RESOLUTE Plasmid Collection
Solute carrier proteins (SLCs) are the largest family of transporters in the human genome with approximately 450 identified members. Many SLCs have mutations associated with disease and could become targets for drug development. RESOLUTE is a public-private partnership of 13 members from industry and academia financed by the Innovative Medicine Initiative (IMI) of the European Union. The RESOLUTE mission is to develop data and reagents to boost the research focused on SLCs.
Through the coupling of an inclusive, ‘open-access ethos’ to the results, techniques and reagents with the highest-possible quality of research output, RESOLUTE expects to accelerate the pace of research in the field of SLCs to the global benefit of basic academic research as well as applied research in small biotech and pharmaceutical companies.
The RESOLUTE project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777372. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA.
This plasmid collection contains codon-optimized ORF sequences for human SLCs in Gateway-compatible pENTR vectors (pDONR221). These vectors allow a fast and efficient sub-cloning into a wide range of Gateway-compatible pDEST vectors.
CRISPR Pooled Libraries are useful tools for genetic screening experiments. These libraries target the solute carrier family of proteins.
|132561||CRISPR activation library targeting human SLC proteins.|
|132552||CRISPR knockout library targeting human SLC proteins.|
|141436||CRISPR knockout library targeting mouse SLC proteins.|