LOCUS       sequence-415587-        1182 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  expresses human P53.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 1182)
  AUTHORS   Wu YQ, Zhang CS, Xiong J, Cai DQ, Wang CZ, Wang Y, Liu YH, Wang Y, 
            Li Y, Wu J, Wu J, Lan B, Wang X, Chen S, Cao X, Wei X, Hu HH, Guo H,
            Yu Y, Ghafoor A, Xie C, Wu Y, Xu Z, Zhang C, Zhu M, Huang X, Sun X, 
            Lin SY, Piao HL, Zhou J, Lin SC
  TITLE     Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine
            synthesis to p53 activation to control cell fate.
  JOURNAL   Cell Res. 2023 Nov;33(11):835-850. doi: 10.1038/s41422-023-00874-4. 
            Epub 2023 Sep 19.
  PUBMED    37726403
REFERENCE   2  (bases 1 to 1182)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: 
            "10.1038/s41422-023-00874-4"; journalName: "Cell Res"; date: 
            "2023-11"; volume: "33"; issue: "11"; pages: "835-850"
COMMENT     Sequence Label: pBOBI TP53 S46A
FEATURES             Location/Qualifiers
     source          1..1182
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     CDS             1..1182
                     /codon_start=1
                     /gene="Homo sapiens TP53"
                     /product="human tumor suppressor protein that is often 
                     mutated in cancers"
                     /label=p53
                     /note="responds to cellular stresses to regulate the 
                     expression of target genes"
                     /translation="MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLML
                     APDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQ
                     GSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIY
                     KQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEP
                     PEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRD
                     RRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEM
                     FRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD"
ORIGIN
        1 atggaggagc cgcagtcaga tcctagcgtc gagccccctc tgagtcagga aacattttca
       61 gacctatgga aactacttcc tgaaaacaac gttctgtccc ccttgccgtc ccaagcaatg
      121 gatgatttga tgctggcccc ggacgatatt gaacaatggt tcactgaaga cccaggtcca
      181 gatgaagctc ccagaatgcc agaggctgct ccccccgtgg cccctgcacc agcagctcct
      241 acaccggcgg cccctgcacc agccccctcc tggcccctgt catcttctgt cccttcccag
      301 aaaacctacc agggcagcta cggtttccgt ctgggcttct tgcattctgg gacagccaag
      361 tctgtgactt gcacgtactc ccctgccctc aacaagatgt tttgccaact ggccaagacc
      421 tgccctgtgc agctgtgggt tgattccaca cccccgcccg gcacccgcgt ccgcgccatg
      481 gccatctaca agcagtcaca gcacatgacg gaggttgtga ggcgctgccc ccaccatgag
      541 cgctgctcag atagcgatgg tctggcccct cctcagcatc ttatccgagt ggaaggaaat
      601 ttgcgtgtgg agtatttgga tgacagaaac acttttcgac atagtgtggt ggtgccctat
      661 gagccgcctg aggttggctc tgactgtacc accatccact acaactacat gtgtaacagt
      721 tcctgcatgg gcggcatgaa ccggaggccc atcctcacca tcatcacact ggaagactcc
      781 agtggtaatc tactgggacg gaacagcttt gaggtgcgtg tttgtgcctg tcctgggaga
      841 gaccggcgca cagaggagga gaatctccgc aagaaagggg agcctcacca cgagctgccc
      901 ccagggagca ctaagcgagc actgcccaac aacaccagct cctctcccca gccaaagaag
      961 aaaccactgg atggagaata tttcaccctt cagatccgtg ggcgtgagcg cttcgagatg
     1021 ttccgagagc tgaatgaggc cttggaactc aaggatgccc aggctgggaa ggagccaggg
     1081 gggagcaggg ctcactccag ccacctgaag tccaaaaagg gtcagtctac ctcccgccat
     1141 aaaaaactca tgttcaagac agaagggcct gactcagact ga
//
