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Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis.
Alsaffar H, Martino N, Garrett JP, Adam AP
Am J Physiol Cell Physiol. 2018 Jan 10. doi: 10.1152/ajpcell.00235.2017.
PubMed Article

Plasmids from Article

ID Plasmid Purpose
99260pAdCMV/V5-DEST-STAT3-3xFlagAdenoviral vector encoding Flag-tagged murine STAT3
99261pAdCMV/V5-DEST-Y705F-STAT3-3xFlagAdenoviral vector encoding Flag-tagged murine STAT3 (Y705F)
99262pAdCMV/V5-DEST-S727A-STAT3-3xFlagAdenoviral vector encoding Flag-tagged murine STAT3 (S727A)
99263pAdCMV/V5-DEST-S727D-STAT3-3xFlagAdenoviral vector encoding Flag-tagged murine STAT3 (S727D)
99264pAdCMV/V5-DEST-STAT3C-3xFlagAdenoviral vector encoding Flag-tagged murine STAT3C (constitutive)

Antibodies from Article