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Robert Lefkowitz Lab Plasmids


The Robert Lefkowitz Lab has deposited plasmids at Addgene for distribution to the research community. Addgene is a non-profit plasmid repository dedicated to improving life science research.

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Title Authors Publication
The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Laporte SA, Oakley RH, Zhang J, Holt JA, Ferguson SS, Caron MG, Barak LS Proc Natl Acad Sci U S A. 1999 Mar 30. 96(7):3712-7.
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ Science. 1999 Jan 29. 283(5402):655-61.
Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. Pitcher JA, Fredericks ZL, Stone WC, Premont RT, Stoffel RH, Koch WJ, Lefkowitz RJ J Biol Chem. 1996 Oct 4. 271(40):24907-13.
Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. Pitcher JA, Tesmer JJ, Freeman JL, Capel WD, Stone WC, Lefkowitz RJ J Biol Chem. 1999 Dec 3. 274(49):34531-4.
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. Koch WJ, Hawes BE, Inglese J, Luttrell LM, Lefkowitz RJ J Biol Chem. 1994 Feb 25. 269(8):6193-7.
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. Tang Y, Hu LA, Miller WE, Ringstad N, Hall RA, Pitcher JA, DeCamilli P, Lefkowitz RJ Proc Natl Acad Sci U S A. 1999 Oct 26. 96(22):12559-64.
Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. Ahn S, Kim J, Lucaveche CL, Reedy MC, Luttrell LM, Lefkowitz RJ, Daaka Y J Biol Chem. 2002 Jul 19;277(29):26642-51. Epub 2002 May 13.
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, Madabushi S, Reiter E, Premont RT, Lichtarge O, Lefkowitz RJ J Biol Chem. 2006 Jan 13;281(2):1261-73. Epub 2005 Nov 9.
Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. Premont RT, Macrae AD, Stoffel RH, Chung N, Pitcher JA, Ambrose C, Inglese J, MacDonald ME, Lefkowitz RJ J Biol Chem. 1996 Mar 15;271(11):6403-10.
A stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1. Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368.
Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Nelson CD, Perry SJ, Regier DS, Prescott SM, Topham MK, Lefkowitz RJ Science. 2007 Feb 2;315(5812):663-6.
Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. Shenoy SK, Lefkowitz RJ J Biol Chem. 2005 Apr 15;280(15):15315-24. Epub 2005 Feb 7.
G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. Violin JD, Ren XR, Lefkowitz RJ J Biol Chem. 2006 Jul 21;281(29):20577-88. Epub 2006 May 10.
The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2. Nobles KN, Guan Z, Xiao K, Oas TG, Lefkowitz RJ J Biol Chem. 2007 Jul 20;282(29):21370-81. Epub 2007 May 18.
Activation-dependent conformational changes in {beta}-arrestin 2. Xiao K, Shenoy SK, Nobles K, Lefkowitz RJ J Biol Chem. 2004 Dec 31;279(53):55744-53. Epub 2004 Oct 22.
Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. Nelson CD, Kovacs JJ, Nobles KN, Whalen EJ, Lefkowitz RJ J Biol Chem. 2008 Jul 25;283(30):21093-101. Epub 2008 Jun 5.
Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. Freedman NJ, Liggett SB, Drachman DE, Pei G, Caron MG, Lefkowitz RJ J Biol Chem. 1995 Jul 28;270(30):17953-61.
beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. Miller WE, Maudsley S, Ahn S, Khan KD, Luttrell LM, Lefkowitz RJ J Biol Chem. 2000 Apr 14;275(15):11312-9.
Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway. Lee JS, Ishimoto A, Yanagawa S J Biol Chem. 1999 Jul 23;274(30):21464-70.
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ Science. 2003 Sep 5;301(5638):1391-4.
The role of a conserved region of the second intracellular loop in AT1 angiotensin receptor activation and signaling. Gaborik Z, Jagadeesh G, Zhang M, Spat A, Catt KJ, Hunyady L Endocrinology. 2003 Jun;144(6):2220-8.
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ Science. 2001 Nov 9;294(5545):1307-13. Epub 2001 Oct 4.
Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. Wei H, Ahn S, Barnes WG, Lefkowitz RJ J Biol Chem. 2004 Nov 12;279(46):48255-61. Epub 2004 Sep 7.
Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype. Schwinn DA, Lomasney JW, Lorenz W, Szklut PJ, Fremeau RT Jr, Yang-Feng TL, Caron MG, Lefkowitz RJ, Cotecchia S J Biol Chem. 1990 May 15;265(14):8183-9.
Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. Shukla AK, Kim J, Ahn S, Xiao K, Shenoy SK, Liedtke W, Lefkowitz RJ J Biol Chem. 2010 Sep 24;285(39):30115-25. doi: 10.1074/jbc.M110.141549. Epub 2010 Jul 22.
ID Plasmid Gene/Insert Vector Type Publication Hidden Extra Search Info  
14685pcDNA3 Barr2 flagbeta-arrestin 2 (Rattus norvegicus)Mammalian ExpressionThe beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Proc Natl Acad Sci U S A. 1999 Mar 30. 96(7):3712-7. pcDNA3 Arrb2 BARRES Add to Cart
14687pcDNA3 barr1 flagbeta arrestin 1 (Rattus norvegicus)Mammalian ExpressionBeta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 1999 Jan 29. 283(5402):655-61. pcDNA3 Arrb1 BARRES Add to Cart
14690pRK5 bovine GRK5GRK5 (Bos taurus)Mammalian ExpressionPhosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. J Biol Chem. 1996 Oct 4. 271(40):24907-13. pRK5 GRK5 GPRK5 Add to Cart
14691pRK5 bovine GRK2GRK2 (Bos taurus)Mammalian ExpressionFeedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. J Biol Chem. 1999 Dec 3. 274(49):34531-4. pRK5 ADRBK1 GRK2 Add to Cart
14692pcDNA3 barr2 HAbeta-arrestin 2 (Rattus norvegicus)Mammalian ExpressionBeta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 1999 Jan 29. 283(5402):655-61. pcDNA3 Arrb2 BARRES Add to Cart
14693pcDNA3 barr1 HAbeta arrestin 1 (Rattus norvegicus)Mammalian ExpressionBeta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 1999 Jan 29. 283(5402):655-61. pcDNA3 Arrb1 BARRES Add to Cart
14695pRK5 BARK1 minigeneBARK1 minigene (Bos taurus)Mammalian ExpressionCellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. J Biol Chem. 1994 Feb 25. 269(8):6193-7. pRK5 ADRBK1 GRK2 Add to Cart
14697pcDNA3 Flag beta-2-adrenergic-receptorB2AR (Homo sapiens)Mammalian ExpressionIdentification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. Proc Natl Acad Sci U S A. 1999 Oct 26. 96(22):12559-64. pcDNA3 ADRB2 ADRB2R, ADRBR, B2AR, BAR, BETA2AR Add to Cart
14698pcDNA3 Flag beta-1-adrenergic-receptorB1AR (Homo sapiens)Mammalian ExpressionIdentification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. Proc Natl Acad Sci U S A. 1999 Oct 26. 96(22):12559-64. pcDNA3 ADRB1 ADRB1R, B1AR, BETA1AR, RHR Add to Cart
32689pcDNA-GRK3GRK3 (Bos taurus)Mammalian ExpressionPhosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. J Biol Chem. 1996 Oct 4. 271(40):24907-13. pcDNA3 ADRBK2 BARK2, GRK3 Add to Cart
32690pRK5-hGRK4GRK4 (Homo sapiens)Mammalian ExpressionCharacterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. J Biol Chem. 1996 Mar 15;271(11):6403-10. pRK5 GRK4 GPRK2L, GPRK4, GRK4a, IT11 Add to Cart
32693pRK5-GRK6GRK6 (Homo sapiens)Mammalian ExpressionPhosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. J Biol Chem. 1996 Oct 4. 271(40):24907-13. pRK5 GRK6 GPRK6 Add to Cart
32694Beta2-AR-TYYβ2AR (Homo sapiens)Mammalian Expressionbeta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem. 2006 Jan 13;281(2):1261-73. Epub 2005 Nov 9. pcDNA3 ADRB2 ADRB2R, ADRBR, B2AR, BAR, BETA2AR Add to Cart
32695Dynamin I-K44A-non-taggedDynamin I (Rattus norvegicus)Mammalian ExpressionSrc-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. J Biol Chem. 2002 Jul 19;277(29):26642-51. Epub 2002 May 13. pcDNA3 Dnm1 Dnm Add to Cart
32696Dynamin-I-K44A-6His/FlagDynamin I (Rattus norvegicus)Mammalian ExpressionSrc-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. J Biol Chem. 2002 Jul 19;277(29):26642-51. Epub 2002 May 13. pcDNA3 Dnm1 Dnm Add to Cart
35401Arrb1-RFPbeta-arrestin-1 (Rattus norvegicus)Mammalian ExpressionA stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1. Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368. pcDNA3.1 Arrb1 BARRES Add to Cart
35402Arrb1-Q394Lbeta-arrestin-1 (Rattus norvegicus)Mammalian ExpressionA stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1. Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368. pcDNA3.1
  • Tag / Fusion Protein
    • Flag (C terminal on backbone)
  • Arrb1 BARRES
    Add to Cart
    35403GRK2-K220RGRK2 (Bos taurus)Mammalian ExpressionPhosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. J Biol Chem. 1995 Jul 28;270(30):17953-61. pRK5 ADRBK1 GRK2 Add to Cart
    35404DGK alphaDGK alpha (Homo sapiens)Mammalian ExpressionTargeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science. 2007 Feb 2;315(5812):663-6. pCMV5 DGKA DAGK, DAGK1, DGK-alpha Add to Cart
    35405DGK betaDGK beta (Homo sapiens)Mammalian ExpressionTargeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science. 2007 Feb 2;315(5812):663-6. pCMV5
  • Tag / Fusion Protein
    • HA (N terminal on backbone)
  • DGKB DAGK2, DGK, DGK-BETA
    Add to Cart
    35406DGK deltaDGK delta (Homo sapiens)Mammalian ExpressionTargeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science. 2007 Feb 2;315(5812):663-6. pCMV5
  • Tag / Fusion Protein
    • HA (N terminal on backbone)
  • DGKD DGKdelta, dgkd-2
    Add to Cart
    35407DGK epsilonDGK epsilon (Homo sapiens)Mammalian ExpressionTargeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science. 2007 Feb 2;315(5812):663-6. pCMV5 DGKE DAGK5, DAGK6, DGK, NPHS7 Add to Cart
    35408DGK gammaDGK gamma (Homo sapiens)Mammalian ExpressionTargeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science. 2007 Feb 2;315(5812):663-6. pCMV5 DGKG DAGK3, DGK-GAMMA Add to Cart
    35409DGK iotaDGK iota (Homo sapiens)Mammalian ExpressionTargeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science. 2007 Feb 2;315(5812):663-6. pCMV5 DGKI DGK-IOTA Add to Cart
    35410DGK zetaDGK zeta (Homo sapiens)Mammalian ExpressionTargeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science. 2007 Feb 2;315(5812):663-6. pCMV5 DGKZ DAGK5, DAGK6, DGK-ZETA, hDGKzeta Add to Cart
    35411Beta-arrestin2 GFP WTβarrestin2 (Rattus norvegicus)Mammalian ExpressionReceptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. J Biol Chem. 2005 Apr 15;280(15):15315-24. Epub 2005 Feb 7. pEGFP-N1 Arrb2 BARRES Add to Cart
    35412Beta-arrestin2 K11,12R GFPβarrestin2 (Rattus norvegicus)Mammalian ExpressionReceptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. J Biol Chem. 2005 Apr 15;280(15):15315-24. Epub 2005 Feb 7. pEGFP-N1
  • Tag / Fusion Protein
    • EGFP (C terminal on backbone)
  • Arrb2 BARRES
    Add to Cart
    36916beta-arrestin1 mYFPbeta-arrestin1 (Rattus norvegicus)Mammalian ExpressionG-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. J Biol Chem. 2006 Jul 21;281(29):20577-88. Epub 2006 May 10. pcDNA3.1 zeo Arrb1 BARRES Add to Cart
    36917beta-arrestin2 mYFPbeta-arrestin2 (Rattus norvegicus)Mammalian ExpressionG-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. J Biol Chem. 2006 Jul 21;281(29):20577-88. Epub 2006 May 10. pcDNA3.1 zeo
  • Tag / Fusion Protein
    • mYFP (C terminal on insert)
  • Arrb2 BARRES
    Add to Cart
    36918GST-beta-arrestin1beta-arrestin1 (Rattus norvegicus)Bacterial ExpressionThe active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2. J Biol Chem. 2007 Jul 20;282(29):21370-81. Epub 2007 May 18. pGEX-4T1 Arrb1 BARRES Add to Cart
    36919GST-beta-arrestin2beta-arrestin2 (Rattus norvegicus)Bacterial ExpressionActivation-dependent conformational changes in {beta}-arrestin 2. J Biol Chem. 2004 Dec 31;279(53):55744-53. Epub 2004 Oct 22. pGEX-4T1
  • Tag / Fusion Protein
    • GST (N terminal on insert)
  • Arrb2 BARRES
    Add to Cart
    38260β₂AR-mCFPβ₂AR (Homo sapiens)Mammalian ExpressionG-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. J Biol Chem. 2006 Jul 21;281(29):20577-88. Epub 2006 May 10. pcDNA3.1-mCFP Add to Cart
    38261FLAG-β-arrestin2 RRK/Qβ-arrestin2 (Rattus norvegicus)Mammalian ExpressionBeta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. J Biol Chem. 2008 Jul 25;283(30):21093-101. Epub 2008 Jun 5. pcDNA3 Arrb2 BARRES Add to Cart
    38262FLAG-β-arrestin2 RRK/Q-5-kinase domain fusion protein (RRK5K)β-arrestin2 (Rattus norvegicus)Mammalian ExpressionBeta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. J Biol Chem. 2008 Jul 25;283(30):21093-101. Epub 2008 Jun 5. pCDNA 3.1 zeo-
  • Tag / Fusion Protein
    • Flag (N terminal on insert)
  • Arrb2 BARRES
    Add to Cart
    42194pRc/CMV2 Dvl-2-MycDvl 2 (Mus musculus)Mammalian ExpressionCharacterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway. J Biol Chem. 1999 Jul 23;274(30):21464-70. pRc/CMV2 Dvl2 Add to Cart
    42195pcDNA3 βarr1 S412A Flagβ-arrestin 1 S412A (Rattus norvegicus)Mammalian ExpressionBeta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 1999 Jan 29. 283(5402):655-61. pcDNA3 Arrb1 BARRES Add to Cart
    42196pcDNA3 βarr1 S412D Flagβ-arrestin 1 S412D (Rattus norvegicus)Mammalian ExpressionBeta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 1999 Jan 29. 283(5402):655-61. pcDNA3
  • Tag / Fusion Protein
    • Flag (C terminal on insert)
  • Arrb1 BARRES
    Add to Cart
    42197Fz4-GFPFrizzled 4 (Mus musculus)Mammalian ExpressionDishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science. 2003 Sep 5;301(5638):1391-4. pEGFP-N2 Fzd4 Fz4 Add to Cart
    42202pcDNA3 c-SRC (WT)c-SRC (Homo sapiens)Mammalian ExpressionBeta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 1999 Jan 29. 283(5402):655-61. pcDNA3 SRC ASV, SRC1, THC6, c-SRC, p60-Src Add to Cart
    42204pcDNA3 c-SRC (1-249)c-SRC (1-249) (Homo sapiens)Mammalian Expressionbeta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. J Biol Chem. 2000 Apr 14;275(15):11312-9. pcDNA3 SRC ASV, SRC1, THC6, c-SRC, p60-Src Add to Cart
    42205pcDNA3 c-SRC (1-397)c-SRC (1-397) (Homo sapiens)Mammalian Expressionbeta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. J Biol Chem. 2000 Apr 14;275(15):11312-9. pcDNA3 SRC ASV, SRC1, THC6, c-SRC, p60-Src Add to Cart
    42206pcDNA3 c-SRC (91-536)c-SRC (91-536) (Homo sapiens)Mammalian Expressionbeta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. J Biol Chem. 2000 Apr 14;275(15):11312-9. pcDNA3 SRC ASV, SRC1, THC6, c-SRC, p60-Src Add to Cart
    42207pcDNA3 c-SRC (151-536)c-SRC (151-536) (Homo sapiens)Mammalian Expressionbeta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. J Biol Chem. 2000 Apr 14;275(15):11312-9. pcDNA3 SRC ASV, SRC1, THC6, c-SRC, p60-Src Add to Cart
    42208pcDNA3 c-SRC (250-536)c-SRC (250-536) (Homo sapiens)Mammalian Expressionbeta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. J Biol Chem. 2000 Apr 14;275(15):11312-9. pcDNA3 SRC ASV, SRC1, THC6, c-SRC, p60-Src Add to Cart
    42209pcDNA3 c-SRC (250-536) HAc-SRC (250-536) HA (Homo sapiens)Mammalian Expressionbeta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. J Biol Chem. 2000 Apr 14;275(15):11312-9. pcDNA3 SRC ASV, SRC1, THC6, c-SRC, p60-Src Add to Cart
    42210pcDNA3 c-SRC (250-536) K298M HAc-SRC (250-536) HA (Homo sapiens)Mammalian Expressionbeta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. J Biol Chem. 2000 Apr 14;275(15):11312-9. pcDNA3
  • Tag / Fusion Protein
    • HA (C terminal on insert)
  • SRC ASV, SRC1, THC6, c-SRC, p60-Src
    Add to Cart
    45634pCDNA3.1 AT1AR-TSTS/4AAT1AR-TSTS/A (Rattus norvegicus)Mammalian ExpressionStable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. J Biol Chem. 2004 Nov 12;279(46):48255-61. Epub 2004 Sep 7. pcDNA3.1/Zeo Agtr1a AT1, AT1A, AT1R, Agtr1 Add to Cart
    45635pCDNA3.1 AT1AR-324deltaAT1AR-324delta (Rattus norvegicus)Mammalian ExpressionStable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. J Biol Chem. 2004 Nov 12;279(46):48255-61. Epub 2004 Sep 7. pcDNA3.1/Zeo Agtr1a AT1, AT1A, AT1R, Agtr1 Add to Cart
    45751pcDNA3.0 FLAG TRPV4TRPV4 (Rattus norvegicus)Mammalian ExpressionArresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. J Biol Chem. 2010 Sep 24;285(39):30115-25. doi: 10.1074/jbc.M110.141549. Epub 2010 Jul 22. pcDNA3 Add to Cart
    45754pcDNA3 MDM2 1-400MDM2 1-400 (Homo sapiens)Mammalian ExpressionRegulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science. 2001 Nov 9;294(5545):1307-13. Epub 2001 Oct 4. pcDNA3 MDM2 ACTFS, HDMX, hdm2 Add to Cart
    45755GRK2 S670AGRK2 S670A (Bos taurus)Mammalian ExpressionFeedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. J Biol Chem. 1999 Dec 3. 274(49):34531-4. pcDNA3 ADRBK1 GRK2 Add to Cart
    45756pcDNA3 GRK2 S670DGRK2 S670D (Bos taurus)Mammalian ExpressionFeedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. J Biol Chem. 1999 Dec 3. 274(49):34531-4. pcDNA3 ADRBK1 GRK2 Add to Cart
    45759pcDNA3.1 AT1R DRY-AAYAT1R DRY-AAY (Rattus norvegicus)Mammalian ExpressionThe role of a conserved region of the second intracellular loop in AT1 angiotensin receptor activation and signaling. Endocrinology. 2003 Jun;144(6):2220-8. pcDNA3.1 Agtr1a AT1, AT1A, AT1R, Agtr1 Add to Cart
    45760pCMV5 alpha 1A ARalpha 1A AR (Rattus norvegicus)Mammalian ExpressionMolecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype. J Biol Chem. 1990 May 15;265(14):8183-9. pCMV5 Adra1a Adra1c Add to Cart