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Mutational processes shape the landscape of TP53 mutations in human cancer.
Giacomelli AO, Yang X, Lintner RE, McFarland JM, Duby M, Kim J, Howard TP, Takeda DY, Ly SH, Kim E, Gannon HS, Hurhula B, Sharpe T, Goodale A, Fritchman B, Steelman S, Vazquez F, Tsherniak A, Aguirre AJ, Doench JG, Piccioni F, Roberts CWM, Meyerson M, Getz G, Johannessen CM, Root DE, Hahn WC
Nat Genet. 2018 Oct;50(10):1381-1387. doi: 10.1038/s41588-018-0204-y. PubMed Article

Plasmids from Article

ID Plasmid Purpose  
113569TP53 MITE LibraryPooled lentiviral plasmid library containing ~8,000 single amino acid substitution and nonsense mutant variants of p53
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118014pLX313-TP53-WTConstitutive expression of wild-type human Tumor Protein p53 (TP53)
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118015pLX313-TP53-P278AConstitutive expression of mutant human Tumor Protein p53 (TP53)
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118016pLX313-Renilla luciferaseConstitutive expression of Renilla luciferase
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118017pLX313-Firefly luciferaseConstitutive expression of Firefly luciferase
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118018pLX311-Cas9Constitutive expression of Cas9
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118019pXPR003-sgTP53-1Constitutive expression of sgRNA targeting human TP53
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118020pXPR003-sgTP53-2Constitutive expression of sgRNA targeting human TP53
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118021pXPR003-sgTP53-3Constitutive expression of sgRNA targeting human TP53
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118022pXPR003-sgTP53-4Constitutive expression of sgRNA targeting human TP53
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118023pXPR003-sgTP53-5Constitutive expression of sgRNA targeting human TP53
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