EGFR WT Citations (64)
Originally described in: Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants.Greulich H, Chen TH, Feng W, Janne PA, Alvarez JV, Zappaterra M, Bulmer SE, Frank DA, Hahn WC, Sellers WR, Meyerson M PLoS Med. 2005 Oct 4. 2(11):e313. PubMed Journal
Articles Citing EGFR WT
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| GLI1 repression of ERK activity correlates with colony formation and impaired migration in human epidermal keratinocytes. Neill GW, Harrison WJ, Ikram MS, Williams TD, Bianchi LS, Nadendla SK, Green JL, Ghali L, Frischauf AM, O'Toole EA, Aberger F, Philpott MP. Carcinogenesis. 2008 Apr;29(4):738-46. doi: 10.1093/carcin/bgn037. Epub 2008 Feb 14. PubMed |
| Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway. Hoover AC, Strand GL, Nowicki PN, Anderson ME, Vermeer PD, Klingelhutz AJ, Bossler AD, Pottala JV, Hendriks WJ, Lee JH. Oncogene. 2009 Nov 12;28(45):3960-70. doi: 10.1038/onc.2009.251. Epub 2009 Sep 7. PubMed |
| miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways. Saydam O, Senol O, Wurdinger T, Mizrak A, Ozdener GB, Stemmer-Rachamimov AO, Yi M, Stephens RM, Krichevsky AM, Saydam N, Brenner GJ, Breakefield XO. Cancer Res. 2011 Feb 1;71(3):852-61. doi: 10.1158/0008-5472.CAN-10-1219. Epub 2010 Dec 13. PubMed |
| EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas. Fukuoka H, Cooper O, Ben-Shlomo A, Mamelak A, Ren SG, Bruyette D, Melmed S. J Clin Invest. 2011 Dec;121(12):4712-21. doi: 10.1172/JCI60417. Epub 2011 Nov 21. PubMed |
A method for stable transgenesis of radial glia lineage in rat neocortex by piggyBac mediated transposition.
Chen F, LoTurco J.
J Neurosci Methods. 2012 Jun 15;207(2):172-80. Epub 2012 Apr 11.
PubMed
Associated Plasmids |
| Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion. Whitsett TG, Cheng E, Inge L, Asrani K, Jameson NM, Hostetter G, Weiss GJ, Kingsley CB, Loftus JC, Bremner R, Tran NL, Winkles JA. Am J Pathol. 2012 Jul;181(1):111-20. doi: 10.1016/j.ajpath.2012.03.026. Epub 2012 May 23. PubMed |
| ERbeta1 represses basal breast cancer epithelial to mesenchymal transition by destabilizing EGFR. Thomas C, Rajapaksa G, Nikolos F, Hao R, Katchy A, McCollum CW, Bondesson M, Quinlan P, Thompson A, Krishnamurthy S, Esteva FJ, Gustafsson JA. Breast Cancer Res. 2012 Nov 16;14(6):R148. doi: 10.1186/bcr3358. PubMed |
| Alterations of EGFR, p53 and PTEN that mimic changes found in basal-like breast cancer promote transformation of human mammary epithelial cells. Pires MM, Hopkins BD, Saal LH, Parsons RE. Cancer Biol Ther. 2013 Mar;14(3):246-53. doi: 10.4161/cbt.23297. Epub 2013 Jan 4. PubMed |
| Targeting ERBB receptors shifts their partners and triggers persistent ERK signaling through a novel ERBB/EFNB1 complex. Vermeer PD, Colbert PL, Wieking BG, Vermeer DW, Lee JH. Cancer Res. 2013 Sep 15;73(18):5787-97. doi: 10.1158/0008-5472.CAN-13-0760. Epub 2013 Jun 28. PubMed |
| Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling. Kitade M, Factor VM, Andersen JB, Tomokuni A, Kaji K, Akita H, Holczbauer A, Seo D, Marquardt JU, Conner EA, Lee SB, Lee YH, Thorgeirsson SS. Genes Dev. 2013 Aug 1;27(15):1706-17. doi: 10.1101/gad.214601.113. PubMed |
| Directed evolution of a virus exclusively utilizing human epidermal growth factor receptor as the entry receptor. Dai HS, Liu Z, Jiang W, Kuhn RJ. J Virol. 2013 Oct;87(20):11231-43. doi: 10.1128/JVI.01054-13. Epub 2013 Aug 7. PubMed |
| Coordinated targeting of the EGFR signaling axis by microRNA-27a*. Wu X, Bhayani MK, Dodge CT, Nicoloso MS, Chen Y, Yan X, Adachi M, Thomas L, Galer CE, Jiffar T, Pickering CR, Kupferman ME, Myers JN, Calin GA, Lai SY. Oncotarget. 2013 Sep;4(9):1388-98. PubMed |
| Role of epidermal growth factor receptor signaling in the interaction of Neisseria meningitidis with endothelial cells. Slanina H, Mundlein S, Hebling S, Schubert-Unkmeir A. Infect Immun. 2014 Mar;82(3):1243-55. doi: 10.1128/IAI.01346-13. Epub 2013 Dec 30. PubMed |
| ERbeta regulates NSCLC phenotypes by controlling oncogenic RAS signaling. Nikolos F, Thomas C, Rajapaksa G, Bado I, Gustafsson JA. Mol Cancer Res. 2014 Jun;12(6):843-54. doi: 10.1158/1541-7786.MCR-13-0663. Epub 2014 Mar 11. PubMed |
| Metformin and erlotinib synergize to inhibit basal breast cancer. Lau YK, Du X, Rayannavar V, Hopkins B, Shaw J, Bessler E, Thomas T, Pires MM, Keniry M, Parsons RE, Cremers S, Szabolcs M, Maurer MA. Oncotarget. 2014 Nov 15;5(21):10503-17. PubMed |
| Novel agents that downregulate EGFR, HER2, and HER3 in parallel. Ferreira RB, Law ME, Jahn SC, Davis BJ, Heldermon CD, Reinhard M, Castellano RK, Law BK. Oncotarget. 2015 Apr 30;6(12):10445-59. PubMed |
| Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer. Min HY, Yun HJ, Lee JS, Lee HJ, Cho J, Jang HJ, Park SH, Liu D, Oh SH, Lee JJ, Wistuba II, Lee HY. Mol Cancer. 2015 Jun 4;14:113. doi: 10.1186/s12943-015-0392-3. PubMed |
| G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program. Yim CY, Sekula DJ, Hever-Jardine MP, Liu X, Warzecha JM, Tam J, Freemantle SJ, Dmitrovsky E, Spinella MJ. Cancer Res. 2016 Mar 1;76(5):1204-13. doi: 10.1158/0008-5472.CAN-15-2265. Epub 2016 Feb 2. PubMed |
| Low dose of GRP78-targeting subtilase cytotoxin improves the efficacy of photodynamic therapy in vivo. Gabrysiak M, Wachowska M, Barankiewicz J, Pilch Z, Ratajska A, Skrzypek E, Winiarska M, Domagala A, Rygiel TP, Jozkowicz A, Boon L, Golab J, Firczuk M. Oncol Rep. 2016 Jun;35(6):3151-8. doi: 10.3892/or.2016.4723. Epub 2016 Apr 1. PubMed |
| AZD9291 overcomes T790 M-mediated resistance through degradation of EGFR(L858R/T790M) in non-small cell lung cancer cells. Ku BM, Bae YH, Koh J, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ. Invest New Drugs. 2016 Aug;34(4):407-15. doi: 10.1007/s10637-016-0350-y. Epub 2016 Apr 5. PubMed |
| Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfbeta/Smad Signaling. Yeo SK, Wen J, Chen S, Guan JL. Cancer Res. 2016 Jun 1;76(11):3397-410. doi: 10.1158/0008-5472.CAN-15-2946. Epub 2016 Apr 13. PubMed |
| EGFR Signal-Network Reconstruction Demonstrates Metabolic Crosstalk in EMT. Choudhary KS, Rohatgi N, Halldorsson S, Briem E, Gudjonsson T, Gudmundsson S, Rolfsson O. PLoS Comput Biol. 2016 Jun 2;12(6):e1004924. doi: 10.1371/journal.pcbi.1004924. eCollection 2016 Jun. PubMed |
| CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment. Law ME, Ferreira RB, Davis BJ, Higgins PJ, Kim JS, Castellano RK, Chen S, Luesch H, Law BK. Breast Cancer Res. 2016 Aug 5;18(1):80. doi: 10.1186/s13058-016-0741-1. PubMed |
| GPRC5A exerts its tumor-suppressive effects in breast cancer cells by inhibiting EGFR and its downstream pathway. Yang L, Ma T, Zhang J. Oncol Rep. 2016 Nov;36(5):2983-2990. doi: 10.3892/or.2016.5062. Epub 2016 Sep 2. PubMed |
| Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1. Lee HW, Khan SQ, Khaliqdina S, Altintas MM, Grahammer F, Zhao JL, Koh KH, Tardi NJ, Faridi MH, Geraghty T, Cimbaluk DJ, Susztak K, Moita LF, Baltimore D, Tharaux PL, Huber TB, Kretzler M, Bitzer M, Reiser J, Gupta V. J Biol Chem. 2017 Jan 13;292(2):732-747. doi: 10.1074/jbc.M116.753822. Epub 2016 Dec 2. PubMed |
| Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3Kalpha-selective Inhibitors in Breast Cancer. Xu YC, Wang X, Chen Y, Chen SM, Yang XY, Sun YM, Geng MY, Ding J, Meng LH. Theranostics. 2017 Feb 23;7(4):974-986. doi: 10.7150/thno.17830. eCollection 2017. PubMed |
| Disulfide bond disrupting agents activate the unfolded protein response in EGFR- and HER2-positive breast tumor cells. Ferreira RB, Wang M, Law ME, Davis BJ, Bartley AN, Higgins PJ, Kilberg MS, Santostefano KE, Terada N, Heldermon CD, Castellano RK, Law BK. Oncotarget. 2017 Apr 25;8(17):28971-28989. doi: 10.18632/oncotarget.15952. PubMed |
| Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non-small cell lung cancer. Hidaka N, Iwama E, Kubo N, Harada T, Miyawaki K, Tanaka K, Okamoto I, Baba E, Akashi K, Sasaki H, Nakanishi Y. Lung Cancer. 2017 Jun;108:75-82. doi: 10.1016/j.lungcan.2017.02.019. Epub 2017 Mar 1. PubMed |
| A novel multi-target inhibitor harboring selectivity of inhibiting EGFR T790M sparing wild-type EGFR. Song X, Qi X, Wang Q, Zhu W, Li J. Am J Cancer Res. 2017 Sep 1;7(9):1884-1898. eCollection 2017. PubMed |
| Multiplex picoliter-droplet digital PCR for quantitative assessment of EGFR mutations in circulating cell-free DNA derived from advanced non-small cell lung cancer patients. Yu Q, Huang F, Zhang M, Ji H, Wu S, Zhao Y, Zhang C, Wu J, Wang B, Pan B, Zhang X, Guo W. Mol Med Rep. 2017 Aug;16(2):1157-1166. doi: 10.3892/mmr.2017.6712. Epub 2017 Jun 7. PubMed |
| Sortilin limits EGFR signaling by promoting its internalization in lung cancer. Al-Akhrass H, Naves T, Vincent F, Magnaudeix A, Durand K, Bertin F, Melloni B, Jauberteau MO, Lalloue F. Nat Commun. 2017 Oct 30;8(1):1182. doi: 10.1038/s41467-017-01172-5. PubMed |
Time-gated detection of protein-protein interactions with transcriptional readout.
Kim MW, Wang W, Sanchez MI, Coukos R, von Zastrow M, Ting AY.
Elife. 2017 Nov 30;6. doi: 10.7554/eLife.30233.
PubMed
Associated Plasmids |
| Single Particle Imaging of Polarized Hepatoma Organoids upon Hepatitis C Virus Infection Reveals an Ordered and Sequential Entry Process. Baktash Y, Madhav A, Coller KE, Randall G. Cell Host Microbe. 2018 Mar 14;23(3):382-394.e5. doi: 10.1016/j.chom.2018.02.005. PubMed |
| Dual Targeting of ERBB2/ERBB3 for the Treatment of SLC3A2-NRG1-Mediated Lung Cancer. Shin DH, Jo JY, Han JY. Mol Cancer Ther. 2018 Sep;17(9):2024-2033. doi: 10.1158/1535-7163.MCT-17-1178. Epub 2018 Jun 29. PubMed |
| EpCAM ectodomain EpEX is a ligand of EGFR that counteracts EGF-mediated epithelial-mesenchymal transition through modulation of phospho-ERK1/2 in head and neck cancers. Pan M, Schinke H, Luxenburger E, Kranz G, Shakhtour J, Libl D, Huang Y, Gaber A, Pavsic M, Lenarcic B, Kitz J, Jakob M, Schwenk-Zieger S, Canis M, Hess J, Unger K, Baumeister P, Gires O. PLoS Biol. 2018 Sep 27;16(9):e2006624. doi: 10.1371/journal.pbio.2006624. eCollection 2018 Sep. PubMed |
| Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen. Deygas M, Gadet R, Gillet G, Rimokh R, Gonzalo P, Mikaelian I. Nat Commun. 2018 Oct 31;9(1):4545. doi: 10.1038/s41467-018-06988-3. PubMed |
| Direct visualization of single-molecule membrane protein interactions in living cells. Kim DH, Park S, Kim DK, Jeong MG, Noh J, Kwon Y, Zhou K, Lee NK, Ryu SH. PLoS Biol. 2018 Dec 13;16(12):e2006660. doi: 10.1371/journal.pbio.2006660. eCollection 2018 Dec. PubMed |
| Integrative Genomic Analyses Identifies GGA2 as a Cooperative Driver of EGFR-Mediated Lung Tumorigenesis. O'Farrell H, Harbourne B, Kurlawala Z, Inoue Y, Nagelberg AL, Martinez VD, Lu D, Oh MH, Coe BP, Thu KL, Somwar R, Lam S, Lam WL, Unni AM, Beverly L, Lockwood WW. J Thorac Oncol. 2019 Apr;14(4):656-671. doi: 10.1016/j.jtho.2018.12.004. Epub 2018 Dec 19. PubMed |
| FGFR1 Cooperates with EGFR in Lung Cancer Oncogenesis, and Their Combined Inhibition Shows Improved Efficacy. Quintanal-Villalonga A, Molina-Pinelo S, Cirauqui C, Ojeda-Marquez L, Marrugal A, Suarez R, Conde E, Ponce-Aix S, Enguita AB, Carnero A, Ferrer I, Paz-Ares L. J Thorac Oncol. 2019 Apr;14(4):641-655. doi: 10.1016/j.jtho.2018.12.021. Epub 2019 Jan 9. PubMed |
| A novel proteotoxic combination therapy for EGFR+ and HER2+ cancers. Wang M, Ferreira RB, Law ME, Davis BJ, Yaaghubi E, Ghilardi AF, Sharma A, Avery BA, Rodriguez E, Chiang CW, Narayan S, Heldermon CD, Castellano RK, Law BK. Oncogene. 2019 May;38(22):4264-4282. doi: 10.1038/s41388-019-0717-6. Epub 2019 Feb 4. PubMed |
| An unbiased in vitro screen for activating epidermal growth factor receptor mutations. Chakroborty D, Kurppa KJ, Paatero I, Ojala VK, Koivu M, Tamirat MZ, Koivunen JP, Janne PA, Johnson MS, Elo LL, Elenius K. J Biol Chem. 2019 Jun 14;294(24):9377-9389. doi: 10.1074/jbc.RA118.006336. Epub 2019 Apr 5. PubMed |
| CRISPR-Directed Gene Editing Catalyzes Precise Gene Segment Replacement In Vitro Enabling a Novel Method for Multiplex Site-Directed Mutagenesis. Sansbury BM, Wagner AM, Tarcic G, Barth S, Nitzan E, Goldfus R, Vidne M, Kmiec EB. CRISPR J. 2019 Apr;2:121-132. doi: 10.1089/crispr.2018.0054. PubMed |
| FGFR4 increases EGFR oncogenic signaling in lung adenocarcinoma, and their combined inhibition is highly effective. Quintanal-Villalonga A, Molina-Pinelo S, Yague P, Marrugal A, Ojeda-Marquez L, Suarez R, Ponce-Aix S, Enguita AB, Carnero A, Ferrer I, Paz-Ares L. Lung Cancer. 2019 May;131:112-121. doi: 10.1016/j.lungcan.2019.02.007. Epub 2019 Feb 8. PubMed |
| Preclinical Modeling of Osimertinib for NSCLC With EGFR Exon 20 Insertion Mutations. Lee Y, Kim TM, Kim DW, Kim S, Kim M, Keam B, Ku JL, Heo DS. J Thorac Oncol. 2019 May 17. pii: S1556-0864(19)30369-7. doi: 10.1016/j.jtho.2019.05.006. PubMed |
| Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway. Wang M, Law ME, Davis BJ, Yaaghubi E, Ghilardi AF, Ferreira RB, Chiang CW, Guryanova OA, Kopinke D, Heldermon CD, Castellano RK, Law BK. Cell Death Discov. 2019 Dec 10;5:153. doi: 10.1038/s41420-019-0228-9. eCollection 2019. PubMed |
| Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition. Mondal G, Lee JC, Ravindranathan A, Villanueva-Meyer JE, Tran QT, Allen SJ, Barreto J, Gupta R, Doo P, Van Ziffle J, Onodera C, Devine P, Grenert JP, Samuel D, Li R, Metrock LK, Jin LW, Antony R, Alashari M, Cheshier S, Whipple NS, Bruggers C, Raffel C, Gupta N, Kline CN, Reddy A, Banerjee A, Hall MD, Mehta MP, Khatib Z, Maher OM, Brathwaite C, Pekmezci M, Phillips JJ, Bollen AW, Tihan T, Lucas JT Jr, Broniscer A, Berger MS, Perry A, Orr BA, Solomon DA. Acta Neuropathol. 2020 Jun;139(6):1071-1088. doi: 10.1007/s00401-020-02155-5. Epub 2020 Apr 17. PubMed |
| Detection of epidermal growth factor receptor T790M mutation by allele-specific loop mediated isothermal amplification. Arjuna S, Chakraborty G, Venkataram R, Dechamma PN, Chakraborty A. J Carcinog. 2020 Jun 11;19:3. doi: 10.4103/jcar.JCar_6_20. eCollection 2020. PubMed |
| Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer. Vaishnavi A, Scherzer MT, Kinsey CG, Parkman GL, Truong A, Ghazi P, Schuman S, Battistone B, Garrido-Laguna I, McMahon M. Cell Rep. 2020 Aug 4;32(5):107994. doi: 10.1016/j.celrep.2020.107994. PubMed |
| Non-invasive detection of EGFR mutations by cell-free loop-mediated isothermal amplification (CF-LAMP). Arjuna S, Venkataram R, Dechamma PN, Chakraborty G, Babu N, D'Cruz A, Hosmane GB, Chakraborty A. Sci Rep. 2020 Oct 16;10(1):17559. doi: 10.1038/s41598-020-74689-3. PubMed |
| Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids. Sun G, Chiuppesi F, Chen X, Wang C, Tian E, Nguyen J, Kha M, Trinh D, Zhang H, Marchetto MC, Song H, Ming GL, Gage FH, Diamond DJ, Wussow F, Shi Y. Cell Rep Med. 2020 Mar 25;1(1):100002. doi: 10.1016/j.xcrm.2020.100002. eCollection 2020 Apr 21. PubMed |
| Erb-b2 Receptor Tyrosine Kinase 2 (ERBB2) Promotes ATG12-Dependent Autophagy Contributing to Treatment Resistance of Breast Cancer Cells. Chen Y, Wang R, Huang S, Henson ES, Bi J, Gibson SB. Cancers (Basel). 2021 Mar 2;13(5). pii: cancers13051038. doi: 10.3390/cancers13051038. PubMed |
| FGFR leads to sustained activation of STAT3 to mediate resistance to EGFR-TKIs treatment. Song X, Tang W, Peng H, Qi X, Li J. Invest New Drugs. 2021 Oct;39(5):1201-1212. doi: 10.1007/s10637-021-01061-1. Epub 2021 Apr 7. PubMed |
| SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma. Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, Cardarelli L, Troyanskaya O, Sidhu SS, Roybal KT, Okada H, Lim WA. Sci Transl Med. 2021 Apr 28;13(591). pii: 13/591/eabe7378. doi: 10.1126/scitranslmed.abe7378. PubMed |
| Acquired Resistance Mechanism of EGFR Kinase Domain Duplication to EGFR TKIs in Non-Small Cell Lung Cancer. Lee C, Kim M, Kim DW, Kim TM, Kim S, Im SW, Jeon YK, Keam B, Ku JL, Heo DS. Cancer Res Treat. 2021 May 3. pii: crt.2021.385. doi: 10.4143/crt.2021.385. PubMed |
| EGFR Transgene Stimulates Spontaneous Formation of MCF7 Breast Cancer Cells Spheroids with Partly Loss of HER3 Receptor. Troitskaya O, Novak D, Nushtaeva A, Savinkova M, Varlamov M, Ermakov M, Richter V, Koval O. Int J Mol Sci. 2021 Nov 29;22(23). pii: ijms222312937. doi: 10.3390/ijms222312937. PubMed |
| Calcineurin and huntingtin form a calcium-sensing machinery that directs neurotrophic signals to the nucleus. Scaramuzzino C, Cuoc EC, Pla P, Humbert S, Saudou F. Sci Adv. 2022 Jan 7;8(1):eabj8812. doi: 10.1126/sciadv.abj8812. Epub 2022 Jan 5. PubMed |
| USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K. Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Bozkurt S, Pahor N, Fuss C, Schirbel A, Schulein-Volk C, Buchberger A, Calzado Canale MA, Rosenfeldt M, Dikic I, Munch C, Diefenbacher ME. Mol Oncol. 2022 Sep;16(17):3082-3106. doi: 10.1002/1878-0261.13217. Epub 2022 Apr 30. PubMed |
| Identification of Activating Mutations in the Transmembrane and Extracellular Domains of EGFR. Wagner A, Galicia-Andres E, Teufl M, Gold L, Obinger C, Sykacek P, Oostenbrink C, Traxlmayr MW. Biochemistry. 2022 Oct 4;61(19):2049-2062. doi: 10.1021/acs.biochem.2c00384. Epub 2022 Sep 22. PubMed |
| Mutant forms of EGFR promote HER2 trafficking through efficient formation of HER2-EGFR heterodimers. Tsutsumi H, Iwama E, Ibusuki R, Shimauchi A, Ota K, Yoneshima Y, Inoue H, Tanaka K, Nakanishi Y, Okamoto I. Lung Cancer. 2023 Jan;175:101-111. doi: 10.1016/j.lungcan.2022.11.018. Epub 2022 Nov 29. PubMed |
| EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer. Kang J, Chun J, Hwang JS, Pan C, Li J, Boese AC, Young I, Malin CM, Kang Y, Gibbons DL, Sica G, Fu H, Ramalingam SS, Jin L, Kang S. Cell Rep. 2022 Dec 13;41(11):111827. doi: 10.1016/j.celrep.2022.111827. PubMed |
| Dioscin inhibiting EGFR-mediated Survivin expression promotes apoptosis in oral squamous cell carcinoma cells. Li M, Zhao Q, Liao J, Wang X, Liu L, Zhang X, Liu L, Liu H, Zhang S. J Cancer. 2023 Jul 9;14(11):2027-2038. doi: 10.7150/jca.85011. eCollection 2023. PubMed |
Knockout of all ErbB-family genes delineates their roles in proliferation, survival, and migration.
Matsuda K, Hirayama D, Hino N, Kuno S, Sakaue-Sawano A, Miyawaki A, Matsuda M, Terai K.
J Cell Sci. 2023 Jul 31:jcs.261199. doi: 10.1242/jcs.261199.
PubMed
Associated Plasmids |
| YAP mediates resistance to EGF-induced apoptosis in EGFR-mutated non-small cell lung cancer cells. Nakajima M, Tanaka K, Yoneshima Y, Yamashita S, Shibahara D, Iwama E, Okamoto I. Biochem Biophys Res Commun. 2023 Nov 12;681:120-126. doi: 10.1016/j.bbrc.2023.09.067. Epub 2023 Sep 23. PubMed |
| Cathepsin L-mediated EGFR cleavage affects intracellular signalling pathways in cancer. Grozdanic M, Sobotic B, Biasizzo M, Sever T, Vidmar R, Vizovisek M, Turk B, Fonovic M. Biol Chem. 2023 Oct 30. doi: 10.1515/hsz-2023-0213. PubMed |
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