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Plasmid-Reference_book.png Nuclear Receptor Plasmid Collection


Nuclear Receptors; Image is released to public domain by author. Source: Wikipedia, accessed November 6, 2013. Author: Boghog2

Image is released to public domain by author. Source: Wikipedia, accessed November 6, 2013. Author: Boghog2

Nuclear receptors are a class of transcription factors modulated by ligands. Two of the important regions of nuclear receptors are: 1) a ligand binding domain, which interacts with hormones or other molecules, and 2) a DNA binding domain, which targets the receptor to specific DNA sequences. Ligand binding triggers a conformational change in the receptor and results in activation or repression of target gene expression. Nuclear receptors play a key role in development and homeostasis, and the receptors and their downstream genes are associated with numerous disease pathways.

In collaboration with research labs from around the globe, Addgene has assembled a Nuclear Receptor plasmid collection for the community. If you have created plasmids that you would like to add to this collection, email [email protected] to be paired with an Addgene scientist.


Nuclear Receptor Plasmids

Find Plasmids by Gene Name Alternative Gene Names NURSA ID and Information Gene Description
AR plasmids AR, RP11-383C12.1, AIS, DHTR, HUMARA,HYSP1, KD, NR3C4, SBMA, SMAX1, TFM NR3C4 androgen receptor
ESR2 Plasmids ESR2, ER-BETA, ESR-BETA,ESRB, ESTRB, Erb, NR3A2 NR3A2 estrogen receptor 2 (ER beta)
ESRRA Plasmids ESRRA, ERR1, ERRa, ERRalpha, ESRL1, NR3B1 NR3B1 estrogen-related receptor alpha
ESRRB Plasmids ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2 NR3B2 estrogen-related receptor beta
ESRRG Plasmids ESRRG, ERR3, ERRgamma, NR3B3 NR3B3 estrogen-related receptor gamma
HNF4A Plasmids HNF4A, RP5-1013A22.1, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14 NR2A1 hepatocyte nuclear factor 4, alpha
NR0B1 Plasmids NR0B1, AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG, NROB1, SRXY2 NR0B1 nuclear receptor subfamily 0, group B, member 1
NR1D1 Plasmids NR1D1, EAR1, hRev, THRA1, THRAL, ear-1 NR1D1 nuclear receptor subfamily 1, group D, member 1
NR1D2 Plasmids NR1D2, RVR, BD73, EAR-1R NR1D2 nuclear receptor subfamily 1, group D, member 2
NR1H3 Plasmids NR1H3, LXR-a, LXRA, RLD-1 NR1H3 nuclear receptor subfamily 1, group H, member 3
NR2E1 Plasmids NR2E1, RP3-429G5.1, TLL, TLX, XTLL NR2E1 nuclear receptor subfamily 2, group E, member 1
NR2F1 plasmids NR2F1, COUP-TFI, EAR-3, EAR3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1 NR2F1 nuclear receptor subfamily 2, group F, member 1
NR3C1 Plasmids NR3C1, GCCR, GCR, GR, GRL NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 Plasmids NR3C2, MCR, MLR, MR, NR3C2VIT NR3C2 nuclear receptor subfamily 3, group C, member 2
NR4A1 Plasmids NR4A1, GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3 NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 Plasmids NR4A2, HZF-3, NOT, NURR1, RNR1, TINUR NR4A2 nuclear receptor subfamily 4, group A, member 2
NR5A1 Plasmids NR5A1, RP11-101K10.1, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3 NR5A1 nuclear receptor subfamily 5, group A, member 1
NR5A2 Plasmids NR5A2, B1F, B1F2, CPF, FTF, FTZ-F1, FTZ-F1beta, LRH-1, LRH1, hB1F-2 NR5A2 nuclear receptor subfamily 5, group A, member 2
NR6A1 Plasmids NR6A1, GCNF, GCNF1, NR61, RTR, hGCNF, hRTR NR6A1 nuclear receptor subfamily 6, group A, member 1
PGR Plasmids PGR, NR3C3, PR NR3C3 progesterone receptor
PPARA Plasmids PPARA, SC22CB-5E3.5, NR1C1, PPAR, PPARalpha, hPPAR NR1C1 peroxisome proliferator-activated receptor alpha
PPARD Plasmids PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB NR1C2 peroxisome proliferator-activated receptor delta
PPARG Plasmids PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma NR1C3 peroxisome proliferator-activated receptor gamma
RARA Plasmids RARA, NR1B1, RAR NR1B1 retinoic acid receptor, alpha
RORA Plasmids RORA, ROR1, ROR2, ROR3, RZRA, NR1F1, MGC119326, MGC119329, RZR-ALPHA, DKFZp686M2414 NR1F1 RAR-related orphan receptor A
RORB Plasmids RORB, NR1F2, ROR-BETA, RZR-BETA, RZRB, bA133M9.1 NR1F2 RAR-related orphan receptor B
RORC Plasmids RORC, RP11-98D18.11-001, NR1F3, RORG, RZR-GAMMA, RZRG, TOR NR1F3 RAR-related orphan receptor C
RXRA Plasmids RXRA, NR2B1 NR2B1 retinoid X receptor, alpha
RXRG Plasmids RXRG, NR2B3, RXRC NR2B3 retinoid X receptor, gamma

References