Weak binding to the A2RE RNA rigidifies hnRNPA2 RRMs and reduces liquid-liquid phase separation and aggregation.
Ryan VH, Watters S, Amaya J, Khatiwada B, Venditti V, Naik MT, Fawzi NL
Nucleic Acids Res. 2020 Sep 1. pii: 5900113. doi: 10.1093/nar/gkaa710.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 139109 | pJ4M_hnRNPA2_FL_WT | Express FL hnRNPA2 with a C-terminal MBP tag |
| 139110 | pJ4M_hnRNPA2_FL_D290V | Express FL hnRNPA2 D290V with a C-terminal MBP tag |
| 139111 | pJ4M_hnRNPA2_FL_P298L | Express FL hnRNPA2 P298L with a C-terminal MBP tag |
| 157864 | hnRNPA2_RRMs | express His tagged hnRNPA2 RRMs |
| 157865 | hnRNPA2_RRM1 | express His tagged hnRNPA2 RRM1 |
| 157866 | hnRNPA2_RRM2 | express His tagged hnRNPA2 RRM2 |