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Baoji Xu Lab: Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation.
Xu H, An JJ, Xu B
PLoS One. 2017 May 11;12(5):e0177610. doi: 10.1371/journal.pone.0177610. eCollection 2017.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
110486Ultra-Exon1Q23-Myc-ALentiviral vector to express wild-type N terminal HTT gene with short 3'UTR in mammalian cells (encodes Myc-tagged wild type huntingtin exon1 fragment with 23 repeats of Q)
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110487Ultra-Exon1Q145-Myc-ALentiviral vector to express mutant N terminal HTT gene with short 3'UTR in mammalian cells (encodes Myc-tagged mutant huntingtin exon1 fragment with 145 repeats of Q)
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110488pUltra-Exon1Q23-Myc-BLentiviral vector to express wild-type N terminal HTT gene with partial long 3'UTR in mammalian cells (encodes Myc-tagged wild-type huntingtin exon1 fragment with 23 repeats of Q)
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110489pUltra-Exon1Q145-Myc-BLentiviral vector to express mutant N terminal HTT gene with partial long 3'UTR in mammalian cells (encodes Myc-tagged mutant huntingtin exon1 fragment with 145 repeats of Q)
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Recombinant Antibodies from Article