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viral-service-icon-v3.png Viral Service: Optogenetics AAV

Optogenetic tools can be used to control cell activity in living tissue with light. Optogenetics is typically used in neuroscience to control electrical potentials in neurons. See our Optogenetics Plasmids and Optogenetics Guide page for more information about this field.

Use the table and filters below to find ready-to-use AAV preparations of optogenetics plasmids available in Addgene's collection.


  • Excitatory
  • Inhibitory





ID Name Promoter Opsin Variant Tag Activity Serotype PI
Excitatory: Wild-type ChR2
20071 pACAGW-ChR2-Venus-AAV CAG ChR2 Venus Constitutive 1, 9 Svoboda
83898 pAAV-mDlx-ChR2-mCherry-Fishell-3 Dlx ChR2 mCherry Constitutive 1, 9, rg* Fishell
137163 pAAV-nEF-Con/Foff 2.0-ChR2-EYFP nEF ChR2 EYFP Cre dependent 8 Deisseroth
Excitatory: ChR2/H134R
20297 pAAV-EF1a-double floxed-hChR2(H134R)-mCherry-WPRE-HGHpA EF1a ChR2/H134R mCherry Cre dependent 1, 5, 8, 9, rg* Deisseroth
20298 pAAV-EF1a-double floxed-hChR2(H134R)-EYFP-WPRE-HGHpA EF1a ChR2/H134R EYFP Cre dependent 1, 5, 9, rg*, PHPeB Deisseroth
26969 pAAV-CaMKIIa-hChR2(H134R)-EYFP CaMKII ChR2/H134R EYFP Constitutive 1, 2, 5, 9 Deisseroth
26973 pAAV-hSyn-hChR2(H134R)-EYFP Syn ChR2/H134R EYFP Constitutive 1, 5, 9, rg*, PHPeB Deisseroth
26975 pAAV-CaMKIIa-hChR2(H134R)-mCherry CaMKII ChR2/H134R mCherry Constitutive 1, 5, 9, rg* Deisseroth
26976 pAAV-hSyn-hChR2(H134R)-mCherry Syn ChR2/H134R mCherry Constitutive 5 Deisseroth
28017 AAV-CAG-hChR2-H134R-tdTomato CAG ChR2/H134R tdTomato Constitutive rg* Svoboda
75470 pAAV-CAG-FLEXFRT-ChR2(H134R)-mCherry CAG ChR2/H134R mCherry Flp dependent 1 Cepko
55645 pAAV-hSyn Con/Fon hChR2(H134R)-EYFP Syn ChR2/H134R EYFP Cre and Flp dependent 5, 8, 9, rg* Deisseroth
58880 pAAV-Syn-ChR2(H134R)-GFP Syn ChR2/H134R GFP Constitutive 8, rg* Boyden
100054 pAAV.CAG.hChR2(H134R)-mCherry.WPRE.SV40 CAG ChR2/H134R mCherry Constitutive 1, 2, 5, 9 Deisseroth
127090 pAAV-CAG-DIO-ChR2(H134R)-eYFP CAG ChR2/H134R EYFP Cre dependent PHPeB Gradinaru
Excitatory: CoChr
107708 pAAV-hSynapsin- soCoChR-GFP Syn CoChR (soma-targeting) GFP Constitutive 9 Boyden
107712 pAAV-hSynapsin-FLEX-soCoChR-GFP Syn CoChR (soma-targeting) GFP Cre dependent 9 Boyden
Excitatory: ChR2/other mutants
35503 pAAV-Ef1a-DIO hChR2(C128S/D156A)-EYFP EF1a ChR2(C128S/D156A) EYFP Cre dependent 9 Deisseroth
35505 pAAV-CaMKIIa-hChR2(E123A)-EYFP CaMKII ChR2(E123A) EYFP Constitutive 9 Deisseroth
35506 pAAV-CaMKIIa-hChR2(E123A)-mCherry CaMKII ChR2(E123A) mCherry Constitutive 9 Deisseroth
35507 pAAV-Ef1a-DIO hChR2(E123A)-EYFP EF1a ChR2(E123A) EYFP Cre dependent 9 Deisseroth
35509 pAAV-Ef1a-DIO hChR2(E123T/T159C)-EYFP EF1a ChR2(E123T/T159C) EYFP Cre dependent 5 Deisseroth
35512 pAAV-CaMKIIa-hChR2(E123T/T159C)-mCherry CaMKII ChR2(E123T/T159C) mCherry Constitutive 9 Deisseroth
Excitatory: Chronos, Chrimson, ChRmine, ChETA, C1V1 (t/t)
26968 pAAV-Ef1a-DIO ChETA-EYFP EF1a ChETA EYFP Cre dependent 1, 5, 9 Deisseroth
35497 pAAV-Ef1a-DIO C1V1 (t/t)-TS-EYFP EF1a C1V1 (t/t) EYFP Cre dependent 9 Deisseroth
35499 pAAV-CaMKIIa-C1V1 (t/t)-TS-EYFP CaMKII C1V1 (t/t) EYFP Constitutive 9 Deisseroth
124650 pAAV-CamKIIa-C1V1(t/t)-mScarlet-KV2.1 CaMKII C1V1 (t/t) mScarlet Constitutive 9 Harvey
59170 pAAV-Syn-Chronos-GFP Syn Chronos GFP Constitutive 1, 5, rg* Boyden
59171 pAAV-Syn-ChrimsonR-tdT Syn ChrimsonR tdTomato Constitutive 1, 5, 9 Boyden
62723 pAAV-Syn-FLEX-rc[ChrimsonR-tdTomato] Syn ChrimsonR tdTomato Cre dependent 5 Boyden
100049 pAAV.hSynap.ChETA(E123T/H134R)-eYFP.WPRE.hGH Syn ChETA EYFP Constitutive 1, 9 Deisseroth
100050 pAAV.CaMKIIa.ChETA(E123T/H134R)-eYFP.WPRE.hGH CaMKII ChETA EYFP Constitutive 5, 9 Deisseroth
135633 pAAV-S5E2-C1V1-eYFP E2 C1V1 EYFP Constitutive 5 Dimidschstein
100061 pAAV-Ef1a-DIO C1V1 (t/t)-TS-mCherry EF1a C1V1 (t/t) mCherry Cre dependent 9 Deisseroth
105448 pAAV-hSyn-DIO-ChrimsonR-mRuby2-ST Syn ChrimsonR (soma-targeting) mRuby2 Cre dependent 9 Adesnik
124603 pAAV-EF1a-DIO-ChrimsonR-mRuby2-KV2.1-WPRE-SV40 EF1a ChrimsonR (soma-targeting) mRuby2 Cre dependent 9 Harvey
108912 pAAV-CAG-DIO-ChroME-ST-P2A-H2B-mRuby3 CAG ChroME (soma-targeting) mRuby3 Cre dependent 9 Adesnik
124651 pAAV-CamKIIa-ChrimsonR-mScarlet-KV2.1 CaMKII ChrimsonR (soma-targeting) mScarlet Constitutive 9 Harvey
131004 pAAV-hSyn-GCaMP 6m-p2A-ChRmine-Kv2.1-WPRE Syn ChRmine (high-photocurrent, red-shifted) GCaMP6m Constitutive 8 Deisseroth
137159 pAAV-nEF-Con/Fon-ChRmine-oScarlet nEF ChRmine (high-photocurrent, red-shifted) oScarlet Cre and Flp dependent 8 Deisseroth
137160 pAAV-nEF-Coff/Fon-ChRmine-oScarlet nEF ChRmine (high-photocurrent, red-shifted) oScarlet Flp dependent 8 Deisseroth
137161 pAAV-nEF-Con/Foff 2.0-ChRmine-oScarlet nEF ChRmine (high-photocurrent, red-shifted) oScarlet Cre dependent 8 Deisseroth
Inhibitory: Arch and variants
22222 AAV-FLEX-Arch-GFP CAG Arch GFP Cre dependent 1, 9 Boyden
28305 pAAV-FLEX-ArchT-tdTomato CAG ArchT tdTomato Cre dependent 5 Boyden
99039 pAAV-CamKII-ArchT-GFP (PV2527) CaMKII ArchT GFP Constitutive 1, 5, 9, rg* Boyden
Inhibitory: eNpHR and variants
20949 pAAV-double floxed-eNpHR-EYFP-WPRE-pA EF1a eNpHR EYFP Cre dependent 9 Deisseroth
26966 AAV-Ef1a-DIO eNpHR 3.0-EYFP EF1a eNpHR 3.0 EYFP Cre dependent 1, 5, 9 Deisseroth
26971 pAAV-CaMKIIa-eNpHR 3.0-EYFP CaMKII eNpHR 3.0 EYFP Constitutive 1, 9 Deisseroth
26972 pAAV-hSyn-eNpHR 3.0-EYFP Syn eNpHR 3.0 EYFP Constitutive 5 Deisseroth
Inhibitory: Jaws
65014 pAAV-hsyn-Jaws-KGC-GFP-ER2 Syn Jaws GFP Constitutive 5, 8, rg* Boyden
84445 pAAV-CAG-FLEX-rc [Jaws-KGC-GFP-ER2] CAG Jaws GFP Cre dependent 1, 5, rg* Boyden
Inhibitory: stGtACR
105669 pAAV-CKIIa-stGtACR2-FusionRed CaMKII GtACR2 (soma-targeting) FusionRed Constitutive 1, rg* Yizhar
105677 pAAV_hSyn1-SIO-stGtACR2-FusionRed Syn GtACR2 (soma-targeting) FusionRed Cre dependent 1, rg* Yizhar
105678 pAAV_hSyn1-SIO-stGtACR1-FusionRed Syn GtACR1 (soma-targeting) FusionRed Cre dependent 5 Yizhar
105679 pAAV-CKIIa-stGtACR1-FusionRed CaMKII GtACR1 (soma-targeting) FusionRed Constitutive 5 Yizhar
Inhibitory: iC++
137155 pAAV-nEF-Con/Fon-iC++-EYFP nEF iC++ EYFP Cre and Flp dependent 8 Deisseroth
137156 pAAV-nEF-Con/Foff 2.0-iC++-EYFP nEF iC++ EYFP Cre dependent 8 Deisseroth

No available items found to match all requested criteria. Please consider using fewer filtering options.

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*AAVrg = retrograde serotype, produced with the AAV retro helper plasmid from the Karpova and Schaffer labs. See the Retrograde AAV Inventory Page.

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