LOCUS       sequence-78113-e         730 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  Expresses a TALE-TET1CD (catalytic domain of TET1) fusion protein 
            engineered to bind a site in the human RHOXF2/2B homeobox (RHOXF2) 
            gene and demethylate CpGs adjacent to the binding site.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 730)
  AUTHORS   Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai 
            SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson 
            MF, Joung JK
  TITLE     Targeted DNA demethylation and activation of endogenous genes using 
            programmable TALE-TET1 fusion proteins.
  JOURNAL   Nat Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726.
  PUBMED    24108092
REFERENCE   2  (bases 1 to 730)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Nat 
            Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726."
COMMENT     Sequence Label: SL542
FEATURES             Location/Qualifiers
     source          1..730
                     /mol_type="genomic DNA"
                     /organism="unspecified"
ORIGIN
        1 agctcgacac cgggcagctg ctgaagatcg cgaagagagg gggagtaaca gcggtagagg
       61 cagtgcacgc ctggcgcaat gcgctcaccg gggccccctt gaacctgacc ccagaccagg
      121 tagtcgcaat cgcgtcgaac attgggggaa agcaagccct ggaaaccgtg caaaggttgt
      181 tgccggtcct ttgtcaagac cacggcctta caccggagca agtcgtggcc attgcatccc
      241 acgacggtgg caaacaggct cttgagacgg ttcagagact tctcccagtt ctctgtcaag
      301 cccacgggct gactcccgat caagttgtag cgattgcgtc caacggtgga gggaaacaag
      361 cattggagac tgtccaacgg ctccttcccg tgttgtgtca agcccacggt ttgacgcctg
      421 cacaagtggt cgccatcgcc agccatgatg gcggtaagca ggcgctggaa acagtacagc
      481 gcctgctgcc tgtactgtgc caggatcatg gactgacccc agaccaggta gtcgcaatcg
      541 cgtcacatga cgggggaaag caagccctgg aaaccgtgca aaggttgttg ccggtccttt
      601 gtcaagacca cggccttaca ccggagcaag tcgtggccat tgcatcccac gacggtggca
      661 aacaggctct tgagacggtt cagagacttc tcccagttct ctgtcaagcc cacgggctga
      721 ctcccgatca
//
