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Bob Weinberg Lab Plasmids


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Title Authors Publication
Slug and Sox9 cooperatively determine the mammary stem cell state. Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, Itzkovitz S, Noske A, Zurrer-Hardi U, Bell G, Tam WL, Mani SA, van Oudenaarden A, Weinberg RA Cell. 2012 Mar 2;148(5):1015-28.
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Ma L, Reinhardt F, Pan E, Soutschek J, Bhat B, Marcusson EG, Teruya-Feldstein J, Bell GW, Weinberg RA Nat Biotechnol. 2010 Apr . 28(4):341-7.
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S, Westermann F, Speleman F, Vandesompele J, Weinberg RA Nat Cell Biol. 2010 Mar . 12(3):247-56.
A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Valastyan S, Reinhardt F, Benaich N, Calogrias D, Szasz AM, Wang ZC, Brock JE, Richardson AL, Weinberg RA Cell. 2009 Jun 12. 137(6):1032-46.
Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Shibue T, Weinberg RA Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10290-5. Epub 2009 Jun 5.
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Rai P, Onder TT, Young JJ, McFaline JL, Pang B, Dedon PC, Weinberg RA Proc Natl Acad Sci U S A. 2009 Jan 6. 106(1):169-74.
Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Godar S, Ince TA, Bell GW, Feldser D, Donaher JL, Bergh J, Liu A, Miu K, Watnick RS, Reinhardt F, McAllister SS, Jacks T, Weinberg RA Cell. 2008 Jul 11. 134(1):62-73.
The epithelial-mesenchymal transition generates cells with properties of stem cells. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA Cell. 2008 May 16. 133(4):704-15.
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA Cancer Res. 2008 May 15. 68(10):3645-54.
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Ma L, Teruya-Feldstein J, Weinberg RA Nature. 2007 Oct 11. 449(7163):682-8.
Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Mani SA, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N, Kutok JL, Hartwell K, Richardson AL, Weinberg RA Proc Natl Acad Sci U S A. 2007 Jun 12. 104(24):10069-74.
The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Hartwell KA, Muir B, Reinhardt F, Carpenter AE, Sgroi DC, Weinberg RA Proc Natl Acad Sci U S A. 2006 Dec 12. 103(50):18969-74.
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Gupta PB, Kuperwasser C, Brunet JP, Ramaswamy S, Kuo WL, Gray JW, Naber SP, Weinberg RA Nat Genet. 2005 Oct . 37(10):1047-54.
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA Cell. 2005 May 6. 121(3):335-48.
Species- and cell type-specific requirements for cellular transformation. Rangarajan A, Hong SJ, Gifford A, Weinberg RA Cancer Cell. 2004 Aug . 6(2):171-83.
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A, Weinberg RA Cell 2004 Jun 25;117(7):927-39.
Lentivirus-delivered stable gene silencing by RNAi in primary cells. Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD RNA 2003 Apr;9(4):493-501.
Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, Sabatini DM, DeCaprio JA, Weinberg RA Mol Cell Biol 2002 Apr;22(7):2111-23.
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA Cell 2001 Oct 19;107(2):149-59.
SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling. Sun Y, Liu X, Ng-Eaton E, Lodish HF, Weinberg RA Proc Natl Acad Sci U S A. 1999 Oct 26. 96(22):12442-7.
Inhibition of telomerase limits the growth of human cancer cells. Hahn WC, Stewart SA, Brooks MW, York SG, Eaton E, Kurachi A, Beijersbergen RL, Knoll JH, Meyerson M, Weinberg RA Nat Med 1999 Oct;5(10):1164-70.
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Counter CM, Hahn WC, Wei W, Caddle SD, Beijersbergen RL, Lansdorp PM, Sedivy JM, Weinberg RA Proc Natl Acad Sci U S A 1998 Dec 8;95(25):14723-8.
Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Liu X, Sun Y, Constantinescu SN, Karam E, Weinberg RA, Lodish HF Proc Natl Acad Sci U S A. 1997 Sep 30. 94(20):10669-74.
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD, Ziaugra L, Beijersbergen RL, Davidoff MJ, Liu Q, Bacchetti S, Haber DA, Weinberg RA Cell 1997 Aug 22;90(4):785-95.
Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Geng Y, Eaton EN, Picon M, Roberts JM, Lundberg AS, Gifford A, Sardet C, Weinberg RA Oncogene 1996 Mar 21;12(6):1173-80.
Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA Nature. 1993 May 6. 363(6424):45-51.
E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA Proc Natl Acad Sci U S A. 1995 Mar 14. 92(6):2403-7.
Growth suppression by p16ink4 requires functional retinoblastoma protein. Medema RH, Herrera RE, Lam F, Weinberg RA Proc Natl Acad Sci U S A. 1995 Jul 3. 92(14):6289-93.
Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Bargmann CI, Hung MC, Weinberg RA Cell. 1986 Jun 6. 45(5):649-57.
Expression cloning and characterization of the TGF-beta type III receptor. Wang XF, Lin HY, Ng-Eaton E, Downward J, Lodish HF, Weinberg RA Cell. 1991 Nov 15. 67(4):797-805.
Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA Cell. 1992 Sep 18. 70(6):993-1006.
empty vector (unpublished)
pBABE-vectors (unpublished)
Rb-plasmids (unpublished)
Plasmid Gene/Insert Vector Type Publication Hidden Extra Search Info  
PBSK HRbc human Rb (Homo sapiens) Bacterial Expression Rb-plasmids (unpublished) pBSK+ RB1 RP11-174I10.1, OSRC, PPP1R130, RB, p105-Rb, pRb, pp110 Add to Cart
HRbc-SVE+ human Rb (Homo sapiens) Bacterial Expression Rb-plasmids (unpublished) pBSK+ RB1 RP11-174I10.1, OSRC, PPP1R130, RB, p105-Rb, pRb, pp110 Add to Cart
RcCMV/Rb human Rb (Homo sapiens) Mammalian Expression Rb-plasmids (unpublished) Rc/CMV RB1 RP11-174I10.1, OSRC, PPP1R130, RB, p105-Rb, pRb, pp110 Add to Cart
pBabe-puro Ras V12 ras V12 (Homo sapiens) Mammalian Expression, Retroviral pBABE-vectors (unpublished) pBABE-puro HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras Add to Cart
pYESir2-puro Sir2 (Homo sapiens) Mammalian Expression, Retroviral hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Vaziri et al Cell 2001 Oct 19;107(2):149-59. pBABE-puro SIRT1 RP11-57G10.3, SIR2L1 Add to Cart
pYESir2HY-puro Sir2 (Homo sapiens) Mammalian Expression, Retroviral hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Vaziri et al Cell 2001 Oct 19;107(2):149-59. pBABE-puro SIRT1 RP11-57G10.3, SIR2L1 Add to Cart
pBABE-puro-hTERT hTERT (Homo sapiens) Mammalian Expression, Retroviral Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Counter et al Proc Natl Acad Sci U S A 1998 Dec 8;95(25):14723-8. Retroviral expression of hTERT. Used to create immortalized cell lines. pBABE-puro TERT CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Add to Cart
pBABE-puro-hTERT-HA hTERT (Homo sapiens) Mammalian Expression, Retroviral Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Counter et al Proc Natl Acad Sci U S A 1998 Dec 8;95(25):14723-8. pBABE-puro TERT CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Add to Cart
pBABE-hygro-hTERT hTERT (Homo sapiens) Mammalian Expression, Retroviral Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Counter et al Proc Natl Acad Sci U S A 1998 Dec 8;95(25):14723-8. Retroviral expression of hTERT. Used to create immortalized cell lines. pBABE-hygro TERT CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Add to Cart
pBABE-neo-hTERT hTERT (Homo sapiens) Mammalian Expression, Retroviral Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Counter et al Proc Natl Acad Sci U S A 1998 Dec 8;95(25):14723-8. Retroviral expression of hTERT. Used to create immortalized cell lines. pBABE-neo TERT CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Add to Cart
pBABE-puro-DN-hTERT hTERT (Homo sapiens) Mammalian Expression, Retroviral Inhibition of telomerase limits the growth of human cancer cells. Hahn et al Nat Med 1999 Oct;5(10):1164-70. pBABE-puro TERT CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Add to Cart
pBABE-zeo largeTgenomic large T and small T antigen Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pBABE-zeo SV40gp6 SV40gp6 Add to Cart
pBABE-zeo largeTcDNA large T antigen Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pBABE-zeo SV40gp6 SV40gp6 Add to Cart
pBABE-neo largeTcDNA large T antigen Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. Retroviral expression of Large T Antigen. Used to create immortalized cell lines. pBABE-neo SV40gp6 SV40gp6 Add to Cart
pCI neo-hEST2 hTERT (Homo sapiens) Mammalian Expression hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Meyerson et al Cell 1997 Aug 22;90(4):785-95. pCI neo TERT CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Add to Cart
pCI neo-hEST2-HA hTERT (Homo sapiens) Mammalian Expression hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Meyerson et al Cell 1997 Aug 22;90(4):785-95. pCI neo TERT CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Add to Cart
pBABE-puro-mTwist Twist (Mus musculus) Mammalian Expression, Retroviral Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Yang et al Cell 2004 Jun 25;117(7):927-39. pBABE-puro Twist1 AA960487, M-Twist, Pde, Ska10, Ska<m10Jus>, Twist, bHLHa38, pdt Add to Cart
Twist-siRNA3 siTwist (Mus musculus) Mammalian Expression Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Yang et al Cell 2004 Jun 25;117(7):927-39. pSP-108 Twist1 AA960487, M-Twist, Pde, Ska10, Ska<m10Jus>, Twist, bHLHa38, pdt Add to Cart
pUMVC Mammalian Expression, Retroviral Lentivirus-delivered stable gene silencing by RNAi in primary cells. Stewart et al RNA 2003 Apr;9(4):493-501. Packaging plasmid for producing MuLV retroviral particles. Use in conjunction with an envelope plasmid such as pCMV-VSV-G. pUMVC Add to Cart
Retrohair Mammalian Expression, Retroviral, RNAi Lentivirus-delivered stable gene silencing by RNAi in primary cells. Stewart et al RNA 2003 Apr;9(4):493-501. pBABE Add to Cart
Lentihair s1GFP siRNA against GFP Mammalian Expression, Lentiviral, RNAi Lentivirus-delivered stable gene silencing by RNAi in primary cells. Stewart et al RNA 2003 Apr;9(4):493-501. pLentihair Add to Cart
pMKO.1 puro Mammalian Expression, Retroviral, RNAi Lentivirus-delivered stable gene silencing by RNAi in primary cells. Stewart et al RNA 2003 Apr;9(4):493-501. pMSCV Add to Cart
pLKO.1 puro Mammalian Expression, Lentiviral, RNAi Lentivirus-delivered stable gene silencing by RNAi in primary cells. Stewart et al RNA 2003 Apr;9(4):493-501. 3rd gen lentiviral backbone for cloning and expression of new shRNA sequences. Uses puromycin for selection. pLKO.1 Add to Cart
pCMV-VSV-G Mammalian Expression Lentivirus-delivered stable gene silencing by RNAi in primary cells. Stewart et al RNA 2003 Apr;9(4):493-501. Envelope protein for producing lentiviral and MuLV retroviral particles. Use in conjunction with a packaging vector such as pCMV-dR8.2 dvpr (lentiviral) or pUMVC (MuLV retroviral). na Add to Cart
pCMV-dR8.2 dvpr Mammalian Expression, Lentiviral Lentivirus-delivered stable gene silencing by RNAi in primary cells. Stewart et al RNA 2003 Apr;9(4):493-501. 2nd generation lentiviral packaging plasmid. Can be used with 2nd and 3rd generation transfer vectors. Use in conjunction with an envelope plasmid such as pCMV-VSV-G. na Add to Cart
Twist-siRNA5 siTwist (Mus musculus) Mammalian Expression Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Yang et al Cell 2004 Jun 25;117(7):927-39. pSP-108 Twist1 AA960487, M-Twist, Pde, Ska10, Ska<m10Jus>, Twist, bHLHa38, pdt Add to Cart
Twist-siRNA7 siTwist (Mus musculus) Mammalian Expression Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Yang et al Cell 2004 Jun 25;117(7):927-39. pSP-108 Twist1 AA960487, M-Twist, Pde, Ska10, Ska<m10Jus>, Twist, bHLHa38, pdt Add to Cart
10-4 cyclin E promoter human cyclin E promoter (Homo sapiens) Mammalian Expression, Luciferase Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Geng et al Oncogene 1996 Mar 21;12(6):1173-80. pGL-2 CCNE1 CCNE Add to Cart
EE-mut SV40 luc human cyclin E promoter fragment, mutant (Homo sapiens) Mammalian Expression, Luciferase Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Geng et al Oncogene 1996 Mar 21;12(6):1173-80. pGL2-Promoter CCNE1 CCNE Add to Cart
pBABE-neo largeTcDNA K1 large T antigen Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pBABE-neo SV40gp6 SV40gp6 Add to Cart
pBABE-neo largeTcDNA delta434-444 large T antigen Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pBABE-neo SV40gp6 SV40gp6 Add to Cart
pBABE-zeo smallT SV40 small T Antigen Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pBABE-zeo SV40gp7 SV40gp7 Add to Cart
Rc/CMV cyclin A cyclin A (Homo sapiens) Mammalian Expression Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Hinds et al Cell. 1992 Sep 18. 70(6):993-1006. pRc/CMV CCNA2 CCN1, CCNA Add to Cart
Rc/CMV cyclin C cyclin C (Homo sapiens) Mammalian Expression Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Hinds et al Cell. 1992 Sep 18. 70(6):993-1006. pRc/CMV CCNC CycC Add to Cart
Rc/CMV cyclin D1 cyclin D1 (Homo sapiens) Mammalian Expression Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Hinds et al Cell. 1992 Sep 18. 70(6):993-1006. pRc/CMV CCND1 BCL1, D11S287E, PRAD1, U21B31 Add to Cart
Rc/CMV cyclin E cyclin E (Homo sapiens) Mammalian Expression Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Hinds et al Cell. 1992 Sep 18. 70(6):993-1006. pRc/CMV CCNE1 CCNE Add to Cart
pBABE-neo largeTcDNA H42Q large T antigen Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pBABE-neo SV40gp6 SV40gp6 Add to Cart
pBABE-hygro p53 DD p53 DD (Mus musculus) Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pBABE hygro Trp53 RP23-56I20.1, Tp53, bbl, bfy, bhy, p44, p53 Add to Cart
pMIG small T SV40 small T Antigen Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pMIG SV40gp7 SV40gp7 Add to Cart
pMIG small T C97S E102Q SV40 small T Antigen 97, 102 Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pMIG SV40gp7 SV40gp7 Add to Cart
pMIG small T 110 SV40 small T Antigen 110 Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pMIG SV40gp7 SV40gp7 Add to Cart
pMIG small T H42Q SV40 small T Antigen H42Q Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pMIG SV40gp7 SV40gp7 Add to Cart
pBABE-zeo small T 110 SV40 small T Antigen 110 Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pBABE-zeo SV40gp7 SV40gp7 Add to Cart
pBABE-zeo small T C97S E102Q SV40 small T Antigen 97, 102 Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pBABE-zeo SV40gp7 SV40gp7 Add to Cart
pBABE-zeo small T H42Q SV40 small T Antigen Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pBABE-zeo SV40gp7 SV40gp7 Add to Cart
pBABE-zeo small T 88 SV40 small T Antigen 88 Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pBABE-zeo SV40gp7 SV40gp7 Add to Cart
pMIG small T 88 SV40 small T Antigen 88 Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pMIG SV40gp7 SV40gp7 Add to Cart
GFP-siRNA control siGFP Mammalian Expression Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Yang et al Cell 2004 Jun 25;117(7):927-39. pSP-108 Add to Cart
pBABE-puro HGF HGF (Homo sapiens) Mammalian Expression, Retroviral The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Gupta et al Nat Genet. 2005 Oct . 37(10):1047-54. pBABE-puro HGF DFNB39, F-TCF, HGFB, HPTA, SF Add to Cart
pBABE-puro TPR-Met TPR-Met (Homo sapiens) Mammalian Expression, Retroviral The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Gupta et al Nat Genet. 2005 Oct . 37(10):1047-54. pBABE-puro MET AUTS9, HGFR, RCCP2, c-Met TPR Add to Cart
siSlug1 siSlug (Homo sapiens) Mammalian Expression, Lentiviral, RNAi The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Gupta et al Nat Genet. 2005 Oct . 37(10):1047-54. pLKO.1 SNAI2 SLUG, SLUGH1, SNAIL2, WS2D Add to Cart
siSlug2 siSlug (Homo sapiens) Mammalian Expression, Lentiviral, RNAi The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Gupta et al Nat Genet. 2005 Oct . 37(10):1047-54. pLKO.1 SNAI2 SLUG, SLUGH1, SNAIL2, WS2D Add to Cart
siSlug3 siSlug (Homo sapiens) Mammalian Expression, Lentiviral, RNAi The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Gupta et al Nat Genet. 2005 Oct . 37(10):1047-54. pLKO.1 SNAI2 SLUG, SLUGH1, SNAIL2, WS2D Add to Cart
pCI-Neo HA-hSnoN SnoN (Homo sapiens) Mammalian Expression SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling. Sun et al Proc Natl Acad Sci U S A. 1999 Oct 26. 96(22):12442-7. pCI-neo SKIL SNO, SnoA, SnoI, SnoN Add to Cart
pCI-Neo HA-hSki Ski (Homo sapiens) Mammalian Expression SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling. Sun et al Proc Natl Acad Sci U S A. 1999 Oct 26. 96(22):12442-7. pCI-neo SKI SGS, SKV Add to Cart
Rc/CMV cyclin B2 cyclin B2 (Homo sapiens) Mammalian Expression Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Hinds et al Cell. 1992 Sep 18. 70(6):993-1006. pRc/CMV CCNB2 HsT17299 Add to Cart
Rc/CMV cyclin D3 cyclin D3 (Homo sapiens) Mammalian Expression Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Hinds et al Cell. 1992 Sep 18. 70(6):993-1006. pRc/CMV CCND3 RP5-973N23.3 Add to Cart
pcDNA type III TGF beta receptor (R3-OFF) R3-OFF (Rattus norvegicus) Mammalian Expression Expression cloning and characterization of the TGF-beta type III receptor. Wang et al Cell. 1991 Nov 15. 67(4):797-805. pcDNAI neo Tgfbr3 betaglycan Add to Cart
pcDNA3-E2F4 E2F4 (Homo sapiens) Mammalian Expression E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Sardet et al Proc Natl Acad Sci U S A. 1995 Mar 14. 92(6):2403-7. pcDNA3 E2F4 E2F-4 Add to Cart
pCMV p16 INK4A p16 INK4 (Homo sapiens) Mammalian Expression Growth suppression by p16ink4 requires functional retinoblastoma protein. Medema et al Proc Natl Acad Sci U S A. 1995 Jul 3. 92(14):6289-93. pcDNA3 CDKN2A ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16 Add to Cart
pSV2 neuN neuN (Rattus norvegicus) Mammalian Expression Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Bargmann et al Cell. 1986 Jun 6. 45(5):649-57. pSV2 neo Erbb2 Add to Cart
pSV2 neuNT neuNT (Rattus norvegicus) Mammalian Expression Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Bargmann et al Cell. 1986 Jun 6. 45(5):649-57. pSV2 neo Erbb2 Add to Cart
pSV2 neuT neuT (Rattus norvegicus) Mammalian Expression Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Bargmann et al Cell. 1986 Jun 6. 45(5):649-57. pSV2-dhfr Erbb2 Add to Cart
pEXL flag Smad3 Smad3 (Homo sapiens) Mammalian Expression Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Liu et al Proc Natl Acad Sci U S A. 1997 Sep 30. 94(20):10669-74. pEXL (derived from pEGFP-N1) SMAD3 HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 Add to Cart
pBABE-hygro CDK4 R24C CDK4 (Homo sapiens) Mammalian Expression, Retroviral Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23. pBABE-hygro CDK4 CMM3, PSK-J3 Add to Cart
pWZL Blast GFP EGFP Mammalian Expression, Retroviral Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Orimo et al Cell. 2005 May 6. 121(3):335-48. pWZL Blast Add to Cart
pBABE puro SDF-1 alpha SDF-1 alpha (Homo sapiens) Mammalian Expression, Retroviral Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Orimo et al Cell. 2005 May 6. 121(3):335-48. pBABE-puro CXCL12 IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1 Add to Cart
pLKO.1 puro CXCR4 siRNA-1 CXCR4 siRNA (Homo sapiens) Mammalian Expression, Lentiviral, RNAi Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Orimo et al Cell. 2005 May 6. 121(3):335-48. pLKO.1 CXCR4 CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM Add to Cart
pLKO.1 puro CXCR4 siRNA-2 CXCR4 siRNA (Homo sapiens) Mammalian Expression, Lentiviral, RNAi Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Orimo et al Cell. 2005 May 6. 121(3):335-48. pLKO.1 CXCR4 CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM Add to Cart
pLKO.1 puro GFP siRNA GFP siRNA Mammalian Expression, Lentiviral, RNAi Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Orimo et al Cell. 2005 May 6. 121(3):335-48. pLKO.1 Add to Cart
pBabe puro H-Ras G12V T35S H-Ras G12V T35S (Homo sapiens) Mammalian Expression, Retroviral Species- and cell type-specific requirements for cellular transformation. Rangarajan et al Cancer Cell. 2004 Aug . 6(2):171-83. pBABE-puro HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras Add to Cart
pBabe puro H-Ras G12V E37G H-Ras G12V E37G (Homo sapiens) Mammalian Expression, Retroviral Species- and cell type-specific requirements for cellular transformation. Rangarajan et al Cancer Cell. 2004 Aug . 6(2):171-83. pBABE-puro HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras Add to Cart
pBabe puro H-Ras G12V Y40C H-Ras G12V Y40C (Homo sapiens) Mammalian Expression, Retroviral Species- and cell type-specific requirements for cellular transformation. Rangarajan et al Cancer Cell. 2004 Aug . 6(2):171-83. pBABE-puro HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras Add to Cart
pWZL Blast H-Ras G12V E37G H-Ras G12V E37G (Homo sapiens) Mammalian Expression, Retroviral Species- and cell type-specific requirements for cellular transformation. Rangarajan et al Cancer Cell. 2004 Aug . 6(2):171-83. pWZL Blast HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras Add to Cart
pWZL Blast H-Ras G12V T35S H-Ras G12V T35S (Homo sapiens) Mammalian Expression, Retroviral Species- and cell type-specific requirements for cellular transformation. Rangarajan et al Cancer Cell. 2004 Aug . 6(2):171-83. pWZL Blast HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras Add to Cart
pWZL Blast H-Ras G12V Y40C H-Ras G12V Y40C (Homo sapiens) Mammalian Expression, Retroviral Species- and cell type-specific requirements for cellular transformation. Rangarajan et al Cancer Cell. 2004 Aug . 6(2):171-83. pWZL Blast HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras Add to Cart
pWZL blast goosecoid goosecoid (Mus musculus) Mammalian Expression, Retroviral The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Hartwell et al Proc Natl Acad Sci U S A. 2006 Dec 12. 103(50):18969-74. pWZL Blast Gsc Add to Cart
pWZL blast HA goosecoid goosecoid (Mus musculus) Mammalian Expression, Retroviral The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Hartwell et al Proc Natl Acad Sci U S A. 2006 Dec 12. 103(50):18969-74. pWZL Blast Gsc Add to Cart
pBabe human FOXC2 FOXC2 (Homo sapiens) Mammalian Expression, Retroviral Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Mani et al Proc Natl Acad Sci U S A. 2007 Jun 12. 104(24):10069-74. pBabe puro FOXC2 FKHL14, LD, MFH-1, MFH1 Add to Cart
MDH1-PGK-GFP microRNA-10b microRNA-10b (Homo sapiens) Mammalian Expression, Retroviral, RNAi Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Ma et al Nature. 2007 Oct 11. 449(7163):682-8. MDH1-PGK-GFP 2.0 MIR10B MIRN10B, hsa-mir-10b, miRNA10B, mir-10b Add to Cart
pWZL Blast Snail ER snail (Homo sapiens) Mammalian Expression, Retroviral The epithelial-mesenchymal transition generates cells with properties of stem cells. Mani et al Cell. 2008 May 16. 133(4):704-15. pWZL-Blast SNAI1 SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1 Add to Cart
pWZL Blast Twist ER twist (Mus musculus) Mammalian Expression, Retroviral The epithelial-mesenchymal transition generates cells with properties of stem cells. Mani et al Cell. 2008 May 16. 133(4):704-15. pWZL-Blast Twist1 AA960487, M-Twist, Pde, Ska10, Ska<m10Jus>, Twist, bHLHa38, pdt Add to Cart
pWZL Blast DN E-cadherin Dom neg E-cadherin (Mus musculus) Mammalian Expression, Retroviral Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Onder et al Cancer Res. 2008 May 15. 68(10):3645-54. pWZL-Blast Cdh1 AA960649, E-cad, Ecad, L-CAM, UVO, Um Add to Cart
pLKO.1 puro shRNA E-cadherin E-cadherin shRNA (Homo sapiens) Mammalian Expression, Lentiviral, RNAi Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Onder et al Cancer Res. 2008 May 15. 68(10):3645-54. pLKO.1 puro CDH1 Arc-1, CD324, CDHE, ECAD, LCAM, UVO Add to Cart
pLKO.1 hygro shRNA E-cadherin E-cadherin shRNA (Homo sapiens) Mammalian Expression, Lentiviral, RNAi Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Onder et al Cancer Res. 2008 May 15. 68(10):3645-54. pLKO.1 hygro CDH1 Arc-1, CD324, CDHE, ECAD, LCAM, UVO Add to Cart
pLKO.1 puro shRNA beta-catenin b-catenin shRNA (Homo sapiens) Mammalian Expression, Lentiviral, RNAi Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Onder et al Cancer Res. 2008 May 15. 68(10):3645-54. 3rd gen lentiviral vector for knocking down beta-catenin gene expression pLKO.1 puro CTNNB1 OK/SW-cl.35, CTNNB, MRD19, armadillo Add to Cart
pWZL Blast mouse E-cadherin E-cadherin (Mus musculus) Mammalian Expression, Retroviral Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Onder et al Cancer Res. 2008 May 15. 68(10):3645-54. pWZL-Blast Cdh1 AA960649, E-cad, Ecad, L-CAM, UVO, Um Add to Cart
pMIR-D10 mutUTR HOXD10 mut 3' UTR (Homo sapiens) Mammalian Expression Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Ma et al Nature. 2007 Oct 11. 449(7163):682-8. pMIR-report HOXD10 HOX4, HOX4D, HOX4E, Hox-4.4 Add to Cart
pMIR-D10 UTR HOXD10 3' UTR (Homo sapiens) Mammalian Expression Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Ma et al Nature. 2007 Oct 11. 449(7163):682-8. pMIR-report HOXD10 HOX4, HOX4D, HOX4E, Hox-4.4 Add to Cart
pMIR-10b microRNA 10b (Homo sapiens) Mammalian Expression Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Ma et al Nature. 2007 Oct 11. 449(7163):682-8. pMIR-report MIR10B MIRN10B, hsa-mir-10b, miRNA10B, mir-10b Add to Cart
shp53 pLKO.1 puro small hairpin RNA against tumor protein p53 (Homo sapiens) Mammalian Expression, Lentiviral, RNAi Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Godar et al Cell. 2008 Jul 11. 134(1):62-73. 3rd gen lentiviral vector for knocking down p53 gene expression pLKO.1 puro TP53 BCC7, LFS1, P53, TRP53 Add to Cart
shp63alpha pLKO.1 puro small hairpin RNA against tumor protein p63 (Homo sapiens) Mammalian Expression, Lentiviral, RNAi Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Godar et al Cell. 2008 Jul 11. 134(1):62-73. pLKO.1 puro TP63 AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L Add to Cart
CD44P pGL3 CD44 promoter (Homo sapiens) Non viral cloning vector Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Godar et al Cell. 2008 Jul 11. 134(1):62-73. pGL3-Basic CD44 AL133330.1, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 Add to Cart
shCD44-2 pRRL small hairpin RNA against CD44 (Homo sapiens) Mammalian Expression, Lentiviral Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Godar et al Cell. 2008 Jul 11. 134(1):62-73. pRRL-U6-siluc-cppt-hPGKGFPSIN CD44 AL133330.1, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 Add to Cart
shCD44-3 pRRL small hairpin RNA against CD44 (Homo sapiens) Mammalian Expression, Lentiviral Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Godar et al Cell. 2008 Jul 11. 134(1):62-73. pRRL-U6-siluc-cppt-hPGKGFPSIN CD44 AL133330.1, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 Add to Cart
shLuc pRRL control shRNA Mammalian Expression, Lentiviral Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Godar et al Cell. 2008 Jul 11. 134(1):62-73. pRRL-U6-siluc-cppt-hPGKGFPSIN Add to Cart
CD44S pWZL-Blast CD44 standard (Homo sapiens) Mammalian Expression, Retroviral Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Godar et al Cell. 2008 Jul 11. 134(1):62-73. pWZL Blast CD44 AL133330.1, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 Add to Cart
CD44S pBabe-puro CD44 standard (Homo sapiens) Mammalian Expression, Retroviral Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Godar et al Cell. 2008 Jul 11. 134(1):62-73. pBABE-puro CD44 AL133330.1, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 Add to Cart
pBabe puro MTH1 MTH1 (Homo sapiens) Mammalian Expression, Retroviral Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Rai et al Proc Natl Acad Sci U S A. 2009 Jan 6. 106(1):169-74. pBABE-puro NUDT1 MTH1 Add to Cart
pBabe hygro MTH1 MTH1 (Homo sapiens) Mammalian Expression, Retroviral Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Rai et al Proc Natl Acad Sci U S A. 2009 Jan 6. 106(1):169-74. pBABE-hygro NUDT1 MTH1 Add to Cart
pLKO.1 shMTH1-1 shMTH1-1 (Homo sapiens) Mammalian Expression, Lentiviral, RNAi Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Rai et al Proc Natl Acad Sci U S A. 2009 Jan 6. 106(1):169-74. pLKO.1 puro NUDT1 MTH1 Add to Cart
pLKO.1 shMTH1-2 shMTH1-2 (Homo sapiens) Mammalian Expression, Lentiviral, RNAi Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Rai et al Proc Natl Acad Sci U S A. 2009 Jan 6. 106(1):169-74. pLKO.1 puro NUDT1 MTH1 Add to Cart
pISI-mmP16 3' UTR mmP16 3'UTR Mammalian Expression A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Valastyan et al Cell. 2009 Jun 12. 137(6):1032-46. pIS1 Add to Cart
pBABE-puro-mIR-31 sponge miR-31 (Homo sapiens) Mammalian Expression, Retroviral A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Valastyan et al Cell. 2009 Jun 12. 137(6):1032-46. Stable suppression of miR-31 function pBABE-puro MIR31 MIRN31, hsa-mir-31, miR-31 Add to Cart
pBp-Control Sponge (CXCR4 sponge) CXCR4 control sponge Mammalian Expression, Retroviral A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Valastyan et al Cell. 2009 Jun 12. 137(6):1032-46. pBABE-puro Add to Cart
pBabe puro Snail Snail (Homo sapiens) Mammalian Expression, Retroviral Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Mani et al Proc Natl Acad Sci U S A. 2007 Jun 12. 104(24):10069-74. pBabe puro SNAI1 SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1 Add to Cart
pLKO.1 hygro Mammalian Expression, Lentiviral, RNAi empty vector (unpublished) 3rd gen lentiviral backbone for cloning and expression of new shRNA sequences. Uses hygromycin for selection. pLKO.1 - TRC cloning vector (no stuffer) Add to Cart
pIS1-miR-31 site synthetic miR-31 site Mammalian Expression, Luciferase A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Valastyan et al Cell. 2009 Jun 12. 137(6):1032-46. pIS1 Add to Cart
pIS1-mutant Fzd3 3'UTR mutant Fzd3 3'UTR Mammalian Expression, Luciferase A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Valastyan et al Cell. 2009 Jun 12. 137(6):1032-46. pIS1 Add to Cart
pIS1-wt Fzd3 3'UTR wt Fzd3 3'UTR Mammalian Expression, Luciferase A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Valastyan et al Cell. 2009 Jun 12. 137(6):1032-46. pIS1 Add to Cart
CMV-miR-31 sponge CMV-miR-31 sponge Mammalian Expression A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Valastyan et al Cell. 2009 Jun 12. 137(6):1032-46. pcDNA5-CMV-d2eGFP Add to Cart
pIS1-miR-126 site synthetic miR-126 site Mammalian Expression, Luciferase A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Valastyan et al Cell. 2009 Jun 12. 137(6):1032-46. pIS1 Add to Cart
pIS1-miR-206 site synthetic miR-206 site Mammalian Expression, Luciferase A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Valastyan et al Cell. 2009 Jun 12. 137(6):1032-46. pIS1 Add to Cart
pIS1-miR-335 site synthetic miR-335 site Mammalian Expression, Luciferase A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Valastyan et al Cell. 2009 Jun 12. 137(6):1032-46. pIS1 Add to Cart
MDH1-PGK-GFP-miR9 mir-9-3 (Homo sapiens) Mammalian Expression, Retroviral, RNAi miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Ma et al Nat Cell Biol. 2010 Mar . 12(3):247-56. MDH1-PGK-GFP 2.0 MIR9-3 MIRN9-3, miRNA9-3, hsa-mir-9-3 Add to Cart
pMIR-9 miR-9 binding site (Homo sapiens) Mammalian Expression, Luciferase miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Ma et al Nat Cell Biol. 2010 Mar . 12(3):247-56. pMIR-report Add to Cart
pMIR-CDH1 wtUTR CDH1 3'UTR (Homo sapiens) Mammalian Expression, Luciferase miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Ma et al Nat Cell Biol. 2010 Mar . 12(3):247-56. pMIR-report CDH1 Arc-1, CD324, CDHE, ECAD, LCAM, UVO Add to Cart
pMIR-CDH1 mutUTR CDH1 mutant 3'UTR (Homo sapiens) Mammalian Expression, Luciferase miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Ma et al Nat Cell Biol. 2010 Mar . 12(3):247-56. pMIR-report CDH1 Arc-1, CD324, CDHE, ECAD, LCAM, UVO Add to Cart
pBabe-puro-miR-9 sponge miR-9 sponge Mammalian Expression, Retroviral miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Ma et al Nat Cell Biol. 2010 Mar . 12(3):247-56. pBabe-puro Add to Cart
pBabe-puro-miR-10b sponge miR-10b sponge Mammalian Expression, Retroviral Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Ma et al Nat Biotechnol. 2010 Apr . 28(4):341-7. pBabe-puro Add to Cart
pSVE Grb2 myc 49L Grb2 P49L (Homo sapiens) Mammalian Expression Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Egan et al Nature. 1993 May 6. 363(6424):45-51. pSVE GRB2 ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 Add to Cart
pSVE Grb2 myc 49L/203R Grb2 49L/203R (Homo sapiens) Mammalian Expression Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Egan et al Nature. 1993 May 6. 363(6424):45-51. pSVE GRB2 ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 Add to Cart
pBabe-puro-mIR-31 miR-31 (Homo sapiens) Mammalian Expression, Retroviral A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Valastyan et al Cell. 2009 Jun 12. 137(6):1032-46. pBABE-puro MIR31 MIRN31, hsa-mir-31, miR-31 Add to Cart
pIS1-wt RhoA 3'UTR wt RhoA 3'UTR (Homo sapiens) Mammalian Expression, Luciferase A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Valastyan et al Cell. 2009 Jun 12. 137(6):1032-46. pIS1 RHOA ARH12, ARHA, RHO12, RHOH12 Add to Cart
pIS1-mutant RhoA 3'UTR mutant RhoA 3'UTR (Homo sapiens) Mammalian Expression, Luciferase A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Valastyan et al Cell. 2009 Jun 12. 137(6):1032-46. pIS1 RHOA ARH12, ARHA, RHO12, RHOH12 Add to Cart
pTK-Snail Snail (Mus musculus) Lentiviral Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pTK380 (tetracycline inducible) Snai1 RP23-118A2.5, AI194338, Sna, Sna1, Snail, Snail1 Add to Cart
pTK-Twist Twist Lentiviral Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pTK380 (tetracycline inducible) Twist1 AA960487, M-Twist, Pde, Ska10, Ska<m10Jus>, Twist, bHLHa38, pdt Add to Cart
FUW-Sox10 Sox10 (Homo sapiens) Mammalian Expression, Lentiviral Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. FUW-LPT2 (tetracycline-inducible) SOX10 RP5-1039K5.9, DOM, PCWH, WS2E, WS4, WS4C Add to Cart
pWPXL-Sox9 Sox9 (Mus musculus) Mammalian Expression, Lentiviral Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pWPXL Sox9 RP23-36D5.1, 2010306G03Rik, AV220920, mKIAA4243 Add to Cart
pWPXL-c-Myc c-Myc (Mus musculus) Mammalian Expression, Lentiviral Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pWPXL Myc AU016757, Myc2, Niard, Nird, bHLHe39 Add to Cart
pWPXL-Klf4 Klf4 (Mus musculus) Mammalian Expression, Lentiviral Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pWPXL Klf4 RP23-322L22.2, EZF, Gklf, Zie Add to Cart
pWPXL-Hes1 Hes1 (Mus musculus) Mammalian Expression, Lentiviral Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pWPXL Hes1 Hry, bHLHb39 Add to Cart
pWPXL-Sox4 Sox4 (Homo sapiens) Mammalian Expression, Lentiviral Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pWPXL SOX4 EVI16 Add to Cart
pLV-beta-catenin deltaN90 beta-catenin deltaN90 (Homo sapiens) Mammalian Expression, Lentiviral Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pLV-IRES-neo CTNNB1 OK/SW-cl.35, CTNNB, MRD19, armadillo Add to Cart
pTK-Slug slug (Mus musculus) Lentiviral Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pTK380 (tetracycline inducible) Snai2 Slug, Slugh, Snail2 Add to Cart
pLKO.1-sh-mSox10-2 sh-mSox10-2 (Mus musculus) Mammalian Expression, Lentiviral, RNAi Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pLKO.1 puro (Addgene plasmid 8453) Sox10 Dom, Sox21 Add to Cart
pLV-neo-CD2-FAK CD2-FAK (Homo sapiens) Mammalian Expression, Lentiviral Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Shibue et al Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10290-5. Epub 2009 Jun 5. pLV-IRES-neo CD2 RP4-655N15.2, LFA-2, SRBC, T11 PTK2 FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK Add to Cart
pLKO-puro-sh-mFAK C sh-mFAK C (Mus musculus) Mammalian Expression, Lentiviral, RNAi Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Shibue et al Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10290-5. Epub 2009 Jun 5. pLKO.1 puro (Addgene plasmid 8453) Ptk2 FAK, FRNK, Fadk, mKIAA4203, p125FAK Add to Cart
pLKO-puro-sh-mFAK B sh-mFAK B (Mus musculus) Mammalian Expression, Lentiviral, RNAi Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Shibue et al Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10290-5. Epub 2009 Jun 5. pLKO.1 puro (Addgene plasmid 8453) Ptk2 FAK, FRNK, Fadk, mKIAA4203, p125FAK Add to Cart
pLKO.1-sh-hSOX9-1 sh-hSOX9-1 (Homo sapiens) Mammalian Expression, Lentiviral, RNAi Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pLKO.1 puro (Addgene plasmid 8453) Add to Cart
pLKO.1-sh-mSOX9-2 sh-mSOX9-2 (Mus musculus) Mammalian Expression, Lentiviral, RNAi Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pLKO.1 puro (Addgene plasmid 8453) Add to Cart
pLKO.1-sh-mSOX9-5 sh-mSOX9-5 (Mus musculus) Mammalian Expression, Lentiviral, RNAi Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pLKO.1 puro (Addgene plasmid 8453) Add to Cart
pLKO.1-sh-mSlug-3 sh-mSlug-3 (Mus musculus) Mammalian Expression, Lentiviral, RNAi Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pLKO.1 puro (Addgene plasmid 8453) Add to Cart
pLKO.1-sh-mSlug-4 sh-mSlug-4 (Mus musculus) Mammalian Expression, Lentiviral, RNAi Slug and Sox9 cooperatively determine the mammary stem cell state. Guo et al Cell. 2012 Mar 2;148(5):1015-28. pLKO.1 puro (Addgene plasmid 8453) Add to Cart