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Robert Lefkowitz Lab Plasmids


The Robert Lefkowitz Lab has deposited plasmids at Addgene for distribution to the research community. Addgene is a non-profit plasmid repository dedicated to improving life science research.

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Title Authors Publication
A stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1. Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368.
Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. Shukla AK, Kim J, Ahn S, Xiao K, Shenoy SK, Liedtke W, Lefkowitz RJ J Biol Chem. 2010 Sep 24;285(39):30115-25. doi: 10.1074/jbc.M110.141549. Epub 2010 Jul 22.
Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. Nelson CD, Kovacs JJ, Nobles KN, Whalen EJ, Lefkowitz RJ J Biol Chem. 2008 Jul 25;283(30):21093-101. Epub 2008 Jun 5.
The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2. Nobles KN, Guan Z, Xiao K, Oas TG, Lefkowitz RJ J Biol Chem. 2007 Jul 20;282(29):21370-81. Epub 2007 May 18.
Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Nelson CD, Perry SJ, Regier DS, Prescott SM, Topham MK, Lefkowitz RJ Science. 2007 Feb 2;315(5812):663-6.
G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. Violin JD, Ren XR, Lefkowitz RJ J Biol Chem. 2006 Jul 21;281(29):20577-88. Epub 2006 May 10.
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, Madabushi S, Reiter E, Premont RT, Lichtarge O, Lefkowitz RJ J Biol Chem. 2006 Jan 13;281(2):1261-73. Epub 2005 Nov 9.
Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. Shenoy SK, Lefkowitz RJ J Biol Chem. 2005 Apr 15;280(15):15315-24. Epub 2005 Feb 7.
Activation-dependent conformational changes in {beta}-arrestin 2. Xiao K, Shenoy SK, Nobles K, Lefkowitz RJ J Biol Chem. 2004 Dec 31;279(53):55744-53. Epub 2004 Oct 22.
Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. Wei H, Ahn S, Barnes WG, Lefkowitz RJ J Biol Chem. 2004 Nov 12;279(46):48255-61. Epub 2004 Sep 7.
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ Science. 2003 Sep 5;301(5638):1391-4.
The role of a conserved region of the second intracellular loop in AT1 angiotensin receptor activation and signaling. Gaborik Z, Jagadeesh G, Zhang M, Spat A, Catt KJ, Hunyady L Endocrinology. 2003 Jun;144(6):2220-8.
Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. Ahn S, Kim J, Lucaveche CL, Reedy MC, Luttrell LM, Lefkowitz RJ, Daaka Y J Biol Chem. 2002 Jul 19;277(29):26642-51. Epub 2002 May 13.
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ Science. 2001 Nov 9;294(5545):1307-13. Epub 2001 Oct 4.
beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. Miller WE, Maudsley S, Ahn S, Khan KD, Luttrell LM, Lefkowitz RJ J Biol Chem. 2000 Apr 14;275(15):11312-9.
Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. Pitcher JA, Tesmer JJ, Freeman JL, Capel WD, Stone WC, Lefkowitz RJ J Biol Chem. 1999 Dec 3. 274(49):34531-4.
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. Tang Y, Hu LA, Miller WE, Ringstad N, Hall RA, Pitcher JA, DeCamilli P, Lefkowitz RJ Proc Natl Acad Sci U S A. 1999 Oct 26. 96(22):12559-64.
Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway. Lee JS, Ishimoto A, Yanagawa S J Biol Chem. 1999 Jul 23;274(30):21464-70.
The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Laporte SA, Oakley RH, Zhang J, Holt JA, Ferguson SS, Caron MG, Barak LS Proc Natl Acad Sci U S A. 1999 Mar 30. 96(7):3712-7.
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ Science. 1999 Jan 29. 283(5402):655-61.
Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. Pitcher JA, Fredericks ZL, Stone WC, Premont RT, Stoffel RH, Koch WJ, Lefkowitz RJ J Biol Chem. 1996 Oct 4. 271(40):24907-13.
Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. Premont RT, Macrae AD, Stoffel RH, Chung N, Pitcher JA, Ambrose C, Inglese J, MacDonald ME, Lefkowitz RJ J Biol Chem. 1996 Mar 15;271(11):6403-10.
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. Koch WJ, Hawes BE, Inglese J, Luttrell LM, Lefkowitz RJ J Biol Chem. 1994 Feb 25. 269(8):6193-7.
Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. Freedman NJ, Liggett SB, Drachman DE, Pei G, Caron MG, Lefkowitz RJ J Biol Chem. 1995 Jul 28;270(30):17953-61.
Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype. Schwinn DA, Lomasney JW, Lorenz W, Szklut PJ, Fremeau RT Jr, Yang-Feng TL, Caron MG, Lefkowitz RJ, Cotecchia S J Biol Chem. 1990 May 15;265(14):8183-9.
Plasmid Gene/Insert Vector Type Publication Hidden Extra Search Info  
pcDNA3 Barr2 flag beta-arrestin 2 (Rattus norvegicus) Mammalian Expression The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Laporte et al Proc Natl Acad Sci U S A. 1999 Mar 30. 96(7):3712-7. pcDNA3 Arrb2 BARRES Add to Cart
pcDNA3 barr1 flag beta arrestin 1 (Rattus norvegicus) Mammalian Expression Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Luttrell et al Science. 1999 Jan 29. 283(5402):655-61. pcDNA3 Arrb1 BARRES Add to Cart
pRK5 bovine GRK5 GRK5 (Bos taurus) Mammalian Expression Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. Pitcher et al J Biol Chem. 1996 Oct 4. 271(40):24907-13. pRK5 GRK5 GPRK5 Add to Cart
pRK5 bovine GRK2 GRK2 (Bos taurus) Mammalian Expression Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. Pitcher et al J Biol Chem. 1999 Dec 3. 274(49):34531-4. pRK5 ADRBK1 BOS_24950, GRK2 Add to Cart
pcDNA3 barr2 HA beta-arrestin 2 (Rattus norvegicus) Mammalian Expression Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Luttrell et al Science. 1999 Jan 29. 283(5402):655-61. pcDNA3 Arrb2 BARRES Add to Cart
pcDNA3 barr1 HA beta arrestin 1 (Rattus norvegicus) Mammalian Expression Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Luttrell et al Science. 1999 Jan 29. 283(5402):655-61. pcDNA3 Arrb1 BARRES Add to Cart
pRK5 BARK1 minigene BARK1 minigene (Bos taurus) Mammalian Expression Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. Koch et al J Biol Chem. 1994 Feb 25. 269(8):6193-7. pRK5 ADRBK1 BOS_24950, GRK2 Add to Cart
pcDNA3 Flag beta-2-adrenergic-receptor B2AR (Homo sapiens) Mammalian Expression Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. Tang et al Proc Natl Acad Sci U S A. 1999 Oct 26. 96(22):12559-64. pcDNA3 ADRB2 ADRB2R, ADRBR, B2AR, BAR, BETA2AR Add to Cart
pcDNA3 Flag beta-1-adrenergic-receptor B1AR (Homo sapiens) Mammalian Expression Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. Tang et al Proc Natl Acad Sci U S A. 1999 Oct 26. 96(22):12559-64. pcDNA3 ADRB1 ADRB1R, B1AR, BETA1AR, RHR Add to Cart
pcDNA-GRK3 GRK3 (Bos taurus) Mammalian Expression Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. Pitcher et al J Biol Chem. 1996 Oct 4. 271(40):24907-13. pcDNA3 ADRBK2 BARK2, GRK3 Add to Cart
pRK5-hGRK4 GRK4 (Homo sapiens) Mammalian Expression Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. Premont et al J Biol Chem. 1996 Mar 15;271(11):6403-10. pRK5 GRK4 GPRK2L, GPRK4, GRK4a, IT11 Add to Cart
pRK5-GRK6 GRK6 (Homo sapiens) Mammalian Expression Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. Pitcher et al J Biol Chem. 1996 Oct 4. 271(40):24907-13. pRK5 GRK6 GPRK6 Add to Cart
Beta2-AR-TYY β2AR (Homo sapiens) Mammalian Expression beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. Shenoy et al J Biol Chem. 2006 Jan 13;281(2):1261-73. Epub 2005 Nov 9. pcDNA3 ADRB2 ADRB2R, ADRBR, B2AR, BAR, BETA2AR Add to Cart
Dynamin I-K44A-non-tagged Dynamin I (Rattus norvegicus) Mammalian Expression Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. Ahn et al J Biol Chem. 2002 Jul 19;277(29):26642-51. Epub 2002 May 13. pcDNA3 Dnm1 Dnm Add to Cart
Dynamin-I-K44A-6His/Flag Dynamin I (Rattus norvegicus) Mammalian Expression Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. Ahn et al J Biol Chem. 2002 Jul 19;277(29):26642-51. Epub 2002 May 13. pcDNA3 Dnm1 Dnm Add to Cart
Arrb1-RFP beta-arrestin-1 (Rattus norvegicus) Mammalian Expression A stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1. Hara et al Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368. pcDNA3.1 Arrb1 BARRES Add to Cart
Arrb1-Q394L beta-arrestin-1 (Rattus norvegicus) Mammalian Expression A stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1. Hara et al Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368. pcDNA3.1
  • Tag / Fusion Protein
    • Flag (C terminal on backbone)
  • Arrb1 BARRES
    Add to Cart
    GRK2-K220R GRK2 (Bos taurus) Mammalian Expression Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. Freedman et al J Biol Chem. 1995 Jul 28;270(30):17953-61. pRK5 ADRBK1 BOS_24950, GRK2 Add to Cart
    DGK alpha DGK alpha (Homo sapiens) Mammalian Expression Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Nelson et al Science. 2007 Feb 2;315(5812):663-6. pCMV5 DGKA DAGK, DAGK1, DGK-alpha Add to Cart
    DGK beta DGK beta (Homo sapiens) Mammalian Expression Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Nelson et al Science. 2007 Feb 2;315(5812):663-6. pCMV5
  • Tag / Fusion Protein
    • HA (N terminal on backbone)
  • DGKB DAGK2, DGK, DGK-BETA
    Add to Cart
    DGK delta DGK delta (Homo sapiens) Mammalian Expression Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Nelson et al Science. 2007 Feb 2;315(5812):663-6. pCMV5
  • Tag / Fusion Protein
    • HA (N terminal on backbone)
  • DGKD DGKdelta, dgkd-2
    Add to Cart
    DGK epsilon DGK epsilon (Homo sapiens) Mammalian Expression Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Nelson et al Science. 2007 Feb 2;315(5812):663-6. pCMV5 DGKE DAGK5, DAGK6, DGK, NPHS7 Add to Cart
    DGK gamma DGK gamma (Homo sapiens) Mammalian Expression Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Nelson et al Science. 2007 Feb 2;315(5812):663-6. pCMV5 DGKG DAGK3, DGK-GAMMA Add to Cart
    DGK iota DGK iota (Homo sapiens) Mammalian Expression Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Nelson et al Science. 2007 Feb 2;315(5812):663-6. pCMV5 DGKI DGK-IOTA Add to Cart
    DGK zeta DGK zeta (Homo sapiens) Mammalian Expression Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Nelson et al Science. 2007 Feb 2;315(5812):663-6. pCMV5 DGKZ DAGK5, DAGK6, DGK-ZETA, hDGKzeta Add to Cart
    Beta-arrestin2 GFP WT βarrestin2 (Rattus norvegicus) Mammalian Expression Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. Shenoy et al J Biol Chem. 2005 Apr 15;280(15):15315-24. Epub 2005 Feb 7. pEGFP-N1 Arrb2 BARRES Add to Cart
    Beta-arrestin2 K11,12R GFP βarrestin2 (Rattus norvegicus) Mammalian Expression Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. Shenoy et al J Biol Chem. 2005 Apr 15;280(15):15315-24. Epub 2005 Feb 7. pEGFP-N1
  • Tag / Fusion Protein
    • EGFP (C terminal on backbone)
  • Arrb2 BARRES
    Add to Cart
    beta-arrestin1 mYFP beta-arrestin1 (Rattus norvegicus) Mammalian Expression G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. Violin et al J Biol Chem. 2006 Jul 21;281(29):20577-88. Epub 2006 May 10. pcDNA3.1 zeo Arrb1 BARRES Add to Cart
    beta-arrestin2 mYFP beta-arrestin2 (Rattus norvegicus) Mammalian Expression G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. Violin et al J Biol Chem. 2006 Jul 21;281(29):20577-88. Epub 2006 May 10. pcDNA3.1 zeo
  • Tag / Fusion Protein
    • mYFP (C terminal on insert)
  • Arrb2 BARRES
    Add to Cart
    GST-beta-arrestin1 beta-arrestin1 (Rattus norvegicus) Bacterial Expression The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2. Nobles et al J Biol Chem. 2007 Jul 20;282(29):21370-81. Epub 2007 May 18. pGEX-4T1 Arrb1 BARRES Add to Cart
    GST-beta-arrestin2 beta-arrestin2 (Rattus norvegicus) Bacterial Expression Activation-dependent conformational changes in {beta}-arrestin 2. Xiao et al J Biol Chem. 2004 Dec 31;279(53):55744-53. Epub 2004 Oct 22. pGEX-4T1
  • Tag / Fusion Protein
    • GST (N terminal on insert)
  • Arrb2 BARRES
    Add to Cart
    β₂AR-mCFP β₂AR (Homo sapiens) Mammalian Expression G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. Violin et al J Biol Chem. 2006 Jul 21;281(29):20577-88. Epub 2006 May 10. pcDNA3.1-mCFP Add to Cart
    FLAG-β-arrestin2 RRK/Q β-arrestin2 (Rattus norvegicus) Mammalian Expression Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. Nelson et al J Biol Chem. 2008 Jul 25;283(30):21093-101. Epub 2008 Jun 5. pcDNA3 Arrb2 BARRES Add to Cart
    FLAG-β-arrestin2 RRK/Q-5-kinase domain fusion protein (RRK5K) β-arrestin2 (Rattus norvegicus) Mammalian Expression Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. Nelson et al J Biol Chem. 2008 Jul 25;283(30):21093-101. Epub 2008 Jun 5. pCDNA 3.1 zeo-
  • Tag / Fusion Protein
    • Flag (N terminal on insert)
  • Arrb2 BARRES
    Add to Cart
    pRc/CMV2 Dvl-2-Myc Dvl 2 (Mus musculus) Mammalian Expression Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway. Lee et al J Biol Chem. 1999 Jul 23;274(30):21464-70. pRc/CMV2 Dvl2 RP23-172M21.1 Add to Cart
    pcDNA3 βarr1 S412A Flag β-arrestin 1 S412A (Rattus norvegicus) Mammalian Expression Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Luttrell et al Science. 1999 Jan 29. 283(5402):655-61. pcDNA3 Arrb1 BARRES Add to Cart
    pcDNA3 βarr1 S412D Flag β-arrestin 1 S412D (Rattus norvegicus) Mammalian Expression Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Luttrell et al Science. 1999 Jan 29. 283(5402):655-61. pcDNA3
  • Tag / Fusion Protein
    • Flag (C terminal on insert)
  • Arrb1 BARRES
    Add to Cart
    Fz4-GFP Frizzled 4 (Mus musculus) Mammalian Expression Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Chen et al Science. 2003 Sep 5;301(5638):1391-4. pEGFP-N2 Fzd4 Fz4 Add to Cart
    pcDNA3 c-SRC (WT) c-SRC (Homo sapiens) Mammalian Expression Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Luttrell et al Science. 1999 Jan 29. 283(5402):655-61. pcDNA3 SRC RP5-823N20.1, ASV, SRC1, c-SRC, p60-Src Add to Cart
    pcDNA3 c-SRC (1-249) c-SRC (1-249) (Homo sapiens) Mammalian Expression beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. Miller et al J Biol Chem. 2000 Apr 14;275(15):11312-9. pcDNA3 SRC RP5-823N20.1, ASV, SRC1, c-SRC, p60-Src Add to Cart
    pcDNA3 c-SRC (1-397) c-SRC (1-397) (Homo sapiens) Mammalian Expression beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. Miller et al J Biol Chem. 2000 Apr 14;275(15):11312-9. pcDNA3 SRC RP5-823N20.1, ASV, SRC1, c-SRC, p60-Src Add to Cart
    pcDNA3 c-SRC (91-536) c-SRC (91-536) (Homo sapiens) Mammalian Expression beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. Miller et al J Biol Chem. 2000 Apr 14;275(15):11312-9. pcDNA3 SRC RP5-823N20.1, ASV, SRC1, c-SRC, p60-Src Add to Cart
    pcDNA3 c-SRC (151-536) c-SRC (151-536) (Homo sapiens) Mammalian Expression beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. Miller et al J Biol Chem. 2000 Apr 14;275(15):11312-9. pcDNA3 SRC RP5-823N20.1, ASV, SRC1, c-SRC, p60-Src Add to Cart
    pcDNA3 c-SRC (250-536) c-SRC (250-536) (Homo sapiens) Mammalian Expression beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. Miller et al J Biol Chem. 2000 Apr 14;275(15):11312-9. pcDNA3 SRC RP5-823N20.1, ASV, SRC1, c-SRC, p60-Src Add to Cart
    pcDNA3 c-SRC (250-536) HA c-SRC (250-536) HA (Homo sapiens) Mammalian Expression beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. Miller et al J Biol Chem. 2000 Apr 14;275(15):11312-9. pcDNA3 SRC RP5-823N20.1, ASV, SRC1, c-SRC, p60-Src Add to Cart
    pcDNA3 c-SRC (250-536) K298M HA c-SRC (250-536) HA (Homo sapiens) Mammalian Expression beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. Miller et al J Biol Chem. 2000 Apr 14;275(15):11312-9. pcDNA3
  • Tag / Fusion Protein
    • HA (C terminal on insert)
  • SRC RP5-823N20.1, ASV, SRC1, c-SRC, p60-Src
    Add to Cart
    pCDNA3.1 AT1AR-TSTS/4A AT1AR-TSTS/A (Rattus norvegicus) Mammalian Expression Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. Wei et al J Biol Chem. 2004 Nov 12;279(46):48255-61. Epub 2004 Sep 7. pcDNA3.1/Zeo Agtr1a AT1, AT1A, AT1R, Agtr1 Add to Cart
    pCDNA3.1 AT1AR-324delta AT1AR-324delta (Rattus norvegicus) Mammalian Expression Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. Wei et al J Biol Chem. 2004 Nov 12;279(46):48255-61. Epub 2004 Sep 7. pcDNA3.1/Zeo Agtr1a AT1, AT1A, AT1R, Agtr1 Add to Cart
    pcDNA3.0 FLAG TRPV4 TRPV4 (Rattus norvegicus) Mammalian Expression Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. Shukla et al J Biol Chem. 2010 Sep 24;285(39):30115-25. doi: 10.1074/jbc.M110.141549. Epub 2010 Jul 22. pcDNA3 Add to Cart
    pcDNA3 MDM2 1-400 MDM2 1-400 (Homo sapiens) Mammalian Expression Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Shenoy et al Science. 2001 Nov 9;294(5545):1307-13. Epub 2001 Oct 4. pcDNA3 MDM2 ACTFS, HDMX, hdm2 Add to Cart
    GRK2 S670A GRK2 S670A (Bos taurus) Mammalian Expression Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. Pitcher et al J Biol Chem. 1999 Dec 3. 274(49):34531-4. pcDNA3 ADRBK1 BOS_24950, GRK2 Add to Cart
    pcDNA3 GRK2 S670D GRK2 S670D (Bos taurus) Mammalian Expression Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. Pitcher et al J Biol Chem. 1999 Dec 3. 274(49):34531-4. pcDNA3 ADRBK1 BOS_24950, GRK2 Add to Cart
    pcDNA3.1 AT1R DRY-AAY AT1R DRY-AAY (Rattus norvegicus) Mammalian Expression The role of a conserved region of the second intracellular loop in AT1 angiotensin receptor activation and signaling. Gaborik et al Endocrinology. 2003 Jun;144(6):2220-8. pcDNA3.1 Agtr1a AT1, AT1A, AT1R, Agtr1 Add to Cart
    pCMV5 alpha 1A AR alpha 1A AR (Rattus norvegicus) Mammalian Expression Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype. Schwinn et al J Biol Chem. 1990 May 15;265(14):8183-9. pCMV5 Adra1a Adra1c Add to Cart