LOCUS       sequence-76971-e         823 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  Expresses a TALE-TET1CD (catalytic domain of TET1) fusion protein 
            engineered to bind a site in the human beta-globin (HBB) gene and 
            demethylate CpGs adjacent to the binding site.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 823)
  AUTHORS   Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai 
            SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson 
            MF, Joung JK
  TITLE     Targeted DNA demethylation and activation of endogenous genes using 
            programmable TALE-TET1 fusion proteins.
  JOURNAL   Nat Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726.
  PUBMED    24108092
REFERENCE   2  (bases 1 to 823)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Nat 
            Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726."
COMMENT     Sequence Label: JA1261
FEATURES             Location/Qualifiers
     source          1..823
                     /mol_type="genomic DNA"
                     /organism="unspecified"
ORIGIN
        1 gttcatggag tatgtacttt aatggctgta agtttggtag aagcccaagc cccagaagat
       61 ttagaattga tccaagctct cccttacatg aaaaaaacct tgaagataac ttacagagtt
      121 tggctacacg attagctcca atttataagc agtatgctcc agtagcttac caaaatcagg
      181 tggaatatga aaatgttgcc cgagaatgtc ggcttggcag caaggaaggt cgacccttct
      241 ctggggtcac tgcttgcctg gacttctgtg ctcatcccca cagggacatt cacaacatga
      301 ataatggaag cactgtggtt tgtaccttaa ctcgagaaga taaccgctct ttgggtgtta
      361 ttcctcaaga tgagcagctc catgtgctac ctctttataa gctttcagac acagatgagt
      421 ttggctccaa ggaaggaatg gaagccaaga tcaaatctgg ggccatcgag gtcctggcac
      481 cccgccgcaa aaaaagaacg tgtttcactc agcctgttcc ccgttctgga aagaagaggg
      541 ctgcgatgat gacagaggtt cttgcacata agataagggc agtggaaaag aaacctattc
      601 cccgaatcaa gcggaagaat aactcaacaa caacaaacaa cagtaagcct tcgtcactgc
      661 caaccttagg gagtaacact gagaccgtgc aacctgaagt aaaaagtgaa accgaacccc
      721 attttatctt aaaaagttca gacaacacta aaacttattc gctgatgcca tccgctcctc
      781 acccagtgaa agaggcatct ccaggcttct cctggtcccc gaa
//
