LOCUS       sequence-78009-e         959 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  Expresses a 3x Flag TALE-TET1CD (catalytic domain of TET1) fusion 
            protein engineered to bind a site in the human beta-globin (HBB) 
            gene and demethylate CpGs adjacent to the binding site.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 959)
  AUTHORS   Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai 
            SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson 
            MF, Joung JK
  TITLE     Targeted DNA demethylation and activation of endogenous genes using 
            programmable TALE-TET1 fusion proteins.
  JOURNAL   Nat Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726.
  PUBMED    24108092
REFERENCE   2  (bases 1 to 959)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Nat 
            Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726."
COMMENT     Sequence Label: MLM3727
FEATURES             Location/Qualifiers
     source          1..959
                     /mol_type="genomic DNA"
                     /organism="unspecified"
ORIGIN
        1 ggattgatcc agagacttgt ggagcttcat tctcttttgg ctgttcatgg agtatgtact
       61 ttaatggctg taagtttggt agaagcccaa gccccagaag atttagaatt gatccaagct
      121 ctcccttaca tgaaaaaaac cttgaagata acttacagag tttggctaca cgattagctc
      181 caatttataa gcagtatgct ccagtagctt accaaaatca ggtggaatat gaaaatgttg
      241 cccgagaatg tcggcttggc agcaaggaag gtcgaccctt ctctggggtc actgcttgcc
      301 tggacttctg tgctcatccc cacagggaca ttcacaacat gaataatgga agcactgtgg
      361 tttgtacctt aactcgagaa gataaccgct ctttgggtgt tattcctcaa gatgagcagc
      421 tccatgtgct acctctttat aagctttcag acacagatga gtttggctcc aaggaaggaa
      481 tggaagccaa gatcaaatct ggggccatcg aggtcctggc accccgccgc aaaaaaagaa
      541 cgtgtttcac tcagcctgtt ccccgttctg gaaagaagag ggctgcgatg atgacagagg
      601 ttcttgcaca taagataagg gcagtggaaa agaaacctat tccccgaatc aagcggaaga
      661 ataactcaac aacaacaaac aacagtaagc cttcgtcact gccaacctta gggagtaaca
      721 ctgagaccgt gcaacctgaa gtaaaaagtg aaaccgaacc ccattttatc ttaaaaagtt
      781 cagacaacac taaaacttat tcgctgatgc catccgctcc tcacccagtg aaagaggcat
      841 ctccaggctt ctcctggtcc ccgaagactg cttcagccac accagctcca ctgaagaatg
      901 acgcaacagc ctcatgcggg ttttcagaaa gaagcagcac tccccactgt acgatgcct
//
