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David Sabatini Lab Plasmids


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Title Authors Publication
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM Science 2005 Feb 18;307(5712):1098-101.
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM Curr Biol 2004 Jul 27;14(14):1296-302.
Structure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. Ali SM, Sabatini DM J Biol Chem 2005 Apr 4;.
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM Cell 2002 Jul 26;110(2):163-75.
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM Mol Cell 2003 Apr;11(4):895-904.
myc mTOR kinase dead (unpublished)
mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA, Sabatini DM Curr Biol. 2006 Aug 15. ():.
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM Mol Cell. 2007 Mar 23. 25(6):903-15.
Unpublished plasmid (unpublished)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM Science. 2008 Jun 13. 320(5882):1496-501.
DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival. Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM Cell. 2009 May 13. ():.
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS J Biol Chem. 2009 Mar 20. 284(12):8023-32.
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM Cell. 2010 Apr 16. 141(2):290-303.
Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo. Sheen JH, Zoncu R, Kim D, Sabatini DM Cancer Cell. 2011 May 17. 19(5):613-28.
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway. Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM Cell. 2011 Aug 5;146(3):408-20.
pLJM1-Flag (unpublished)
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H-ATPase. Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM Science. 2011 Nov 4;334(6056):678-83.
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, Marto JA, Sabatini DM Science. 2011 Jun 10;332(6035):1317-22.
A unifying model for mTORC1-mediated regulation of mRNA translation. Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, Sabatini DM Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083.
Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1. Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032.
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044.
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM Science. 2013 Jul 26;341(6144):1236566. doi: 10.1126/science.1236566.
Genetic screens in human cells using the CRISPR-Cas9 system. Wang T, Wei JJ, Sabatini DM, Lander ES Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12.
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM Cell. 2014 Aug 28;158(5):1094-109. doi: 10.1016/j.cell.2014.07.032.
Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, Anderson GR, Winter PS, Wang T, Alley HM, Kwong LN, Cooper ZA, Tetzlaff M, Chen PL, Rathmell JC, Flaherty KT, Wargo JA, McDonnell DP, Sabatini DM, Wood KC Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877.
Identification and characterization of essential genes in the human genome. Wang T, Birsoy K, Hughes NW, Krupczak KM, Post Y, Wei JJ, Lander ES, Sabatini DM Science. 2015 Oct 15. pii: aac7041.
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14.
Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness. Katajisto P, Dohla J, Chaffer CL, Pentinmikko N, Marjanovic N, Iqbal S, Zoncu R, Chen W, Weinberg RA, Sabatini DM Science. 2015 Apr 17;348(6232):340-3. doi: 10.1126/science.1260384. Epub 2015 Apr 2.
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3.
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L, Spooner E, Isasa M, Gygi SP, Sabatini DM Cell Rep. 2014 Oct 9;9(1):1-8. doi: 10.1016/j.celrep.2014.09.014. Epub 2014 Sep 25.
pLenti-sgRNA (unpublished)
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7.
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8.
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Birsoy K, Possemato R, Lorbeer FK, Bayraktar EC, Thiru P, Yucel B, Wang T, Chen WW, Clish CB, Sabatini DM Nature. 2014 Apr 3;508(7494):108-12. doi: 10.1038/nature13110. Epub 2014 Mar 16.
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis. Birsoy K, Wang T, Chen WW, Freinkman E, Abu-Remaileh M, Sabatini DM Cell. 2015 Jul 30;162(3):540-51. doi: 10.1016/j.cell.2015.07.016.
Sestrin2 is a leucine sensor for the mTORC1 pathway. Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8.
Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism. Chen WW, Freinkman E, Wang T, Birsoy K, Sabatini DM Cell. 2016 Aug 25;166(5):1324-1337.e11. doi: 10.1016/j.cell.2016.07.040.
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25.
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Chantranupong L, Scaria SM, Saxton RA, Gygi MP, Shen K, Wyant GA, Wang T, Harper JW, Gygi SP, Sabatini DM Cell. 2016 Mar 24;165(1):153-64. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10.
RagA, but not RagB, is essential for embryonic development and adult mice. Efeyan A, Schweitzer LD, Bilate AM, Chang S, Kirak O, Lamming DW, Sabatini DM Dev Cell. 2014 May 12;29(3):321-9. doi: 10.1016/j.devcel.2014.03.017. Epub 2014 Apr 24.
Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells. Chen WW, Birsoy K, Mihaylova MM, Snitkin H, Stasinski I, Yucel B, Bayraktar EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, Sabatini DM Cell Rep. 2014 Apr 10;7(1):27-34. doi: 10.1016/j.celrep.2014.02.046. Epub 2014 Mar 27.
ID Plasmid Gene/Insert Vector Type Publication Hidden Extra Search Info  
1853Rictor_1 shRNARictor (Homo sapiens)Mammalian Expression, Lentiviral, RNAiPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005 Feb 18;307(5712):1098-101. pLKO.1 RICTOR AVO3, PIA, hAVO3 Add to Cart
1854Rictor_2 shRNARictor (Homo sapiens)Mammalian Expression, Lentiviral, RNAiPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005 Feb 18;307(5712):1098-101. pLKO.1 RICTOR AVO3, PIA, hAVO3 Add to Cart
1855mTOR_1 shRNAmTOR (Homo sapiens)Mammalian Expression, Lentiviral, RNAiPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005 Feb 18;307(5712):1098-101. pLKO.1 MTOR FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS Add to Cart
1856mTOR_2 shRNAmTOR (Homo sapiens)Mammalian Expression, Lentiviral, RNAiPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005 Feb 18;307(5712):1098-101. pLKO.1 MTOR FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS Add to Cart
1857Raptor_1 shRNARaptor (Homo sapiens)Mammalian Expression, Lentiviral, RNAiPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005 Feb 18;307(5712):1098-101. pLKO.1 RPTOR KOG1, Mip1 Add to Cart
1858Raptor_2 shRNARaptor (Homo sapiens)Mammalian Expression, Lentiviral, RNAiPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005 Feb 18;307(5712):1098-101. pLKO.1 RPTOR KOG1, Mip1 Add to Cart
1859myc-RaptorRaptor (Homo sapiens)Mammalian ExpressionRictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004 Jul 27;14(14):1296-302. pRK-5 RPTOR KOG1, Mip1 Add to Cart
1860myc-RictorRictor (Homo sapiens)Mammalian ExpressionRictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004 Jul 27;14(14):1296-302. Please see Addgene item #11367 for an updated version of this plasmid. pRK-5 RICTOR AVO3, PIA, hAVO3 Add to Cart
1861myc-mTORmTOR (Rattus norvegicus)Mammalian ExpressionRictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004 Jul 27;14(14):1296-302. pRK5 Mtor Frap1, RAFT1 Add to Cart
1864scramble shRNAscrambleMammalian Expression, Lentiviral, RNAiPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005 Feb 18;307(5712):1098-101. 3rd gen lentiviral negative control vector containing scrambled shRNA pLKO.1 Add to Cart
1865HA-GbLGbL (Homo sapiens)Mammalian ExpressionRictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004 Jul 27;14(14):1296-302. pRK-5 MLST8 GBL, GbetaL, LST8, POP3, WAT1 Add to Cart
8463delta NT delta CT p70S6K1 MSCV purodelta NT delta CT p70 S6K1 (Rattus norvegicus)Mammalian Expression, RetroviralStructure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J Biol Chem 2005 Apr 4;. mscv puro Rps6kb1 Add to Cart
8464F5A deltaCT S6K1 MSCV purof5a delta ctp70 S6K1 (Rattus norvegicus)Mammalian Expression, RetroviralStructure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J Biol Chem 2005 Apr 4;. mscv puro Rps6kb1 Add to Cart
8465deltaCT S6K1 MSCV purodelta ct p70 S6K1 (Rattus norvegicus)Mammalian Expression, RetroviralStructure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J Biol Chem 2005 Apr 4;. mscv puro Rps6kb1 Add to Cart
8466HA GST p85 S6K1 pRK5p85 s6k1 (Rattus norvegicus)Mammalian ExpressionStructure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J Biol Chem 2005 Apr 4;. prk5 Rps6kb1 Add to Cart
8467HA GST F5A deltaCT S6K1 pRK5f5a delta CT p85 s6k1 (Rattus norvegicus)Mammalian ExpressionStructure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J Biol Chem 2005 Apr 4;. prk5 Rps6kb1 Add to Cart
8468HA GST deltaCT S6K1 pRK5delta CT p85 s6k1 (Rattus norvegicus)Mammalian ExpressionStructure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J Biol Chem 2005 Apr 4;. prk5 Rps6kb1 Add to Cart
8470HA Raptor mutant 1Raptor (Homo sapiens)Mammalian ExpressionmTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002 Jul 26;110(2):163-75. prk5 RPTOR KOG1, Mip1 Add to Cart
8471HA Raptor mutant 2Raptor (Homo sapiens)Mammalian ExpressionmTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002 Jul 26;110(2):163-75. prk5 RPTOR KOG1, Mip1 Add to Cart
8473HA Raptor mutant 3Raptor (Homo sapiens)Mammalian ExpressionmTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002 Jul 26;110(2):163-75. prk5 RPTOR KOG1, Mip1 Add to Cart
8474HA Raptor mutant 4Raptor (Homo sapiens)Mammalian ExpressionmTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002 Jul 26;110(2):163-75. prk5 RPTOR KOG1, Mip1 Add to Cart
8475HA Raptor mutant 7Raptor (Homo sapiens)Mammalian ExpressionmTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002 Jul 26;110(2):163-75. prk5 RPTOR KOG1, Mip1 Add to Cart
8476HA Raptor mutant 9Raptor (Homo sapiens)Mammalian ExpressionmTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002 Jul 26;110(2):163-75. prk5 RPTOR KOG1, Mip1 Add to Cart
8477myc GbetaL mutant 1GbetaL (Homo sapiens)Mammalian ExpressionGbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003 Apr;11(4):895-904. prk5 MLST8 GBL, GbetaL, LST8, POP3, WAT1 Add to Cart
8478myc GbetaL mutant 2GbetaL (Homo sapiens)Mammalian ExpressionGbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003 Apr;11(4):895-904. prk5 MLST8 GBL, GbetaL, LST8, POP3, WAT1 Add to Cart
8479myc GbetaL mutant 5GbetaL (Homo sapiens)Mammalian ExpressionGbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003 Apr;11(4):895-904. prk5 MLST8 GBL, GbetaL, LST8, POP3, WAT1 Add to Cart
8480myc GbetaL mutant 6GbetaL (Homo sapiens)Mammalian ExpressionGbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003 Apr;11(4):895-904. prk5 MLST8 GBL, GbetaL, LST8, POP3, WAT1 Add to Cart
8481myc GbetaL mutant 7GbetaL (Homo sapiens)Mammalian ExpressionGbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003 Apr;11(4):895-904. prk5 MLST8 GBL, GbetaL, LST8, POP3, WAT1 Add to Cart
8482myc mTOR kinase deadmTOR (Rattus norvegicus)Mammalian Expression myc mTOR kinase dead (unpublished) prk5 Mtor Frap1, RAFT1 Add to Cart
8513HA RaptorRaptor (Homo sapiens)Mammalian ExpressionmTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002 Jul 26;110(2):163-75. prk5 RPTOR KOG1, Mip1 Add to Cart
11367myc-Rictor correctedRictor (Homo sapiens)Mammalian ExpressionRictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004 Jul 27;14(14):1296-302. Mammalian expression of myc tagged human RICTOR pRK-5 RICTOR AVO3, PIA, hAVO3 Add to Cart
12570pMSCV-TAPMammalian Expression, RetroviralmSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Curr Biol. 2006 Aug 15. ():. pMSCV-TAP Add to Cart
12575pMSCV-TAP mLST8 (aka: GbL)mLST8 (Homo sapiens)Mammalian Expression, RetroviralmSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Curr Biol. 2006 Aug 15. ():. pMSCV-TAP MLST8 GBL, GbetaL, LST8, POP3, WAT1 Add to Cart
12576pMSCV mSin1.1 mycmSin1.1 (Homo sapiens)Mammalian Expression, RetroviralmSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Curr Biol. 2006 Aug 15. ():. pMSCV MAPKAP1 JC310, MIP1, SIN1, SIN1b, SIN1g Add to Cart
12577pMSCV mSin1.2 mycmSin1.2 (Homo sapiens)Mammalian Expression, RetroviralmSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Curr Biol. 2006 Aug 15. ():. pMSCV MAPKAP1 JC310, MIP1, SIN1, SIN1b, SIN1g Add to Cart
12578pMSCV mSin1.4 mycmSin1.4 (Homo sapiens)Mammalian Expression, RetroviralmSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Curr Biol. 2006 Aug 15. ():. pMSCV MAPKAP1 JC310, MIP1, SIN1, SIN1b, SIN1g Add to Cart
12579pMSCV mSin1.5 mycmSin1.5 (Homo sapiens)Mammalian Expression, RetroviralmSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Curr Biol. 2006 Aug 15. ():. pMSCV MAPKAP1 JC310, MIP1, SIN1, SIN1b, SIN1g Add to Cart
12580pMSCV mLST8 myc (aka: GbL-myc)mLST8 (Homo sapiens)Mammalian Expression, RetroviralmSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Curr Biol. 2006 Aug 15. ():. pMSCV MLST8 GBL, GbetaL, LST8, POP3, WAT1 Add to Cart
12581pMSCV tubulin myctubulin (Homo sapiens)Mammalian Expression, RetroviralmSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Curr Biol. 2006 Aug 15. ():. pMSCV TUBG1 CDCBM4, GCP-1, TUBG, TUBGCP1 Add to Cart
12582pMSCV mSin1.1 HAmSin1.1 (Homo sapiens)Mammalian Expression, RetroviralmSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Curr Biol. 2006 Aug 15. ():. pMSCV MAPKAP1 JC310, MIP1, SIN1, SIN1b, SIN1g Add to Cart
12583pMSCV mSin1.2 HAmSin1.2 (Homo sapiens)Mammalian Expression, RetroviralmSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Curr Biol. 2006 Aug 15. ():. pMSCV MAPKAP1 JC310, MIP1, SIN1, SIN1b, SIN1g Add to Cart
12587pMSCV-TAP RaptorRaptor (Homo sapiens)Mammalian Expression, RetroviralmSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Curr Biol. 2006 Aug 15. ():. pMSCV RPTOR KOG1, Mip1 Add to Cart
13483mSin1 shRNA #1mSin1 (Homo sapiens)Mammalian Expression, Lentiviral, RNAimSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Curr Biol. 2006 Aug 15. ():. pLKO.1 MAPKAP1 JC310, MIP1, SIN1, SIN1b, SIN1g Add to Cart
13484mSin1 shRNA #2mSin1 (Homo sapiens)Mammalian Expression, Lentiviral, RNAimSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s. Curr Biol. 2006 Aug 15. ():. pLKO.1 MAPKAP1 JC310, MIP1, SIN1, SIN1b, SIN1g Add to Cart
14950pRK5 Flag PRAS40PRAS40 (Homo sapiens)Mammalian ExpressionPRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell. 2007 Mar 23. 25(6):903-15. Flag-pRK5 AKT1S1 Lobe, PRAS40 Add to Cart
14951pRK5 HA GST Rheb1Rheb1 (Homo sapiens)Mammalian ExpressionPRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell. 2007 Mar 23. 25(6):903-15. HA-GST-pRK5 RHEB RHEB2 Add to Cart
14952pRK5 HA GST rap2arap2a (Homo sapiens)Mammalian ExpressionPRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell. 2007 Mar 23. 25(6):903-15. HA-GST-pRK5 RAP2A K-REV, KREV, RAP2, RbBP-30 Add to Cart
15511HA GST PreScission p70 S6K1p70 S6K1 (Rattus norvegicus)Mammalian ExpressionPRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell. 2007 Mar 23. 25(6):903-15. HA-GST-pRK5 Rps6kb1 Add to Cart
17923pMT-puroInsect Expression ; Drosophila metallothionein gene promoter drives expression Unpublished plasmid (unpublished) Insect expression vector pMT-puro Add to Cart
19298pRK5-HA GST RagA wtRas-related GTP binding A (Homo sapiens)Mammalian ExpressionThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pRK5 RRAGA FIP-1, FIP1, RAGA Add to Cart
19299pRK5-HA GST RagA 21LRas-related GTP binding A (Homo sapiens)Mammalian ExpressionThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pRK5 RRAGA FIP-1, FIP1, RAGA Add to Cart
19300pRK5-HA GST RagA 66LRas-related GTP binding A (Homo sapiens)Mammalian ExpressionThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pRK5 RRAGA FIP-1, FIP1, RAGA Add to Cart
19301pRK5-HA GST RagB wtRas-related GTP binding B (Homo sapiens)Mammalian ExpressionThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pRK5 RRAGB RAGB, bA465E19.1 Add to Cart
19302pRK5-HA GST RagB 54LRas-related GTP binding B (Homo sapiens)Mammalian ExpressionThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pRK5 RRAGB RAGB, bA465E19.1 Add to Cart
19303pRK5-HA GST RagB 99LRas-related GTP binding B (Homo sapiens)Mammalian ExpressionThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pRK5 RRAGB RAGB, bA465E19.1 Add to Cart
19304pRK5-HA GST RagC wtRas-related GTP binding C (Homo sapiens)Mammalian ExpressionThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pRK5 RRAGC GTR2, RAGC, TIB929 Add to Cart
19305pRK5-HA GST RagC 75LRas-related GTP binding C (Homo sapiens)Mammalian ExpressionThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pRK5 RRAGC GTR2, RAGC, TIB929 Add to Cart
19306pRK5-HA GST RagC 120LRas-related GTP binding C (Homo sapiens)Mammalian ExpressionThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pRK5 RRAGC GTR2, RAGC, TIB929 Add to Cart
19307pRK5-HA GST RagD wtRas-related GTP binding D (Homo sapiens)Mammalian ExpressionThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pRK5 RRAGD RAGD, bA11D8.2.1 Add to Cart
19308pRK5-HA GST RagD 77LRas-related GTP binding D (Homo sapiens)Mammalian ExpressionThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pRK5 RRAGD RAGD, bA11D8.2.1 Add to Cart
19309pRK5-HA GST RagD 121LRas-related GTP binding D (Homo sapiens)Mammalian ExpressionThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pRK5 RRAGD RAGD, bA11D8.2.1 Add to Cart
19310pRK5-HA GST Rheb1RHEB Ras homolog enriched in brain (Homo sapiens)Mammalian ExpressionThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pRK5 RHEB RHEB2 Add to Cart
19311Flag pLJM1 Rap2ARAP2A, member of RAS oncogene family (Homo sapiens)Mammalian Expression, LentiviralThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLJM1 RAP2A K-REV, KREV, RAP2, RbBP-30 Add to Cart
19312Flag pLJM1 Rheb1RHEB Ras homolog enriched in brain (Homo sapiens)Mammalian Expression, LentiviralThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLJM1 RHEB RHEB2 Add to Cart
19313Flag pLJM1 RagB wtRas-related GTP binding B (Homo sapiens)Mammalian Expression, LentiviralThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLJM1 RRAGB RAGB, bA465E19.1 Add to Cart
19314Flag pLJM1 RagB 54LRas-related GTP binding B (Homo sapiens)Mammalian Expression, LentiviralThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLJM1 RRAGB RAGB, bA465E19.1 Add to Cart
19315Flag pLJM1 RagB 99LRas-related GTP binding B (Homo sapiens)Mammalian Expression, LentiviralThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLJM1 RRAGB RAGB, bA465E19.1 Add to Cart
19316Flag pLJM1 RagD wtRas-related GTP binding D (Homo sapiens)Mammalian Expression, LentiviralThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLJM1 RRAGD RAGD, bA11D8.2.1 Add to Cart
19317Flag pLJM1 RagD 77LRas-related GTP binding D (Homo sapiens)Mammalian Expression, LentiviralThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLJM1 RRAGD RAGD, bA11D8.2.1 Add to Cart
19318Flag pLJM1 RagD 121LRas-related GTP binding D (Homo sapiens)Mammalian Expression, LentiviralThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLJM1 RRAGD RAGD, bA11D8.2.1 Add to Cart
19319pLJM1-EGFPnoneMammalian Expression, LentiviralThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. 3rd gen lentiviral vector for EGFP fusion; PGK driven puromycin pLJM1
  • Tag / Fusion Protein
    • EGFP
  • Add to Cart
    21334pRK5 FLAG human DEPTORDEPTOR (Homo sapiens)Mammalian ExpressionDEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival. Cell. 2009 May 13. ():. pRK5-FLAG DEPTOR DEP.6, DEPDC6 Add to Cart
    21335pLKO human shRNA 1 DEPTORDEPTOR shRNA 1 (Homo sapiens)Mammalian Expression, Lentiviral, RNAiDEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival. Cell. 2009 May 13. ():. pLKO.1 DEPTOR DEP.6, DEPDC6 Add to Cart
    21336pLKO human shRNA 2 DEPTORDEPTOR shRNA 2 (Homo sapiens)Mammalian Expression, Lentiviral, RNAiDEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival. Cell. 2009 May 13. ():. pLKO.1 DEPTOR DEP.6, DEPDC6 Add to Cart
    21337pLKO mouse shRNA 1 DEPTORDEPTOR shRNA 1 (Mus musculus)Mammalian Expression, Lentiviral, RNAiDEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival. Cell. 2009 May 13. ():. pLKO.1 Deptor 4731402B04Rik, 9130412E02Rik, D15Ertd336e, D15Ertd597e, Depdc6, Depdc6-001, Depdc6-002, R75183, mKIAA4200 Add to Cart
    21338pLKO mouse shRNA 2 DEPTORDEPTOR shRNA 2 (Mus musculus)Mammalian Expression, Lentiviral, RNAiDEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival. Cell. 2009 May 13. ():. pLKO.1 Deptor 4731402B04Rik, 9130412E02Rik, D15Ertd336e, D15Ertd597e, Depdc6, Depdc6-001, Depdc6-002, R75183, mKIAA4200 Add to Cart
    21339pLKO mouse shRNA 1 raptorraptor shRNA 1 (Mus musculus)Mammalian Expression, Lentiviral, RNAiAn ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem. 2009 Mar 20. 284(12):8023-32. pLKO.1 Rptor 4932417H02Rik, Rap, Raptor, mKIAA1303 Add to Cart
    21340pLKO mouse shRNA 2 raptorraptor shRNA 2 (Mus musculus)Mammalian Expression, Lentiviral, RNAiDEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival. Cell. 2009 May 13. ():. pLKO.1 Rptor 4932417H02Rik, Rap, Raptor, mKIAA1303 Add to Cart
    21341pLKO mouse shRNA 1 rictorrictor shRNA 1 (Mus musculus)Mammalian Expression, Lentiviral, RNAiAn ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem. 2009 Mar 20. 284(12):8023-32. pLKO.1 Rictor 4921505C17Rik, 6030405M08Rik, AVO3, AW492497, D530039E11Rik Add to Cart
    21700pRK5 FLAG DEPTOR (DEP domains)DEPTOR DEP domains (Homo sapiens)Mammalian ExpressionDEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival. Cell. 2009 May 13. ():. pRK5-FLAG DEPTOR DEP.6, DEPDC6 Add to Cart
    21701pRK5 FLAG DEPTOR (PDZ domain)DEPTOR PDZ domain (Homo sapiens)Mammalian ExpressionDEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival. Cell. 2009 May 13. ():. pRK5-FLAG DEPTOR DEP.6, DEPDC6 Add to Cart
    21702pRK5 FLAG DEPTOR (13×S/T->A)DEPTOR 13xA (Homo sapiens)Mammalian ExpressionDEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival. Cell. 2009 May 13. ():. pRK5-FLAG DEPTOR DEP.6, DEPDC6 Add to Cart
    21745myc-mTOR (1-1482 aa)mTOR (1-1482) (Rattus norvegicus)Mammalian ExpressionGbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003 Apr;11(4):895-904. pRK5 Mtor Frap1, RAFT1 Add to Cart
    21746myc-mTOR (1271-2008 aa)mTOR (1271-2008) (Rattus norvegicus)Mammalian ExpressionGbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003 Apr;11(4):895-904. pRK5 Mtor Frap1, RAFT1 Add to Cart
    21747myc-mTOR (1750-2549 aa)mTOR (1750-2549) (Rattus norvegicus)Mammalian ExpressionGbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003 Apr;11(4):895-904. pRK5 Mtor Frap1, RAFT1 Add to Cart
    26625pLKO.1 Rheb1 shRNA #1Rheb1 shRNA (Homo sapiens)Mammalian Expression, Lentiviral, RNAiThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLKO.1 puro RHEB RHEB2 Add to Cart
    26626pLKO.1 Rheb1 shRNA #2Rheb1 shRNA (Homo sapiens)Mammalian Expression, Lentiviral, RNAiThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLKO.1 puro RHEB RHEB2 Add to Cart
    26627pLKO.1 RagB shRNA #1RagB shRNA (Homo sapiens)Mammalian Expression, Lentiviral, RNAiThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLKO.1 puro RRAGB RAGB, bA465E19.1 Add to Cart
    26628pLKO.1 RagB shRNA #2RagB shRNA (Homo sapiens)Mammalian Expression, Lentiviral, RNAiThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLKO.1 puro RRAGB RAGB, bA465E19.1 Add to Cart
    26629pLKO.1 RagC shRNA #1RagC shRNA (Homo sapiens)Mammalian Expression, Lentiviral, RNAiThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLKO.1 puro RRAGC GTR2, RAGC, TIB929 Add to Cart
    26630pLKO.1 RagC shRNA #2RagC shRNA (Homo sapiens)Mammalian Expression, Lentiviral, RNAiThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLKO.1 puro RRAGC GTR2, RAGC, TIB929 Add to Cart
    26631pLKO.1 p18 shRNAp18 shRNA (Homo sapiens)Mammalian Expression, Lentiviral, RNAiRagulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010 Apr 16. 141(2):290-303. pLKO.1 puro LAMTOR1 C11orf59, PDRO, Ragulator1, p18, p27RF-Rho Add to Cart
    26632pLKO.1 MP1 shRNAMP1 shRNA (Homo sapiens)Mammalian Expression, Lentiviral, RNAiRagulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010 Apr 16. 141(2):290-303. pLKO.1 puro LAMTOR3 MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3 Add to Cart
    26633pLJM1 Flag Raptorraptor (Homo sapiens)Mammalian Expression, LentiviralRagulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010 Apr 16. 141(2):290-303. pLJM1 RPTOR KOG1, Mip1 Add to Cart
    26634pLJM1 Flag Raptor Rheb15raptor-Rheb15 (Homo sapiens)Mammalian Expression, LentiviralRagulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010 Apr 16. 141(2):290-303. pLJM1 RPTOR KOG1, Mip1 Add to Cart
    26637pLJM1 Flag Raptor HRas25raptor-HRas25 (Homo sapiens)Mammalian Expression, LentiviralRagulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010 Apr 16. 141(2):290-303. pLJM1 RPTOR KOG1, Mip1 Add to Cart
    26638pLJM1 p18 mitop18 mito (Homo sapiens)Mammalian Expression, LentiviralRagulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010 Apr 16. 141(2):290-303. pLJM1 LAMTOR1 C11orf59, PDRO, Ragulator1, p18, p27RF-Rho Add to Cart
    29432pLKO human shRNA 1 c-MAFc-MAF shRNA 1 (Homo sapiens)Mammalian Expression, Lentiviral, RNAiDEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival. Cell. 2009 May 13. ():. pLKO.1 MAF AYGRP, CCA4, CTRCT21, c-MAF Add to Cart
    29433pLKO human shRNA 2 c-MAFc-MAF shRNA 2 (Homo sapiens)Mammalian Expression, Lentiviral, RNAiDEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival. Cell. 2009 May 13. ():. pLKO.1 MAF AYGRP, CCA4, CTRCT21, c-MAF Add to Cart
    30319pLKO.1 RagA shRNA #1RagA shRNA (Homo sapiens)Mammalian Expression, Lentiviral, RNAiThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLKO.1 puro RRAGA FIP-1, FIP1, RAGA Add to Cart
    30320pLKO.1 RagA shRNA #2RagA shRNA (Homo sapiens)Mammalian Expression, Lentiviral, RNAiThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLKO.1 puro RRAGA FIP-1, FIP1, RAGA Add to Cart
    30321pLKO.1 RagD shRNA #1RagD shRNA (Homo sapiens)Mammalian Expression, Lentiviral, RNAiThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLKO.1 puro RRAGD RAGD, bA11D8.2.1 Add to Cart
    30322pLKO.1 RagD shRNA #2RagD shRNA (Homo sapiens)Mammalian Expression, Lentiviral, RNAiThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLKO.1 puro RRAGD RAGD, bA11D8.2.1 Add to Cart
    30323pLKO.1 GFP shRNAGFP shRNAMammalian Expression, Lentiviral, RNAiThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13. 320(5882):1496-501. pLKO.1 puro Add to Cart
    31182pQCXI Puro DsRed-LC3-GFPDsRed-LC3-GFPMammalian Expression, RetroviralDefective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo. Cancer Cell. 2011 May 17. 19(5):613-28. pQCXIP Add to Cart
    31183pQCXI Neo DsRed-LC3-GFPDsRed-LC3-GFPMammalian Expression, RetroviralDefective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo. Cancer Cell. 2011 May 17. 19(5):613-28. pQCXIN Add to Cart
    32004pRK5 FLAG metap2metap2Mammalian ExpressionmTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway. Cell. 2011 Aug 5;146(3):408-20. pRK5 Metap2 4930584B20Rik, A930035J23Rik, AI047573, AL024412, AU014659, Amp2, MGC102452, Mnpep, p67, p67eIF2 Add to Cart
    32005pRK5 FLAG wildtype, catalytic active lipin 1lipin1 (Mus musculus)Mammalian ExpressionmTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway. Cell. 2011 Aug 5;146(3):408-20. pRK5
  • Tag / Fusion Protein
    • FLAG (N terminal on backbone)
  • Lpin1 4631420P06, Kiaa0188, Lipin1, fld, mKIAA0188
    Add to Cart
    32006pRK5 FLAG wildtype, catalytic dead lipin 1Lipin1 (Mus musculus)Mammalian ExpressionmTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway. Cell. 2011 Aug 5;146(3):408-20. pRK5 Lpin1 4631420P06, Kiaa0188, Lipin1, fld, mKIAA0188 Add to Cart
    32007pRK5 FLAG 17xS/T->A, catalytic active lipin 1lipin1 (Mus musculus)Mammalian ExpressionmTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway. Cell. 2011 Aug 5;146(3):408-20. pRK5
  • Tag / Fusion Protein
    • FLAG (N terminal on backbone)
  • Lpin1 4631420P06, Kiaa0188, Lipin1, fld, mKIAA0188
    Add to Cart
    32008pRK5 FLAG 17xS/T->A, catalytic dead lipin 1Lipin1 (Mus musculus)Mammalian ExpressionmTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway. Cell. 2011 Aug 5;146(3):408-20. pRK5
  • Tag / Fusion Protein
    • FLAG (N terminal on backbone)
  • Lpin1 4631420P06, Kiaa0188, Lipin1, fld, mKIAA0188
    Add to Cart
    32010pLKO-puro FLAG wildtype, catalytic active lipin 1lipin1 (Mus musculus)Mammalian Expression, LentiviralmTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway. Cell. 2011 Aug 5;146(3):408-20. pLKO.1-puro
  • Tag / Fusion Protein
    • FLAG (N terminal on backbone)
  • Lpin1 4631420P06, Kiaa0188, Lipin1, fld, mKIAA0188
    Add to Cart
    32017pLKO-puro FLAG SREBP1SREBP1 (Mus musculus)Mammalian Expression, LentiviralmTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway. Cell. 2011 Aug 5;146(3):408-20. pLKO.1-puro Srebf1 ADD1, SREBP-1a, SREBP1, SREBP1c, bHLHd1 Add to Cart
    32018pLKO-puro FLAG SREBP2SREBP2 (Mus musculus)Mammalian Expression, LentiviralmTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway. Cell. 2011 Aug 5;146(3):408-20. pLKO.1-puro
  • Tag / Fusion Protein
    • FLAG (N terminal on backbone)
  • Srebf2 AI608257, SREBP-2, SREBP2, SREBP2gc, bHLHd2, lop13, nuc
    Add to Cart
    32019pLKO-puro human lipin 1-1 shRNAlipin1 shRNA (Homo sapiens)Mammalian Expression, Lentiviral, RNAimTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway. Cell. 2011 Aug 5;146(3):408-20. pLKO.1-TRC Add to Cart
    34610pLJM60deptor (Homo sapiens)Mammalian Expression, Lentiviral pLJM1-Flag (unpublished) pLJM1-Flag DEPTOR DEP.6, DEPDC6 Add to Cart
    34611LAMP1-mRFP-FLAGLAMP1 (Rattus norvegicus)Mammalian Expression, LentiviralmTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H-ATPase. Science. 2011 Nov 4;334(6056):678-83. 3rd gen lentiviral vector expressing a fusion protein of Lamp1, mRFP, and a FLAG tag pLJM1 Add to Cart
    37481pRK5 Flag Grb10 wt longGrb10 (Homo sapiens)Mammalian ExpressionThe mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science. 2011 Jun 10;332(6035):1317-22. pRK5-FLAG GRB10 GRB-IR, Grb-10, IRBP, MEG1, RSS Add to Cart
    37484pRK5 Flag Grb10 5A shortGrb10 5A (Homo sapiens)Mammalian ExpressionThe mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science. 2011 Jun 10;332(6035):1317-22. pRK5-FLAG
  • Tag / Fusion Protein
    • Flag (N terminal on backbone)
  • GRB10 GRB-IR, Grb-10, IRBP, MEG1, RSS
    Add to Cart
    37485pRK5 Flag Grb10 9A longGrb10 9A (Homo sapiens)Mammalian ExpressionThe mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science. 2011 Jun 10;332(6035):1317-22. pRK5-FLAG
  • Tag / Fusion Protein
    • Flag (N terminal on backbone)
  • GRB10 GRB-IR, Grb-10, IRBP, MEG1, RSS
    Add to Cart
    38234pIS1-Actb5UTR-renillaActb 5'UTR / Renilla (Mus musculus)Mammalian ExpressionA unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. pIS1 Actb Actx, E430023M04Rik, beta-actin Add to Cart
    38235pIS1-Eef25UTR-renillaEef2 5'UTR / Renilla (Mus musculus)Mammalian Expression, LuciferaseA unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. pIS1 Eef2 Ef-2 Add to Cart
    38236pIS1-Eef25UTR-TOPmut-renillaEef2_TOPm_5UTR/Renilla (Mus musculus)Mammalian Expression, LuciferaseA unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. pIS1 Eef2 Ef-2 Add to Cart
    38237pIS1-Vim5UTR-renillaVim 5'UTR / Renilla (Mus musculus)Mammalian Expression, LuciferaseA unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. pIS1 Vim Add to Cart
    38238pIS1-Vim/Actb5UTR-renillaVim promoter with Actb 5UTR/Renilla (Mus musculus)Mammalian Expression, LuciferaseA unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. pIS1 Vim Actb Actx, E430023M04Rik, beta-actin Add to Cart
    38239pLJM60-eIF4EeIF4E (Rattus norvegicus)Mammalian Expression, LentiviralA unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. pLJM60 Eif4e Add to Cart
    38240pCW57.1-4EBP1_4xAla4EBP1 (Rattus norvegicus)Mammalian Expression, Lentiviral ; Doxycycline inducibleA unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. pCW57.1 Eif4ebp1 PHAS-I Add to Cart
    38241pLJM60-SsbSsb (Homo sapiens)Mammalian Expression, LentiviralA unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. pLJM60 SSB LARP3, La, La/SSB Add to Cart
    38242pLJM60-Auf1AUF1 (Homo sapiens)Mammalian Expression, LentiviralA unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. pLJM60
  • Tag / Fusion Protein
    • FLAG (N terminal on backbone)
  • HNRNPD AUF1, AUF1A, HNRPD, P37, hnRNPD0
    Add to Cart
    38243pLJM60-Tia1Tia1 (Mus musculus)Mammalian Expression, LentiviralA unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. pLJM60
  • Tag / Fusion Protein
    • FLAG (N terminal on backbone)
  • Tia1 2310050N03Rik, AI256674, TIA-1, mTIA-1
    Add to Cart
    38244pLJM60-TiarTiar (Mus musculus)Mammalian Expression, LentiviralA unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. pLJM60
  • Tag / Fusion Protein
    • FLAG (N terminal on backbone)
  • Tial1 5330433G13Rik, AL033329, TIAR, mTIAR
    Add to Cart
    38245pLJM60-PtbPtb (Mus musculus)Mammalian Expression, LentiviralA unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. pLJM60
  • Tag / Fusion Protein
    • FLAG (N terminal on backbone)
  • Add to Cart
    38246pLJM60-CnbpCnbp (Mus musculus)Mammalian Expression, LentiviralA unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083. pLJM60
  • Tag / Fusion Protein
    • FLAG (N terminal on backbone)
  • Cnbp AA408710, Cnbp1, Znf9
    Add to Cart
    42324pRK5-FLAG-RagB-D163NRagB D163N (Homo sapiens)Mammalian ExpressionRagulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. pRK5 RRAGB RAGB, bA465E19.1 Add to Cart
    42325pRK5-FLAG-RagC-D181NRagC D181N (Homo sapiens)Mammalian ExpressionRagulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. pRK5 RRAGC GTR2, RAGC, TIB929 Add to Cart
    42326pRK5-FLAG-HBXIPHBXIP (Homo sapiens)Mammalian ExpressionRagulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. pRK5 LAMTOR5 HBXIP, XIP Add to Cart
    42327pRK5-p18G2A-HAp18 G2A (Homo sapiens)Mammalian ExpressionRagulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. pRK5 LAMTOR1 C11orf59, PDRO, Ragulator1, p18, p27RF-Rho Add to Cart
    42328pRK5-HA-HBXIPHBXIP (Homo sapiens)Mammalian ExpressionRagulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. pRK5
  • Tag / Fusion Protein
    • HA (N terminal on insert)
  • LAMTOR5 HBXIP, XIP
    Add to Cart
    42329pRK5-HA-mp1mp1 (Homo sapiens)Mammalian ExpressionRagulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. pRK5 LAMTOR3 MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3 Add to Cart
    42330pRK5-FLAG-p14p14 (Homo sapiens)Mammalian ExpressionRagulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. pRK5 LAMTOR2 ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, ROBLD3, Ragulator2, p14 Add to Cart
    42331pRK5-p18-FLAGp18 (Homo sapiens)Mammalian ExpressionRagulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. pRK5
  • Tag / Fusion Protein
    • Flag (C terminal on insert)
  • LAMTOR1 C11orf59, PDRO, Ragulator1, p18, p27RF-Rho
    Add to Cart
    42332pRK5-FLAG-C7orf59C7orf59 (Homo sapiens)Mammalian ExpressionRagulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. pRK5 LAMTOR4 C7orf59 Add to Cart
    42334N1-p18-EGFPp18 (Homo sapiens)Mammalian ExpressionRagulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. pEGFP-N1
  • Tag / Fusion Protein
    • EGFP (C terminal on backbone)
  • LAMTOR1 C11orf59, PDRO, Ragulator1, p18, p27RF-Rho
    Add to Cart
    42336pRK5-HA-C7orf59C7orf59 (Homo sapiens)Mammalian ExpressionRagulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. pRK5
  • Tag / Fusion Protein
    • HA (N terminal on insert)
  • LAMTOR4 C7orf59
    Add to Cart
    42338pRK5-p18-HAp18 (Homo sapiens)Mammalian ExpressionRagulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. pRK5
  • Tag / Fusion Protein
    • HA (C terminal on insert)
  • LAMTOR1 C11orf59, PDRO, Ragulator1, p18, p27RF-Rho
    Add to Cart
    46326C terminal Flag Mios pRK5Mios (Homo sapiens)Mammalian ExpressionA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pRK5 MIOS MIO, Sea4 Add to Cart
    46327HA Depdc5 pRK5Depdc5 (Homo sapiens)Mammalian ExpressionA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pRK5 DEPDC5 DEP.5, FFEVF Add to Cart
    46328Cterminal HA WDR59 pRK5WDR59 (Homo sapiens)Mammalian ExpressionA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pRK5 WDR59 FP977 Add to Cart
    46329Cterminal HA Mios pRK5Mios (Homo sapiens)Mammalian ExpressionA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pRK5 MIOS MIO, Sea4 Add to Cart
    46330HA Nprl3 pRK5Nprl3 (Homo sapiens)Mammalian ExpressionA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pRK5 NPRL3 C16orf35, CGTHBA, HS-40, MARE, NPR3, RMD11 Add to Cart
    46331HA Seh1L pRK5Seh1 (Homo sapiens)Mammalian ExpressionA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pRK5 SEH1L SEC13L, SEH1A, SEH1B, Seh1 Add to Cart
    46332HA Sec13 pRK5Sec13 (Homo sapiens)Mammalian ExpressionA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pRK5 SEC13 D3S1231E, SEC13L1, SEC13R, npp-20 Add to Cart
    46333Flag Nprl2 pRK5Nprl2 (Homo sapiens)Mammalian ExpressionA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pRK5 NPRL2 NPR2, NPR2L, TUSC4 Add to Cart
    46334Flag WDR24 pRK5WDR24 (Homo sapiens)Mammalian ExpressionA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pRK5 WDR24 LA16c-313D11.2, C16orf21, JFP7 Add to Cart
    46335HA WDR24 pRK5WDR24 (Homo sapiens)Mammalian ExpressionA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pRK5 WDR24 LA16c-313D11.2, C16orf21, JFP7 Add to Cart
    46336Flag Depdc5 pLJM1Depdc5 (Homo sapiens)Mammalian Expression, LentiviralA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pLJM1 DEPDC5 DEP.5, FFEVF Add to Cart
    46337Flag WDR24 pLJM1WDR24 (Homo sapiens)Mammalian Expression, LentiviralA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pLJM1 WDR24 LA16c-313D11.2, C16orf21, JFP7 Add to Cart
    46338Flag Nprl2 pLJM1Nprl2 (Homo sapiens)Mammalian Expression, LentiviralA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pLJM1 NPRL2 NPR2, NPR2L, TUSC4 Add to Cart
    46340Flag Depdc5 pRK5Depdc5 (Homo sapiens)Mammalian ExpressionA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pRK5 DEPDC5 DEP.5, FFEVF Add to Cart
    46341Flag Leucyl tRNA synthetase pRK5leucyl tRNA synthetase (Homo sapiens)Mammalian ExpressionA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pRK5 LARS HSPC192, ILFS1, LARS1, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS, hr025Cl Add to Cart
    46380eGFP Depdc5 pLJM1Depdc5 (Homo sapiens)Mammalian Expression, LentiviralA Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. pLJM1 DEPDC5 DEP.5, FFEVF Add to Cart
    48799pLJM60 mUlk1 (wt) barcodedULK1 (Mus musculus)Mammalian Expression, LentiviralmTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science. 2013 Jul 26;341(6144):1236566. doi: 10.1126/science.1236566. expresses wt Ulk1 pLJM1 Ulk1 AU041434, Unc51.1, mKIAA0722 Add to Cart
    48800pLJM60-S6K1(T389S) barcodedS6K1 T389S (Rattus norvegicus)Mammalian Expression, LentiviralmTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science. 2013 Jul 26;341(6144):1236566. doi: 10.1126/science.1236566. expresses mutant S6K1 pLJM1 Rps6kb1 Add to Cart
    48801pLJM60-S6K1(wt) barcodedS6K1 (Rattus norvegicus)Mammalian Expression, LentiviralmTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science. 2013 Jul 26;341(6144):1236566. doi: 10.1126/science.1236566. expresses wt S6K1 pLJM1 Rps6kb1 Add to Cart
    48805pRK5 HA-GST-Presc-mAkt1 (wt)Akt1 (Mus musculus)Mammalian ExpressionmTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science. 2013 Jul 26;341(6144):1236566. doi: 10.1126/science.1236566. expresses wt Akt1 pRK5 Akt1 Akt, LTR-akt, PKB, PKB/Akt, PKBalpha, Rac Add to Cart
    48806pRK5 HA-GST-Presc-mAkt1 (S473T)Akt1 (Mus musculus)Mammalian ExpressionmTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science. 2013 Jul 26;341(6144):1236566. doi: 10.1126/science.1236566. expresses mutant Akt1 pRK5 Akt1 Akt, LTR-akt, PKB, PKB/Akt, PKBalpha, Rac Add to Cart
    50661pCW-Cas9humanized S. pyogenes Cas9Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Doxycycline-inducible lentiviral expression of SpCas9 pCW57.1 Add to Cart
    50662pLX-sgRNAsgAAVS1Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Lentiviral expression of AAVS1-targeting sgRNA; insert can be replaced with custom sgRNA (see protocol) pLX304 Add to Cart
    51043Human Lentiviral sgRNA Library - Unknown FunctionsgRNA library (enriched for genes of unknown function) (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Sub-pool of Sabatini/Lander sgRNA library enriched for gene targets of unknown function. pLX-sgRNA Add to Cart
    51044Human Lentiviral sgRNA Library - KinasessgRNA library (enriched for kinase targets) (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Sub-pool of Sabatini/Lander sgRNA library enriched for kinase targets. pLX-sgRNA Add to Cart
    51045Human Lentiviral sgRNA Library - Ribosomal ProteinssgRNA library (enriched for ribosomal targets) (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Sub-pool of Sabatini/Lander sgRNA library enriched for ribosomal gene targets. pLX-sgRNA Add to Cart
    51046Human Lentiviral sgRNA Library - Cell CyclesgRNA library (enriched for cell cycle targets) (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Sub-pool of Sabatini/Lander sgRNA library enriched for cell cycle-related targets. pLX-sgRNA Add to Cart
    51047Human Lentiviral sgRNA Library - NuclearsgRNA library (enriched for nuclear targets) (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Sub-pool of Sabatini/Lander sgRNA library enriched for nuclear targets. pLX-sgRNA Add to Cart
    51048Human Lentiviral sgRNA Library - ControlsgRNA library (enriched for control targets) (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Sub-pool of Sabatini/Lander sgRNA library enriched for control targets. pLX-sgRNA Add to Cart
    61614pLJM5-mDPYDdihydropyrimidine dehydrogenase (Mus musculus)Mammalian ExpressionDihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell. 2014 Aug 28;158(5):1094-109. doi: 10.1016/j.cell.2014.07.032. The mouse Dpyd was used to rescue the human DPYD hairpin affect on EMT pLJM5 Dpyd AI315208, DPD, E330028L06Rik Add to Cart
    61615pLJM5-I560S-mDPYDDihydropyrimidine dehydrogenase (Mus musculus)Mammalian ExpressionDihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell. 2014 Aug 28;158(5):1094-109. doi: 10.1016/j.cell.2014.07.032. The mouse Dpyd was used to rescue the human DPYD hairpin affect on EMT pLJM5 Dpyd AI315208, DPD, E330028L06Rik Add to Cart
    61618DPYS-FLAGdihydropyrimidinase (Homo sapiens)Mammalian ExpressionDihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell. 2014 Aug 28;158(5):1094-109. doi: 10.1016/j.cell.2014.07.032. To study the effect of DPYS activity on EMT pLJC2 DPYS DHP, DHPase Add to Cart
    62511pcw107Mammalian Expression, LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. Gateway Expression Vector pcw107 Add to Cart
    64602Kras (G12V)-pcw107KRAS (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5) KRAS C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, c-Ki-ras2 Add to Cart
    64603Hras (G12V)-pcw107HRAS (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5) HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras Add to Cart
    64604MEK1 (S218D,S222D)-pcw107MAP2K1 (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5) MAP2K1 CFC3, MAPKK1, MEK1, MKK1, PRKMK1 Add to Cart
    64605myr-FLAG-PIK3CA-pcw107PIK3CA (Bos taurus)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tags / Fusion Proteins
    • FLAG (N terminal on insert)
    • myristoylated (N terminal on insert)
  • PIK3CA
    Add to Cart
    64606myr-FLAG-AKT1-pcw107AKT1 (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tags / Fusion Proteins
    • FLAG (N terminal on insert)
    • myristoylated (N terminal on insert)
  • AKT1 AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
    Add to Cart
    64607FLAG-Rheb (Q64L)-pcw107RHEB (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • FLAG (N terminal on insert)
  • RHEB RHEB2
    Add to Cart
    64608IKKalpha (S176E,S180E)-pcw107-V5CHUK (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • CHUK IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
    Add to Cart
    64609FLAG-IKKbeta (S177E,S181E)-pcw107IKBKB (Other)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • FLAG (N terminal on insert)
  • Add to Cart
    64610JAK2 (V617F)-pcw107-V5JAK2 (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • JAK2 JTK10, THCYT3
    Add to Cart
    64611Stat3 (A662C,N664C,V667L)-pcw107-V5STAT3 (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • STAT3 ADMIO, ADMIO1, APRF, HIES
    Add to Cart
    64612beta-catenin (S33A, S37A, T41A, S45A)-pcw107 Ctnnb1 (Mus musculus)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5) Ctnnb1 Bfc, Catnb, Mesc Add to Cart
    64613beta-catenin (S33A, S37A, T41A, S45A)-pcw107-V5Ctnnb1 (Mus musculus)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • Ctnnb1 Bfc, Catnb, Mesc
    Add to Cart
    64614GSK3beta (K85A)-pcw107-V5GSK3B (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • GSK3B
    Add to Cart
    64615beta-catenin (S33Y)-pcw107CTNNB1 (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5) CTNNB1 CTNNB, MRD19, armadillo Add to Cart
    64616beta-catenin (S33Y)-pcw107-V5CTNNB1 (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • CTNNB1 CTNNB, MRD19, armadillo
    Add to Cart
    64617JNK2 WT O/E (MAPK9)-pcw107-V5 MAPK9 (transcript variant JNK2-a2) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • MAPK9 JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK
    Add to Cart
    64618FLAG-Mkk7-JNK2 fusion-pcw107 Map2k7 linker MAPK9 (Other)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. Mkk7-JNK2 fusion - barcoded activating construct of JNK pathway pcw107 (V5)
  • Tag / Fusion Protein
    • FLAG (N terminal on insert)
  • Add to Cart
    64619MEK5 DD(S311D,T315D)-pcw107-V5MAP2K5 (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • MAP2K5 HsT17454, MAPKK5, MEK5, PRKMK5
    Add to Cart
    64620myr-FLAG-MEK5-pcw107MAP2K5 (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tags / Fusion Proteins
    • Flag (N terminal on insert)
    • myristoylated (N terminal on insert)
  • MAP2K5 HsT17454, MAPKK5, MEK5, PRKMK5
    Add to Cart
    64621Notch1 intracellular domain-pcw107 NOTCH1 (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5) NOTCH1 AOS5, AOVD1, TAN1, hN1 Add to Cart
    64622Notch1 intracellular domain-pcw107-V5NOTCH1 (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • NOTCH1 AOS5, AOVD1, TAN1, hN1
    Add to Cart
    64623Notch3 intracellular domain-pcw107-V5NOTCH3 (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • NOTCH3 CADASIL, CADASIL1, CASIL, IMF2, LMNS
    Add to Cart
    64624p38 WT O/E (MAPK14)-pcw107-V5MAPK14 (transcript variant 2) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • MAPK14 CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA
    Add to Cart
    64625FLAG-MKK6 (S207E,T211E)-pcw107 MAP2K6 (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • FLAG (N terminal on insert)
  • MAP2K6 MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3
    Add to Cart
    64626Gli2 truncation-pcw107-V5GLI2 (truncation mutant) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • GLI2 CJS, HPE9, PHS2, THP1, THP2
    Add to Cart
    64627SmoM2 (W535L)-pcw107 SMO (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5) SMO CRJS, FZD11, Gx, SMOH Add to Cart
    64628SmoM2 (W535L)-pcw107-V5SMO (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • SMO CRJS, FZD11, Gx, SMOH
    Add to Cart
    64629TGFbetaR1 (T204D)-pcw107-V5TGFBR1 (transcript variant 1) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • TGFBR1 AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I
    Add to Cart
    64630BCL2-pcw107-V5BCL2 (transcript variant alpha) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • BCL2 Bcl-2, PPP1R50
    Add to Cart
    64631BCL-XL-pcw107-V5 BCL2L1 (transcript variant 1) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • BCL2L1 BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52
    Add to Cart
    64632Caspase-8 (C360A)-pcw107-V5CASP8 (transcript variant B) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • CASP8 ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5
    Add to Cart
    64633Caspase-3 (C163A)-pcw107-V5CASP3 (transcript variant beta) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • CASP3 CPP32, CPP32B, SCA-1
    Add to Cart
    64634ERalpha (Y537S mutant)-pcw107-V5ESR1 (transcript variant 1) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • ESR1 ER, ESR, ESRA, ESTRR, Era, NR3A1
    Add to Cart
    64635AR-V7-pcw107 AR (transcript variant 1, splice isoform) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5) AR AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM Add to Cart
    64636AR-V7-pcw107-V5AR (transcript variant 1, splice isoform) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • AR AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
    Add to Cart
    64637FLAG-YAP2 (8SA)-pcw107YAP2 (transcript variant 3) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • FLAG (N terminal on insert)
  • YAP1 COB1, YAP, YAP2, YAP65, YKI
    Add to Cart
    64638p53 (dominant negative R175H mutant)-pcw107-V5 TP53 (transcript variant 3) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • TP53 BCC7, LFS1, P53, TRP53
    Add to Cart
    64639HRas (G12V, E37G)-pcw107 HRAS (transcript variant 3) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5) HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras Add to Cart
    64640HRas (G12V, E37G)-pcw107-V5HRAS (transcript variant 3) (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras
    Add to Cart
    64641Rgl2-CAAX-pcw107-V5Rgl2 plus C-term KRAS (Mus musculus)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • Kras AI929937, K-ras, Ki-ras, Kras-2, Kras2, p21B, ras
    Add to Cart
    64642RalA (G23V)(mature peptide)-pcw107 RALA (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5) RALA RAL Add to Cart
    64643RalA (G23V)(mature peptide)-pcw107-V5 RALA (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • RALA RAL
    Add to Cart
    64644RalA (G23V)( full )-pcw107 RALA (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5) RALA RAL Add to Cart
    64645RalA (G23V)( full )-pcw107-V5RALA (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. (control) when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • RALA RAL
    Add to Cart
    64646HcRed-pcw107 n/a (Synthetic)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. when used to produce lentivirus, express physiological levels of insert pcw107 (V5) Add to Cart
    64647HcRed-pcw107-V5n/a (Other)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. (control) when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • Add to Cart
    64648Luciferase-pcw107 n/a (Other)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. (control) when used to produce lentivirus, express physiological levels of insert pcw107 (V5) Add to Cart
    64649Luciferase-pcw107-V5n/a (Other)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. (control) when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • Add to Cart
    64650MEK1-pcw107-V5MAP2K1 (Homo sapiens)LentiviralSystematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877. (control) when used to produce lentivirus, express physiological levels of insert pcw107 (V5)
  • Tag / Fusion Protein
    • V5 (C terminal on backbone)
  • MAP2K1 CFC3, MAPKK1, MEK1, MKK1, PRKMK1
    Add to Cart
    69006pcDNA3-FLAG-MTOR-L1460PMTOR-L1460P (Homo sapiens)Mammalian ExpressionA diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. activating MTOR mutation pcDNA3 MTOR FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS Add to Cart
    69008pcDNA3-FLAG-MTOR-C1483FMTOR-C1483F (Homo sapiens)Mammalian ExpressionA diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. activating MTOR mutation pcDNA3 MTOR FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS Add to Cart
    69009pcDNA3-FLAG-MTOR-E1799KMTOR-E1799K (Homo sapiens)Mammalian ExpressionA diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. activating MTOR mutation pcDNA3 MTOR FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS Add to Cart
    69010pcDNA3-FLAG-MTOR-F1888LMTOR-F1888L (Homo sapiens)Mammalian ExpressionA diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. activating MTOR mutation pcDNA3 MTOR FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS Add to Cart
    69011pcDNA3-FLAG-MTOR-T1977RMTOR-T1977R (Homo sapiens)Mammalian ExpressionA diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. activating MTOR mutation pcDNA3 MTOR FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS Add to Cart
    69012pcDNA3-FLAG-MTOR-V2006IMTOR (Homo sapiens)Mammalian ExpressionA diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. activating MTOR mutation pcDNA3 MTOR FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS Add to Cart
    69013pcDNA3-FLAG-MTOR-S2215YMTOR (Homo sapiens)Mammalian ExpressionA diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. activating MTOR mutation pcDNA3 MTOR FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS Add to Cart
    69014pcDNA3-FLAG-MTOR-I2500FMTOR-I2500F (Homo sapiens)Mammalian ExpressionA diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. activating MTOR mutation pcDNA3 MTOR FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS Add to Cart
    69015pcDNA3-FLAG-MTOR-R2505PMTOR-R2505P (Homo sapiens)Mammalian ExpressionA diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. activating MTOR mutation pcDNA3 MTOR FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS Add to Cart
    69017pcDNA3-FLAG-MTOR-D2512HMTOR-D2512H (Homo sapiens)Mammalian ExpressionA diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. activating MTOR mutation pcDNA3 MTOR FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS Add to Cart
    69598paGFP-Omp25paGFP-Omp25 (Rattus norvegicus)Mammalian Expression, LentiviralStem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness. Science. 2015 Apr 17;348(6232):340-3. doi: 10.1126/science.1260384. Epub 2015 Apr 2. expresses GFP-labeled mitochondrial outer membrane protein 25 pLJM2 Synj2bp Omp25 Add to Cart
    69599Snap-Omp25Snap-Omp25Mammalian ExpressionStem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness. Science. 2015 Apr 17;348(6232):340-3. doi: 10.1126/science.1260384. Epub 2015 Apr 2. Snap-tag substrates with two different fluorophores (red and green) sequentially to separately label young and old mitochondria pLJM2 Add to Cart
    70264pMXs-C16orf80-gfpC16orf80 (Homo sapiens)Mammalian Expression, RetroviralIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses C16orf80 in mammalian cells with GFP reporter. pMXs CFAP20 C16orf80, EVORF, GTL3, fSAP23 Add to Cart
    70265pMXs-C3orf17-gfpC3orf17 (Homo sapiens)Mammalian Expression, RetroviralIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses C3orf17 in mammalian cells with GFP reporter. pMXs C3orf17 NET17 Add to Cart
    70266pMXs-C9orf114-gfpC9orf114Mammalian Expression, RetroviralIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses C9orf114 in mammalian cells with GFP reporter. pMXs C9orf114 CENP-32, HSPC109 Add to Cart
    70645pMXs-C16orf80-flagC16orf80 (Homo sapiens)Mammalian Expression, RetroviralIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses C16orf80 in mammalian cells with FLAG-tag epitope. pMXs CFAP20 C16orf80, EVORF, GTL3, fSAP23 Add to Cart
    70646pMXs-C3orf17-flagC3orf17 (Homo sapiens)Mammalian Expression, RetroviralIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses C3orf17 in mammalian cells with FLAG-tag epitope. pMXs C3orf17 NET17 Add to Cart
    70647pMXs-C9orf114-flagC9orf114 (Homo sapiens)Mammalian Expression, RetroviralIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses C9orf114 with FLAG-tag epitope. pMXS-IRES-Blast C9orf114 CENP-32, HSPC109 Add to Cart
    70648pMXs-DDX3XDDX3X (Homo sapiens)Mammalian Expression, RetroviralIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses WT DDX3X in mammalian cells under blasticidin selection. pMXs DDX3X CAP-Rf, DBX, DDX14, DDX3, HLP2, MRX102 Add to Cart
    70649pTagRFP-C1-FibrillarinFibrillarin (Homo sapiens)Mammalian ExpressionIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses Fibrillarin nucleolar marker with TurboRFP reporter. pTurboRFP-C1 FBL FIB, FLRN, RNU3IP1 Add to Cart
    70650lentiCRISPR - C16orf80 sgRNA 2sgRNA against C16orf80Mammalian Expression, Lentiviral, CRISPRIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and a C16orf80 targeting synthetic single-guide RNA (sgRNA) element from U6 promoter. Lentiviral backbone. lentiCRISPR v1 Add to Cart
    70651lentiCRISPR - C16orf80 sgRNA 1sgRNA against C16orf80Mammalian Expression, Lentiviral, CRISPRIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and a C16orf80 targeting synthetic single-guide RNA (sgRNA) element from U6 promoter. Lentiviral backbone. lentiCRISPR v1 Add to Cart
    70652lentiCRISPR - C3orf17 sgRNA 1sgRNA against C3orf17Mammalian Expression, Lentiviral, CRISPRIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and a C3orf17 targeting synthetic single-guide RNA (sgRNA) element from U6 promoter. Lentiviral backbone. lentiCRISPR v1 Add to Cart
    70653lentiCRISPR - C3orf17 sgRNA 2sgRNA against C3orf17Mammalian Expression, Lentiviral, CRISPRIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and a C3orf17 targeting synthetic single-guide RNA (sgRNA) element from U6 promoter. Lentiviral backbone. lentiCRISPR v1 Add to Cart
    70654lentiCRISPR - C9orf114 sgRNA 2sgRNA against C9orf114Mammalian Expression, Lentiviral, CRISPRIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and a C9orf114 targeting synthetic single-guide RNA (sgRNA) element from U6 promoter. Lentiviral backbone. lentiCRISPR v1 Add to Cart
    70655lentiCRISPR - C9orf114 sgRNA 1 sgRNA against C9orf114Mammalian Expression, Lentiviral, CRISPRIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and a C9orf114 targeting synthetic single-guide RNA (sgRNA) element from U6 promoter. Lentiviral backbone. lentiCRISPR v1 Add to Cart
    70656lentiCRISPR - DDX3Y sgRNA 1sgRNA against DDX3YMammalian Expression, Lentiviral, CRISPRIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and a DDX3Y targeting synthetic single-guide RNA (sgRNA) element from U6 promoter. Lentiviral backbone. lentiCRISPR v1 Add to Cart
    70657lentiCRISPR - DDX3Y sgRNA 2sgRNA against DDX3YMammalian Expression, Lentiviral, CRISPRIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and a DDX3Y targeting synthetic single-guide RNA (sgRNA) element from U6 promoter. Lentiviral backbone. lentiCRISPR v1 Add to Cart
    70658lentiCRISPR - Amplicon, BCR/ABL sgRNA 2sgRNA against BCR/ABLamplicon found in CML-derived K562 cell lineMammalian Expression, Lentiviral, CRISPRIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and an intergenic BCR/ABL-targeting sgRNA element from U6 promoter. Lentiviral backbone. lentiCRISPR v1 Add to Cart
    70659lentiCRISPR - Amplicon, BCR/ABL sgRNA 1sgRNA against BCR/ABLamplicon found in CML-derived K562 cell lineMammalian Expression, Lentiviral, CRISPRIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and an intergenic BCR/ABL-targeting sgRNA element from U6 promoter. Lentiviral backbone lentiCRISPR v1 Add to Cart
    70660lentiCRISPR - Amplicon, JAK2 sgRNA 2sgRNA against JAK2 amplicon found in AML-derived HEL cell lineMammalian Expression, Lentiviral, CRISPRIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and an intergenic JAK2 amplicon-targeting sgRNA element from U6 promoter. Lentiviral backbone lentiCRISPR v1 JAK2 JTK10, THCYT3 Add to Cart
    70661lentiCRISPR - AAVS1 sgRNAsgRNA against AAVS1Mammalian Expression, Lentiviral, CRISPRIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and an AAVS1-targeting sgRNA element from U6 promoter. Lentiviral backbone lentiCRISPR v1 Add to Cart
    70662lentiCRISPR - CTRL sgRNAnon-targeting sgRNAMammalian Expression, Lentiviral, CRISPRIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and a non-targeting sgRNA element from U6 promoter. Lentiviral backbone lentiCRISPR v1 Add to Cart
    70679lentiCRISPR - Amplicon, JAK2 sgRNA 1 sgRNA against JAK2 amplicon found in AML-derived HEL cell lineMammalian Expression, Lentiviral, CRISPRIdentification and characterization of essential genes in the human genome. Science. 2015 Oct 15. pii: aac7041. Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and an intergenic JAK2 amplicon-targeting sgRNA element from U6 promoter. Lentiviral backbone lentiCRISPR v1 JAK2 JTK10, THCYT3 Add to Cart
    71409pLenti-sgRNALentiviral pLenti-sgRNA (unpublished) There is no gene/insert. It is a backbone plasmid that others can use to insert sgRNAs of interest. The cloning site for this BsmBI pLenti-CRISPR Add to Cart
    71855pRK5-FLAG-SLC38A9.1SLC38A9.1 (Homo sapiens)Mammalian ExpressionMetabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. overexpression pRK5 SLC38A9 URLC11 Add to Cart
    71858pLJM60-FLAG-SLC38A9.1SLC38A9.1 (Homo sapiens)Mammalian Expression, LentiviralMetabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. lentiviral stable expression pLJM60 SLC38A9 URLC11 Add to Cart
    71861pLJM60-FLAG-SLC38A9.1 (delta110)SLC38A9.1 (Homo sapiens)Mammalian Expression, LentiviralMetabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. lentiviral stable expression pLJM60 SLC38A9 URLC11 Add to Cart
    71862pLJM60-FLAG-SLC38A9.1 (1-119aa)SLC38A9.1 (Homo sapiens)Mammalian Expression, LentiviralMetabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. lentiviral stable expression pLJM60 SLC38A9 URLC11 Add to Cart
    71863pLJM60-FLAG-SLC38A9.1 H60ASLC38A9.1 (Homo sapiens)Mammalian Expression, LentiviralMetabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. lentiviral stable expression pLJM60 SLC38A9 URLC11 Add to Cart
    71864pLJM60-FLAG-SLC38A9.1 I68ASLC38A9.1 (Homo sapiens)Mammalian Expression, LentiviralMetabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. lentiviral stable expression pLJM60 SLC38A9 URLC11 Add to Cart
    71865pLJM60-FLAG-SLC38A9.1 Y71ASLC38A9.1 (Homo sapiens)Mammalian Expression, LentiviralMetabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. lentiviral stable expression pLJM60 SLC38A9 URLC11 Add to Cart
    71866pLJM60-FLAG-SLC38A9.1 L74ASLC38A9.1 (Homo sapiens)Mammalian Expression, LentiviralMetabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. lentiviral stable expression pLJM60 SLC38A9 URLC11 Add to Cart
    71867pLJM60-FLAG-SLC38A9.1 P90ASLC38A9.1 (Homo sapiens)Mammalian Expression, LentiviralMetabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. lentiviral stable expression pLJM60 SLC38A9 URLC11 Add to Cart
    71868pRK5-LAMP1-FLAGLAMP1 (Homo sapiens)Mammalian ExpressionMetabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. overexpression pRK5 LAMP1 CD107a, LAMPA, LGP120 Add to Cart
    71869pRK5-HA-SLC38A9.1SLC38A9.1 (Homo sapiens)Mammalian ExpressionMetabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. overexpression pRK5 SLC38A9 URLC11 Add to Cart
    72289FLCN-eGFPFLCN (Homo sapiens)Mammalian ExpressionThe folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3. Expresses human FLCN tagged with eGFP at C terminus Clontech N1 Add to Cart
    72290pRK5-FLAG-FLCNFLCN (Homo sapiens)Mammalian ExpressionThe folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3. overexpression pRK5 FLCN BHD, FLCL Add to Cart
    72291pRK5-HA-FLCNFLCN (Homo sapiens)Mammalian ExpressionThe folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3. overexpression pRK5 FLCN BHD, FLCL Add to Cart
    72292pRK5-FLAG-FNIP1FNIP1 (Homo sapiens)Mammalian ExpressionThe folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3. overexpression pRK5 FNIP1 Add to Cart
    72293pRK5-HA-FNIP1FNIP1 (Homo sapiens)Mammalian ExpressionThe folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3. overexpression pRK5 FNIP1 Add to Cart
    72294pRK5-FLAG-FNIP2FNIP2 (Homo sapiens)Mammalian ExpressionThe folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3. overexpression pRK5 FNIP2 FNIPL, MAPO1 Add to Cart
    72295pRK5-HA-FNIP2FNIP2 (Homo sapiens)Mammalian ExpressionThe folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3. overexpression pRK5 FNIP2 FNIPL, MAPO1 Add to Cart
    72296pRK5-FLAG-FLCN (C terminus)FLCN C-terminus (Homo sapiens)Mammalian ExpressionThe folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3. overexpression pRK5 FLCN BHD, FLCL Add to Cart
    72297pRK5-HA-FLCN (C terminus)FLCN C-terminus (Homo sapiens)Mammalian ExpressionThe folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3. overexpression pRK5 FLCN BHD, FLCL Add to Cart
    72592pRK5-FLAG-Sestrin3SESN3 (Homo sapiens)Mammalian ExpressionThe Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep. 2014 Oct 9;9(1):1-8. doi: 10.1016/j.celrep.2014.09.014. Epub 2014 Sep 25. overexpression, codon optimized for mammalian expression pRK5 SESN3 SEST3 Add to Cart
    72593pRK5-HA-Sestrin2SESN2 (Homo sapiens)Mammalian ExpressionThe Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep. 2014 Oct 9;9(1):1-8. doi: 10.1016/j.celrep.2014.09.014. Epub 2014 Sep 25. overexpression, codon optimized for mammalian expression pRK5 SESN2 HI95, SES2, SEST2 Add to Cart
    72594pRK5-FLAG-Sestrin1 isoform1SESN1 (Homo sapiens)Mammalian ExpressionThe Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep. 2014 Oct 9;9(1):1-8. doi: 10.1016/j.celrep.2014.09.014. Epub 2014 Sep 25. overexpression, codon optimized for mammalian expression pRK5 SESN1 PA26, SEST1 Add to Cart
    72595pRK5-FLAG-Sestrin2SESN2 (Homo sapiens)Mammalian ExpressionThe Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep. 2014 Oct 9;9(1):1-8. doi: 10.1016/j.celrep.2014.09.014. Epub 2014 Sep 25. overexpression pRK5 SESN2 HI95, SES2, SEST2 Add to Cart
    72872PMXS-GOT1GOT1 (Homo sapiens)Mammalian Expression, RetroviralAn Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis. Cell. 2015 Jul 30;162(3):540-51. doi: 10.1016/j.cell.2015.07.016. The retroviral GOT1 vector was generated by cloning an sgRNA resistant human GOT1 gene block into the pMXS-ires-blast vector by Gibson Assembly. pMXs-IRES-blasticidin GOT1 AST1, ASTQTL1, GIG18, cAspAT, cCAT Add to Cart
    72873PMXS-SLC1A3SLC1A3 (Homo sapiens)Mammalian Expression, RetroviralAn Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis. Cell. 2015 Jul 30;162(3):540-51. doi: 10.1016/j.cell.2015.07.016. The retroviral SLC1A3 vector was generated by cloning an human SLC1A3 PCR fragment (https://www.addgene.org/32813/)into the pMXS-ires-blast vector by Gibson Assembly pMXs-IRES-blasticidin SLC1A3 EA6, EAAT1, GLAST, GLAST1 Add to Cart
    72874plentiCRISPR-sgGOT1sgGOT1LentiviralAn Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis. Cell. 2015 Jul 30;162(3):540-51. doi: 10.1016/j.cell.2015.07.016. The lentiviral sgGOT1 vector was generated via ligation of hybridized oligos (below) into lentiCRISPR-v1 vector linearized with BsmBI using Gibson assembly (NEB). pLentiCRISPR version 1 Add to Cart
    72875plentiCRISPR-sgMDH1sgMDH1LentiviralAn Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis. Cell. 2015 Jul 30;162(3):540-51. doi: 10.1016/j.cell.2015.07.016. The lentiviral sgMDH1 vectors was generated via ligation of hybridized oligos (below) into lentiCRISPR-v1 vector linearized with BsmBI using Gibson assembly (NEB pLentiCRISPR version 1 Add to Cart
    72876PMXS-NDI1NDI1 (Saccharomyces cerevisiae)Mammalian Expression, RetroviralMetabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature. 2014 Apr 3;508(7494):108-12. doi: 10.1038/nature13110. Epub 2014 Mar 16. expresses NDI1 in mammalian cells pMXs-IRES-blasticidin NDI1 YML120C Add to Cart
    72877PMXS-SLC2A3SLC2A3 (Homo sapiens)Mammalian Expression, RetroviralMetabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature. 2014 Apr 3;508(7494):108-12. doi: 10.1038/nature13110. Epub 2014 Mar 16. expresses SLC2A3 in mammalian cells pMXs-IRES-blasticidin SLC2A3 GLUT3 Add to Cart
    72880SHMT2-RESSHMT2 (Homo sapiens)Mammalian Expression, RetroviralSHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8. overexpression PMXS-IRES-Blasticidin SHMT2 GLYA, HEL-S-51e, SHMT Add to Cart
    72881mGLDCGldc (Mus musculus)Mammalian Expression, RetroviralSHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8. overexpression PMXS-IRES-Blasticidin Gldc D030049L12Rik, D19Wsu57e Add to Cart
    72882GLDC-RESGLDC (Homo sapiens)Mammalian Expression, LentiviralSHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8. overexpression pLJM1 GLDC GCE, GCSP, HYGN1 Add to Cart
    72883shGLDC-DOXRNAi hairpin against GLDC (Homo sapiens)Mammalian Expression, LentiviralSHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8. dox inducible knockdown pLKO-GC11 Add to Cart
    72885sgGCAT_2sgGCAT (Homo sapiens)LentiviralSHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8. CRISPR-Cas9 induced gene disruption pLentiCRISPR version 1 Add to Cart
    72886sgGLDC_1sgGLDC (Homo sapiens)LentiviralSHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8. CRISPR-Cas9 induced gene disruption pLentiCRISPR version 1 Add to Cart
    72887sgGLDC_2sgGLDC (Homo sapiens)LentiviralSHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8. CRISPR-Cas9 induced gene disruption pLentiCRISPR version 1 Add to Cart
    73031pLJM1 RagArragA (Homo sapiens)Mammalian Expression, LentiviralRagA, but not RagB, is essential for embryonic development and adult mice. Dev Cell. 2014 May 12;29(3):321-9. doi: 10.1016/j.devcel.2014.03.017. Epub 2014 Apr 24. Expresses human RagA from a CMV promoter for stable expression in mammalian cells pLJM1 RRAGA FIP-1, FIP1, RAGA Add to Cart
    73670pRK5-FLAG-Sestrin2-S190WSesn2 (Homo sapiens)Mammalian ExpressionSestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8. overexpression pRK5 SESN2 HI95, SES2, SEST2 Add to Cart
    73671pRK5-FLAG-Sestrin2-L261ASesn2 (Homo sapiens)Mammalian ExpressionSestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8. overexpression pRK5 SESN2 HI95, SES2, SEST2 Add to Cart
    73672pRK5-HA-Sestrin2-L261ASesn2 (Homo sapiens)Mammalian ExpressionSestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8. overexpression pRK5 SESN2 HI95, SES2, SEST2 Add to Cart
    73673pRK5-FLAG-Sestrin2-E451ASesn2 (Homo sapiens)Mammalian ExpressionSestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8. overexpression pRK5 SESN2 HI95, SES2, SEST2 Add to Cart
    73674pRK5-HA-Sestrin2-E451ASesn2 (Homo sapiens)Mammalian ExpressionSestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8. overexpression pRK5 SESN2 HI95, SES2, SEST2 Add to Cart
    73675pRK5-FLAG-dSestrin (CG11299-PD)Sesn (variant D) (Drosophila melanogaster)Mammalian ExpressionSestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8. overexpression pRK5 Add to Cart
    73676pLJM1-FLAG-Sestrin2-L261ASesn2 (Homo sapiens)Mammalian Expression, LentiviralSestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8. overexpression pLJM1-FLAG SESN2 HI95, SES2, SEST2 Add to Cart
    73677pLJM1-FLAG-Sestrin2-E451ASesn2 (Homo sapiens)Mammalian Expression, LentiviralSestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8. overexpression pLJM1-FLAG SESN2 HI95, SES2, SEST2 Add to Cart
    73678pS2-FLAG-Sestrin2-L261ASesn2 (Homo sapiens)Mammalian Expression, LentiviralSestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8. overexpression pS2 SESN2 HI95, SES2, SEST2 Add to Cart
    73679pS2-FLAG-Sestrin2-E451ASesn2 (Homo sapiens)Mammalian Expression, LentiviralSestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8. overexpression pS2 SESN2 HI95, SES2, SEST2 Add to Cart
    83354pMXs-3XFLAG-EGFP-OMP253XFLAG-EGFP-OMP25Mammalian Expression, RetroviralAbsolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism. Cell. 2016 Aug 25;166(5):1324-1337.e11. doi: 10.1016/j.cell.2016.07.040. For tagging mitochondria with Sigma FLAG epitopes pMXs rtv-016 Add to Cart
    83355pMXs-3XMyc-EGFP-OMP253XMyc-EGFP-OMP25Mammalian Expression, RetroviralAbsolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism. Cell. 2016 Aug 25;166(5):1324-1337.e11. doi: 10.1016/j.cell.2016.07.040. For tagging mitochondria with Myc epitopes (Control-MITO construct) pMXs rtv-016 Add to Cart
    83356pMXs-3XHA-EGFP-OMP253XHA-EGFP-OMP25Mammalian Expression, RetroviralAbsolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism. Cell. 2016 Aug 25;166(5):1324-1337.e11. doi: 10.1016/j.cell.2016.07.040. For tagging mitochondria with HA epitopes (HA-MITO construct) pMXs rtv-016 Add to Cart
    83901pLJM5-WT PHGDHPhosphoglycerate dehydrogenase (Homo sapiens)Mammalian Expression, LentiviralA PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. stable overexpression pLJM5 PHGDH 3-PGDH, 3PGDH, HEL-S-113, NLS, NLS1, PDG, PGAD, PGD, PGDH, PHGDHD, SERA Add to Cart
    83902pLJM5-C234S PHGDHPhosphoglycerate dehydrogenase (Homo sapiens)Mammalian Expression, LentiviralA PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. stable overexpression pLJM5 PHGDH 3-PGDH, 3PGDH, HEL-S-113, NLS, NLS1, PDG, PGAD, PGD, PGDH, PHGDHD, SERA Add to Cart
    83903pLentiCRISPRv1-sgSHMT1-G3Serine hydroxymethyltransferase 1 (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRA PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. stable knockout pLentiCRISPRv1 SHMT1 CSHMT, SHMT Add to Cart
    83904pLJM5-mSHMT1Serine hydroxymethyltransferase 1 (Mus musculus)Mammalian Expression, LentiviralA PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. stable overexpression pLJM5 Shmt1 AI324848, AI385541, C81125, Shmt, mshmt, mshmt1, mshmt2 Add to Cart
    83905pLJM5-mSHMT2Serine hydroxymethyltransferase 2 (Mus musculus)Mammalian Expression, LentiviralA PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. stable overexpression pLJM5 Shmt2 2700043D08Rik, AA408223, AA986903 Add to Cart
    83906pLentiCRISPRv1-sgAAVS1adeno-associated virus integration site 1 (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRA PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. stable knockout pLentiCRISPRv1 AAVS1 AAV Add to Cart
    83907pET30-2-PHGDHPhosphoglycerate dehydrogenase (Homo sapiens)Bacterial ExpressionA PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. stable overexpression pET30-2 PHGDH 3-PGDH, 3PGDH, HEL-S-113, NLS, NLS1, PDG, PGAD, PGD, PGDH, PHGDHD, SERA Add to Cart
    83908pET30-2-PSAT1phosphoserine aminotransferase 1 (Homo sapiens)Bacterial ExpressionA PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. stable overexpression pET30-2 PSAT1 EPIP, NLS2, PSA, PSAT, PSATD Add to Cart
    83909pET30-2-PSPHphosphoserine phosphatase (Homo sapiens)Bacterial ExpressionA PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. stable overexpression pET30-2 PSPH PSP, PSPHD Add to Cart
    83910pET30-2-GAPDHglyceraldehyde-3-phosphate dehydrogenase (Homo sapiens)Bacterial ExpressionA PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. stable overexpression pET30-2 GAPDH G3PD, GAPD, HEL-S-162eP Add to Cart
    83911pET30-2-GPD1glycerol-3-phosphate dehydrogenase 1 (Homo sapiens)Bacterial ExpressionA PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. stable overexpression pET30-2 GPD1 GPD-C, GPDH-C, HTGTI Add to Cart
    83912pET30-2-GPD1Lglycerol-3-phosphate dehydrogenase 1-like (Homo sapiens)Bacterial ExpressionA PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. stable overexpression pET30-2 GPD1L GPD1-L Add to Cart
    83913pLentiCRISPRv1-sgPHGDH-G5Phosphoglycerate dehydrogenase (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRA PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. stable knockout pLentiCRISPRv1 PHGDH 3-PGDH, 3PGDH, HEL-S-113, NLS, NLS1, PDG, PGAD, PGD, PGDH, PHGDHD, SERA Add to Cart
    84487pRK5 CASTOR1-HA CtermCASTOR1 (Homo sapiens)Mammalian ExpressionThe CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. 2016 Mar 24;165(1):153-64. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10. overexpression of CASTOR1 with HA tag pRK5
  • Tag / Fusion Protein
    • HA (C terminal on insert)
  • GATSL3 CASTOR1
    Add to Cart
    84488pRK5 CASTOR1-Flag CtermCASTOR1 (Homo sapiens)Mammalian ExpressionThe CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. 2016 Mar 24;165(1):153-64. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10. overexpression of CASTOR1 with Flag tag pRK5
  • Tag / Fusion Protein
    • FLAG (C terminal on insert)
  • GATSL3 CASTOR1
    Add to Cart
    84489pRK5 CASTOR2-HA CtermCASTOR2 (Homo sapiens)Mammalian ExpressionThe CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. 2016 Mar 24;165(1):153-64. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10. overexpression of CASTOR2 with HA tag pRK5
  • Tag / Fusion Protein
    • HA (C terminal on insert)
  • GATSL2 CASTOR2, GATSL1
    Add to Cart
    84490pRK5 CASTOR2-Flag CtermCASTOR2 (Homo sapiens)Mammalian ExpressionThe CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. 2016 Mar 24;165(1):153-64. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10. overexpression of CASTOR2 with Flag tag pRK5
  • Tag / Fusion Protein
    • FLAG (C terminal on insert)
  • GATSL2 CASTOR2, GATSL1
    Add to Cart
    84491pRK5-Flag CASTOR1 ACT1CASTOR1 ACT1 (Homo sapiens)Mammalian ExpressionThe CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. 2016 Mar 24;165(1):153-64. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10. overexpression of CASTOR1 ACT1 domain (aa 1-169) pRK5
  • Tag / Fusion Protein
    • FLAG (N terminal on insert)
  • GATSL3 CASTOR1
    Add to Cart
    84492pRK5-HA CASTOR1 ACT2CASTOR1 ACT2 (Homo sapiens)Mammalian ExpressionThe CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. 2016 Mar 24;165(1):153-64. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10. overexpression of CASTOR1 ACT2 domain (aa 169-end) pRK5
  • Tag / Fusion Protein
    • HA (N terminal on insert)
  • GATSL3 CASTOR1
    Add to Cart
    84493pRK5-Flag CASTOR2 ACT1CASTOR2 ACT1 (Homo sapiens)Mammalian ExpressionThe CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. 2016 Mar 24;165(1):153-64. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10. overexpression of CASTOR2 ACT1 domain (aa 1-171) pRK5
  • Tag / Fusion Protein
    • FLAG (N terminal on insert)
  • GATSL2 CASTOR2, GATSL1
    Add to Cart
    84494pRK5-HA CASTOR2 ACT2CASTOR2 ACT2 (Homo sapiens)Mammalian ExpressionThe CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. 2016 Mar 24;165(1):153-64. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10. overexpression of CASTOR2 ACT2 domain (aa 171-end) pRK5
  • Tag / Fusion Protein
    • HA (N terminal on insert)
  • GATSL2 CASTOR2, GATSL1
    Add to Cart
    84495pRK5-Flag CASTOR1 I280ACASTOR1 I280A (Homo sapiens)Mammalian ExpressionThe CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. 2016 Mar 24;165(1):153-64. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10. overexpression of CASTOR1 I280A mutant pRK5
  • Tag / Fusion Protein
    • FLAG (C terminal on insert)
  • GATSL3 CASTOR1
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    84496pLJC6-Flag CASTOR1CASTOR1 (Homo sapiens)Mammalian Expression, LentiviralThe CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. 2016 Mar 24;165(1):153-64. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10. Lentiviral expression of CASTOR1 pS2JC6
  • Tag / Fusion Protein
    • FLAG (C terminal on insert)
  • GATSL3 CASTOR1
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    84497pLJC6-Flag CASTOR1 I280ACASTOR1 I280A (Homo sapiens)Mammalian Expression, LentiviralThe CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. 2016 Mar 24;165(1):153-64. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10. Lentiviral expression of CASTOR2 I280A mutant pS2JC6
  • Tag / Fusion Protein
    • FLAG (C terminal on insert)
  • GATSL3 CASTOR1
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    85403pMXs-WT-ATPIF1ATPIF1 (Homo sapiens)Mammalian Expression, RetroviralInhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells. Cell Rep. 2014 Apr 10;7(1):27-34. doi: 10.1016/j.celrep.2014.02.046. Epub 2014 Mar 27. Retroviral vector expressing wild type human ATPIF1 pMXs rtv-016 ATPIF1 ATPI, ATPIP, IP Add to Cart
    85404pMXs-E55A-ATPIF1ATPIF1 (Homo sapiens)Mammalian Expression, RetroviralInhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells. Cell Rep. 2014 Apr 10;7(1):27-34. doi: 10.1016/j.celrep.2014.02.046. Epub 2014 Mar 27. Retroviral vector expressing human ATPIF1 with E55A mutation, which abrogates the interaction between ATPIF1 and the ATP synthase pMXs rtv-016 ATPIF1 ATPI, ATPIP, IP Add to Cart