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Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch.
Dine E, Reed EH, Toettcher JE
Cell Rep. 2021 Jun 22;35(12):109280. doi: 10.1016/j.celrep.2021.109280. PubMed Article

Plasmids from Article

ID Plasmid Purpose
171032pHR LAT-FFF/Zap70 iLID-DropLight-induced LAT-Zap70 dimerization and LAT clustering. Zap70 is TagRFP-tagged. LAT has three Tyr-Phe mutations.
171033pHR Src deltaSH2/3-TagBFPTagBFP-tagged Src variant lacking SH2 and SH3 domains.
171034pHR Lck-TagBFPTagBFP-tagged Lck kinase
171035pHR Fyn-TagBFPTagBFP-tagged Fyn kinase
171036pHR Src-TagBFPTagBFP-tagged Src kinase
171038pHR LAT/Zap70 iLID-DropLight-induced LAT-Zap70 dimerization and LAT clustering. Zap70 is TagRFP-labeled.

Antibodies from Article