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Enter a sequence to perform a BLAST-based search of Addgene plasmid sequence databases.

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We narrowed to 359 results for: Nov

Showing: 81 - 100 of 359 results

  1. TREAT-AD Plasmid Collection

    Type
    Collection
    ...plasmids supporting the evaluation of a diverse set of novel Alzheimer's disease targets....

  3. The CRISPR Software Matchmaker: A New Tool for Choosing the Best CRISPR Software for Your Needs

    Type
    Blog Post
    ...did we get here in the first place? How CRISPR innovation affected software development CRISPR, like the...it, offers an interesting view into how rapid innovation affects the research community. I’ve likened ...That’s just 3 to 4 years ago. It is a bubble of innovation (a piñata), and software development has caught...separate sgRNA design tools into database and de novo solutions. Database tools allow us to view and get...community in order to succeed. With respect to de novo sgRNA design, I again separate it into two categories...future of CRISPR software is promising. Rapid innovation in this space has put us in a good position to...

  4. Production of Virus in Insect Versus Mammalian Cells

    Type
    Blog Post
    ...produce, so most labs opt to purchase adenoviruses from dedicated adenoviral production labs or companies. Production...available. The viruses Lentiviruses, AAV, and adenoviruses can all be produced in mammalian cells. However...make lentiviruses and AAV in-house. High-titer adenoviruses are difficult and time consuming to produce,...transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells. The FASEB Journal...

  5. Delivery Methods for Generating iPSCs

    Type
    Blog Post
    ...Non-integrating iPSC delivery methods Viral Vectors Adenovirus: Adenoviral vectors infect dividing and nondividing...verify excision didn’t introduce mutations Adenovirus Non-integrating Low Medium Generates transgene-free...polycistronic transgene or with four different adenoviruses, each expressing one factor. These vectors don...less likely to cause insertional mutagenesis, adenoviral vectors are considered a safer way to express...Minoru Iijima, Manami Ohtaka, and Mahito Nakanishi. "Novel Strategy to Control Transgene Expression Mediated...

  6. Plasmids 101: Plasmid Incompatibility

    Type
    Blog Post
    ...replication when copy number in the cell falls too low (Novcik, 1987).  Antisense RNAs encoded on the plasmid ...plasmid for replication or partitioning machinery (Novick, 1987). In cases where one plasmid outcompetes ...incompatibility to combat antimicrobial resistance. Using novel plasmids based partly on plasmid incompatibility.../j.1472-765x.2008.02426.x Pubmed PMID: 19241516 Novick RP (1987) Plasmid incompatibility. Microbiology... 25873913 Uraji M, Suzuki K, Yoshida K (2002) A novel plasmid curing method using incompatibility of plant...

  8. Celebrating the 2024 Nobel Prize in Chemistry

    Type
    Blog Post
    ...we’ve seen so far!). They started by designing a novel topology, then iteratively generated 3D models and...Although Top7 was designed simply to be stable and novel, the principles that created it have been applied...the Baker Lab and others. The introduction of de novo designed proteins also helped researchers understand...Stoddard, B. L., & Baker, D. (2003). Design of a Novel Globular Protein Fold with Atomic-Level Accuracy...

  9. All Antibodies

    Type
    Collection
    ... neuroscience research. Institute for Protein Innovation Collection : Antibodies to highly conserved proteins...

  10. Plasmid Collections

    Type
    Collection
    ...Lentivirus Adeno-associated Virus (AAV) γ-Retrovirus Adenovirus All Viral Plasmids Curated Topics Antibody Plasmid...

  11. A History of Genome Engineering in Popular Culture

    Type
    Blog Post
    ...animal testing and modifications. The premise of the novel involves Dr. Moreau who creates human-animal hybrids... writer Jack Williamson who used it in his 1951 novel Dragon’s Island. In 1976, the world’s first genetic...against a genetically engineered superhuman Khan. The novel, Inferno (2013) and the movie version (2016) stars...editors which can help accelerate the engineering of novel base editor proteins. She is particularly interested...Leung E, Meng X, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Meyer BJ (2011) Targeted Genome Editing Across...

  12. Michael Koeris' Journey from Grad Student to Entrepreneur: The Story of Sample 6

    Type
    Blog Post
    ... changed its name from Novophage to Sample 6. To learn more about Novophage's successful transformation...Koeris and Lu founded the biotech startup company, Novophage. As you'll hear Dr. Koeris explain however, the...firm, Flagship Ventures, Koeris helped change Novophage's focus. The company went from developing therapeutics...

  14. Reflections and Looking Ahead

    Type
    Blog Post
    ...our partnership with the Institute for Protein Innovation (IPI), we expanded a growing collection of thoroughly...enter 2025, your feedback continues to guide our innovation.  In response to a demand for more AAV viral ...extensive plasmid database — because we believe that innovation flourishes when data are shared. The scientific...look ahead, I am excited to continue to grow and innovate with your help and guidance. Every plasmid shared...

  15. Hot Plasmids and Viral Preps - July 2021

    Type
    Blog Post
    .... https://doi.org/10.1101/2020.05.04.076067    Novel fluorescent enzyme biosensors provide direct, specific...optimization. Claudia Vickers’s lab has designed novel SL fluorescent biosensors by integrating a SL-insensitive...parasitic Striga hermonthica SL receptor HTL7. This novel type of biosensors could be used in high throughput...As a result, agricultural applications of these novel biosensors could have a major economic impact.   ...

  16. Synthetic Biology - Overview

    Type
    Collection
    ... rational engineering of biological systems for novel functions. Addgene is working with leading synthetic...

  17. Meet the New Addgene Board Members!

    Type
    Blog Post
    ...of the company.  Ultragenyx’s goal is to develop novel products for the treatment of rare and ultra-rare...was the Head of Oncology Target Discovery at the Novartis Institutes for Biomedical Research. Drug development...are less common, they can be very impactful. At Novartis, Stegmeier deposited the ClonTracer Barcoding ...built create inefficiencies that ultimately make innovation and science slow,” Vandenberghe says. “The continuous...

  18. The Crispr Babies Saga Shows the Need for Action, Not More Delays

    Type
    Blog Post
    ..., founding bioethicist of Rogue Bioethics. On November 25, the MIT Technology Review dropped a bombshell...forward” is the June 2012 report on the ethics of “Novel techniques for the prevention of mitochondrial DNA...Nuffield Council began their research into both novel and previously established ethical issues raised...industry to inform her work on emerging issues in novel technologies, including self-driving vehicles, synthetic...

  19. Addgene-Seeding Labs plasmid grant round 3: microbial drug resistance and biofilms, antidiabetic plant components, visualizing brain injury - and a glowing robot fish

    Type
    Blog Post
    ...activity after ischemic brain injury Dr. Gohar Tsakanova, Institute of Molecular Biology of the NationalAcademy...Sciences of the Republic of Armenia, Armenia Gohar Tsakanova is a Senior Researcher who investigates the molecular...become blocked, resulting in reduced blood flow. Novel treatment options, as well as non-pharmacological...two-photon laser scanning microscope will allow Tsakanova to image cortical neurons and study changes in...

  20. Optogenetics + CRISPR, Using Light to Control Genome Editing

    Type
    Blog Post
    ...CRISPR–Cas9 activity switching via a novel optogenetic variant of AcrIIA4 (CASANOVA). As shown in the figure below...release of Cas9. A noteworthy application of the CASANOVA system was its use in light-mediated CRISPR labeling...minutes and red foci formed 20-40 min later. The CASANOVA system is versatile in that it can be adapted ...Light-Dependent Anti-CRISPR Bubeck et al., 2018 CASANOVA LOV2 from A. Sativa AcrIIA4 anti-CRISPR protein...
Showing: 81 - 100 of 359 results