ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.
Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J
Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5. PubMed Article
Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J
Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 190617 | ZMYND8-dTAG | Lentiviral expression plasmid of human ZMYND8 fused with FKBP12G36V for dTAG-mediated degradation |
| 190618 | MYC-PGK-blast | Lentiviral expression plasmid of human MYC, blast selection |
| 190619 | ZMYND8-2A-neo | Lentiviral expression plasmid of human ZMYND8, neomycin selection |
| 190620 | dTAG-IRF8 | Lentiviral expression plasmid of human IRF8 fused with FKBP12G36V for dTAG-mediated degradation |
| 190621 | IRF8-2A-neo | Lentiviral expression plasmid of human IRF8, neomycin selection |