pcDNA4-Beclin1 (FL) Citations (21)

Originally described in: Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.
Sun Q, Fan W, Chen K, Ding X, Chen S, Zhong Q Proc Natl Acad Sci U S A. 2008 Dec 9. 105(49):19211-6. PubMed Journal

---

Articles Citing pcDNA4-Beclin1 (FL)

Articles
Foot-and-mouth disease virus nonstructural protein 2C interacts with Beclin1, modulating virus replication. Gladue DP, O'Donnell V, Baker-Branstetter R, Holinka LG, Pacheco JM, Fernandez-Sainz I, Lu Z, Brocchi E, Baxt B, Piccone ME, Rodriguez L, Borca MV. J Virol. 2012 Nov;86(22):12080-90. doi: 10.1128/JVI.01610-12. Epub 2012 Aug 29. PubMed
Divergent roles of BECN1 in LC3 lipidation and autophagosomal function. He R, Peng J, Yuan P, Xu F, Wei W. Autophagy. 2015;11(5):740-7. doi: 10.1080/15548627.2015.1034404. PubMed
Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3). Fujiwara N, Usui T, Ohama T, Sato K. J Biol Chem. 2016 May 13;291(20):10858-66. doi: 10.1074/jbc.M115.704908. Epub 2016 Mar 18. PubMed
BECN1/Beclin 1 sorts cell-surface APP/amyloid beta precursor protein for lysosomal degradation. Swaminathan G, Zhu W, Plowey ED. Autophagy. 2016 Dec;12(12):2404-2419. Epub 2016 Oct 7. PubMed
Inhibition of TRAF6 ubiquitin-ligase activity by PRDX1 leads to inhibition of NFKB activation and autophagy activation. Min Y, Kim MJ, Lee S, Chun E, Lee KY. Autophagy. 2018;14(8):1347-1358. doi: 10.1080/15548627.2018.1474995. Epub 2018 Jul 23. PubMed
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc(-) Activity. Song X, Zhu S, Chen P, Hou W, Wen Q, Liu J, Xie Y, Liu J, Klionsky DJ, Kroemer G, Lotze MT, Zeh HJ, Kang R, Tang D. Curr Biol. 2018 Aug 6;28(15):2388-2399.e5. doi: 10.1016/j.cub.2018.05.094. Epub 2018 Jul 26. PubMed
17-Hydroxy Wortmannin Restores TRAIL's Response by Ameliorating Increased Beclin 1 Level and Autophagy Function in TRAIL-Resistant Colon Cancer Cells. Dai S, Yang S, Hu X, Sun W, Tawa G, Zhu W, Schimmer AD, He C, Fang B, Zhu H, Zheng W. Mol Cancer Ther. 2019 Jul;18(7):1265-1277. doi: 10.1158/1535-7163.MCT-18-1241. Epub 2019 May 15. PubMed
CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1. Kim MJ, Min Y, Shim JH, Chun E, Lee KY. Front Immunol. 2019 Sep 18;10:2203. doi: 10.3389/fimmu.2019.02203. eCollection 2019. PubMed
Beclin1-mediated ferroptosis activation is associated with isoflurane-induced toxicity in SH-SY5Y neuroblastoma cells. Liu R, Li X, Zhao G. Acta Biochim Biophys Sin (Shanghai). 2019 Nov 18;51(11):1134-1141. doi: 10.1093/abbs/gmz104. PubMed
HUNK Phosphorylates Rubicon to Support Autophagy. Zambrano JN, Eblen ST, Abt M, Rhett JM, Muise-Helmericks R, Yeh ES. Int J Mol Sci. 2019 Nov 19;20(22). pii: ijms20225813. doi: 10.3390/ijms20225813. PubMed
Inhibition of ULK1 and Beclin1 by an alpha-herpesvirus Akt-like Ser/Thr kinase limits autophagy to stimulate virus replication. Rubio RM, Mohr I. Proc Natl Acad Sci U S A. 2019 Dec 16. pii: 1915139116. doi: 10.1073/pnas.1915139116. PubMed
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Gassen NC, Niemeyer D, Muth D, Corman VM, Martinelli S, Gassen A, Hafner K, Papies J, Mosbauer K, Zellner A, Zannas AS, Herrmann A, Holsboer F, Brack-Werner R, Boshart M, Muller-Myhsok B, Drosten C, Muller MA, Rein T. Nat Commun. 2019 Dec 18;10(1):5770. doi: 10.1038/s41467-019-13659-4. PubMed
HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner. Castro-Gonzalez S, Shi Y, Colomer-Lluch M, Song Y, Mowery K, Almodovar S, Bansal A, Kirchhoff F, Sparrer K, Liang C, Serra-Moreno R. Autophagy. 2021 Feb;17(2):553-577. doi: 10.1080/15548627.2020.1725401. Epub 2020 Feb 25. PubMed
p62 is Negatively Implicated in the TRAF6-BECN1 Signaling Axis for Autophagy Activation and Cancer Progression by Toll-Like Receptor 4 (TLR4). Kim MJ, Min Y, Im JS, Son J, Lee JS, Lee KY. Cells. 2020 May 6;9(5). pii: cells9051142. doi: 10.3390/cells9051142. PubMed
Leucine regulates autophagy via acetylation of the mTORC1 component raptor. Son SM, Park SJ, Stamatakou E, Vicinanza M, Menzies FM, Rubinsztein DC. Nat Commun. 2020 Jun 19;11(1):3148. doi: 10.1038/s41467-020-16886-2. PubMed
AMPKalpha1 Regulates Lung and Breast Cancer Progression by Regulating TLR4-Mediated TRAF6-BECN1 Signaling Axis. Kim MJ, Min Y, Son J, Kim JY, Lee JS, Kim DH, Lee KY. Cancers (Basel). 2020 Nov 6;12(11). pii: cancers12113289. doi: 10.3390/cancers12113289. PubMed
USP8 regulates liver cancer progression via the inhibition of TRAF6-mediated signal for NF-kappaB activation and autophagy induction by TLR4. Kim MJ, Choi B, Kim JY, Min Y, Kwon DH, Son J, Lee JS, Lee JS, Chun E, Lee KY. Transl Oncol. 2022 Jan;15(1):101250. doi: 10.1016/j.tranon.2021.101250. Epub 2021 Oct 20. PubMed
Residues T48 and A49 in HIV-1 NL4-3 Nef are responsible for the counteraction of autophagy initiation, which prevents the ubiquitin-dependent degradation of Gag through autophagosomes. Castro-Gonzalez S, Chen Y, Benjamin J, Shi Y, Serra-Moreno R. Retrovirology. 2021 Oct 28;18(1):33. doi: 10.1186/s12977-021-00576-y. PubMed
Hepatitis B virus X Protein Promotes Liver Cancer Progression through Autophagy Induction in Response to TLR4 Stimulation. Son J, Kim MJ, Lee JS, Kim JY, Chun E, Lee KY. Immune Netw. 2021 Oct 26;21(5):e37. doi: 10.4110/in.2021.21.e37. eCollection 2021 Oct. PubMed
USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction. Kim MJ, Min Y, Jeong SK, Son J, Kim JY, Lee JS, Kim DH, Lee JS, Chun E, Lee KY. Cell Death Dis. 2022 Apr 14;13(4):348. doi: 10.1038/s41419-022-04808-7. PubMed
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. Wrobel L, Hill SM, Djajadikerta A, Fernandez-Estevez M, Karabiyik C, Ashkenazi A, Barratt VJ, Stamatakou E, Gunnarsson A, Rasmusson T, Miele EW, Beaton N, Bruderer R, Feng Y, Reiter L, Castaldi MP, Jarvis R, Tan K, Burli RW, Rubinsztein DC. Nat Commun. 2022 Jul 16;13(1):4146. doi: 10.1038/s41467-022-31905-0. PubMed

If you have published an article using this material, please email us at to have your article added to this page.