttgcgatgca gacgggctgc atagtctctc
      901 ctaccaccca gcgcttaatg ctattctggc ggttacctcc cgcggcacga tcaaggtcat
      961 tgatggaaca agtggggcaa cgctccaagc ctccgcgctg tcagccaaac caggcggaca
     1021 ggttaaatgc cagtacattt cagcagtaga taaggttatt ttcgtcgatg actatgccgt
     1081 ggggtgtcgg aaagatttga atgggatact cctgctggat acggcgctcc agaccccggt
     1141 cagtaagcag gacgacgttg tccagctgga actccccgtg accgaagcac agcaattgct
     1201 ctctgcctgc ctcgagaaag tagatatcag cagcaccgaa ggttacgacc tcttcattac
     1261 gcagcttaag gatggcctga agaataccag ccacgagaca gcagcgaatc acaaggtagc
     1321 taaatgggcg accgtaacat tccaccttcc tcaccacgtg cttaaatcta tagcttctgc
     1381 tatagtcaac gagctgaaaa aaataaatca gaacgtcgct gcccttccag tggctagttc
     1441 agttatggat cgcttgagct acctcttgcc tagcgcgcgc ccagagttgg gagttggccc
     1501 cgggcggtcc gtcgatcgat cacttatgta ctctgaagct aatcggagag aaacttttac
     1561 ctcctggccc catgtcggct atcgatgggc tcagccagac ccgatggccc aggctggatt
     1621 ttaccatcaa cctgcgtctt caggtgatga cagagcgatg tgctttacct gctcagtatg
     1681 cctggtatgt tgggagccga ccgatgagcc ttggagcgag catgaacggc attcaccgaa
     1741 ttgcccgttt gtcaagggag aacacacgca gaatgtacca ctctctgtta ctctggctac
     1801 gtcccccgca caatttccgt gtaccgacgg aacagatcga atatcatgct ttgggagcgg
     1861 gtcctgtcca cacttccttg cagcggctac caaacgcgga aaaatatgca tctgggatgt
     1921 ctcaaagctt atgaaagtcc atttgaaatt cgaaatcaat gcatatgacc ctgccatcgt
     1981 acagcaactt atcttgagtg gcgatccctc ctccggtgta gatagccgaa gacctacgct
     2041 tgcgtggctc gaggattcat catcttgctc tgacatcccg aaactcgaag gagatagtga
     2101 tgacctgctc gaggattcag actccgaaga acacagcagg tccgatagcg ttactgggca
     2161 tacctcacaa aaagaggcca tggaagtctc cctcgacatt accgcgcttt ctatcctcca
     2221 acagcctgaa aaactccaat gggaaatagt ggccaatgtg cttgaagaca ctgtaaaaga
     2281 tcttgaggaa ctgggagcga atccctgcct gactaactcc aaatctgaaa aaacgaagga
     2341 gaagcaccag gagcagcata acattccttt cccctgtctg cttgcgggcg gacttctgac
     2401 atacaaatcc ccagctactt cacctattag ttcaaattct cataggtcac tcgatggcct
     2461 ttctcgaacg cagggtgaat ccattagtga gcagggttca acggataatg aatcctgtac
     2521 taatagcgag ctcaattctc ccttggtcag acgcactttg cctgtattgc ttctgtattc
     2581 tatcaaggag agcgatgaaa aagcagggaa aatatttagc caaatgaaca atattatgtc
     2641 caaaagtctt catgatgatg gcttcacggt cccgcaaatt atcgagatgg aactggattc
     2701 acaagaacaa ttgctccttc aagacccacc tgttacatat attcaacaat tcgcagacgc
     2761 cgcagcaaat ctcacgagcc ctgattccga gaaatggaat tcagtattcc ccaagcctgg
     2821 tacgctggtt cagtgtttgc gactgcctaa attcgcggaa gaagagaatc tttgcataga
     2881 ctcaataacg ccttgtgcag atggtattca tttgctggtg ggactgcgca cgtgcccagt
     2941 cgagagcctc tcagcaataa accaagttga agctttgaac aacctgaaca agctgaatag
     3001 cgcactgtgt aatagacgga aaggcgaact cgaatccaat ttggcggttg tcaacggtgc
     3061 aaatatctcc gttatccaac atgaatcccc cgctgatgtt caaactcccc tcataattca
     3121 gcctgaacaa aggaacgtaa gtgggggata tttggtgctc tacaaaatga attacgctac
     3181 acgcatagta actcttgagg aagagcccat aaagattcaa catatcaaag acccgcaaga
     3241 cacgatcaca tcactcattc tcctcccccc cgacatcctc gacaatcggg aagacgactg
     3301 tgaggaacca atagaggaca tgcaacttac gtccaaaaac ggcttcgaac gggagaagac
     3361 ttcagacatc agtacactgg gacacctggt aattacgact caaggcggct acgttaagat
     3421 ccttgatttg agcaatttcg aaatcctggc gaaggttgaa ccgcccaaaa aagaaggaac
     3481 agaagagcaa gacacattcg tctcagtgat ctactgtagt ggcactgacc gcctttgcgc
     3541 gtgcaccaag ggcggggaac ttcattttct gcagatagga ggcacatgtg acgacataga
     3601 cgaggccgac atattggtcg atgggagcct tagtaagggg atagaaccgt cttctgaggg
     3661 ctccaagccc cttagcaacc cttccagtcc gggtatctct ggcgttgacc tgttggtaga
     3721 tcaaccgttc acgctcgaaa tcttgacttc actggtggag ctgactcgat ttgagaccct
     3781 gactccaaga ttctccgcaa ctgttcctcc ctgttgggta gaagtccagc aagagcagca
     3841 gcagcgacgg cacccacaac acctccacca acaacatcac ggggatgccg cgcaacatac
     3901 gagaacgtgg aaactgcaga ccgattcaaa cagttgggac gaacacgtat tcgaattggt
     3961 cctccctaag gcatgcatgg ttggacatgt cgacttcaaa tttgtcctca atagtaacat
     4021 tactaatatt ccgcaaattc aagttactct gctgaaaaac aaggcaccgg ggttgggaaa
     4081 agtcaatgcg ttgaatatag aagtcgagca aaacggaaaa ccctcattgg ttgaccttaa
     4141 tgaagagatg caacacatgg atgttgagga aagtcagtgc ctcagacttt gtcccttcct
     4201 tgaagaccac aaagaagata ttctctgcgg tcccgtttgg ttggcctccg gcctggactt
     4261 gtccggccac gcagggatgc ttacacttac gagtccaaag ctggtgaaag ggatggcggg
     4321 aggcaagtac aggtctttcc tcatacacgt taaagcagta aacgaacggg ggactgagga
     4381 aatatgcaac gggggtatga ggccagtcgt tcgcctccct tcactcaaac atcagagcaa
     4441 caaaggctac tccctcgcta gtttgctcgc aaaagtggct gcggggaagg agaaatcttc
     4501 caatgttaag aatgagaaca ccagtggcac tcgcaaatct gaaaatcttc gaggctgcga
     4561 cctcttgcag gaagtttcag tgacaatcag gcgattcaaa aaaacttcca tatctaagga
     4621 gagagtacaa cgctgtgcta tgttgcaatt tagcgaattt catgaaaagc tcgttaatac
     4681 actgtgtcga aaaacggatg atgggcagat aaccgagcat gcgcagtctc tggtccttga
     4741 cacactctgc tggctggcgg gggtacactc caatggccca ggtagctcca aggaaggtaa
     4801 cgaaaatctc ctgtcaaaaa cccggaaatt cctgagtgat attgtgcgcg tctgcttttt
     4861 cgaagccggg cgaagtatag cacacaaatg cgctaggttt ctcgcgctct gtatctcaaa
     4921 cggtaagtgc gatccttgcc aacccgcgtt cggtccagtc cttttgaagg ccctcctcga
     4981 taacatgtca tttctgccgg ctgccacgac tgggggctca gtgtactggt attttgttct
     5041 tctgaactac gtcaaggatg aagatcttgc tggctgcagt acggcctgtg cctcactttt
     5101 gactgctgtc tcccgccaac tgcaggatcg cttgacaccg atggaagcgc ttctccagac
     5161 acgatatgga ctctactcct ctccgttcga cccagtgctg ttcgaccttg agatgtctgg
     5221 gtcttcatgc aagaatgtat ataacagcag cataggggtc cagtctgacg aaatagattt
     5281 gtccgacgta ctcagtggaa acggtaaggt ttcaagttgt acggcggctg aaggctcatt
     5341 tactagcctt accggacttc ttgaagtcga gccgctccat ttcacatgtg tttcaacatc
     5401 tgacgggacg cggattgagc gagatgatgc tatgagtagc ttcggtgtga caccggcggt
     5461 gggagggctc tcctcaggaa cggtagggga ggcatcaacg gctctgagtt ccgctgcaca
     5521 ggtggctctg cagtctctgt cccatgccat ggccagtgcg gagcagcaac tccaggttct
     5581 gcaggaaaag cagcaacaac ttcttaagct gcaacaacag aaggcgaagt tggaggcgaa
     5641 actgcaccaa acaaccgcag cggcagccgc agctgcgtca gctgtcggcc ccgtacacaa
     5701 tagcgtccct agcaaccccg tcgctgcccc gggcttcttt atacacccaa gcgatgtgat
     5761 cccgcctact ccaaaaacga cacccctgtt tatgactcca cccttgacgc cgccaaatga
     5821 agctgtttct gtcgtcatca acgcagagtt ggcccagctt ttcccgggtt cagttattga
     5881 cccgcctgcc gtcaatctcg cagcacacaa caaaaactca aacaaatccc gaatgaaccc
     5941 tttggggtca ggacttgctc ttgccatctc acacgctagc cacttccttc agccccctcc
     6001 ccatcaatcc atcataattg aacggatgca tagtggagct agacgcttcg ttacgttgga
     6061 tttcggaagg ccaatcctcc tgacagacgt tcttataccc acctgtggcg acttggctag
     6121 cctttccatt gatatatgga ccctgggtga agaggttgac ggtcgcagac tggttgtagc
     6181 aacagacatt agcactcact ccctgatttt gcatgatctc attccgcccc ccgtatgtcg
     6241 cttcatgaaa attacagtca tcggccggta tggttcaacg aatgcaaggg cgaagatacc
     6301 actcggtttt tactatggac acacgtacat tcttccttgg gagtccgagc ttaagttgat
     6361 gcatgaccca ttgaaaggcg aaggggaatc tgccaatcag cccgagattg atcagcacct
     6421 tgccatgatg gtggcattgc aagaagacat tcagtgtcgc tacaatctgg cttgtcaccg
     6481 cttggaaacc ttgctccagt ccattgatct tccaccattg aatagcgcta acaacgcgca
     6541 gtacttcctg aggaaacccg acaaagctgt cgaggaagat tctagggtct tctctgcata
     6601 ccaggactgt attcaacttc agcttcagct caaccttgcc cacaatgctg ttcaacgcct
     6661 gaaggttgcc ttgggggcct caagaaagat gctctctgaa acaagtaatc ccgaagacct
     6721 gatacagaca agctccacag aacaactgcg aacgatcata cggtacttgc tggacacgct
     6781 tctctccttg ttgcacgcaa gcaatggaca ttccgtgcca gcagtcctgc agagcacatt
     6841 ccatgcgcaa gcttgtgagg aactcttcaa gcatttgtgt atttcaggga caccaaagat
     6901 taggcttcac acagggcttt tgctggtgca attgtgcggc ggggagaggt ggtggggtca
     6961 atttctttcc aacgttttgc aggagcttta taattctgaa caacttttga tatttccgca
     7021 agaccgggtg ttcatgttgc tcagctgcat tggacagcga agcttgtcta atagcggtgt
     7081 actcgaatcc ctgctgaacc tcttggataa tttgctttcc ccgttgcagc cacagctccc
     7141 catgcaccga cggactgaag gggttcttga catcccaatg atatcatggg tcgtaatgtt
     7201 ggtcagtcgg ttgcttgact atgtggcaac cgtagaggat gaagcagccg cagcaaaaaa
     7261 acctttgaat ggcaatcagt ggtctttcat aaacaataat cttcatacac aatccttgaa
     7321 ccgctctagc aaagggtcaa gtagcctgga tagattgtac tcaagaaaaa tccggaaaca
     7381 actcgttcat cataagcagc agcttaacct cctcaaggcg aaacaaaagg ctctggttga
     7441 gcagatggag aaagaaaaaa ttcagtcaaa taagggatct agctataagt tgctcgttga
     7501 gcaggccaaa cttaagcaag caacgagtaa gcattttaaa gatctcatta ggctgagacg
     7561 gacggccgag tggagtagaa gtaatcttga tacagaagtt accacggcca aggagtctcc
     7621 ggaaattgaa ccactgcctt tcactttggc ccatgaaagg tgcattagcg tggttcaaaa
     7681 gcttgttctt ttcttgttgt ctatggattt cacatgtcat gccgacctct tgctcttcgt
     7741 ttgtaaggtc ttggcacgaa ttgctaatgc gaccaggcca acaatacact tgtgcgaaat
     7801 tgtaaatgaa ccccaactgg aaagattgct gctcttgttg gtcgggacgg acttcaaccg
     7861 aggcgacatc agctggggcg gcgcctgggc ccaatactca ttgacttgta tgctccaaga
     7921 tatactcgca ggagagttgc ttgctccggt ggccgccgaa gcgatggaag aagggaccgt
     7981 tggtgatgat gttggagcta cggcggggga ttccgatgat agtctgcaac aatcatcagt
     8041 tcagcttctg gagaccattg acgaacccct tacccacgac atcactggtg caccccccct
     8101 gtcatcactt gagaaagaca aagagataga tctcgagctt ctccaggacc ttatggaagt
     8161 agacatcgat ccactcgaca tagacctgga gaaggaccca ttggcggcaa aggtattcaa
     8221 acccatctca tctacttggt acgattattg gggcgcggac tacggtacat ataactataa
     8281 tccttacata ggtggacttg gaatcccagt tgcgaaacct ccagcgaata ctgagaagaa
     8341 cggtagtcag actgtatccg tgtccgtttc tcaagccctg gatgctcgcc tggaagtggg
     8401 tttggagcag caggcagagt tgatgttgaa aatgatgagc actcttgaag cggacagtat
     8461 attgcaggct ctgaccaata cgtcacctac cttgtctcag agcccaactg ggaccgatga
     8521 ttcactcctt ggtgggcttc aagctgcgaa tcaaaccagc cagctgatta tacagctctc
     8581 atctgtacct atgctgaacg tttgtttcaa caaacttttc tccatgctcc aggttcacca
     8641 cgtgcagctt gagtccttgc tccaactgtg gcttacactt tccctgaata gttcctctac
     8701 aggcaataag gaaaatggtg cagatatctt tctgtacaat gccaatagaa taccggtgat
     8761 tagtcttaat caagcctcta tcaccagctt cctcaccgtg ctggcgtggt atcccaacac
     8821 acttttgcgc acctggtgct tggttttgca tagtctgacc ctgatgacaa atatgcaatt
     8881 gaattcaggt agttccagcg ctataggaac tcaggaatct acggcacacc tgttggtgtc
     8941 agatccaaac ctgatccacg tactggttaa attcctctct ggtacttccc cgcatggtac
     9001 gaaccaacac agcccacaag ttggacctac agccacccag gcgatgcagg agtttttgac
     9061 cagactccag gtacaccttt cttcaacctg ccctcagata ttctcagaat tcctcctcaa
     9121 gcttattcat atcctcagta ccgaaagagg ggcgttccag acggggcaag gtcctttgga
     9181 tgctcaagtc aagctgttgg agttcaccct tgaacaaaac ttcgaggttg taagtgtctc
     9241 tactatatct gctgtcatcg aaagcgttac gttccttgta caccattata tcacatgctc
     9301 agataaggtc atgtcaagaa gtggctcaga cagtagtgtg ggcgctcggg cttgttttgg
     9361 tggtctcttc gctaatctga tccgacctgg agacgcaaaa gcagtgtgcg gagagatgac
     9421 cagagatcag ttgatgttcg atcttctgaa gctcgtcaac atccttgtgc aactgccttt
     9481 gagtggcaat agggaataca gtgctagagt aagcgtcaca actaatacga cggattccgt
     9541 ttccgacgaa gaaaaagtgt ccgggggtaa agatggaaat ggttccagca ccagcgtaca
     9601 aggatcccca gcctacgtgg cggatctcgt gctcgccaat caacagataa tgagtcaaat
     9661 tctgtccgca ctcggcttgt gcaattcctc tgcaatggcc atgattatag gagcttctgg
     9721 gttgcatttg actaagcatg aaaactttca tggcggtttg gatgcgatct ctgtgggaga
     9781 tggacttttc acgattctga ctactttgag caagaaagcg tctacggttc acatgatgct
     9841 gcagccgatc ttgacatata tggcatgtgg atacatgggc cggcaggggt cacttgccac
     9901 atgccagttg tctgagcctc tgctgtggtt catactccga gtcctcgata cttctgacgc
     9961 gcttaaagcc ttccatgaca tgggaggagt gcagctcatc tgcaataaca tggttacaag
    10021 cactagagcg attgtcaaca cagcaagatc tatggtctcc accattatga agttccttga
    10081 ctctgggccg aacaaggcag tcgattctac cttgaagacg aggatccttg cctctgagcc
    10141 agataatgct gaaggaatac acaattttgc acctttgggt acaattacga gctcttctcc
    10201 aacggcacag ccggcggaag tcctgcttca agccactcct cctcaccgga gggccagatc
    10261 cgcagcttgg tcatatatat tcttgccaga ggaagcatgg tgcgatctca ctattcatct
    10321 ccctgccgcg gtgctcctta aggaaatcca tattcagcct cacctggctt ctttggctac
    10381 gtgtccatcc tctgtatcag tcgaggttag tgcggatgga gtaaatatgc tcccgctcag
    10441 tactccggtc gtaacttcag gacttaccta cataaagatc caacttgtaa aagctgaggt
    10501 agcttccgcg gtctgcttgc gcttgcaccg cccccgcgac gcttccacgc tcgggctttc
    10561 ccagattaaa ctcctggggc ttacagcgtt tgggaccaca tcttctgcta cggtaaataa
    10621 tccgtttttg ccttccgaag atcaagttag caaaacatct atcggatggc tccggctcct
    10681 ccatcactgt ctcacgcata tctcagatct ggaaggaatg atggcttcag cggctgcccc
    10741 cacggccaat cttctccaga cttgcgccgc acttctcatg tccccctatt gcggaatgca
    10801 ctcacccaat attgaggtcg tcttggttaa aatcggcctc cagtcaactc ggataggtct
    10861 caagcttata gacatcttgt tgcggaattg tgcagctagt ggttctgatc ctacagatct
    10921 gaacagtcca ctgttgtttg gtcggttgaa tggcctctct agcgatagta caatagacat
    10981 tttgtatcaa cttggaacta cccaagatcc gggaaccaaa gatcggattc aggcattgct
    11041 caaatgggta agcgatagcg cgcgcgtagc agctatgaaa agatctggcc gaatgaatta
    11101 catgtgcccg aattccagca ctgtagaata cgggcttctg atgccgtcac cgagtcacct
    11161 gcattgcgtt gcggcaattc tgtggcactc ctatgagttg ctcgttgaat acgacttgcc
    11221 agcactgctg gatcaggagc tctttgagct tctgtttaat tggtccatgt ctctgccgtg
    11281 taatatggtt ctcaaaaagg ctgttgacag cttgctttgc tctatgtgtc acgtacatcc
    11341 taactacttc tctctgttga tgggttggat gggcataacc cccccgccgg ttcaatgcca
    11401 tcaccgcttg tccatgacag atgacagcaa aaagcaagac ttgtcttcat ctctgacaga
    11461 tgattctaaa aatgcccaag cacccttggc gctgactgaa agccacttgg ctaccctcgc
    11521 aagttcttca cagtctcctg aagctattaa gcagctcctg gacagcgggc tgccgagcct
    11581 ccttgttcgg agcttggctt cattctgttt ttcccacata agtagtagtg aatccattgc
    11641 acagagcatt gacatttcac aggataaact ccggcggcat catgttcccc agcaatgtaa
    11701 caaaatgccg attacggcgg atctcgtcgc cccgatattg cggttcctta ccgaggtcgg
    11761 taacagccac atcatgaaag actggctggg tggttccgaa gtcaatcctc tctggactgc
    11821 actgctgttc ttgttgtgtc attctgggag taccagcggc tcacacaatc tcggggccca
    11881 gcagacgagc gctaggtctg ccagcttgag ttctgccgct actacgggtc ttacaacaca
    11941 acaaagaacc gctatagaaa acgcgacagt ggcgtttttt ctccagtgca taagttgcca
    12001 cccaaataat caaaagctta tggctcaagt gctttgcgag ctctttcaga ccagtccaca
    12061 gaggggcaat ctcccgacgt ctggcaacat aagcggtttt atcagacgac tcttccttca
    12121 actcatgctg gaggacgaaa aggtcactat gttcctgcag agcccgtgcc cgctctataa
    12181 gggaaggata aatgccacga gccatgtcat tcagcacccg atgtacgggg ccgggcacaa
    12241 atttagaaca ctccacctgc cagtatctac gacgctttca gatgtccttg atagggtctc
    12301 cgatactccg agcatcaccg ccaagcttat ctccgagcag aaagatgaca aagaaaaaaa
    12361 aaaccacgag gaaaaagaga aagtcaaagc cgaaaatggc tttcaggata actactccgt
    12421 ggtagtcgcc tccgggctca agagtcaaag caagagggcg gtcagcgcga cccctcctcg
    12481 accaccatca cgccgcggga ggacgatacc ggacaagatc ggaagcacga gcggcgccga
    12541 ggcagcgaat aaaatcatca cggtaccagt gtttcatctg ttccataagc ttctcgcagg
    12601 tcagccactg ccagcggaaa tgactctggc tcaactgctc accctgcttt atgaccgcaa
    12661 gttgcctcag gggtacagat ctatagatct tacggttaag ctgggcagtc gggtgattac
    12721 agacccttca ctgtccaaaa ctgattccta taagcgcttg caccctgaaa aggatcacgg
    12781 tgacctcctt gcttcctgcc cagaggacga ggccttgaca cccggcgacg aatgcatgga
    12841 cggaattttg gatgaaagcc tgctggaaac ctgtccgata caatccccgc tccaggtatt
    12901 cgccgggatg ggtggtcttg ctctcatcgc cgagaggttg cccatgcttt atcctgaagt
    12961 gatccagcag gtatcagctc cggttgtaac ctcaaccacc caagagaaac ctaaagattc
    13021 agatcaattt gaatgggtga caattgagca gagcggcgaa ttggtgtatg aggcccccga
    13081 aacggttgct gccgagccgc ccccaataaa atccgccgtc cagacaatgt ctccaatacc
    13141 agcgcactct ttggcggcat ttgggctttt tcttaggctc cctggttacg ctgaagtcct
    13201 gctgaaagaa cgcaagcatg cgcaatgcct tctgcggctc gttttggggg tgacggacga
    13261 tggagaaggt tcccatatcc ttcagagccc cagcgcgaac gtattgccca cacttccttt
    13321 tcatgtgctc cgatccctct tttcaactac ccccctcaca actgatgacg gcgtccttct
    13381 gcgacgaatg gcccttgaga tcggggcctt gcacctcatt ctcgtgtgcc tcagtgcgtt
    13441 gagccaccac agtccccggg tcccaaacag cagcgtgaac cagacggaac cacaggtgag
    13501 cagctcccac aaccccacga gtaccgagga gcagcagctc tactgggcaa aagggaccgg
    13561 atttgggact ggctcaaccg cctccggatg ggatgtggaa caagctctta cgaagcaaag
    13621 gttggaggag gaacatgtaa cttgtctgct ccaggtgctt gcgagctata taaaccctgt
    13681 gtcttcagcg gtgaatggcg aggcacaatc cagtcacgaa acgcgcggtc agaattccaa
    13741 tgctctcccc agtgtgctcc tggagcttct tagccagagt tgtttgatac ctgccatgag
    13801 ttcatacctt cgaaacgact ctgtgctgga catggcgaga catgttccct tgtatagagc
    13861 tcttctggaa ctgctgagag ctatagccag ttgcgctgcc atggtgcctc tcctgctccc
    13921 cctgagcacc gagaatggcg aggaggagga ggagcagagc gagtgccaga ccagtgttgg
    13981 cactctcctt gccaaaatga aaacttgtgt cgatacttat accaaccgcc tgcggtctaa
    14041 gagagagaat gttaaaaccg gagttaagcc agacgcatct gaccaggaac ccgaagggct
    14101 tactttgctc gtaccagata tacagaaaac agctgaaatt gtttacgctg caacaacatc
    14161 actccgacag gccaaccagg agaagaaact tggggagtat tcaaagaaag cggccatgaa
    14221 gcctaagccg ctgtccgtcc tgaaatccct tgaggaaaag tatgtcgcag tgatgaaaaa
    14281 gctccaattc gacacttttg aaatggtgtc tgaagacgag gacggcaagc tgggattcaa
    14341 agtgaactat cattatatga gccaggtcaa aaacgctaac gatgcaaata gtgcagctag
    14401 ggctcggcgc cttgctcaag aagcggttac cctcagtact agtctcccct tgtcatccag
    14461 tagttcagtc ttcgtgagat gtgatgaaga gagattggat attatgaaag ttctgatcac
    14521 cggccccgca gacactcctt atgcaaacgg atgcttcgag tttgacgttt acttcccaca
    14581 ggattaccct tccagcccgc cccttgtcaa tttggaaact accgggggtc actccgtacg
    14641 cttcaacccc aacctgtata acgacggcaa agtttgcctc tcaattctga atacatggca
    14701 tggaagaccc gaagaaaaat ggaacccgca aacatcatca tttctccagg tactcgtgtc
    14761 cgttcaatca ttgatcctcg tggcggaacc ttactttaac gagcctggtt acgagaggtc
    14821 tcgaggcaca ccatctggta ctcaatccag cagggagtac gatggcaata tccgccaagc
    14881 tacagtgaag tgggctatgc tcgaacagat taggaatccc tctccttgct tcaaggaggt
    14941 gatacataaa catttctatt tgaaaagagt agaaattatg gcgcagtgtg aagagtggat
    15001 agcagacatc caacaatatt cctcagacaa acgggtcgga cggactatgt ctcatcacgc
    15061 agcggctctc aaacgacata cggcccaact ccgcgaggaa ctcttgaaat tgccgtgtcc
    15121 tgagggtttg gatcctgaca cggacgacgc cccagaagta tgtagagcca ctacaggtgc
    15181 ggaagagacc cttatgcacg atcaggtaaa accctcaagt tcaaaggaac ttccgtccga
    15241 ctttcagctt tgagcggccg ctacccagct ttcttgtaca aagttggcat tataagaaag
    15301 cattgcttat caatttgttg caacgaacag gtcactatca gtcaaaataa aatcattatt
    15361 tgccatccag ctgatatccc ctatagtgag tcgtattaca tggtcatagc tgtttcctgg
    15421 cagctctggc ccgtgtctca aaatctctga tgttacattg cacaagataa aaatatatca
    15481 tcatgcctcc tctagaccag ccaggacaga aatgcctcga cttcgctgct acccaaggtt
    15541 gccgggtgac gcacaccgtg gaaacggatg aaggcacgaa cccagtggac ataagcctgt
    15601 tcggttcgta agctgtaatg caagtagcgt atgcgctcac gcaactggtc cagaaccttg
    15661 accgaacgca gcggtggtaa cggcgcagtg gcggttttca tggcttgtta tgactgtttt
    15721 tttggggtac agtctatgcc tcgggcatcc aagcagcaag cgcgttacgc cgtgggtcga
    15781 tgtttgatgt tatggagcag caacgatgtt acgcagcagg gcagtcgccc taaaacaaag
    15841 ttaaacatta tgagggaagc ggtgatcgcc gaagtatcga ctcaactatc agaggtagtt
    15901 ggcgtcatcg agcgccatct cgaaccgacg ttgctggccg tacatttgta cggctccgca
    15961 gtggatggcg gcctgaagcc acacagtgat attgatttgc tggttacggt gaccgtaagg
    16021 cttgatgaaa caacgcggcg agctttgatc aacgaccttt tggaaacttc ggcttcccct
    16081 ggagagagcg agattctccg cgctgtagaa gtcaccattg ttgtgcacga cgacatcatt
    16141 ccgtggcgtt atccagctaa gcgcgaactg caatttggag aatggcagcg caatgacatt
    16201 cttgcaggta tcttcgagcc agccacgatc gacattgatc tggctatctt gctgacaaaa
    16261 gcaagagaac atagcgttgc cttggtaggt ccagcggcgg aggaactctt tgatccggtt
    16321 cctgaacagg atctatttga ggcgctaaat gaaaccttaa cgctatggaa ctcgccgccc
    16381 gactgggctg gcgatgagcg aaatgtagtg cttacgttgt cccgcatttg gtacagcgca
    16441 gtaaccggca aaatcgcgcc gaaggatgtc gctgccgact gggcaatgga gcgcctgccg
    16501 gcccagtatc agcccgtcat acttgaagct agacaggctt atcttggaca agaagaagat
    16561 cgcttggcct cgcgcgcaga tcagttggaa gaatttgtcc actacgtgaa aggcgagatc
    16621 accaaggtag tcggcaaata accctcgagc cacccatgac caaaatccct taacgtgagt
    16681 tacgcgtcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat
    16741 cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg
    16801 gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga
    16861 gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac
    16921 tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt
    16981 ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag
    17041 cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc
    17101 gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag
    17161 gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca
    17221 gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt
    17281 cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc
    17341 tttttacggt tcctggcctt ttgctggcct tttgctcaca tgtt
//
