Cancer Research Plasmids and Resources
Addgene has a large variety of resources for use in cancer signaling studies, including mutant, knockdown, and overexpression constructs. Each collection page listed below organizes the plasmids and resources by signaling pathway, focusing on the main pathways involved in cancer development. These pathways are important to normal cell signaling and physiology, and, when dysregulated, can enable cancer cell survival.
Although cancers are partially defined by their location, their pathway dependencies are extremely important for classification and treatment. On each pathway page, click on a component to find plasmids with your gene of interest.
Browse Cancer Research Plasmids by Pathway
mTOR is a protein kinase that anchors a signaling network for transitioning between anabolic and catabolic states.
Kits and Libraries for Cancer Research
RAS Pathway Clone Collection 2.0: Set of vectors from the Esposito Lab for use with the Gateway® Cloning Platform (Life Technologies™) to permit construction of RAS pathway gene expression vectors for in vitro and in vivo research.
Broad Target Accelerator Plasmids: Collection of vectors from the Boehm, Hahn, Meyerson, and Root Labs containing wild-type and mutant alleles described in the initial Target Accelerator publications, focused on somatic variants found in lung adenocarcinoma as well as variants found across cancer types as part of a “pan-cancer” analyses.
New Tool for Lineage Tracing: The ClonTracer Library (Frank Stegmeier)
Tackling Cancers’ Drug Resistance with a New Screening Kit (David Sabatini & Kris Wood)