...factor signals such as tumor growth factor beta (TGFβ) and IL-10 that suppress APCs. T cells that would... by producing C-C motif chemokine 22 (CCL22) and TGFβ. T-regs are suppressive immune cells that restrict...production and activity of other effector immune cells. TGFβ is also known to change CD4+ Th cells into regulatory...removal causes increases in tumor cytokines like TGFβ and IL-6. However, when strengthened through efforts...cytokines produced in the tumor microenvironment TGFβ, IL-10, can also help the immune system attack tumors...