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LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer.
Murray CW, Brady JJ, Han M, Cai H, Tsai MK, Pierce SE, Cheng R, Demeter J, Feldser DM, Jackson PK, Shackelford DB, Winslow MM
Nat Commun. 2022 Feb 28;13(1):1090. doi: 10.1038/s41467-022-28619-8. PubMed Article

Plasmids from Article

ID Plasmid Purpose
177237hU6-sgNT1 (opti)Same as pLL3.3;U6(BstXI)-XhoI-chimeric RNA;PGK-Cre but XhoI stuffer removed, expresses non-targeting gRNA
177238hU6-sgNT2 (opti)Same as pLL3.3;U6(BstXI)-XhoI-chimeric RNA;PGK-Cre but XhoI stuffer removed, expresses non-targeting gRNA
177239hU6-sgNT3 (opti)Same as pLL3.3;U6(BstXI)-XhoI-chimeric RNA;PGK-Cre but XhoI stuffer removed, expresses non-targeting gRNA
177240hU6-sgNeo1 (opti)Same as pLL3.3;U6(BstXI)-XhoI-chimeric RNA;PGK-Cre but XhoI stuffer removed, expresses neomycin gRNA
177241hU6-sgNeo2 (opti)Same as pLL3.3;U6(BstXI)-XhoI-chimeric RNA;PGK-Cre but XhoI stuffer removed, expresses neomycin gRNA
177242hU6-sgNeo3 (opti)Same as pLL3.3;U6(BstXI)-XhoI-chimeric RNA;PGK-Cre but XhoI stuffer removed, expresses neomycin gRNA
177243hU6-sgLkb1_IW (opti)Same as pLL3.3;U6(BstXI)-XhoI-chimeric RNA;PGK-Cre but XhoI stuffer removed, expresses Lkb1 gRNA
177244hU6-sgLkb1_v2 (opti)Same as pLL3.3;U6(BstXI)-XhoI-chimeric RNA;PGK-Cre but XhoI stuffer removed, expresses Lkb1 gRNA
177245hu6-sgCebpa_v1 (opti)Same as pLL3.3;U6(BstXI)-XhoI-chimeric RNA;PGK-Cre but XhoI stuffer removed, expresses Cebpa gRNA
177246hu6-sgCebpa_v2 (opti)Same as pLL3.3;U6(BstXI)-XhoI-chimeric RNA;PGK-Cre but XhoI stuffer removed, expresses Cebpa gRNA
177247hu6-sgCebpb_v1 (opti)Same as pLL3.3;U6(BstXI)-XhoI-chimeric RNA;PGK-Cre but XhoI stuffer removed, expresses Cebpb gRNA
177248hu6-sgCebpb_v2 (opti)Same as pLL3.3;U6(BstXI)-XhoI-chimeric RNA;PGK-Cre but XhoI stuffer removed, expresses Cebpb gRNA
177249hu6-sgCebpd_v1 (opti)Same as pLL3.3;U6(BstXI)-XhoI-chimeric RNA;PGK-Cre but XhoI stuffer removed, expresses Cebpd gRNA
177250hu6-sgCebpd_v2 (opti)Same as pLL3.3;U6(BstXI)-XhoI-chimeric RNA;PGK-Cre but XhoI stuffer removed, expresses Cebpd gRNA
177251mU6-sgCebpa_v1-hu6-sgCebpb_v1Expresses Cebpa_v1 (mU6), Cebpb_v1 (hU6) gRNAs and Cre-recombinase
177252mU6-sgCebpa_v2-hu6-sgCebpb_v2Expresses Cebpa_v2 (mU6), Cebpb_v2(hU6) gRNAs and Cre-recombinase
177253mU6-sgCebpa_v1-hu6-sgCebpd_v1Expresses Cebpa_v1 (mU6), Cebpd_v1 (hU6) gRNAs and Cre-recombinase
177254mU6-sgCebpa_v2-hu6-sgCebpd_v2Expresses Cebpa_v2 (mU6), Cebpd_v2(hU6) gRNAs and Cre-recombinase
177255mU6-sgCebpb_v1-hu6-sgCebpd_v1Expresses Cebpb_v1 (mU6), Cebpd_v1 (hU6) gRNAs and Cre-recombinase
177256mU6-sgCebpb_v2-hu6-sgCebpd_v2Expresses Cebpb_v2 (mU6), Cebpd_v2(hU6) gRNAs and Cre-recombinase
177257bu6-sgCebpa_v1-mU6-sgCebpb_v1-hU6-sgCebpd_v1Expresses Cebpa_v1 (bU6), Cebpb_v1 (mU6), Cebpd_v1 (hU6) gRNAs and Cre-recombinase
177258bu6-sgCebpa_v2-mU6-sgCebpb_v2-hU6-sgCebpd_v2Expresses Cebpa_v2 (bU6), Cebpb_v2 (mU6), Cebpd_v2 (hU6) gRNAs and Cre-recombinase

Antibodies from Article