LOCUS       sequence-76969-e         922 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  Expresses a TALE-TET1CD (catalytic domain of TET1) fusion protein 
            engineered to bind a site in the human beta-globin (HBB) gene and 
            demethylate CpGs adjacent to the binding site.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 922)
  AUTHORS   Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai 
            SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson 
            MF, Joung JK
  TITLE     Targeted DNA demethylation and activation of endogenous genes using 
            programmable TALE-TET1 fusion proteins.
  JOURNAL   Nat Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726.
  PUBMED    24108092
REFERENCE   2  (bases 1 to 922)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Nat 
            Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726."
COMMENT     Sequence Label: JA1246
FEATURES             Location/Qualifiers
     source          1..922
                     /mol_type="genomic DNA"
                     /organism="unspecified"
ORIGIN
        1 tgatccagag acttgtggag cttcattctc ttttggctgt tcatggagta tgtactttaa
       61 tggctgtaag tttggtagaa gcccaagccc cagaagattt agaattgatc caagctctcc
      121 cttacatgaa aaaaaccttg aagataactt acagagtttg gctacacgat tagctccaat
      181 ttataagcag tatgctccag tagcttacca aaatcaggtg gaatatgaaa atgttgcccg
      241 agaatgtcgg cttggcagca aggaaggtcg acccttctct ggggtcactg cttgcctgga
      301 cttctgtgct catccccaca gggacattca caacatgaat aatggaagca ctgtggtttg
      361 taccttaact cgagaagata accgctcttt gggtgttatt cctcaagatg agcagctcca
      421 tgtgctacct ctttataagc tttcagacac agatgagttt ggctccaagg aaggaatgga
      481 agccaagatc aaatctgggg ccatcgaggt cctggcaccc cgccgcaaaa aaagaacgtg
      541 tttcactcag cctgttcccc gttctggaaa gaagagggct gcgatgatga cagaggttct
      601 tgcacataag ataagggcag tggaaaagaa acctattccc cgaatcaagc ggaagaataa
      661 ctcaacaaca acaaacaaca gtaagccttc gtcactgcca accttaggga gtaacactga
      721 gaccgtgcaa cctgaagtaa aaagtgaaac cgaaccccat tttatcttaa aaagttcaga
      781 caacactaaa acttattcgc tgatgccatc cgctcctcac ccagtgaaag aggcatctcc
      841 aggcttctcc tggtccccga agactgcttc agccacacca gctccactga agaatgacgc
      901 aacagcctca tgcgggtttt ca
//
