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viral-service-icon-v3.png Viral Service: AAV


Addgene's viral service provides high-quality and high-titer viral preparations. Addgene's AAV are made from plasmids that are currently in our repository. You can obtain the plasmid from us or receive a ready-to-use viral preparation from the inventory below.

AAV are distributed as 100 µL solutions of purified viral particles that are suitable for in vivo use. Minimum titers are listed on each item's material page. Actual titers are reported with each shipment.

For more details about our viral service, visit our Viral Service landing page.


Browse Available AAV

Chemogenetics icon Chemogenetics (including DREADD) AAV

Use our chemogenetics AAV to chemically induce neuronal activity in specific cell types. See our Chemogenetics Plasmids and Chemogenetics Guide pages for more information about this field.

ID Name Receptor Activity Serotype(s) PI
Syn promoter, Cre-dependent
44361 pAAV-hSyn-DIO-hM3D(Gq)-mCherry hM3D(Gq) Activation 2, 5, 8, rg* Roth
44362 pAAV-hSyn-DIO-hM4D(Gi)-mCherry hM4D(Gi) Inhibition 2, 5, 8, rg* Roth
50459 pAAV-hSyn-DIO-mCherry none Control 2, 5, 8 Roth
65417
New!
pAAV-hSyn-dF-HA-KORD-IRES-mCitrine kappa-opioid receptor (KOR) Inhibition 8 Roth
Syn promoter, Non-cre-dependent
50474
New!
pAAV-hSyn-hM3D(Gq)-mCherry hM3D(Gq) Activation 2, 5, 8, rg* Roth
50475 pAAV-hSyn-hM4D(Gi)-mCherry hM4D(Gi) Inhibition 2, 5, 8, rg* Roth
50465
New!
pAAV-hSyn-EGFP none Control 2, 5, 8, rg* Roth
CaMKIIa promoter, Non-cre-dependent
50476 pAAV-CaMKIIa-hM3D(Gq)-mCherry hM3D(Gq) Activation 5, 8 Roth
50477 pAAV-CaMKIIa-hM4D(Gi)-mCherry hM4D(Gi) Inhibition 5, 8 Roth
50469 pAAV-CaMKIIa-EGFP none Control 5, 8 Roth

*AAVrg = retrograde serotype, produced with the AAV retro helper plasmid from the Karpova and Schaffer labs. See the Retrograde AAV Inventory Page.

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Optogenetics icon Optogenetics AAV

Optogenetic tools can be used to control cell activity in living tissue with light. Optogenetics is typically used in neuroscience to control electrical potentials in neurons. See our Optogenetics Plasmids page for more information about this field.

ID Name Opsin/Variant Tag Serotype PI
Activators
Cre-dependent
20297 pAAV-EF1a-double floxed-hChR2(H134R)-mCherry-WPRE-HGHpA Channelrhodopsin/ H134R mutant mCherry rg* Deisseroth
20298 pAAV-EF1a-double floxed-hChR2(H134R)-EYFP-WPRE-HGHpA Channelrhodopsin/ H134R mutant EYFP 1, rg* Deisseroth
62723 pAAV-Syn-FLEX-rc[ChrimsonR-tdTomato] Channelrhodopsin/ChrimsonR tdTomato 5 Boyden
Non-cre-dependent
28017 AAV-CAG-hChR2-H134R-tdTomato Channelrhodopsin/ H134R mutant tdTomato rg* Svoboda
58880 pAAV-Syn-ChR2(H134R)-GFP Channelrhodopsin/ H134R mutant GFP 8, rg* Boyden
59170 pAAV-Syn-Chronos-GFP Channelrhodopsin/Chronos GFP 5, rg* Boyden
Inhibitors
Cre-dependent
84445 pAAV-CAG-FLEX-rc [Jaws-KGC-GFP-ER2] Halorhodopsin/Jaws GFP rg* Boyden
Non-cre-dependent
65014 pAAV-hsyn-Jaws-KGC-GFP-ER2 Halorhodopsin/Jaws GFP 8, rg* Boyden

*AAVrg = retrograde serotype, produced with the AAV retro helper plasmid from the Karpova and Schaffer labs. See the Retrograde AAV Inventory Page.

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Cre recombinase icon Site-specific recombinases

These AAV encode site-specific recombinases, which can be used to control gene expression.

ID Name Promoter Tag Serotype PI
Cre
51507 AAV pmSyn1-EBFP-Cre Syn1 EBFP 1, 5, rg* Zeng
24593 AAV-pgk-Cre PGK none rg* Aebischer
55632 pAAV-Ef1a-mCherry-IRES-Cre EF1a physically-separate mCherry (not a fusion tag) rg* Deisseroth
Flpo
55634 pAAV-EF1a-mCherry-IRES-Flpo EF1a physically-separate mCherry (not a fusion tag) rg* Deisseroth

*AAVrg = retrograde serotype, produced with the AAV retro helper plasmid from the Karpova and Schaffer labs. See the Retrograde AAV Inventory Page.

Gcamp Icon Calcium Sensors

ID Name Promoter Activity Serotype PI
GCaMP6f
51085 AAV-hSyn1-GCaMP6f-P2A-nls-dTomato Syn1 Calcium sensor and physically separate nuclear dTomato 1, rg* Ting
51083 AAV-EF1a-DIO-GCaMP6f-P2A-nls-dTomato EF1a Cre-dependent calcium sensor and physically separate nuclear dTomato rg* Ting
GCaMP6s
51084 AAV-hSyn1-GCaMP6s-P2A-nls-dTomato Syn1 Calcium sensor and physically separate nuclear dTomato 1, rg* Ting
51082 AAV-EF1a-DIO-GCaMP6s-P2A-nls-dTomato EF1a Cre-dependent calcium sensor and physically separate nuclear dTomato 1 Ting

*AAVrg = retrograde serotype, produced with the AAV retro helper plasmid from the Karpova and Schaffer labs. See the Retrograde AAV Inventory Page.

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controls icon Controls/Reporters

Browse our control AAV that express fluorescent proteins under general promoters. These AAV can be used to compare the activity of different serotypes.

ID Name Promoter Activity Serotype PI
Non-cre-dependent
37825
New!
AAV-CAG-GFP CAG GFP expression 5, rg* Boyden
50465
New!
pAAV-hSyn-EGFP hSyn EGFP expression 2, 5, 8, rg* Roth
50469 pAAV-CaMKIIa-EGFP CaMKIIa EGFP expression 5, 8 Roth
59462 pAAV-CAG-tdTomato CAG tdTomato expression 5, rg* Boyden
Cre-dependent
37120 pAAV-Ef1a-DO_DIO-TdTomato_EGFP-WPRE-pA EF1a Cre-dependent color-flipping reporter. Expresses tdTomato in the absence of Cre, but inverts to express EGFP in Cre-positive cells. rg* Sabatini
50457
New!
pAAV-hSyn-DIO-EGFP hSyn Cre-dependent EGFP expression rg* Roth
50459 pAAV-hSyn-DIO-mCherry hSyn Cre-dependent mCherry expression 2, 5, 8 Roth
50462 pAAV-EF1a-DIO-mCherry EF1a Cre-dependent mCherry expression 5 Roth
51503 AAV pCAG-FLEX-tdTomato-WPRE CAG Cre-dependent tdTomato expression rg* Zeng

*AAVrg = retrograde serotype, produced with the AAV retro helper plasmid from the Karpova and Schaffer labs. See the Retrograde AAV Inventory Page.

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Don’t See What You’re Looking For?

Please let us know what you would like to see available in viral format using the form below. Please note this does not guarantee viral service, but lets us know what viruses would be helpful to the scientific community.