DECIPHER libraries are bar-coded lentiviral shRNA libraries optimized for RNAi Genetic Screens in pooled format. The first human module is intended for the widest possible screening applications. It consists of the following gene groups: * Members of the major canonical and non-canonical pathways, covered by KEGG, Reactome, and other expert-curated pathway databases * Genes on the CSHL Cancer 1000 list and 2500 top-ranking genes from the Cancer Genome Atlas, with priority based on the involvement in canonical pathways and disease association * Approximately 900 genes with gene products that can be targeted by the FDA-approved small molecule compounds * Most important genes involved in top MeSH ranking diseases; these are chosen by their position within the pathway and number of nodes of connectivity Thus, Module 1 is both versatile and wide in scope.