LOCUS       sequence-76806-e         884 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  Expresses a TALE-TET1CD (catalytic domain of TET1) fusion protein 
            engineered to bind a site in the human RHOXF2/2B homeobox (RHOXF2) 
            gene and demethylate CpGs adjacent to the binding site.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 884)
  AUTHORS   Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai 
            SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson 
            MF, Joung JK
  TITLE     Targeted DNA demethylation and activation of endogenous genes using 
            programmable TALE-TET1 fusion proteins.
  JOURNAL   Nat Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726.
  PUBMED    24108092
REFERENCE   2  (bases 1 to 884)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Nat 
            Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726."
COMMENT     Sequence Label: SL537
FEATURES             Location/Qualifiers
     source          1..884
                     /mol_type="genomic DNA"
                     /organism="unspecified"
ORIGIN
        1 gagacttgtg gagcttcatt ctcttttggc tgttcatgga gtatgtactt taatggctgt
       61 aagtttggta gaagcccaag ccccagaaga tttagaattg atccaagctc tcccttacat
      121 gaaaaaaacc ttgaagataa cttacagagt ttggctacac gattagctcc aatttataag
      181 cagtatgctc cagtagctta ccaaaatcag gtggaatatg aaaatgttgc ccgagaatgt
      241 cggcttggca gcaaggaagg tcgacccttc tctggggtca ctgcttgcct ggacttctgt
      301 gctcatcccc acagggacat tcacaacatg aataatggaa gcactgtggt ttgtacctta
      361 actcgagaag ataaccgctc tttgggtgtt attcctcaag atgagcagct ccatgtgcta
      421 cctctttata agctttcaga cacagatgag tttggctcca aggaaggaat ggaagccaag
      481 atcaaatctg gggccatcga ggtcctggca ccccgccgca aaaaaagaac gtgtttcact
      541 cagcctgttc cccgttctgg aaagaagagg gctgcgatga tgacagaggt tcttgcacat
      601 aagataaggg cagtggaaaa gaaacctatt ccccgaatca agcggaagaa taactcaaca
      661 acaacaaaca acagtaagcc ttcgtcactg ccaaccttag ggagtaacac tgagaccgtg
      721 caacctgaag taaaaagtga aaccgaaccc cattttatct taaaaagttc agacaacact
      781 aaaacttatt cgctgatgcc atccgctcct cacccagtga aagaggcatc tccaggcttc
      841 tcctggtccc cgaagactgc ttcagccaca ccagctccac tgaa
//
