LOCUS       sequence-76792-e         863 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  Expresses a TALE-TET1CD (catalytic domain of TET1) fusion protein 
            engineered to bind a site in the human KLF4 gene and demethylate 
            CpGs adjacent to the binding site.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 863)
  AUTHORS   Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai 
            SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson 
            MF, Joung JK
  TITLE     Targeted DNA demethylation and activation of endogenous genes using 
            programmable TALE-TET1 fusion proteins.
  JOURNAL   Nat Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726.
  PUBMED    24108092
REFERENCE   2  (bases 1 to 863)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Nat 
            Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726."
COMMENT     Sequence Label: JA412
FEATURES             Location/Qualifiers
     source          1..863
                     /mol_type="genomic DNA"
                     /organism="unspecified"
ORIGIN
        1 tgccgcacgc gccggccttg atcaaaagaa ccaatcgccg tattcccgaa cgcacatccc
       61 atcgcgttgc cgaccacgcg caagtggttc gcgtgctggg ttttttccag tgccactccc
      121 acccagcgca agcatttgat gacgccatga cgcagttcgg gatgagcgga ggaggatccc
      181 tgcccacctg cagctgtctt gatcgagtta tacaaaaaga caaaggccca tattatacac
      241 accttggggc aggaccaagt gttgctgctg tcagggaaat catggagaat aggtatggtc
      301 aaaaaggaaa cgcaataagg atagaaatag tagtgtacac cggtaaagaa gggaaaagct
      361 ctcatgggtg tccaattgct aagtgggttt taagaagaag cagtgatgaa gaaaaagttc
      421 tttgtttggt ccggcagcgt acaggccacc actgtccaac tgctgtgatg gtggtgctca
      481 tcatggtgtg ggatggcatc cctcttccaa tggccgaccg gctatacaca gagctcacag
      541 agaatctaaa gtcatacaat gggcacccta ccgacagaag atgcaccctc aatgaaaatc
      601 gtacctgtac atgtcaagga attgatccag agacttgtgg agcttcattc tcttttggct
      661 gttcatggag tatgtacttt aatggctgta agtttggtag aagcccaagc cccagaagat
      721 ttagaattga tccaagctct cccttacatg aaaaaaacct tgaagataac ttacagagtt
      781 tggctacacg attagctcca atttataagc agtatgctcc agtagcttac caaaatcagg
      841 tggaatatga aaatgttgcc cga
//
