LOCUS       sequence-95117-e         753 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  Expresses GoF mutant human PCSK9 to be used for rAAV8-mediated gene 
            transfer, hypercholesterolemia and atherosclerosis.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 753)
  AUTHORS   Bjorklund MM, Hollensen AK, Hagensen MK, Dagnaes-Hansen F, 
            Christoffersen C, Mikkelsen JG, Bentzon JF
  TITLE     Induction of atherosclerosis in mice and hamsters without germline 
            genetic engineering.
  JOURNAL   Circ Res. 2014 May 23;114(11):1684-9. doi: 
            10.1161/CIRCRESAHA.114.302937. Epub 2014 Mar 27.
  PUBMED    24677271
REFERENCE   2  (bases 1 to 753)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: 
            "10.1161/CIRCRESAHA.114.302937"; journalName: "Circ Res"; date: 
            "2014-05-23- 23"; volume: "114"; issue: "11"; pages: "1684-9"
COMMENT     Sequence Label: pAAV/D374Y-hPCSK9
FEATURES             Location/Qualifiers
     source          1..753
                     /mol_type="genomic DNA"
                     /organism="unspecified"
ORIGIN
        1 tggggccact ggtggtgctg ctgcccctgg cgggtgggta cagccgcgtc ctcaacgccg
       61 cctgccagcg cctggcgagg gctggggtcg tgctggtcac cgctgccggc aacttccggg
      121 acgatgcctg cctctactcc ccagcctcag ctcccgaggt catcacagtt ggggccacca
      181 atgcccagga ccagccggtg accctgggga ctttggggac caactttggc cgctgtgtgg
      241 acctctttgc cccaggggag gacatcattg gtgcctccag ctactgcagc acctgctttg
      301 tgtcacagag tgggacatca caggctgctg cccacgtggc tggcattgca gccatgatgc
      361 tgtctgccga gccggagctc accctggccg agttgaggca gagactgatc cacttctctg
      421 ccaaagatgt catcaatgag gcctggttcc ctgaggacca gcgggtactg acccccaacc
      481 tggtggccgc cctgcccccc agcacccatg gggcaggttg gcagctgttt tgcaggactg
      541 tgtggtcagc acactcgggg cctacacgga tggccacagc catcgcccgc tgcgccccag
      601 atgaggagct gctgagctgc tccagtttct ccaggagtgg gaagcggcgg ggcgagcgca
      661 tggaggccca agggggcaag ctggtctgcc gggcccacaa cgcttttggg ggtgagggtg
      721 tctacgccat tgccaggtgc tgcctgctac ccc
//
