LOCUS       sequence-76966-e         790 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  Expresses a TALE-TET1CD (catalytic domain of TET1) fusion protein 
            engineered to bind a site in the human beta-globin (HBB) gene and 
            demethylate CpGs adjacent to the binding site.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 790)
  AUTHORS   Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai 
            SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson 
            MF, Joung JK
  TITLE     Targeted DNA demethylation and activation of endogenous genes using 
            programmable TALE-TET1 fusion proteins.
  JOURNAL   Nat Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726.
  PUBMED    24108092
REFERENCE   2  (bases 1 to 790)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Nat 
            Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726."
COMMENT     Sequence Label: JA1238
FEATURES             Location/Qualifiers
     source          1..790
                     /mol_type="genomic DNA"
                     /organism="unspecified"
ORIGIN
        1 ttgatccaga gacttgtgga gcttcattct cttttggctg ttcatggagt atgtacttta
       61 atggctgtaa gtttggtaga agcccaagcc ccagaagatt tagaattgat ccaagctctc
      121 ccttacatga aaaaaacctt gaagataact tacagagttt ggctacacga ttagctccaa
      181 tttataagca gtatgctcca gtagcttacc aaaatcaggt ggaatatgaa aatgttgccc
      241 gagaatgtcg gcttggcagc aaggaaggtc gacccttctc tggggtcact gcttgcctgg
      301 acttctgtgc tcatccccac agggacattc acaacatgaa taatggaagc actgtggttt
      361 gtaccttaac tcgagaagat aaccgctctt tgggtgttat tcctcaagat gagcagctcc
      421 atgtgctacc tctttataag ctttcagaca cagatgagtt tggctccaag gaaggaatgg
      481 aagccaagat caaatctggg gccatcgagg tcctggcacc ccgccgcaaa aaaagaacgt
      541 gtttcactca gcctgttccc cgttctggaa agaagagggc tgcgatgatg acagaggttc
      601 ttgcacataa gataagggca gtggaaaaga aacctattcc ccgaatcaag cggaagaata
      661 actcaacaac aacaaacaac agtaagcctt cgtcactgcc aaccttaggg agtaacactg
      721 agaccgtgca acctgaagta aaaagtgaaa ccgaacccca ttttatctta aaaagttcag
      781 acaacactaa
//
