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Bert Vogelstein Lab Plasmids


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Title Authors Publication
Converting cancer genes into killer genes. Da Costa LT, Jen J, He TC, Chan TA, Kinzler KW, Vogelstein B Proc Natl Acad Sci U S A. 1996 Apr 30. 93(9):4192-6.
A simplified system for generating recombinant adenoviruses. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2509-14.
Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses. Kohli M, Rago C, Lengauer C, Kinzler KW, Vogelstein B Nucleic Acids Res. 2004 . 32(1):e3.
The GLI gene is a member of the Kruppel family of zinc finger proteins. Kinzler KW, Ruppert JM, Bigner SH, Vogelstein B Nature. 1988 Mar 24. 332(6162):371-4.
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Baker SJ, Fearon ER, Nigro JM, Hamilton SR, Preisinger AC, Jessup JM, vanTuinen P, Ledbetter DH, Barker DF, Nakamura Y, White R, Vogelstein B Science. 1989 Apr 14. 244(4901):217-21.
Suppression of human colorectal carcinoma cell growth by wild-type p53. Baker SJ, Markowitz S, Fearon ER, Willson JK, Vogelstein B Science. 1990 Aug 24. 249(4971):912-5.
Amplification of a gene encoding a p53-associated protein in human sarcomas. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B Nature. 1992 Jul 2. 358(6381):80-3.
WAF1, a potential mediator of p53 tumor suppression. el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B Cell. 1993 Nov 19. 75(4):817-25.
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Leach FS, Nicolaides NC, Papadopoulos N, Liu B, Jen J, Parsons R, Peltomaki P, Sistonen P, Aaltonen LA, Nystroem-Lahti M Cell. 1993 Dec 17. 75(6):1215-25.
Deletion of p16 and p15 genes in brain tumors. Jen J, Harper JW, Bigner SH, Bigner DD, Papadopoulos N, Markowitz S, Willson JK, Kinzler KW, Vogelstein B Cancer Res. 1994 Dec 15. 54(24):6353-8.
Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nicolaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, Ruben SM, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM Nature. 1994 Sep 1. 371(6492):75-80.
Mutation of a mutL homolog in hereditary colon cancer. Papadopoulos N, Nicolaides NC, Wei YF, Ruben SM, Carter KC, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD Science. 1994 Mar 18. 263(5153):1625-9.
Identification of a chromosome 18q gene that is altered in colorectal cancers. Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, Preisinger AC, Thomas G, Kinzler KW Science. 1990 Jan 5. 247(4938):49-56.
Paradoxical inhibition of solid tumor cell growth by bcl2. Pietenpol JA, Papadopoulos N, Markowitz S, Willson JK, Kinzler KW, Vogelstein B Cancer Res. 1994 Jul 15. 54(14):3714-7.
Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. el-Deiry WS, Tokino T, Waldman T, Oliner JD, Velculescu VE, Burrell M, Hill DE, Healy E, Rees JL, Hamilton SR Cancer Res. 1995 Jul 1. 55(13):2910-9.
PAK1, a gene that can regulate p53 activity in yeast. Thiagalingam S, Kinzler KW, Vogelstein B Proc Natl Acad Sci U S A. 1995 Jun 20. 92(13):6062-6.
Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene. Nicolaides NC, Kinzler KW, Vogelstein B Genomics. 1995 Sep 20. 29(2):329-34.
APC binds to the novel protein EB1. Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW Cancer Res. 1995 Jul 15. 55(14):2972-7.
A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype. Nicolaides NC, Littman SJ, Modrich P, Kinzler KW, Vogelstein B Mol Cell Biol. 1998 Mar . 18(3):1635-41.
Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. Pietenpol JA, Bohlander SK, Sato Y, Papadopoulos N, Liu B, Friedman C, Trask BJ, Roberts JM, Kinzler KW, Rowley JD Cancer Res. 1995 Mar 15. 55(6):1206-10.
Mad-related genes in the human. Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B Nat Genet. 1996 Jul . 13(3):347-9.
Apoptosis and APC in colorectal tumorigenesis. Morin PJ, Vogelstein B, Kinzler KW Proc Natl Acad Sci U S A. 1996 Jul 23. 93(15):7950-4.
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW Science. 1997 Mar 21. 275(5307):1787-90.
A model for p53-induced apoptosis. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B Nature. 1997 Sep 18. 389(6648):300-5.
Human Smad3 and Smad4 are sequence-specific transcription activators. Zawel L, Dai JL, Buckhaults P, Zhou S, Kinzler KW, Vogelstein B, Kern SE Mol Cell. 1998 Mar . 1(4):611-7.
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B, Clevers H Science. 1997 Mar 21. 275(5307):1784-7.
14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Hermeking H, Lengauer C, Polyak K, He TC, Zhang L, Thiagalingam S, Kinzler KW, Vogelstein B Mol Cell. 1997 Dec . 1(1):3-11.
Characterization of human FAST-1, a TGF beta and activin signal transducer. Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B Mol Cell. 1998 Jul . 2(1):121-7.
PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. He TC, Chan TA, Vogelstein B, Kinzler KW Cell. 1999 Oct 29. 99(3):335-45.
Identification and classification of p53-regulated genes. Yu J, Zhang L, Hwang PM, Rago C, Kinzler KW, Vogelstein B Proc Natl Acad Sci U S A. 1999 Dec 7. 96(25):14517-22.
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B Nature. 1999 Oct 7. 401(6753):616-20.
CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. da Costa LT, He TC, Yu J, Sparks AB, Morin PJ, Polyak K, Laken S, Vogelstein B, Kinzler KW Oncogene. 1999 Sep 2. 18(35):5010-4.
Identification of CDK4 as a target of c-MYC. Hermeking H, Rago C, Schuhmacher M, Li Q, Barrett JF, Obaya AJ, O'Connell BC, Mateyak MK, Tam W, Kohlhuber F, Dang CV, Sedivy JM, Eick D, Vogelstein B, Kinzler KW Proc Natl Acad Sci U S A. 2000 Feb 29. 97(5):2229-34.
The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression. Shih IM, Yu J, He TC, Vogelstein B, Kinzler KW Cancer Res. 2000 Mar 15. 60(6):1671-6.
Cell surface tumor endothelial markers are conserved in mice and humans. Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B Cancer Res. 2001 Sep 15. 61(18):6649-55.
Assessing tumors in living animals through measurement of urinary beta-human chorionic gonadotropin. Shih IM, Torrance C, Sokoll LJ, Chan DW, Kinzler KW, Vogelstein B Nat Med. 2000 Jun . 6(6):711-4.
Role of BAX in the apoptotic response to anticancer agents. Zhang L, Yu J, Park BH, Kinzler KW, Vogelstein B Science. 2000 Nov 3. 290(5493):989-92.
Securin is required for chromosomal stability in human cells. Jallepalli PV, Waizenegger IC, Bunz F, Langer S, Speicher MR, Peters JM, Kinzler KW, Vogelstein B, Lengauer C Cell. 2001 May 18. 105(4):445-57.
PUMA induces the rapid apoptosis of colorectal cancer cells. Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B Mol Cell. 2001 Mar . 7(3):673-82.
Identification of c-MYC as a target of the APC pathway. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW Science. 1998 Sep 4. 281(5382):1509-12.
Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Hwang PM, Bunz F, Yu J, Rago C, Chan TA, Murphy MP, Kelso GF, Smith RA, Kinzler KW, Vogelstein B Nat Med. 2001 Oct . 7(10):1111-7.
Use of isogenic human cancer cells for high-throughput screening and drug discovery. Torrance CJ, Agrawal V, Vogelstein B, Kinzler KW Nat Biotechnol. 2001 Oct . 19(10):940-5.
A phosphatase associated with metastasis of colorectal cancer. Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, Romans KE, Choti MA, Lengauer C, Kinzler KW, Vogelstein B Science. 2001 Nov 9. 294(5545):1343-6.
Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells. Park BH, Vogelstein B, Kinzler KW Proc Natl Acad Sci U S A. 2001 Feb 27. 98(5):2598-603.
Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells. Zhou S, Buckhaults P, Zawel L, Bunz F, Riggins G, Dai JL, Kern SE, Kinzler KW, Vogelstein B Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2412-6.
Mutations of mitotic checkpoint genes in human cancers. Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B Nature. 1998 Mar 19. 392(6673):300-3.
Mutational analysis of the tyrosine phosphatome in colorectal cancers. Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE Science. 2004 May 21. 304(5674):1164-6.
High frequency of mutations of the PIK3CA gene in human cancers. Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE Science. 2004 Apr 23. 304(5670):554.
DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities. Zawel L, Yu J, Torrance CJ, Markowitz S, Kinzler KW, Vogelstein B, Zhou S Proc Natl Acad Sci U S A. 2002 Mar 5. 99(5):2848-53.
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B Nature. 2002 Apr 4. 416(6880):552-6.
Inactivation of hCDC4 can cause chromosomal instability. Rajagopalan H, Jallepalli PV, Rago C, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C Nature. 2004 Mar 4. 428(6978):77-81.
HAUSP is required for p53 destabilization. Cummins JM, Vogelstein B Cell Cycle. 2004 Jun . 3(6):689-92.
The colorectal microRNAome. Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE Proc Natl Acad Sci U S A. 2006 Mar 7. 103(10):3687-92.
A bacterial protein enhances the release and efficacy of liposomal cancer drugs. Cheong I, Huang X, Bettegowda C, Diaz LA, Kinzler KW, Zhou S, Vogelstein B Science. 2006 Nov 24. 314(5803):1308-11.
Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Samuels Y, Diaz LA, Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE Cancer Cell. 2005 Jun . 7(6):561-73.
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B Nature. 1993 Apr 29. 362(6423):857-60.
ID Plasmid Gene/Insert Vector Type Publication Hidden Extra Search Info  
12516pGRE-GFPEGFPMammalian ExpressionConverting cancer genes into killer genes. Proc Natl Acad Sci U S A. 1996 Apr 30. 93(9):4192-6. na Add to Cart
16398BJ5183 cellsBJ5183 bacterial cellsA simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2509-14. n/a Add to Cart
16399AdEasier-1 cells (strain)AdEasier-1 bacterial cellsA simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2509-14. n/a Add to Cart
16400pAdEasy-1Mammalian Expression, AdenoviralA simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2509-14. Adenoviral vector for use in AdEasy System. pAdEasy and reg-1 Add to Cart
16401pAdEasy-2Mammalian Expression, AdenoviralA simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2509-14. Adenoviral vector for use in AdEasy System, for use with large inserts. pAdEasy-2 Add to Cart
16402pShuttleMammalian Expression, AdenoviralA simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2509-14. Shuttle vector for us in AdEasy System. Used for expression of transgenes under a chosen (non-CMV) promoter when no GFP tracer is desired. pShuttle Add to Cart
16403pShuttle-CMVMammalian Expression, AdenoviralA simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2509-14. Shuttle vector for use in AdEasy System. Used for expression of transgenes under a CMV promoter when no GFP tracer is desired. pShuttle-CMV Add to Cart
16404pAdTrackMammalian Expression, AdenoviralA simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2509-14. Shuttle vector for us in AdEasy System. Used for expression of transgenes under a chosen (non-CMV) promoter when a GFP tracer is desired. pAdTrack Add to Cart
16405pAdTrack-CMVMammalian Expression, AdenoviralA simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2509-14. Shuttle vector for us in AdEasy System. For expression of transgenes under a CMV promoter when a GFP tracer is desired. pAdTrack-CMV Add to Cart
16407pAdEasy 2-GFP beta-galbeta-galactosidase with stufferMammalian Expression, AdenoviralA simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2509-14. pAdEasy-2 Add to Cart
16410pAAV-Hyg-FHITFHIT Hyg targeting (Homo sapiens)Mammalian Expression, AAV ; adeno-associated viralFacile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses. Nucleic Acids Res. 2004 . 32(1):e3. pAAV-MCS FHIT AP3Aase, FRA3B Add to Cart
16411pAAV-Neo-PTENPTEN Neo targeting (Homo sapiens)Mammalian Expression, AAV ; adeno-associated viralFacile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses. Nucleic Acids Res. 2004 . 32(1):e3. pAAV-MCS PTEN 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 Add to Cart
16413pNeDaKO-NeoPGK-NeoR & ZeoRMammalian Expression, Cre/LoxFacile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses. Nucleic Acids Res. 2004 . 32(1):e3. pBluescript SK+ Add to Cart
16414pNeDaKO-HygPGK-HygR & ZeoRMammalian Expression, Cre/LoxFacile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses. Nucleic Acids Res. 2004 . 32(1):e3. pBluescript SK+ Add to Cart
16419GLI K12GLI (Homo sapiens)Bacterial ExpressionThe GLI gene is a member of the Kruppel family of zinc finger proteins. Nature. 1988 Mar 24. 332(6162):371-4. pBluescript KS GLI1 GLI Add to Cart
16420GLI-3 bs-2GLI3 (Homo sapiens)Bacterial ExpressionThe GLI gene is a member of the Kruppel family of zinc finger proteins. Nature. 1988 Mar 24. 332(6162):371-4. pBluescript SK GLI3 ACLS, GCPS, GLI3-190, GLI3FL, PAP-A, PAPA, PAPA1, PAPB, PHS, PPDIV Add to Cart
16421pBSK-SN3 (wt p53)p53 (Homo sapiens)Bacterial ExpressionChromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science. 1989 Apr 14. 244(4901):217-21. pBluescript SK TP53 BCC7, LFS1, P53, TRP53 Add to Cart
16434pCMV-Neo-Bam p53 wtp53 (Homo sapiens)Mammalian ExpressionSuppression of human colorectal carcinoma cell growth by wild-type p53. Science. 1990 Aug 24. 249(4971):912-5. pCMV-Neo-Bam TP53 BCC7, LFS1, P53, TRP53 Add to Cart
16435pCMV-Neo-Bam p53 V143Ap53 V143A (Homo sapiens)Mammalian ExpressionSuppression of human colorectal carcinoma cell growth by wild-type p53. Science. 1990 Aug 24. 249(4971):912-5. pCMV-Neo-Bam TP53 BCC7, LFS1, P53, TRP53 Add to Cart
16436pCMV-Neo-Bam p53 R175Hp53 R175H (Homo sapiens)Mammalian ExpressionSuppression of human colorectal carcinoma cell growth by wild-type p53. Science. 1990 Aug 24. 249(4971):912-5. pCMV-Neo-Bam TP53 BCC7, LFS1, P53, TRP53 Add to Cart
16437pCMV-Neo-Bam p53 R248Wp53 R248W (Homo sapiens)Mammalian ExpressionSuppression of human colorectal carcinoma cell growth by wild-type p53. Science. 1990 Aug 24. 249(4971):912-5. pCMV-Neo-Bam TP53 BCC7, LFS1, P53, TRP53 Add to Cart
16438pCMV-Neo-Bam p53 R249Sp53 R249S (Homo sapiens)Mammalian ExpressionSuppression of human colorectal carcinoma cell growth by wild-type p53. Science. 1990 Aug 24. 249(4971):912-5. pCMV-Neo-Bam TP53 BCC7, LFS1, P53, TRP53 Add to Cart
16439pCMV-Neo-Bam p53 R273Hp53 R273H (Homo sapiens)Mammalian ExpressionSuppression of human colorectal carcinoma cell growth by wild-type p53. Science. 1990 Aug 24. 249(4971):912-5. pCMV-Neo-Bam TP53 BCC7, LFS1, P53, TRP53 Add to Cart
16440pCMV-Neo-BamMammalian ExpressionSuppression of human colorectal carcinoma cell growth by wild-type p53. Science. 1990 Aug 24. 249(4971):912-5. Contains two independent transcription units--a CMV promoter/enhancer upstream of a MCS and a HSV thymidine kinase promoter/enhancer upstream of the neomycin resistance gene. pCMV-Neo-Bam Add to Cart
16441pCMV MDM-2MDM2 (Homo sapiens)Mammalian ExpressionAmplification of a gene encoding a p53-associated protein in human sarcomas. Nature. 1992 Jul 2. 358(6381):80-3. pCMV-Neo-Bam MDM2 ACTFS, HDMX, hdm2 Add to Cart
16442PG13-luc (wt p53 binding sites)p53-binding siteMammalian Expression, LuciferaseWAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19. 75(4):817-25. Luciferase reporter containing 13 copies of the p53-binding consensus sequence pBluescript II SK + luc TP53 BCC7, LFS1, P53, TRP53 Add to Cart
16443MG15-luc (mut p53 binding sites)p53-binding site (mutant)Mammalian Expression, LuciferaseWAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19. 75(4):817-25. n/a TP53 BCC7, LFS1, P53, TRP53 Add to Cart
16446PG13-gal (wt p53 binding sites)p53-binding siteMammalian Expression ; beta-gal reporterWAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19. 75(4):817-25. pBluescript II SK + bgal TP53 BCC7, LFS1, P53, TRP53 Add to Cart
16447MG15-gal (mut p53 binding sites)p53-binding site (mutant)Mammalian Expression ; beta-gal reporterWAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19. 75(4):817-25. pBluescript II SK + bgal TP53 BCC7, LFS1, P53, TRP53 Add to Cart
16448pCEP-WAF1-ASWAF1 antisense (Homo sapiens)Mammalian ExpressionWAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19. 75(4):817-25. pCEP4 CDKN1A CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 Add to Cart
16449pCEP-WAF1-ESWAF1 stop codon mut (Homo sapiens)Mammalian ExpressionWAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19. 75(4):817-25. pCEP4 CDKN1A CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 Add to Cart
16450pCEP-WAF1WAF1 (Homo sapiens)Mammalian ExpressionWAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19. 75(4):817-25. pCEP4 CDKN1A CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 Add to Cart
16451WWP-Luc (p21/WAF1 promoter)WAF1 promoter (Homo sapiens)Mammalian Expression, LuciferaseWAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19. 75(4):817-25. pBluescript II KS (+) + luc CDKN1A CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 Add to Cart
16452D3 clone (p21/WAF1 promoter)WAF1 promoter (Homo sapiens)Mammalian ExpressionWAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19. 75(4):817-25. pBluescript SK(+) CDKN1A CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 Add to Cart
16453hMSH2 Clone E3 (full-length)MSH2 (Homo sapiens)Bacterial ExpressionMutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell. 1993 Dec 17. 75(6):1215-25. pBluescript SK MSH2 COCA1, FCC1, HNPCC, HNPCC1, LCFS2 Add to Cart
16454pCRII p15p15 (Homo sapiens)Bacterial ExpressionDeletion of p16 and p15 genes in brain tumors. Cancer Res. 1994 Dec 15. 54(24):6353-8. pCRII CDKN2B CDK4I, INK4B, MTS2, P15, TP15, p15INK4b Add to Cart
16455pCRII p16p16 (Homo sapiens)Bacterial ExpressionDeletion of p16 and p15 genes in brain tumors. Cancer Res. 1994 Dec 15. 54(24):6353-8. pCRII CDKN2A ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16 Add to Cart
16457pBluescript PMS2PMS2 (Homo sapiens)Bacterial ExpressionMutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature. 1994 Sep 1. 371(6492):75-80. pBluescript SK PMS2 HNPCC4, MLH4, PMS2CL, PMSL2 Add to Cart
16458pCEP9 MLH1MLH1 (Homo sapiens)Mammalian ExpressionMutation of a mutL homolog in hereditary colon cancer. Science. 1994 Mar 18. 263(5153):1625-9. pCEP9 MLH1 COCA2, FCC2, HNPCC, HNPCC2, hMLH1 Add to Cart
16459pCMV DCCDCC (Homo sapiens)Mammalian ExpressionIdentification of a chromosome 18q gene that is altered in colorectal cancers. Science. 1990 Jan 5. 247(4938):49-56. pCMV-Neo-XhoI DCC CRC18, CRCR1, IGDCC1, MRMV1, NTN1R1 Add to Cart
16460pCMV DCC mutDCC (Homo sapiens)Mammalian ExpressionIdentification of a chromosome 18q gene that is altered in colorectal cancers. Science. 1990 Jan 5. 247(4938):49-56. pCMV-Neo-XhoI DCC CRC18, CRCR1, IGDCC1, MRMV1, NTN1R1 Add to Cart
16461pCEP4 Bcl-2Bcl-2 (Homo sapiens)Mammalian ExpressionParadoxical inhibition of solid tumor cell growth by bcl2. Cancer Res. 1994 Jul 15. 54(14):3714-7. pCEP4 BCL2 Bcl-2, PPP1R50 Add to Cart
16462p21 promoter Ap21 promoter (Homo sapiens)Mammalian ExpressionTopological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res. 1995 Jul 1. 55(13):2910-9. pJFCAT1 CDKN1A CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 Add to Cart
16463p21 promoter Bp21 promoter (Homo sapiens)Mammalian ExpressionTopological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res. 1995 Jul 1. 55(13):2910-9. pJFCAT1 CDKN1A CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 Add to Cart
16464p21 promoter Cp21 promoter (Homo sapiens)Mammalian ExpressionTopological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res. 1995 Jul 1. 55(13):2910-9. pJFCAT1 CDKN1A CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 Add to Cart
16465p21 promoter Dp21 promoter (Homo sapiens)Mammalian ExpressionTopological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res. 1995 Jul 1. 55(13):2910-9. pJFCAT1 CDKN1A CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 Add to Cart
16466p21 promoter Ep21 promoter (Homo sapiens)Mammalian ExpressionTopological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res. 1995 Jul 1. 55(13):2910-9. pJFCAT1 CDKN1A CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 Add to Cart
16467p21 promoter Fp21 promoter (Homo sapiens)Mammalian ExpressionTopological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res. 1995 Jul 1. 55(13):2910-9. pJFCAT1 CDKN1A CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 Add to Cart
16468p21 promoter Gp21 promoter (Homo sapiens)Mammalian ExpressionTopological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res. 1995 Jul 1. 55(13):2910-9. pJFCAT1 CDKN1A CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 Add to Cart
16469pCZ45aip53 binding site (Homo sapiens)Yeast ExpressionPAK1, a gene that can regulate p53 activity in yeast. Proc Natl Acad Sci U S A. 1995 Jun 20. 92(13):6062-6. pCZ TP53 BCC7, LFS1, P53, TRP53 Add to Cart
16473pBluescript JTV-1JTV-1 (Homo sapiens)Bacterial ExpressionAnalysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene. Genomics. 1995 Sep 20. 29(2):329-34. pBluescript SK AIMP2 JTV-1, JTV1, P38 Add to Cart
16474pCMV-Neo-Bam EB-1EB-1 (Homo sapiens)Mammalian ExpressionAPC binds to the novel protein EB1. Cancer Res. 1995 Jul 15. 55(14):2972-7. pCMV-Neo-Bam MAPRE1 EB1 Add to Cart
16475pSG5 PMS2-wtPMS2 (Homo sapiens)Mammalian ExpressionA naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype. Mol Cell Biol. 1998 Mar . 18(3):1635-41. pSG5 PMS2 HNPCC4, MLH4, PMS2CL, PMSL2 Add to Cart
16476pSG5 PMS2-134PMS2 1-134 (Homo sapiens)Mammalian ExpressionA naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype. Mol Cell Biol. 1998 Mar . 18(3):1635-41. pSG5 PMS2 HNPCC4, MLH4, PMS2CL, PMSL2 Add to Cart
16477pCRW0.8 p21 (rat)p21 (Rattus norvegicus)Bacterial ExpressionTopological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res. 1995 Jul 1. 55(13):2910-9. pBluescript SK Cdkn1a Cip1, UV96, Waf1 Add to Cart
16478pCMW35 p21 (mouse)p21 (Mus musculus)Bacterial ExpressionTopological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res. 1995 Jul 1. 55(13):2910-9. pBluescript SK Cdkn1a CAP20, CDKI, CIP1, Cdkn1, P21, SDI1, Waf1, mda6, p21Cip1, p21WAF Add to Cart
16479pCEP4 p27p27 (Homo sapiens)Mammalian ExpressionAssignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. Cancer Res. 1995 Mar 15. 55(6):1206-10. pCEP4 CDKN1B CDKN4, KIP1, MEN1B, MEN4, P27KIP1 Add to Cart
16483pCEP4 Smad4Smad4 (Homo sapiens)Mammalian ExpressionMad-related genes in the human. Nat Genet. 1996 Jul . 13(3):347-9. pCEP4 SMAD4 DPC4, JIP, MADH4, MYHRS Add to Cart
16484pCEP4 Smad2Smad2 (Homo sapiens)Mammalian ExpressionMad-related genes in the human. Nat Genet. 1996 Jul . 13(3):347-9. pCEP4 SMAD2 JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 Add to Cart
16485pSAR-MTMammalian ExpressionApoptosis and APC in colorectal tumorigenesis. Proc Natl Acad Sci U S A. 1996 Jul 23. 93(15):7950-4. pSAR-MT Add to Cart
16486pSAR-MT-beta-galbeta-galactosidaseMammalian ExpressionApoptosis and APC in colorectal tumorigenesis. Proc Natl Acad Sci U S A. 1996 Jul 23. 93(15):7950-4. pSAR-MT Add to Cart
16487pSAR-MT-APCAPC (Homo sapiens)Mammalian ExpressionApoptosis and APC in colorectal tumorigenesis. Proc Natl Acad Sci U S A. 1996 Jul 23. 93(15):7950-4. pSAR-MT APC BTPS2, DP2, DP2.5, DP3, GS, PPP1R46 Add to Cart
16488pGST TCF4 DBDTCF4 DNA binding domain (Homo sapiens)Bacterial ExpressionActivation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 1997 Mar 21. 275(5307):1787-90. pGEX-2TK TCF7L2 TCF-4, TCF4 Add to Cart
16489Pig3 PromoterPIG3 promoter (Homo sapiens)Mammalian ExpressionA model for p53-induced apoptosis. Nature. 1997 Sep 18. 389(6648):300-5. pBR322pl-LUC TP53I3 PIG3 Add to Cart
16490Pig3 Delta PromoterPIG3 promoter (Homo sapiens)Mammalian ExpressionA model for p53-induced apoptosis. Nature. 1997 Sep 18. 389(6648):300-5. pBR322pl-LUC TP53I3 PIG3 Add to Cart
16491pET-SMAD4Smad4 (Homo sapiens)Bacterial ExpressionHuman Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell. 1998 Mar . 1(4):611-7. pET-33b SMAD4 DPC4, JIP, MADH4, MYHRS Add to Cart
16492GST-Smad4-MH1Smad4 (Homo sapiens)Bacterial ExpressionHuman Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell. 1998 Mar . 1(4):611-7. pGEX-2TK SMAD4 DPC4, JIP, MADH4, MYHRS Add to Cart
16493GST-Smad3-MH1Smad3 (Homo sapiens)Bacterial ExpressionHuman Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell. 1998 Mar . 1(4):611-7. pGEX-2TK SMAD3 HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 Add to Cart
16494pCEP4 Pig1Pig1 (Homo sapiens)Mammalian ExpressionA model for p53-induced apoptosis. Nature. 1997 Sep 18. 389(6648):300-5. pCEP4 LGALS7 GAL7, LGALS7A Add to Cart
16495SBE4-LucSmad binding elementMammalian Expression, LuciferaseHuman Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell. 1998 Mar . 1(4):611-7. Luciferase reporter containing four copies of the Smad binding site pBV-Luc Add to Cart
16496pBK-CMV Pig3Pig3 (Homo sapiens)Mammalian ExpressionA model for p53-induced apoptosis. Nature. 1997 Sep 18. 389(6648):300-5. pBK-CMV TP53I3 PIG3 Add to Cart
16498pCEP4 Pig4Pig4 (Homo sapiens)Mammalian ExpressionA model for p53-induced apoptosis. Nature. 1997 Sep 18. 389(6648):300-5. pCEP4 SAA1 PIG4, SAA, SAA2, TP53I4 Add to Cart
16499pCRII Pig5Pig5 (Homo sapiens)Bacterial ExpressionA model for p53-induced apoptosis. Nature. 1997 Sep 18. 389(6648):300-5. pCRII ANO9 PIG5, TP53I5, TMEM16J Add to Cart
16500SBE2-LucSmad binding elementMammalian Expression, LuciferaseHuman Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell. 1998 Mar . 1(4):611-7. pGL3 Add to Cart
16501Vg4-LucMad-binding element from VgMammalian Expression, LuciferaseHuman Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell. 1998 Mar . 1(4):611-7. pGL3 Add to Cart
16503pCRII Pig9Pig9 (Homo sapiens)Bacterial ExpressionA model for p53-induced apoptosis. Nature. 1997 Sep 18. 389(6648):300-5. pCRII MAD1L1 MAD1, PIG9, TP53I9, TXBP181 Add to Cart
16504pBK-CMV Pig10Pig10 (Homo sapiens)Mammalian ExpressionA model for p53-induced apoptosis. Nature. 1997 Sep 18. 389(6648):300-5. pBK-CMV ENC1 CCL28, ENC-1, KLHL35, KLHL37, NRPB, PIG10, TP53I10 Add to Cart
16506pBK-CMV Pig12Pig12 (Homo sapiens)Mammalian ExpressionA model for p53-induced apoptosis. Nature. 1997 Sep 18. 389(6648):300-5. pBK-CMV PTGES MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1 Add to Cart
16507pCMV-Neo-Bam APCAPC (Homo sapiens)Mammalian ExpressionActivation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 1997 Mar 21. 275(5307):1787-90. pCMV-Neo-Bam APC BTPS2, DP2, DP2.5, DP3, GS, PPP1R46 Add to Cart
16508pCMV-Neo-Bam APC 1-331APC (Homo sapiens)Mammalian ExpressionActivation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 1997 Mar 21. 275(5307):1787-90. pCMV-Neo-Bam APC BTPS2, DP2, DP2.5, DP3, GS, PPP1R46 Add to Cart
16509pCMV-Neo-Bam APC 1-1309APC (Homo sapiens)Mammalian ExpressionActivation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 1997 Mar 21. 275(5307):1787-90. pCMV-Neo-Bam APC BTPS2, DP2, DP2.5, DP3, GS, PPP1R46 Add to Cart
16510pCMV-Neo-Bam APC 1-1941APC (Homo sapiens)Mammalian ExpressionActivation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 1997 Mar 21. 275(5307):1787-90. pCMV-Neo-Bam APC BTPS2, DP2, DP2.5, DP3, GS, PPP1R46 Add to Cart
16511pCMV-Neo-Bam APC 1-2644APC (Homo sapiens)Mammalian ExpressionActivation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 1997 Mar 21. 275(5307):1787-90. pCMV-Neo-Bam APC BTPS2, DP2, DP2.5, DP3, GS, PPP1R46 Add to Cart
16512pcDNA/Myc TCF4TCF4 (Homo sapiens)Mammalian ExpressionConstitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science. 1997 Mar 21. 275(5307):1784-7. pcDNA? TCF7L2 TCF-4, TCF4 Add to Cart
16513pcDNA/Myc DeltaN TCF4TCF4 (Homo sapiens)Mammalian ExpressionConstitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science. 1997 Mar 21. 275(5307):1784-7. pcDNA? TCF7L2 TCF-4, TCF4 Add to Cart
16514pHR TCF4TCF4 (Homo sapiens)Mammalian ExpressionConstitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science. 1997 Mar 21. 275(5307):1784-7. pHR TCF7L2 TCF-4, TCF4 Add to Cart
16515BDS-2 3x WT (p53 binding site)p53 binding site (Homo sapiens)Mammalian Expression14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell. 1997 Dec . 1(1):3-11. pBV-Luc SFN YWHAS Add to Cart
16516BDS-2 3x MUT (p53 binding site)p53 binding site (Homo sapiens)Mammalian Expression14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell. 1997 Dec . 1(1):3-11. pBV-Luc SFN YWHAS Add to Cart
16517pBR322 14-3-3 Promoter14-3-3 promoter (Homo sapiens)Bacterial Expression14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell. 1997 Dec . 1(1):3-11. pBR322 SFN YWHAS Add to Cart
16518pCI-neo beta catenin WTbeta catenin (Homo sapiens)Mammalian ExpressionActivation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 1997 Mar 21. 275(5307):1787-90. pCI-neo CTNNB1 CTNNB, MRD19, armadillo Add to Cart
16519pCI-neo beta catenin S33Ybeta catenin (Homo sapiens)Mammalian ExpressionActivation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 1997 Mar 21. 275(5307):1787-90. pCI-neo CTNNB1 CTNNB, MRD19, armadillo Add to Cart
16520pCI-neo beta catenin delta45beta catenin (Homo sapiens)Mammalian ExpressionActivation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 1997 Mar 21. 275(5307):1787-90. pCI-neo CTNNB1 CTNNB, MRD19, armadillo Add to Cart
16521CMV-Fast-1 wild-typeFAST-1 (Homo sapiens)Mammalian ExpressionCharacterization of human FAST-1, a TGF beta and activin signal transducer. Mol Cell. 1998 Jul . 2(1):121-7. pCI-Neo FOXH1 FAST-1, FAST1 Add to Cart
16522CMV-Fast-1 H83RFAST-1 H83R (Homo sapiens)Mammalian ExpressionCharacterization of human FAST-1, a TGF beta and activin signal transducer. Mol Cell. 1998 Jul . 2(1):121-7. pCI-Neo FOXH1 FAST-1, FAST1 Add to Cart
16523GST-FAST-FLFAST-1 (Homo sapiens)Bacterial ExpressionCharacterization of human FAST-1, a TGF beta and activin signal transducer. Mol Cell. 1998 Jul . 2(1):121-7. pGEX-2TK FOXH1 FAST-1, FAST1 Add to Cart
16524GST-FAST-FHFAST-1 (FH domain) (Homo sapiens)Bacterial ExpressionCharacterization of human FAST-1, a TGF beta and activin signal transducer. Mol Cell. 1998 Jul . 2(1):121-7. pGEX-2TK FOXH1 FAST-1, FAST1 Add to Cart
16525FBE/SBE-LucFBE/SBEMammalian Expression, LuciferaseCharacterization of human FAST-1, a TGF beta and activin signal transducer. Mol Cell. 1998 Jul . 2(1):121-7. pBV-Luc Add to Cart
16526FBE-LucFAST-1 binding elementMammalian Expression, LuciferaseCharacterization of human FAST-1, a TGF beta and activin signal transducer. Mol Cell. 1998 Jul . 2(1):121-7. pBV-Luc FOXH1 FAST-1, FAST1 Add to Cart
16527SBE-LucSmad binding elementMammalian Expression, LuciferaseCharacterization of human FAST-1, a TGF beta and activin signal transducer. Mol Cell. 1998 Jul . 2(1):121-7. pBV-Luc Add to Cart
16529pAdTrack-PPARdeltaPPAR delta (Homo sapiens)Mammalian Expression, AdenoviralPPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999 Oct 29. 99(3):335-45. pAdTrack-CMV PPARD FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB Add to Cart
16532mNP-Luc (PPARdelta promoter)PPAR delta promoter NP (Homo sapiens)Mammalian Expression, LuciferasePPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999 Oct 29. 99(3):335-45. pBV-Luc PPARD FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB Add to Cart
16533p4xACO-Luc4xACOMammalian Expression, LuciferasePPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999 Oct 29. 99(3):335-45. pBV-Luc Add to Cart
16534p4xDRE-Luc4xDREMammalian Expression, LuciferasePPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999 Oct 29. 99(3):335-45. pBV-Luc Add to Cart
16535p4xTRE1-Luc4xTRE1Mammalian Expression, LuciferasePPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999 Oct 29. 99(3):335-45. pBV-Luc Add to Cart
16536p4xTRE2-Luc4xTRE2Mammalian Expression, LuciferasePPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999 Oct 29. 99(3):335-45. pBV-Luc Add to Cart
16538p4xmTRE2-Luc4xmTRE2Mammalian Expression, LuciferasePPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999 Oct 29. 99(3):335-45. pBV-Luc Add to Cart
16539pBV-LucMammalian Expression, LuciferasePPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999 Oct 29. 99(3):335-45. luciferase reporter plasmid with very low basal activity pBV-Luc Add to Cart
16541tTA-IRES-NeotTAMammalian ExpressionIdentification and classification of p53-regulated genes. Proc Natl Acad Sci U S A. 1999 Dec 7. 96(25):14517-22. pMk10-59 Add to Cart
16542pBI-MCS-EGFPMammalian ExpressionIdentification and classification of p53-regulated genes. Proc Natl Acad Sci U S A. 1999 Dec 7. 96(25):14517-22. pBI-MCS-EGFP Add to Cart
16543pBI-p53 wt/EGFPp53 (Homo sapiens)Mammalian ExpressionIdentification and classification of p53-regulated genes. Proc Natl Acad Sci U S A. 1999 Dec 7. 96(25):14517-22. pBI-MCS-EGFP TP53 BCC7, LFS1, P53, TRP53 Add to Cart
16544pBI-p53 R175H/EGFPp53 (Homo sapiens)Mammalian ExpressionIdentification and classification of p53-regulated genes. Proc Natl Acad Sci U S A. 1999 Dec 7. 96(25):14517-22. pBI-MCS-EGFP TP53 BCC7, LFS1, P53, TRP53 Add to Cart
16545pBI-p73 wt/EGFPp73 (Homo sapiens)Mammalian ExpressionIdentification and classification of p53-regulated genes. Proc Natl Acad Sci U S A. 1999 Dec 7. 96(25):14517-22. pBI-MCS-EGFP TP73 P73 Add to Cart
16547pGST-RXRalphaRXR alpha (Homo sapiens)Bacterial ExpressionPPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999 Oct 29. 99(3):335-45. pGEX-2TK RXRA NR2B1 Add to Cart
16548pGST-PPARdeltaPPAR delta (Homo sapiens)Bacterial ExpressionPPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999 Oct 29. 99(3):335-45. pGEX-2TK PPARD FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB Add to Cart
16549pGST-PPARgammaPPAR gamma (Homo sapiens)Bacterial ExpressionPPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999 Oct 29. 99(3):335-45. pGEX-2TK PPARG CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma Add to Cart
16550pGST-PPARalphaPPAR alpha (Homo sapiens)Bacterial ExpressionPPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 1999 Oct 29. 99(3):335-45. pGEX-2TK PPARA NR1C1, PPAR, PPARalpha, hPPAR Add to Cart
1655114-3-3 KO vector14-3-3 knockout (Homo sapiens)Bacterial Expression14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature. 1999 Oct 7. 401(6753):616-20. pBluescript SFN YWHAS Add to Cart
16552pHRCMV 14-3-3 sigma14-3-3 sigma (Homo sapiens)Mammalian Expression, Adenoviral14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell. 1997 Dec . 1(1):3-11. pHRCMV SFN YWHAS Add to Cart
16553CMV-CDX2-WTCDX2 (Homo sapiens)Mammalian Expression, AdenoviralCDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. Oncogene. 1999 Sep 2. 18(35):5010-4. pHRCMV CDX2 CDX-3, CDX2/AS, CDX3 Add to Cart
16554CMV-CDX2-MUTCDX2 (Homo sapiens)Mammalian Expression, AdenoviralCDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. Oncogene. 1999 Sep 2. 18(35):5010-4. pHRCMV CDX2 CDX-3, CDX2/AS, CDX3 Add to Cart
16556deltaMyc-HAc-MYC (Homo sapiens)Mammalian ExpressionIdentification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A. 2000 Feb 29. 97(5):2229-34. n/a MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16557MadMyc-HAMADMYC (Homo sapiens)Mammalian ExpressionIdentification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A. 2000 Feb 29. 97(5):2229-34. n/a MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16558pGL3-OT (wt TCF-4 sites)TCF-4 binding sites (Homo sapiens)Mammalian Expression, LuciferaseThe beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression. Cancer Res. 2000 Mar 15. 60(6):1671-6. pGL3-Basic Add to Cart
16559pGL3-OF (mutant TCF-4 sites)TCF-4 binding sites (Homo sapiens)Mammalian Expression, LuciferaseThe beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression. Cancer Res. 2000 Mar 15. 60(6):1671-6. pGL3-Basic Add to Cart
16560pGEX TEM-1TEM1 (Homo sapiens)Bacterial ExpressionCell surface tumor endothelial markers are conserved in mice and humans. Cancer Res. 2001 Sep 15. 61(18):6649-55. pGEX-2TK CD248 CD164L1, TEM1 Add to Cart
16562pIVEX2.3 TEM-7TEM7 (Homo sapiens)Bacterial ExpressionCell surface tumor endothelial markers are conserved in mice and humans. Cancer Res. 2001 Sep 15. 61(18):6649-55. pIVEX2.3-MCS Add to Cart
16563pIVEX2.3 TEM-8TEM8 (Homo sapiens)Bacterial ExpressionCell surface tumor endothelial markers are conserved in mice and humans. Cancer Res. 2001 Sep 15. 61(18):6649-55. pIVEX2.3-MCS Add to Cart
16564pBV-Luc wt MBS1-4c-MYC binding sites (Homo sapiens)Mammalian Expression, LuciferaseIdentification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A. 2000 Feb 29. 97(5):2229-34. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16565pBV-Luc mut MBS1-4c-MYC binding sites (Homo sapiens)Mammalian Expression, LuciferaseIdentification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A. 2000 Feb 29. 97(5):2229-34. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16566pBV-Luc mut MBS1c-MYC binding sites (Homo sapiens)Mammalian Expression, LuciferaseIdentification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A. 2000 Feb 29. 97(5):2229-34. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16567pBV-Luc mut MBS2c-MYC binding sites (Homo sapiens)Mammalian Expression, LuciferaseIdentification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A. 2000 Feb 29. 97(5):2229-34. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16568pBV-Luc mut MBS1-3c-MYC binding sites (Homo sapiens)Mammalian Expression, LuciferaseIdentification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A. 2000 Feb 29. 97(5):2229-34. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16569pBV-Luc mut MBS3+4c-MYC binding sites (Homo sapiens)Mammalian Expression, LuciferaseIdentification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A. 2000 Feb 29. 97(5):2229-34. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16570pBV-Luc mut MBS4c-MYC binding sites (Homo sapiens)Mammalian Expression, LuciferaseIdentification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A. 2000 Feb 29. 97(5):2229-34. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16571pBR322 hCDK4 promoterCDK4 promoter (Homo sapiens)Bacterial ExpressionIdentification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A. 2000 Feb 29. 97(5):2229-34. pBR322 CDK4 CMM3, PSK-J3 Add to Cart
16572pBR322 mCDK4 promoterCDK4 promoter (Mus musculus)Bacterial ExpressionIdentification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A. 2000 Feb 29. 97(5):2229-34. pBR322 Cdk4 Crk3 Add to Cart
16573G1BgSVNA-CDK4CDK4 (Homo sapiens)Mammalian Expression, RetroviralIdentification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A. 2000 Feb 29. 97(5):2229-34. G1BgSVNA CDK4 CMM3, PSK-J3 Add to Cart
16574pCI-neo-hCGBeta-hCG (Homo sapiens)Mammalian ExpressionAssessing tumors in living animals through measurement of urinary beta-human chorionic gonadotropin. Nat Med. 2000 Jun . 6(6):711-4. pCI-neo CGB3 CGB, CGB5, CGB7, CGB8, hCGB Add to Cart
16575BAX KO vectorBAX knockout (Homo sapiens)Bacterial ExpressionRole of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3. 290(5493):989-92. pBluescript II SK BAX BCL2L4 Add to Cart
16576Ad-CBR (GFP/cAPC)cAPC (Homo sapiens)Mammalian Expression, AdenoviralThe beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression. Cancer Res. 2000 Mar 15. 60(6):1671-6. pShuttle / pAdTrack ? APC BTPS2, DP2, DP2.5, DP3, GS, PPP1R46 Add to Cart
16581pFredAMammalian ExpressionSecurin is required for chromosomal stability in human cells. Cell. 2001 May 18. 105(4):445-57. pFredA Add to Cart
16582pFredBMammalian ExpressionSecurin is required for chromosomal stability in human cells. Cell. 2001 May 18. 105(4):445-57. pFredB Add to Cart
16584pFredA-PTTG1PTTG1 (Homo sapiens)Mammalian ExpressionSecurin is required for chromosomal stability in human cells. Cell. 2001 May 18. 105(4):445-57. pFredA PTTG1 EAP1, HPTTG, PTTG, TUTR1 Add to Cart
16585pFredB-PTTG1PTTG1 (Homo sapiens)Mammalian ExpressionSecurin is required for chromosomal stability in human cells. Cell. 2001 May 18. 105(4):445-57. pFredB PTTG1 EAP1, HPTTG, PTTG, TUTR1 Add to Cart
16586pHAHAMammalian ExpressionPUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001 Mar . 7(3):673-82. pCEP4 Add to Cart
16587pCEP4-HA-BAXBAX alpha (Homo sapiens)Mammalian ExpressionPUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001 Mar . 7(3):673-82. pCEP4 BAX BCL2L4 Add to Cart
16588pHA-PUMAPUMA (Homo sapiens)Mammalian ExpressionPUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001 Mar . 7(3):673-82. pCEP4 BBC3 JFY-1, JFY1, PUMA Add to Cart
16589pHA-PUMA DeltaBH3PUMA (Homo sapiens)Mammalian ExpressionPUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001 Mar . 7(3):673-82. pCEP4 BBC3 JFY-1, JFY1, PUMA Add to Cart
16590pBI-EGFP-PUMAPUMA (Homo sapiens)Mammalian ExpressionPUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001 Mar . 7(3):673-82. pBI-MCS-EGFP BBC3 JFY-1, JFY1, PUMA Add to Cart
16591PUMA Frag1-LucPUMA promotor fragment (Homo sapiens)Mammalian Expression, LuciferasePUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001 Mar . 7(3):673-82. pBV-Luc BBC3 JFY-1, JFY1, PUMA Add to Cart
16592PUMA Frag2-LucPUMA promotor fragment (Homo sapiens)Mammalian Expression, LuciferasePUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001 Mar . 7(3):673-82. pBV-Luc BBC3 JFY-1, JFY1, PUMA Add to Cart
165934XBS2WT-Lucp53 binding sites (Homo sapiens)Mammalian Expression, LuciferasePUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001 Mar . 7(3):673-82. pBV-Luc Add to Cart
16595c-myc promoter (TBE 1/2 - wt)c-myc promoter (TBE 1/2 wt) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16596c-myc promoter (TBE 1m/2m - mut)c-myc promoter (TBE 1m/2m mut) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16597c-myc promoter (4x TBE1 - wt)c-myc promoter (4xTBE1 wt) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16598c-myc promoter (4x TBE1 - mut)c-myc promoter (4xTBE1 mut) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16599c-myc promoter (4x TBE2 - wt)c-myc promoter (4xTBE2 wt) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16600c-myc promoter (4x TBE2 - mut)c-myc promoter (4xTBE2 mut) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16601c-myc promoter (Del 1)c-myc promoter (Del 1) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16602c-myc promoter (Del 2)c-myc promoter (Del 2) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16603c-myc promoter (Del 3)c-myc promoter (Del 3) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16604c-myc promoter (Del 4)c-myc promoter (Del 4) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16605c-myc promoter (Frag A)c-myc promoter (Frag A) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16606c-myc promoter (Frag B)c-myc promoter (Frag B) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16607c-myc promoter (Frag C)c-myc promoter (Frag C) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16608c-myc promoter (Frag D)c-myc promoter (Frag D) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16609c-myc promoter (Frag E)c-myc promoter (Frag E) (Homo sapiens)Mammalian Expression, LuciferaseIdentification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4. 281(5382):1509-12. pBV-Luc MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart
16610pTRE-FDXR wtFDXR (Homo sapiens)Mammalian ExpressionFerredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Nat Med. 2001 Oct . 7(10):1111-7. pTRE FDXR ADXR Add to Cart
16611pTRE-FDXR mutFDXR (Homo sapiens)Mammalian ExpressionFerredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Nat Med. 2001 Oct . 7(10):1111-7. pTRE FDXR ADXR Add to Cart
16612pBI-EGFP-MnSODMnSOD (Homo sapiens)Mammalian ExpressionFerredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Nat Med. 2001 Oct . 7(10):1111-7. pBI-EGFP2 SOD2 IPO-B, IPOB, MNSOD, MVCD6, Mn-SOD Add to Cart
16613FDXR KO-1FDXR knockout (Homo sapiens)Bacterial ExpressionFerredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Nat Med. 2001 Oct . 7(10):1111-7. pBluescript II KS FDXR ADXR Add to Cart
16614FDXR KO-2AFDXR knockout (Homo sapiens)Mammalian ExpressionFerredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Nat Med. 2001 Oct . 7(10):1111-7. pFredA FDXR ADXR Add to Cart
16616IRES-puro-GFPGFPMammalian ExpressionUse of isogenic human cancer cells for high-throughput screening and drug discovery. Nat Biotechnol. 2001 Oct . 19(10):940-5. pIRESpuro2 Add to Cart
16618pCEP4-PRL-3PRL-3 (Homo sapiens)Mammalian ExpressionA phosphatase associated with metastasis of colorectal cancer. Science. 2001 Nov 9. 294(5545):1343-6. pCEP4 PTP4A3 PRL-3, PRL-R, PRL3 Add to Cart
16619PPARdelta KO vectorPPAR delta (Homo sapiens)Bacterial ExpressionGenetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells. Proc Natl Acad Sci U S A. 2001 Feb 27. 98(5):2598-603. pBluescript II KS PPARD FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB Add to Cart
16622pTBRII / CEP-Zeo / HygroTGF beta type II receptor (Homo sapiens)Mammalian ExpressionTargeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells. Proc Natl Acad Sci U S A. 1998 Mar 3. 95(5):2412-6. pCEP4 TGFBR2 AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII Add to Cart
16623pBI-GFPMammalian ExpressionMutations of mitotic checkpoint genes in human cancers. Nature. 1998 Mar 19. 392(6673):300-3. pBI-GFP Add to Cart
16624pBI-GFP-Bub1-wtBUB1 (Homo sapiens)Mammalian ExpressionMutations of mitotic checkpoint genes in human cancers. Nature. 1998 Mar 19. 392(6673):300-3. pBI-GFP BUB1 BUB1A, BUB1L, hBUB1 Add to Cart
16625pBI-GFP-Bub1-S492YBUB1 S492Y (Homo sapiens)Mammalian ExpressionMutations of mitotic checkpoint genes in human cancers. Nature. 1998 Mar 19. 392(6673):300-3. pBI-GFP BUB1 BUB1A, BUB1L, hBUB1 Add to Cart
16626pBI-GFP-Bub1-deletion mutantBUB1 deletion mutant (Homo sapiens)Mammalian ExpressionMutations of mitotic checkpoint genes in human cancers. Nature. 1998 Mar 19. 392(6673):300-3. pBI-GFP BUB1 BUB1A, BUB1L, hBUB1 Add to Cart
16627pCAR-OF reporterCAR-OFMammalian ExpressionA naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype. Mol Cell Biol. 1998 Mar . 18(3):1635-41. pCEP4 Add to Cart
16628pCAR-IF reporterCAR-IFMammalian ExpressionA naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype. Mol Cell Biol. 1998 Mar . 18(3):1635-41. pCEP4 Add to Cart
16629pCI-Neo-PTPRT (R632X)PTPRT R632X (Homo sapiens)Mammalian ExpressionMutational analysis of the tyrosine phosphatome in colorectal cancers. Science. 2004 May 21. 304(5674):1164-6. pCI-Neo PTPRT RP5-1121H13.2, RPTPrho Add to Cart
16630pCI-Neo-PTPRT (WT)PTPRT (Homo sapiens)Mammalian ExpressionMutational analysis of the tyrosine phosphatome in colorectal cancers. Science. 2004 May 21. 304(5674):1164-6. pCI-Neo PTPRT RP5-1121H13.2, RPTPrho Add to Cart
16639PIK3CA - Exon20 H1047RPIK3CA H1047R (Homo sapiens)Mammalian ExpressionHigh frequency of mutations of the PIK3CA gene in human cancers. Science. 2004 Apr 23. 304(5670):554. pCMV2-Tag 2A PIK3CA CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha Add to Cart
16640PIK3CA - Exon9 E545K (pFastBac)PIK3CA E545K (Homo sapiens)Mammalian Expression ; BaculoviralHigh frequency of mutations of the PIK3CA gene in human cancers. Science. 2004 Apr 23. 304(5670):554. pFastBac HT PIK3CA CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha Add to Cart
16641PIK3CA - Exon20 H1047R (pFastBac)PIK3CA H1047R (Homo sapiens)Mammalian Expression ; BaculoviralHigh frequency of mutations of the PIK3CA gene in human cancers. Science. 2004 Apr 23. 304(5670):554. pFastBac HT PIK3CA CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha Add to Cart
16642PIK3CA - Exon9 E545KPIK3CA E545K (Homo sapiens)Mammalian ExpressionHigh frequency of mutations of the PIK3CA gene in human cancers. Science. 2004 Apr 23. 304(5670):554. pCMV2-Tag 2A PIK3CA CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha Add to Cart
16643PIK3CA-WTPIK3CA (Homo sapiens)Mammalian ExpressionHigh frequency of mutations of the PIK3CA gene in human cancers. Science. 2004 Apr 23. 304(5670):554. pCMV2-Tag 2A PIK3CA CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha Add to Cart
16644PIK3CA-WT (pFastBac)PIK3CA (Homo sapiens)Mammalian Expression ; BaculoviralHigh frequency of mutations of the PIK3CA gene in human cancers. Science. 2004 Apr 23. 304(5670):554. pFastBac HT PIK3CA CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha Add to Cart
16645SMAD4 KO HygSmad4 knock-out construct (Homo sapiens)Bacterial ExpressionDEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities. Proc Natl Acad Sci U S A. 2002 Mar 5. 99(5):2848-53. pBluescript II SK SMAD4 DPC4, JIP, MADH4, MYHRS Add to Cart
16646SMAD4 KO NeoSmad4 knock-out construct (Homo sapiens)Bacterial ExpressionDEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities. Proc Natl Acad Sci U S A. 2002 Mar 5. 99(5):2848-53. pBluescript II SK SMAD4 DPC4, JIP, MADH4, MYHRS Add to Cart
16648DNMT1 KO HygDNMT1 knock-out construct (Homo sapiens)Bacterial ExpressionDNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature. 2002 Apr 4. 416(6880):552-6. pSL301 DNMT1 ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI Add to Cart
16649DNMT1 KO NeoDNMT1 knock-out construct (Homo sapiens)Bacterial ExpressionDNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature. 2002 Apr 4. 416(6880):552-6. pSL301 DNMT1 ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI Add to Cart
16650DNMT3b KO HygDNMT3b knock-out construct (Homo sapiens)Bacterial ExpressionDNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature. 2002 Apr 4. 416(6880):552-6. pSL301 DNMT3B ICF, ICF1, M.HsaIIIB Add to Cart
16651DNMT3b KO NeoDNMT3b knock-out construct (Homo sapiens)Bacterial ExpressionDNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature. 2002 Apr 4. 416(6880):552-6. pSL301 DNMT3B ICF, ICF1, M.HsaIIIB Add to Cart
16652pCMV-Myc CDC4 WT*CDC4 (Homo sapiens)Mammalian ExpressionInactivation of hCDC4 can cause chromosomal instability. Nature. 2004 Mar 4. 428(6978):77-81. pCMV-Myc FBXW7 AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4 Add to Cart
16653pCMV-Myc CDC4 R465CCDC4 R465C (Homo sapiens)Mammalian ExpressionInactivation of hCDC4 can cause chromosomal instability. Nature. 2004 Mar 4. 428(6978):77-81. pCMV-Myc FBXW7 AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4 Add to Cart
16654Cyclin E-pBI-EGFPCyclin E (Homo sapiens)Mammalian ExpressionInactivation of hCDC4 can cause chromosomal instability. Nature. 2004 Mar 4. 428(6978):77-81. pBI-EGFP CCNE1 CCNE, pCCNE1 Add to Cart
16655pCI-neo Flag HAUSPHAUSP (Homo sapiens)Mammalian ExpressionHAUSP is required for p53 destabilization. Cell Cycle. 2004 Jun . 3(6):689-92. pCI-Neo USP7 HAUSP, TEF1 Add to Cart
16656DICER KO vectorDicer knock-out (Homo sapiens)Mammalian Expression ; adeno-associated viralThe colorectal microRNAome. Proc Natl Acad Sci U S A. 2006 Mar 7. 103(10):3687-92. pBluescript DICER1 DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2 Add to Cart
16657LIP-WTLiposomaseBacterial ExpressionA bacterial protein enhances the release and efficacy of liposomal cancer drugs. Science. 2006 Nov 24. 314(5803):1308-11. pCR2.1 / T7-GFP Add to Cart
17539RS314-SNGal1-p53 (Homo sapiens)Yeast ExpressionPAK1, a gene that can regulate p53 activity in yeast. Proc Natl Acad Sci U S A. 1995 Jun 20. 92(13):6062-6. pRS314 TP53 BCC7, LFS1, P53, TRP53 Add to Cart
17541RS314-HGal1-p53 (Homo sapiens)Yeast ExpressionPAK1, a gene that can regulate p53 activity in yeast. Proc Natl Acad Sci U S A. 1995 Jun 20. 92(13):6062-6. pRS314 TP53 BCC7, LFS1, P53, TRP53 Add to Cart
17542RS314Yeast ExpressionPAK1, a gene that can regulate p53 activity in yeast. Proc Natl Acad Sci U S A. 1995 Jun 20. 92(13):6062-6. pRS314 Add to Cart
17743pFastBac1 PIK3R1PIK3R1 (Homo sapiens)Insect ExpressionMutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell. 2005 Jun . 7(6):561-73. pFastBac1 PIK3R1 AGM7, GRB1, IMD36, p85, p85-ALPHA Add to Cart
17744pFastBac1 PIK3R1-NiPIK3R1-Ni (Homo sapiens)Insect ExpressionMutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell. 2005 Jun . 7(6):561-73. pFastBac1 PIK3R1 AGM7, GRB1, IMD36, p85, p85-ALPHA Add to Cart
18654pRS314-MDM2MDM2 (Homo sapiens)Yeast ExpressionOncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature. 1993 Apr 29. 362(6423):857-60. pRS314 w/Gal1 MDM2 ACTFS, HDMX, hdm2 Add to Cart