LOCUS       sequence-452310-       18614 bp    DNA     circular SYN 15-DEC-2025
DEFINITION  T-DNA vector for PmCDA1-CBE_V04 based C-to-T base editing for dicot 
            plants; NGG PAM; 5' editing window; PmCDA1-CBE_V04 was driven by 
            ZmUbi1 and the sgRNA was driven by AtU3; BASTA for plants select..
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      synthetic DNA construct
  ORGANISM  synthetic DNA construct
REFERENCE   1  (bases 1 to 18614)
  AUTHORS   Cheng Y, Li G, Qi A, Mandlik R, Pan C, Wang D, Ge S, Qi Y
  TITLE     A comprehensive all-in-one CRISPR toolbox for large-scale screens in
            plants.
  JOURNAL   Plant Cell. 2025 Apr 9:koaf081. doi: 10.1093/plcell/koaf081.
  PUBMED    40202185
REFERENCE   2  (bases 1 to 18614)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Plant Cell.
            2025 Apr 9:koaf081. doi: 10.1093/plcell/koaf081."
COMMENT     Sequence Label: pYPQAT26
FEATURES             Location/Qualifiers
     source          1..18614
                     /mol_type="other DNA"
                     /organism="synthetic DNA construct"
     misc_feature    283..307
                     /label=RB T-DNA repeat
                     /note="right border repeat from nopaline C58 T-DNA"
     primer_bind     510..526
                     /label=M13 fwd
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     promoter        542..2539
                     /label=Ubi promoter
                     /note="maize polyubiquitin gene promoter"
     protein_bind    2582..2606
                     /gene="mutant version of attB"
                     /label=attB1
                     /bound_moiety="BP Clonase(TM)"
                     /note="recombination site for the Gateway(R) BP reaction"
     CDS             2628..2693
                     /codon_start=1
                     /product="three tandem FLAG(R) epitope tags, followed by an
                     enterokinase cleavage site"
                     /label=3xFLAG
                     /translation="DYKDHDGDYKDHDIDYKDDDDK"
     CDS             2700..2720
                     /codon_start=1
                     /product="nuclear localization signal of SV40 (simian virus
                     40) large T antigen"
                     /label=SV40 NLS
                     /translation="PKKKRKV"
     CDS             join(2745..2768,2769..2771,2772..6845)
                     /codon_start=1
                     /product="nickase mutant of the Cas9 endonuclease from the 
                     Streptococcus pyogenes Type II CRISPR/Cas system"
                     /label=Cas9(D10A)
                     /note="generates RNA-guided single strand nicks in DNA due 
                     to the D10A mutation in the RuvC catalytic domain"
                     /translation="DKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKN
                     LIGALLFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESF
                     LVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKF
                     RGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLE
                     NLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQI
                     GDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQ
                     QLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLR
                     KQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGN
                     SRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYF
                     TVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDS
                     VEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERL
                     KTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQ
                     LIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRH
                     KPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYL
                     YYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPS
                     EEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHV
                     AQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLN
                     AVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTE
                     ITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKE
                     SILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGIT
                     IMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNEL
                     ALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADA
                     NLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLD
                     ATLIHQSITGLYETRIDLSQLGGD"
     RBS             6758..6766
                     /label=Shine-Dalgarno sequence
                     /note="full consensus sequence for ribosome-binding sites 
                     upstream of start codons in E. coli; complementary to a 
                     region in the 3' end of the 16S rRNA (Chen et al., 1994)"
     CDS             6846..6893
                     /codon_start=1
                     /product="bipartite nuclear localization signal from 
                     nucleoplasmin"
                     /label=nucleoplasmin NLS
                     /translation="KRPAATKKAGQAKKKK"
     CDS             7110..7175
                     /codon_start=1
                     /product="three tandem FLAG(R) epitope tags, followed by an
                     enterokinase cleavage site"
                     /label=3xFLAG
                     /translation="DYKDHDGDYKDHDIDYKDDDDK"
     CDS             7809..7829
                     /codon_start=1
                     /product="nuclear localization signal of SV40 (simian virus
                     40) large T antigen"
                     /label=SV40 NLS
                     /translation="PKKKRKV"
     CDS             7836..8087
                     /codon_start=1
                     /product="uracil-DNA glycosylase inhibitor from a Bacillus 
                     subtilis bacteriophage (Mol et al., 1995)"
                     /label=UGI
                     /translation="MTNLSDIIEKETGKQLVIQESILMLPEEVEEVIGNKPESDILVHT
                     AYDESTDENVMLLTSDAPEYKPWALVIQDSNGENKIKML"
     CDS             8088..8141
                     /codon_start=1
                     /product="2A peptide from Thosea asigna virus capsid 
                     protein"
                     /label=T2A
                     /note="Eukaryotic ribosomes fail to insert a peptide bond 
                     between the Gly and Pro residues, yielding separate 
                     polypeptides."
                     /translation="EGRGSLLTCGDVEENPGP"
     CDS             8316..8369
                     /codon_start=1
                     /product="2A peptide from Thosea asigna virus capsid 
                     protein"
                     /label=T2A
                     /note="Eukaryotic ribosomes fail to insert a peptide bond 
                     between the Gly and Pro residues, yielding separate 
                     polypeptides."
                     /translation="EGRGSLLTCGDVEENPGP"
     CDS             8376..8396
                     /codon_start=1
                     /product="nuclear localization signal of SV40 (simian virus
                     40) large T antigen"
                     /label=SV40 NLS
                     /translation="PKKKRKV"
     CDS             8424..8810
                     /codon_start=1
                     /product="bacteriophage MS2 coat protein"
                     /label=MS2-N55K
                     /note="binds with high affinity to a specific stem-loop 
                     structure in the viral RNA (Lim et al., 1994)"
                     /translation="ASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVT
                     CSVRQSSAQKRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELI
                     VKAMQGLLKDGNPIPSAIAANSGIY"
     CDS             8859..9107
                     /codon_start=1
                     /product="uracil-DNA glycosylase inhibitor from a Bacillus 
                     subtilis bacteriophage (Mol et al., 1995)"
                     /label=UGI
                     /translation="TNLSDIIEKETGKQLVIQESILMLPEEVEEVIGNKPESDILVHTA
                     YDESTDENVMLLTSDAPEYKPWALVIQDSNGENKIKML"
     CDS             9120..9140
                     /codon_start=1
                     /product="nuclear localization signal of SV40 (simian virus
                     40) large T antigen"
                     /label=SV40 NLS
                     /translation="PKKKRKV"
     CDS             9147..9194
                     /codon_start=1
                     /product="bipartite nuclear localization signal from 
                     nucleoplasmin"
                     /label=nucleoplasmin NLS
                     /translation="KRPAATKKAGQAKKKK"
     terminator      9216..9468
                     /label=NOS terminator
                     /note="nopaline synthase terminator and poly(A) signal"
     protein_bind    9513..9533
                     /gene="mutant version of attB"
                     /label=attB5
                     /bound_moiety="BP Clonase(TM)"
                     /note="core recombination site for the Gateway(R) BP 
                     reaction"
     CDS             complement(9894..10199)
                     /codon_start=1
                     /gene="lacZ fragment"
                     /product="LacZ-alpha fragment of beta-galactosidase"
                     /label=lacZ-alpha
                     /translation="MTMITPSAQLTLTKGNKSWRTSRGGPVPNSPYSESYYARSLAVVL
                     QRRDWENPGVTQLNRLAAHPPFASWRNSEEARTDRPSQQLRSLNGEWDAPCSGAGL"
     primer_bind     10064..10080
                     /label=M13 fwd
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     primer_bind     10090..10109
                     /label=T7
                     /note="T7 promoter, forward primer"
     promoter        10090..10108
                     /label=T7 promoter
                     /note="promoter for bacteriophage T7 RNA polymerase"
     primer_bind     complement(10156..10176)
                     /label=T3
                     /note="T3 promoter, forward primer"
     promoter        complement(10156..10174)
                     /label=T3 promoter
                     /note="promoter for bacteriophage T3 RNA polymerase"
     primer_bind     complement(10195..10211)
                     /label=M13 rev
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     protein_bind    10219..10235
                     /label=lac operator
                     /bound_moiety="lac repressor encoded by lacI"
                     /note="The lac repressor binds to the lac operator to 
                     inhibit transcription in E. coli. This inhibition can be 
                     relieved by adding lactose or 
                     isopropyl-beta-D-thiogalactopyranoside (IPTG)."
     promoter        complement(join(10243..10249,10250..10267,10268..10273))
                     /label=lac promoter
                     /note="promoter for the E. coli lac operon"
     protein_bind    10288..10309
                     /label=CAP binding site
                     /bound_moiety="E. coli catabolite activator protein"
                     /note="CAP binding activates transcription in the presence 
                     of cAMP."
     misc_RNA        10368..10386
                     /label=MS2 stem loop
                     /note="stem loop that binds the bacteriophage MS2 coat 
                     protein"
     misc_RNA        10438..10456
                     /label=MS2 stem loop
                     /note="stem loop that binds the bacteriophage MS2 coat 
                     protein"
     protein_bind    complement(10689..10713)
                     /gene="mutant version of attB"
                     /label=attB2
                     /bound_moiety="BP Clonase(TM)"
                     /note="recombination site for the Gateway(R) BP reaction"
     primer_bind     complement(10781..10797)
                     /label=M13 rev
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     protein_bind    10805..10821
                     /label=lac operator
                     /bound_moiety="lac repressor encoded by lacI"
                     /note="The lac repressor binds to the lac operator to 
                     inhibit transcription in E. coli. This inhibition can be 
                     relieved by adding lactose or 
                     isopropyl-beta-D-thiogalactopyranoside (IPTG)."
     promoter        complement(join(10829..10835,10836..10853,10854..10859))
                     /label=lac promoter
                     /note="promoter for the E. coli lac operon"
     protein_bind    10874..10895
                     /label=CAP binding site
                     /bound_moiety="E. coli catabolite activator protein"
                     /note="CAP binding activates transcription in the presence 
                     of cAMP."
     promoter        11086..11762
                     /label=CaMV 35S promoter (enhanced)
                     /note="cauliflower mosaic virus 35S promoter with a 
                     duplicated enhancer region"
     primer_bind     11699..11719
                     /label=35S promoter
                     /note="CaMV 35S promoter, forward primer"
     CDS             11807..12358
                     /codon_start=1
                     /gene="Streptomyces hygroscopicus bar"
                     /product="phosphinothricin acetyltransferase"
                     /label=BlpR
                     /note="confers resistance to bialophos or phosphinothricin"
                     /translation="MSPERRPADIRRATEADMPAVCTIVNHYIETSTVNFRTEPQEPQE
                     WTDDLVRLRERYPWLVAEVDGEVAGIAYAGPWKARNAYDWTAESTVYVSPRHQRTGLGS
                     TLYTHLLKSLEAQGFKSVVAVIGLPNDPSVRMHEALGYAPRGMLRAAGFKHGNWHDVGF
                     WQLDFSLPVPPRPVLPVTEI"
     polyA_signal    12365..12539
                     /label=CaMV poly(A) signal
                     /note="cauliflower mosaic virus polyadenylation signal"
     misc_feature    12617..12641
                     /label=LB T-DNA repeat
                     /note="left border repeat from nopaline C58 T-DNA"
     CDS             13066..13860
                     /codon_start=1
                     /gene="aphA-3"
                     /product="aminoglycoside phosphotransferase"
                     /label=KanR
                     /note="confers resistance to kanamycin"
                     /translation="MAKMRISPELKKLIEKYRCVKDTEGMSPAKVYKLVGENENLYLKM
                     TDSRYKGTTYDVEREKDMMLWLEGKLPVPKVLHFERHDGWSNLLMSEADGVLCSEEYED
                     EQSPEKIIELYAECIRLFHSIDISDCPYTNSLDSRLAELDYLLNNDLADVDCENWEEDT
                     PFKDPRELYDFLKTEKPEEELVFSHGDLGDSNIFVKDGKVSGFIDLGRSGRADKWYDIA
                     FCVRSIREDIGEEQYVELFFDLLGIKPDWEKIKYYILLDELF"
     rep_origin      13947..14535
                     /direction=RIGHT
                     /label=ori
                     /note="high-copy-number ColE1/pMB1/pBR322/pUC origin of 
                     replication"
     primer_bind     14436..14455
                     /label=pBR322ori-F
                     /note="pBR322 origin, forward primer"
     primer_bind     14689..14706
                     /label=L4440
                     /note="L4440 vector, forward primer"
     misc_feature    14721..14861
                     /label=bom
                     /note="basis of mobility region from pBR322"
     primer_bind     complement(14787..14806)
                     /label=pRS-marker
                     /note="pRS vectors, use to sequence yeast selectable 
                     marker"
     primer_bind     14947..14969
                     /label=pGEX 3'
                     /note="pGEX vectors, reverse primer"
     rep_origin      15205..15399
                     /label=pVS1 oriV
                     /note="origin of replication for the Pseudomonas plasmid 
                     pVS1 (Heeb et al., 2000)"
     CDS             complement(15465..16538)
                     /codon_start=1
                     /product="replication protein from the Pseudomonas plasmid 
                     pVS1 (Heeb et al., 2000)"
                     /label=pVS1 RepA
                     /translation="MSGRKPSGPVQIGAALGDDLVEKLKAAQAAQRQRIEAEARPGESW
                     QAAADRIRKESRQPPAAGAPSIRKPPKGDEQPDFFVPMLYDVGTRDSRSIMDVAVFRLS
                     KRDRRAGEVIRYELPDGHVEVSAGPAGMASVWDYDLVLMAVSHLTESMNRYREGKGDKP
                     GRVFRPHVADVLKFCRRADGGKQKDDLVETCIRLNTTHVAMQRTKKAKNGRLVTVSEGE
                     ALISRYKIVKSETGRPEYIEIELADWMYREITEGKNPDVLTVHPDYFLIDPGIGRFLYR
                     LARRAAGKAEARWLFKTIYERSGSAGEFKKFCFTVRKLIGSNDLPEYDLKEEAGQAGPI
                     LVMRYRNLIEGEASAGS"
     CDS             complement(16967..17596)
                     /codon_start=1
                     /product="stability protein from the Pseudomonas plasmid 
                     pVS1 (Heeb et al., 2000)"
                     /label=pVS1 StaA
                     /translation="MKVIAVLNQKGGSGKTTIATHLARALQLAGADVLLVDSDPQGSAR
                     DWAAVREDQPLTVVGIDRPTIDRDVKAIGRRDFVVIDGAPQAADLAVSAIKAADFVLIP
                     VQPSPYDIWATADLVELVKQRIEVTDGRLQAAFVVSRAIKGTRIGGEVAEALAGYELPI
                     LESRITQRVSYPGTAAAGTTVLESEPEGDAAREVQALAAEIKSKLI"
ORIGIN
        1 ctactttatg cgactaaaac acgcgacaag aaaacgccag gaaaagggca gggcggcagc
       61 ctgtcgcgta acttaggact tgtgcgacat gtcgttttca gaagacggct gcactgaacg
      121 tcagaagccg actgcactat agcagcggag gggttggatc aaagtacttt gatcccgagg
      181 ggaaccctgt ggttggcatg cacatacaaa tggacgaacg gataaacctt ttcacgccct
      241 tttaaatatc cgattattct aataaacgct cttttctctt aggtttaccc gccaatatat
      301 cctgtcaaac actgatagtt taaactgaag gcgggaaacg acaatctgat ccaagctcaa
      361 gctgctctag cattcgccat tcaggctgcg caactgttgg gaagggcgat cggtgcgggc
      421 ctcttcgcta ttacgccagc tggcgaaagg gggatgtgct gcaaggcgat taagttgggt
      481 aacgccaggg ttttcccagt cacgacgttg taaaacgacg gccagtgcca agcttgcatg
      541 cctgcagtgc agcgtgaccc ggtcgtgccc ctctctagag ataatgagca ttgcatgtct
      601 aagttataaa aaattaccac atattttttt tgtcacactt gtttgaagtg cagtttatct
      661 atctttatac atatatttaa actttactct acgaataata taatctatag tactacaata
      721 atatcagtgt tttagagaat catataaatg aacagttaga catggtctaa aggacaattg
      781 agtattttga caacaggact ctacagtttt atctttttag tgtgcatgtg ttctcctttt
      841 tttttgcaaa tagcttcacc tatataatac ttcatccatt ttattagtac atccatttag
      901 ggtttagggt taatggtttt tatagactaa tttttttagt acatctattt tattctattt
      961 tagcctctaa attaagaaaa ctaaaactct attttagttt ttttatttaa taatttagat
     1021 ataaaataga ataaaataaa gtgactaaaa attaaacaaa taccctttaa gaaattaaaa
     1081 aaactaagga aacatttttc ttgtttcgag tagataatgc cagcctgtta aacgccgtcg
     1141 acgagtctaa cggacaccaa ccagcgaacc agcagcgtcg cgtcgggcca agcgaagcag
     1201 acggcacggc atctctgtcg ctgcctctgg acccctctcg agagttccgc tccaccgttg
     1261 gacttgctcc gctgtcggca tccagaaatt gcgtggcgga gcggcagacg tgagccggca
     1321 cggcaggcgg cctcctcctc ctctcacggc accggcagct acgggggatt cctttcccac
     1381 cgctccttcg ctttcccttc ctcgcccgcc gtaataaata gacaccccct ccacaccctc
     1441 tttccccaac ctcgtgttgt tcggagcgca cacacacaca accagatctc ccccaaatcc
     1501 acccgtcggc acctccgctt caaggtacgc cgctcgtcct cccccccccc cccctctcta
     1561 ccttctctag atcggcgttc cggtccatgg ttagggcccg gtagttctac ttctgttcat
     1621 gtttgtgtta gatccgtgtt tgtgttagat ccgtgctgct agcgttcgta cacggatgcg
     1681 acctgtacgt cagacacgtt ctgattgcta acttgccagt gtttctcttt ggggaatcct
     1741 gggatggctc tagccgttcc gcagacggga tcgatttcat gatttttttt gtttcgttgc
     1801 atagggtttg gtttgccctt ttcctttatt tcaatatatg ccgtgcactt gtttgtcggg
     1861 tcatcttttc atgctttttt ttgtcttggt tgtgatgatg tggtctggtt gggcggtcgt
     1921 tctagatcgg agtagaatta attctgtttc aaactacctg gtggatttat taattttgga
     1981 tctgtatgtg tgtgccatac atattcatag ttacgaattg aagatgatgg atggaaatat
     2041 cgatctagga taggtataca tgttgatgcg ggttttactg atgcatatac agagatgctt
     2101 tttgttcgct tggttgtgat gatgtggtgt ggttgggcgg tcgttcattc gttctagatc
     2161 ggagtagaat actgtttcaa actacctggt gtatttatta attttggaac tgtatgtgtg
     2221 tgtcatacat cttcatagtt acgagtttaa gatggatgga aatatcgatc taggataggt
     2281 atacatgttg atgtgggttt tactgatgca tatacatgat ggcatatgca gcatctattc
     2341 atatgctcta accttgagta cctatctatt ataataaaca agtatgtttt ataattattt
     2401 tgatcttgat atacttggat gatggcatat gcagcagcta tatgtggatt tttttagccc
     2461 tgccttcata cgctatttat ttgcttggta ctgtttcttt tgtcgatgct caccctgttg
     2521 tttggtgtta cttctgcagg tcgactctag aggatcccct cgaggcgcgc caagctatca
     2581 aacaagtttg tacaaaaaag caggctccga attcgccctt caccatggat tacaaggacc
     2641 acgacgggga ttacaaggac cacgacattg attacaagga tgatgatgac aagatggctc
     2701 cgaagaagaa gaggaaggtt ggcatccacg gggtgccagc tgctgacaag aagtactcga
     2761 tcggcctcgc tattgggact aactctgttg gctgggccgt gatcaccgac gagtacaagg
     2821 tgccctcaaa gaagttcaag gtcctgggca acaccgatcg gcattccatc aagaagaatc
     2881 tcattggcgc tctcctgttc gacagcggcg agacggctga ggctacgcgg ctcaagcgca
     2941 ccgcccgcag gcggtacacg cgcaggaaga atcgcatctg ctacctgcag gagattttct
     3001 ccaacgagat ggcgaaggtt gacgattctt tcttccacag gctggaggag tcattcctcg
     3061 tggaggagga taagaagcac gagcggcatc caatcttcgg caacattgtc gacgaggttg
     3121 cctaccacga gaagtaccct acgatctacc atctgcggaa gaagctcgtg gactccacag
     3181 ataaggcgga cctccgcctg atctacctcg ctctggccca catgattaag ttcaggggcc
     3241 atttcctgat cgagggggat ctcaacccgg acaatagcga tgttgacaag ctgttcatcc
     3301 agctcgtgca gacgtacaac cagctcttcg aggagaaccc cattaatgcg tcaggcgtcg
     3361 acgcgaaggc tatcctgtcc gctaggctct cgaagtctcg gcgcctcgag aacctgatcg
     3421 cccagctgcc gggcgagaag aagaacggcc tgttcgggaa tctcattgcg ctcagcctgg
     3481 ggctcacgcc caacttcaag tcgaatttcg atctcgctga ggacgccaag ctgcagctct
     3541 ccaaggacac atacgacgat gacctggata acctcctggc ccagatcggc gatcagtacg
     3601 cggacctgtt cctcgctgcc aagaatctgt cggacgccat cctcctgtct gatattctca
     3661 gggtgaacac cgagattacg aaggctccgc tctcagcctc catgatcaag cgctacgacg
     3721 agcaccatca ggatctgacc ctcctgaagg cgctggtcag gcagcagctc cccgagaagt
     3781 acaaggagat cttcttcgat cagtcgaaga acggctacgc tgggtacatt gacggcgggg
     3841 cctctcagga ggagttctac aagttcatca agccgattct ggagaagatg gacggcacgg
     3901 aggagctgct ggtgaagctc aatcgcgagg acctcctgag gaagcagcgg acattcgata
     3961 acggcagcat cccacaccag attcatctcg gggagctgca cgctatcctg aggaggcagg
     4021 aggacttcta ccctttcctc aaggataacc gcgagaagat cgagaagatt ctgactttca
     4081 ggatcccgta ctacgtcggc ccactcgcta ggggcaactc ccgcttcgct tggatgaccc
     4141 gcaagtcaga ggagacgatc acgccgtgga acttcgagga ggtggtcgac aagggcgcta
     4201 gcgctcagtc gttcatcgag aggatgacga atttcgacaa gaacctgcca aatgagaagg
     4261 tgctccctaa gcactcgctc ctgtacgagt acttcacagt ctacaacgag ctgactaagg
     4321 tgaagtatgt gaccgagggc atgaggaagc cggctttcct gtctggggag cagaagaagg
     4381 ccatcgtgga cctcctgttc aagaccaacc ggaaggtcac ggttaagcag ctcaaggagg
     4441 actacttcaa gaagattgag tgcttcgatt cggtcgagat ctctggcgtt gaggaccgct
     4501 tcaacgcctc cctggggacc taccacgatc tcctgaagat cattaaggat aaggacttcc
     4561 tggacaacga ggagaatgag gatatcctcg aggacattgt gctgacactc actctgttcg
     4621 aggaccggga gatgatcgag gagcgcctga agacttacgc ccatctcttc gatgacaagg
     4681 tcatgaagca gctcaagagg aggaggtaca ccggctgggg gaggctgagc aggaagctca
     4741 tcaacggcat tcgggacaag cagtccggga agacgatcct cgacttcctg aagagcgatg
     4801 gcttcgcgaa ccgcaatttc atgcagctga ttcacgatga cagcctcaca ttcaaggagg
     4861 atatccagaa ggctcaggtg agcggccagg gggactcgct gcacgagcat atcgcgaacc
     4921 tcgctggctc gccagctatc aagaagggga ttctgcagac cgtgaaggtt gtggacgagc
     4981 tggtgaaggt catgggcagg cacaagcctg agaacatcgt cattgagatg gcccgggaga
     5041 atcagaccac gcagaagggc cagaagaact cacgcgagag gatgaagagg atcgaggagg
     5101 gcattaagga gctggggtcc cagatcctca aggagcaccc ggtggagaac acgcagctgc
     5161 agaatgagaa gctctacctg tactacctcc agaatggccg cgatatgtat gtggaccagg
     5221 agctggatat taacaggctc agcgattacg acgtcgatca tatcgttcca cagtcattcc
     5281 tgaaggatga ctccattgac aacaaggtcc tcaccaggtc ggacaagaac cggggcaagt
     5341 ctgataatgt tccttcagag gaggtcgtta agaagatgaa gaactactgg cgccagctcc
     5401 tgaatgccaa gctgatcacg cagcggaagt tcgataacct cacaaaggct gagaggggcg
     5461 ggctctctga gctggacaag gcgggcttca tcaagaggca gctggtcgag acacggcaga
     5521 tcactaagca cgttgcgcag attctcgact cacggatgaa cactaagtac gatgagaatg
     5581 acaagctgat ccgcgaggtg aaggtcatca ccctgaagtc aaagctcgtc tccgacttca
     5641 ggaaggattt ccagttctac aaggttcggg agatcaacaa ttaccaccat gcccatgacg
     5701 cgtacctgaa cgcggtggtc ggcacagctc tgatcaagaa gtacccaaag ctcgagagcg
     5761 agttcgtgta cggggactac aaggtttacg atgtgaggaa gatgatcgcc aagtcggagc
     5821 aggagattgg caaggctacc gccaagtact tcttctactc taacattatg aatttcttca
     5881 agacagagat cactctggcc aatggcgaga tccggaagcg ccccctcatc gagacgaacg
     5941 gcgagacggg ggagatcgtg tgggacaagg gcagggattt cgcgaccgtc aggaaggttc
     6001 tctccatgcc acaagtgaat atcgtcaaga agacagaggt ccagactggc gggttctcta
     6061 aggagtcaat tctgcctaag cggaacagcg acaagctcat cgcccgcaag aaggactggg
     6121 atccgaagaa gtacggcggg ttcgacagcc ccactgtggc ctactcggtc ctggttgtgg
     6181 cgaaggttga gaagggcaag tccaagaagc tcaagagcgt gaaggagctg ctggggatca
     6241 cgattatgga gcgctccagc ttcgagaaga acccgatcga tttcctggag gcgaagggct
     6301 acaaggaggt gaagaaggac ctgatcatta agctccccaa gtactcactc ttcgagctgg
     6361 agaacggcag gaagcggatg ctggcttccg ctggcgagct gcagaagggg aacgagctgg
     6421 ctctgccgtc caagtatgtg aacttcctct acctggcctc ccactacgag aagctcaagg
     6481 gcagccccga ggacaacgag cagaagcagc tgttcgtcga gcagcacaag cattacctcg
     6541 acgagatcat tgagcagatt tccgagttct ccaagcgcgt gatcctggcc gacgcgaatc
     6601 tggataaggt cctctccgcg tacaacaagc accgcgacaa gccaatcagg gagcaggctg
     6661 agaatatcat tcatctcttc accctgacga acctcggcgc ccctgctgct ttcaagtact
     6721 tcgacacaac tatcgatcgc aagaggtaca caagcactaa ggaggtcctg gacgcgaccc
     6781 tcatccacca gtcgattacc ggcctctacg agacgcgcat cgacctgtct cagctcgggg
     6841 gcgacaagcg gccagcggcg acgaagaagg cggggcaggc gaagaagaag aagggagacg
     6901 acggaggtgg cggtacagga gggggtgggt ccgctgagta tgtcagggcg ttgttcgact
     6961 tcaatggaaa cgacgaggaa gatctgcctt ttaaaaaggg agatattctc aggatcagag
     7021 ataagccgga agaacaatgg tggaacgctg aagactctga aggtaagaga ggtatgattc
     7081 ttgtccccta cgtcgagaag tattcgggtg actataaaga ccacgatgga gattataagg
     7141 accacgatat agattataag gatgatgatg ataagagcgg aatgaccgat gcagagtacg
     7201 tcaggattca tgagaaactt gacatctaca cgtttaagaa acagtttttc aacaacaaaa
     7261 aatctgttag tcaccgctgt tacgtgctgt tcgaattgaa acgcagaggt gagaggagag
     7321 cctgcttttg gggctatgcc gtcaacaagc cgcaaagcgg cacagaaagg ggcattcacg
     7381 cggagatatt tagcattaga aaggtcgagg aataccttcg ggataatccc gggcaattca
     7441 ctatcaattg gtactcttca tggtccccgt gtgcagattg cgctgaaaag atactggagt
     7501 ggtataatca agaactcaga ggaaacggtc acaccctcaa gatttgggct tgcaagcttt
     7561 actacgagaa aaatgcaagg aaccagatcg gcctctggaa cttgcgcgac aacggcgtgg
     7621 ggttgaatgt gatggtgtcg gagcattacc agtgctgccg gaagatattc attcagtcgt
     7681 cacataatca attgaacgag aataggtggc tcgaaaaaac cctgaagcgg gccgagaagt
     7741 ggaggagtga actctcgata atgatccagg ttaaaatact gcatactacc aaatctccgg
     7801 cggtgggacc gaagaagaag cgcaaggtgg ggaccatgac taatctctca gatataatcg
     7861 agaaggaaac aggaaagcaa ctggtcatcc aagaatcgat tttgatgctt cccgaagaag
     7921 tcgaagaagt tataggaaat aagcccgagt ctgacatact ggttcacaca gcgtacgatg
     7981 aaagtacgga cgagaatgtc atgttgctga catcggacgc acctgaatac aagccttggg
     8041 ctctggtcat acaagatagt aacggagaaa ataagattaa aatgcttgaa ggaaggggct
     8101 ccctgctgac atgtggagat gtggaagaga atccaggacc atccaggatg atagagcaag
     8161 atggttgtac ccaagtgctg cggcccctcg gatggcgggg gtacagcgcc atgactggcc
     8221 ataatagaca gtccgctgct ctcatgcctc catgcagcgg atgtcagagg aggggagcta
     8281 ggttcttcct gtctagacct acctgccccg tgcccgaggg cagaggaagt cttctaacat
     8341 gcggtgacgt ggaggagaat cccggcccta tggctcctaa gaagaagcgg aaggttggta
     8401 ttcacggggt gcctgcggct atggcgtcaa atttcacgca gtttgttttg gttgataacg
     8461 gcgggactgg cgacgttaca gtagctccat caaattttgc gaacggagtc gctgagtgga
     8521 ttagctcaaa ttcaaggtcc caggcctaca aggttacctg ttctgttagg cagagttctg
     8581 cgcaaaaaag aaaatatacc atcaaggttg aagtccctaa agttgcaaca caaacagtcg
     8641 gtggtgttga gctccctgtg gcagcctgga gatcttactt aaacatggag ctaacaattc
     8701 caatattcgc tacaaactct gattgtgaac tgattgttaa ggcgatgcaa ggactcttga
     8761 aagatggaaa ccctataccg tccgctatcg cagctaacag cggtatctat ggctctggat
     8821 cggggtcggg ttctggctca actagttcag gcgggtcaac aaacctcagt gacatcatag
     8881 agaaggaaac tggtaagcaa ctggttattc aagagagcat tctgatgctc cctgaggaag
     8941 tcgaggaagt tataggaaac aagcctgaga gcgatatact cgtgcatacg gcgtatgacg
     9001 agagcacgga tgaaaatgtg atgctcttga ccagcgatgc gccagaatat aaaccctggg
     9061 cactggttat tcaggactct aacggggaaa ataaaatcaa gatgctctca ggtggctccc
     9121 caaagaagaa acgcaaggtt ggtaccaagc gtcctgctgc caccaaaaag gccggacagg
     9181 ctaagaaaaa gaagtagtgg cggccgccga cgtccgatcg ttcaaacatt tggcaataaa
     9241 gtttcttaag attgaatcct gttgccggtc ttgcgatgat tatcatataa tttctgttga
     9301 attacgttaa gcatgtaata attaacatgt aatgcatgac gttatttatg agatgggttt
     9361 ttatgattag agtcccgcaa ttatacattt aatacgcgat agaaaacaaa atatagcgcg
     9421 caaactagga taaattatcg cgcgcggtgt catctatgtt actagatcgg gaattgatcc
     9481 cccctcgaca gcttccggaa agggcgaatt cgcaactttg tatacaaaag ttgccccatg
     9541 gcgttccctc tagataacgc aggatcctat ttactttaaa tttttcttat ggctcagcct
     9601 gtgatggata actgaatcaa acaaatggcg tctgggttta agaacatctg ttttggctat
     9661 gttggacgaa acaagtgaac ttttaggatc aacttccgtt tatatacgga gcttatatcg
     9721 agcaataaga taagtgggct ttttatgtaa tttaatgggc tatcgtccat atattcacta
     9781 atacccatgc ccagtaccca tgtatgcgtt tcatataagc tcctaatttc tcccacatcg
     9841 ctcaaatcta aacaaatctt gttgtatata taacactgag ggagcaccat tggtcagaga
     9901 ccggcgccgc tacagggcgc gtcccattcg ccattcaggc tgcgcaactg ttgggaaggg
     9961 cgatcggtgc gggcctcttc gctattacgc cagctggcga aagggggatg tgctgcaagg
    10021 cgattaagtt gggtaacgcc agggttttcc cagtcacgac gttgtaaaac gacggccagt
    10081 gagcgcgcgt aatacgactc actatagggc gaattgggta ccgggccccc cctcgaggtc
    10141 ctccagcttt tgttcccttt agtgagggtt aattgcgcgc ttggcgtaat catggtcata
    10201 gctgtttcct gtgtgaaatt gttatccgct cacaattcca cacaacatac gagccggaag
    10261 cataaagtgt aaagcctggg gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg
    10321 ctcactgccc gctttccacc ggtggtctct gttttagagc taggccaaca tgaggatcac
    10381 ccatgtctgc agggcctagc aagttaaaat aaggctagtc cgttatcaac ttggccaaca
    10441 tgaggatcac ccatgtctgc agggccaagt ggcaccgagt cggtgctttt ttttcccttt
    10501 ccttttttct tttttttgcc ataaacttaa atttgtatat cgatcattgt agatattgaa
    10561 aacctagaac aaaccaacat ccatgtgaat gtctttcatg actgatttag agataattct
    10621 tgaattttgg aactagaatc tataatgagc ctaaattaaa acattgtgaa ctagtaaggg
    10681 cgaattcgac ccagctttct tgtacaaagt ggttcgataa ttcttaatta actagttcta
    10741 gagcggccgc caccgcggtg gagctcgaat tcgtaatcat gtcatagctg tttcctgtgt
    10801 gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata aagtgtaaag
    10861 cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca ctgcccgctt
    10921 tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag
    10981 gcggtttgcg tattggctag agcagcttgc caacatggtg gagcacgaca ctctcgtcta
    11041 ctccaagaat atcaaagata cagtctcaga agaccaaagg gctattgaga cttttcaaca
    11101 aagggtaata tcgggaaacc tcctcggatt ccattgccca gctatctgtc acttcatcaa
    11161 aaggacagta gaaaaggaag gtggcaccta caaatgccat cattgcgata aaggaaaggc
    11221 tatcgttcaa gatgcctctg ccgacagtgg tcccaaagat ggacccccac ccacgaggag
    11281 catcgtggaa aaagaagacg ttccaaccac gtcttcaaag caagtggatt gatgtgaaca
    11341 tggtggagca cgacactctc gtctactcca agaatatcaa agatacagtc tcagaagacc
    11401 aaagggctat tgagactttt caacaaaggg taatatcggg aaacctcctc ggattccatt
    11461 gcccagctat ctgtcacttc atcaaaagga cagtagaaaa ggaaggtggc acctacaaat
    11521 gccatcattg cgataaagga aaggctatcg ttcaagatgc ctctgccgac agtggtccca
    11581 aagatggacc cccacccacg aggagcatcg tggaaaaaga agacgttcca accacgtctt
    11641 caaagcaagt ggattgatgt gatatctcca ctgacgtaag ggatgacgca caatcccact
    11701 atccttcgca agacccttcc tctatataag gaagttcatt tcatttggag aggacacgct
    11761 gaaatcacca gtctctctct acaaatctat ctctctcgag tctaccatga gcccagaacg
    11821 acgcccggcc gacatccgcc gtgccaccga ggcggacatg ccggcggtct gcaccatcgt
    11881 caaccactac atcgagacaa gcacggtcaa cttccgtacc gagccgcagg aaccgcagga
    11941 gtggacggac gacctcgtcc gtctgcggga gcgctatccc tggctcgtcg ccgaggtgga
    12001 cggcgaggtc gccggcatcg cctacgcggg cccctggaag gcacgcaacg cctacgactg
    12061 gacggccgag tcgaccgtgt acgtctcccc ccgccaccag cggacgggac tgggctccac
    12121 gctctacacc cacctgctga agtccctgga ggcacagggc ttcaagagcg tggtcgctgt
    12181 catcgggctg cccaacgacc cgagcgtgcg catgcacgag gcgctcggat atgccccccg
    12241 cggcatgctg cgggcggccg gcttcaagca cgggaactgg catgacgtgg gtttctggca
    12301 gctggacttc agcctgccgg taccgccccg tccggtcctg cccgtcaccg agatttgact
    12361 cgagtttctc cataataatg tgtgagtagt tcccagataa gggaattagg gttcctatag
    12421 ggtttcgctc atgtgttgag catataagaa acccttagta tgtatttgta tttgtaaaat
    12481 acttctatca ataaaatttc taattcctaa aaccaaaatc cagtactaaa atccagatcc
    12541 cccgaattaa ttcggcgtta attcagtaca ttaaaaacgt ccgcaatgtg ttattaagtt
    12601 gtctaagcgt caatttgttt acaccacaat atatcctgcc accagccagc caacagctcc
    12661 ccgaccggca gctcggcaca aaatcaccac tcgatacagg cagcccatca gtccgggacg
    12721 gcgtcagcgg gagagccgtt gtaaggcggc agactttgct catgttaccg atgctattcg
    12781 gaagaacggc aactaagctg ccgggtttga aacacggatg atctcgcgga gggtagcatg
    12841 ttgattgtaa cgatgacaga gcgttgctgc ctgtgatcac cgcggtttca aaatcggctc
    12901 cgtcgatact atgttatacg ccaactttga aaacaacttt gaaaaagctg ttttctggta
    12961 tttaaggttt tagaatgcaa ggaacagtga attggagttc gtcttgttat aattagcttc
    13021 ttggggtatc tttaaatact gtagaaaaga ggaaggaaat aataaatggc taaaatgaga
    13081 atatcaccgg aattgaaaaa actgatcgaa aaataccgct gcgtaaaaga tacggaagga
    13141 atgtctcctg ctaaggtata taagctggtg ggagaaaatg aaaacctata tttaaaaatg
    13201 acggacagcc ggtataaagg gaccacctat gatgtggaac gggaaaagga catgatgcta
    13261 tggctggaag gaaagctgcc tgttccaaag gtcctgcact ttgaacggca tgatggctgg
    13321 agcaatctgc tcatgagtga ggccgatggc gtcctttgct cggaagagta tgaagatgaa
    13381 caaagccctg aaaagattat cgagctgtat gcggagtgca tcaggctctt tcactccatc
    13441 gacatatcgg attgtcccta tacgaatagc ttagacagcc gcttagccga attggattac
    13501 ttactgaata acgatctggc cgatgtggat tgcgaaaact gggaagaaga cactccattt
    13561 aaagatccgc gcgagctgta tgatttttta aagacggaaa agcccgaaga ggaacttgtc
    13621 ttttcccacg gcgacctggg agacagcaac atctttgtga aagatggcaa agtaagtggc
    13681 tttattgatc ttgggagaag cggcagggcg gacaagtggt atgacattgc cttctgcgtc
    13741 cggtcgatca gggaggatat cggggaagaa cagtatgtcg agctattttt tgacttactg
    13801 gggatcaagc ctgattggga gaaaataaaa tattatattt tactggatga attgttttag
    13861 tacctagaat gcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac
    13921 cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc
    13981 ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca
    14041 actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta
    14101 gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct
    14161 ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg
    14221 gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc
    14281 acacagccca gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta
    14341 tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg
    14401 gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt
    14461 cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg
    14521 cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg
    14581 ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc
    14641 gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg
    14701 agcgaggaag cggaagagcg cctgatgcgg tattttctcc ttacgcatct gtgcggtatt
    14761 tcacaccgca tatggtgcac tctcagtaca atctgctctg atgccgcata gttaagccag
    14821 tatacactcc gctatcgcta cgtgactggg tcatggctgc gccccgacac ccgccaacac
    14881 ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga
    14941 ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgaggc
    15001 agggtgcctt gatgtgggcg ccggcggtcg agtggcgacg gcgcggcttg tccgcgccct
    15061 ggtagattgc ctggccgtag gccagccatt tttgagcggc cagcggccgc gataggccga
    15121 cgcgaagcgg cggggcgtag ggagcgcagc gaccgaaggg taggcgcttt ttgcagctct
    15181 tcggctgtgc gctggccaga cagttatgca caggccaggc gggttttaag agttttaata
    15241 agttttaaag agttttaggc ggaaaaatcg ccttttttct cttttatatc agtcacttac
    15301 atgtgtgacc ggttcccaat gtacggcttt gggttcccaa tgtacgggtt ccggttccca
    15361 atgtacggct ttgggttccc aatgtacgtg ctatccacag gaaacagacc ttttcgacct
    15421 ttttcccctg ctagggcaat ttgccctagc atctgctccg tacattagga accggcggat
    15481 gcttcgccct cgatcaggtt gcggtagcgc atgactagga tcgggccagc ctgccccgcc
    15541 tcctccttca aatcgtactc cggcaggtca tttgacccga tcagcttgcg cacggtgaaa
    15601 cagaacttct tgaactctcc ggcgctgcca ctgcgttcgt agatcgtctt gaacaaccat
    15661 ctggcttctg ccttgcctgc ggcgcggcgt gccaggcggt agagaaaacg gccgatgccg
    15721 ggatcgatca aaaagtaatc ggggtgaacc gtcagcacgt ccgggttctt gccttctgtg
    15781 atctcgcggt acatccaatc agctagctcg atctcgatgt actccggccg cccggtttcg
    15841 ctctttacga tcttgtagcg gctaatcaag gcttcaccct cggataccgt caccaggcgg
    15901 ccgttcttgg ccttcttcgt acgctgcatg gcaacgtgcg tggtgtttaa ccgaatgcag
    15961 gtttctacca ggtcgtcttt ctgctttccg ccatcggctc gccggcagaa cttgagtacg
    16021 tccgcaacgt gtggacggaa cacgcggccg ggcttgtctc ccttcccttc ccggtatcgg
    16081 ttcatggatt cggttagatg ggaaaccgcc atcagtacca ggtcgtaatc ccacacactg
    16141 gccatgccgg ccggccctgc ggaaacctct acgtgcccgt ctggaagctc gtagcggatc
    16201 acctcgccag ctcgtcggtc acgcttcgac agacggaaaa cggccacgtc catgatgctg
    16261 cgactatcgc gggtgcccac gtcatagagc atcggaacga aaaaatctgg ttgctcgtcg
    16321 cccttgggcg gcttcctaat cgacggcgca ccggctgccg gcggttgccg ggattctttg
    16381 cggattcgat cagcggccgc ttgccacgat tcaccggggc gtgcttctgc ctcgatgcgt
    16441 tgccgctggg cggcctgcgc ggccttcaac ttctccacca ggtcatcacc cagcgccgcg
    16501 ccgatttgta ccgggccgga tggtttgcga ccgctcacgc cgattcctcg ggcttggggg
    16561 ttccagtgcc attgcagggc cggcaggcaa cccagccgct tacgcctggc caaccgcccg
    16621 ttcctccaca catggggcat tccacggcgt cggtgcctgg ttgttcttga ttttccatgc
    16681 cgcctccttt agccgctaaa attcatctac tcatttattc atttgctcat ttactctggt
    16741 agctgcgcga tgtattcaga tagcagctcg gtaatggtct tgccttggcg taccgcgtac
    16801 atcttcagct tggtgtgatc ctccgccggc aactgaaagt tgacccgctt catggctggc
    16861 gtgtctgcca ggctggccaa cgttgcagcc ttgctgctgc gtgcgctcgg acggccggca
    16921 cttagcgtgt ttgtgctttt gctcattttc tctttacctc attaactcaa atgagttttg
    16981 atttaatttc agcggccagc gcctggacct cgcgggcagc gtcgccctcg ggttctgatt
    17041 caagaacggt tgtgccggcg gcggcagtgc ctgggtagct cacgcgctgc gtgatacggg
    17101 actcaagaat gggcagctcg tacccggcca gcgcctcggc aacctcaccg ccgatgcgcg
    17161 tgcctttgat cgcccgcgac acgacaaagg ccgcttgtag ccttccatcc gtgacctcaa
    17221 tgcgctgctt aaccagctcc accaggtcgg cggtggccca tatgtcgtaa gggcttggct
    17281 gcaccggaat cagcacgaag tcggctgcct tgatcgcgga cacagccaag tccgccgcct
    17341 ggggcgctcc gtcgatcact acgaagtcgc gccggccgat ggccttcacg tcgcggtcaa
    17401 tcgtcgggcg gtcgatgccg acaacggtta gcggttgatc ttcccgcacg gccgcccaat
    17461 cgcgggcact gccctgggga tcggaatcga ctaacagaac atcggccccg gcgagttgca
    17521 gggcgcgggc tagatgggtt gcgatggtcg tcttgcctga cccgcctttc tggttaagta
    17581 cagcgataac cttcatgcgt tccccttgcg tatttgttta tttactcatc gcatcatata
    17641 cgcagcgacc gcatgacgca agctgtttta ctcaaataca catcaccttt ttagacggcg
    17701 gcgctcggtt tcttcagcgg ccaagctggc cggccaggcc gccagcttgg catcagacaa
    17761 accggccagg atttcatgca gccgcacggt tgagacgtgc gcgggcggct cgaacacgta
    17821 cccggccgcg atcatctccg cctcgatctc ttcggtaatg aaaaacggtt cgtcctggcc
    17881 gtcctggtgc ggtttcatgc ttgttcctct tggcgttcat tctcggcggc cgccagggcg
    17941 tcggcctcgg tcaatgcgtc ctcacggaag gcaccgcgcc gcctggcctc ggtgggcgtc
    18001 acttcctcgc tgcgctcaag tgcgcggtac agggtcgagc gatgcacgcc aagcagtgca
    18061 gccgcctctt tcacggtgcg gccttcctgg tcgatcagct cgcgggcgtg cgcgatctgt
    18121 gccggggtga gggtagggcg ggggccaaac ttcacgcctc gggccttggc ggcctcgcgc
    18181 ccgctccggg tgcggtcgat gattagggaa cgctcgaact cggcaatgcc ggcgaacacg
    18241 gtcaacacca tgcggccggc cggcgtggtg gtgtcggccc acggctctgc caggctacgc
    18301 aggcccgcgc cggcctcctg gatgcgctcg gcaatgtcca gtaggtcgcg ggtgctgcgg
    18361 gccaggcggt ctagcctggt cactgtcaca acgtcgccag ggcgtaggtg gtcaagcatc
    18421 ctggccagct ccgggcggtc gcgcctggtg ccggtgatct tctcggaaaa cagcttggtg
    18481 cagccggccg cgtgcagttc ggcccgttgg ttggtcaagt cctggtcgtc ggtgctgacg
    18541 cgggcatagc ccagcaggcc agcggcggcg ctcttgttca tggcgtaatg tctccggttc
    18601 tagtcgcaag tatt
//
