LOCUS       sequence-78114-e         753 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  Expresses a TALE-TET1CD (catalytic domain of TET1) fusion protein 
            engineered to bind a site in the human beta-globin (HBB) gene and 
            demethylate CpGs adjacent to the binding site.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 753)
  AUTHORS   Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai 
            SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson 
            MF, Joung JK
  TITLE     Targeted DNA demethylation and activation of endogenous genes using 
            programmable TALE-TET1 fusion proteins.
  JOURNAL   Nat Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726.
  PUBMED    24108092
REFERENCE   2  (bases 1 to 753)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Nat 
            Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726."
COMMENT     Sequence Label: JA1290
FEATURES             Location/Qualifiers
     source          1..753
                     /mol_type="genomic DNA"
                     /organism="unspecified"
ORIGIN
        1 gacaccgggc agctgctgaa gatcgcgaag agagggggag taacagcggt agaggcagtg
       61 cacgcctggc gcaatgcgct caccggggcc cccttgaacc tgaccccaga ccaggtagtc
      121 gcaatcgcgt cgaacattgg gggaaagcaa gccctggaaa ccgtgcaaag gttgttgccg
      181 gtcctttgtc aagaccacgg ccttacaccg gagcaagtcg tggccattgc atcccacgac
      241 ggtggcaaac aggctcttga gacggttcag agacttctcc cagttctctg tcaagcccac
      301 gggctgactc ccgatcaagt tgtagcgatt gcgtcgcatg acggagggaa acaagcattg
      361 gagactgtcc aacggctcct tcccgtgttg tgtcaagccc acggtttgac gcctgcacaa
      421 gtggtcgcca tcgcctccaa tattggcggt aagcaggcgc tggaaacagt acagcgcctg
      481 ctgcctgtac tgtgccagga tcatggactg accccagacc aggtagtcgc aatcgcgtcg
      541 aacattgggg gaaagcaagc cctggaaacc gtgcaaaggt tgttgccggt cctttgtcaa
      601 gaccacggcc ttacaccgga gcaagtcgtg gccattgcat cccacgacgg tggcaaacag
      661 gctcttgaga cggttcagag acttctccca gttctctgtc aagcccacgg gctgactccc
      721 gatcaagttg tagcgattgc gtcgcatgac gga
//
