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Eric Lander Lab Plasmids


The Eric Lander Lab has deposited plasmids at Addgene for distribution to the research community. Addgene is a nonprofit plasmid repository dedicated to improving life science research.

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Title Authors Publication
Genetic screens in human cells using the CRISPR-Cas9 system. Wang T, Wei JJ, Sabatini DM, Lander ES Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12.
pLenti-sgRNA (unpublished)
Systematic mapping of functional enhancer-promoter connections with CRISPR interference. Fulco CP, Munschauer M, Anyoha R, Munson G, Grossman SR, Perez EM, Kane M, Cleary B, Lander ES, Engreitz JM Science. 2016 Sep 29. pii: aag2445.
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Wang T, Yu H, Hughes NW, Liu B, Kendirli A, Klein K, Chen WW, Lander ES, Sabatini DM Cell. 2017 Feb 1. pii: S0092-8674(17)30061-2. doi: 10.1016/j.cell.2017.01.013.
Identification and characterization of essential genes in the human genome. Wang T, Birsoy K, Hughes NW, Krupczak KM, Post Y, Wei JJ, Lander ES, Sabatini DM Science. 2015 Oct 15. pii: aac7041.
ID Plasmid Gene/Insert Vector Type Publication Hidden Extra Search Info  
50661pCW-Cas9humanized S. pyogenes Cas9Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Doxycycline-inducible lentiviral expression of SpCas9 pCW57.1 Add to Cart
50662pLX-sgRNAsgAAVS1Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Lentiviral expression of AAVS1-targeting sgRNA; insert can be replaced with custom sgRNA (see protocol) pLX304 Add to Cart
51043Human Lentiviral sgRNA Library - Unknown FunctionsgRNA library (enriched for genes of unknown function) (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Sub-pool of Sabatini/Lander sgRNA library enriched for gene targets of unknown function. pLX-sgRNA Add to Cart
51044Human Lentiviral sgRNA Library - KinasessgRNA library (enriched for kinase targets) (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Sub-pool of Sabatini/Lander sgRNA library enriched for kinase targets. pLX-sgRNA Add to Cart
51045Human Lentiviral sgRNA Library - Ribosomal ProteinssgRNA library (enriched for ribosomal targets) (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Sub-pool of Sabatini/Lander sgRNA library enriched for ribosomal gene targets. pLX-sgRNA Add to Cart
51046Human Lentiviral sgRNA Library - Cell CyclesgRNA library (enriched for cell cycle targets) (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Sub-pool of Sabatini/Lander sgRNA library enriched for cell cycle-related targets. pLX-sgRNA Add to Cart
51047Human Lentiviral sgRNA Library - NuclearsgRNA library (enriched for nuclear targets) (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Sub-pool of Sabatini/Lander sgRNA library enriched for nuclear targets. pLX-sgRNA Add to Cart
51048Human Lentiviral sgRNA Library - ControlsgRNA library (enriched for control targets) (Homo sapiens)Mammalian Expression, Lentiviral, CRISPRGenetic screens in human cells using the CRISPR-Cas9 system. Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12. Sub-pool of Sabatini/Lander sgRNA library enriched for control targets. pLX-sgRNA Add to Cart
71409pLenti-sgRNALentiviral pLenti-sgRNA (unpublished) There is no gene/insert. It is a backbone plasmid that others can use to insert sgRNAs of interest. The cloning site for this BsmBI pLenti-CRISPR Add to Cart
85449TRE-KRAB-dCas9-IRES-BFPKRAB-dCas9-IRES-BFP (Synthetic)Mammalian Expression, Lentiviral, CRISPRSystematic mapping of functional enhancer-promoter connections with CRISPR interference. Science. 2016 Sep 29. pii: aag2445. Lentiviral vector expressing a KRAB-dCas9 fusion protein and BFP pHR Add to Cart
85681sgOptiMammalian Expression, Lentiviral, CRISPRSystematic mapping of functional enhancer-promoter connections with CRISPR interference. Science. 2016 Sep 29. pii: aag2445. Lentiviral vector to express sgRNAs. The cloning site is BsmBI. pLenti-sgRNA Add to Cart
92352Sabatini/Lander Lab Ras synthetic lethal candidate focused human sgRNA library in lentiCRISPRv1499 intergenic cntrl sgRNAs and 6162 sgRNAs targeting 132 control & candidate Ras synthetic lethal genes at up to 50 sgRNAs/gene (Homo sapiens)Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Cell. 2017 Feb 1. pii: S0092-8674(17)30061-2. doi: 10.1016/j.cell.2017.01.013. contains 6,661 sgRNAs (comprising 499 intergenic control sgRNAs and 6,162 sgRNAs targeting 132 control and candidate Ras synthetic lethal genes at up to 50 sgRNAs per gene) lentiCRISPRv1 Add to Cart