Copper induces cell death by targeting lipoylated TCA cycle proteins.
Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR
Science. 2022 Mar 18;375(6586):1254-1261. doi: 10.1126/science.abf0529. Epub 2022 Mar 17. PubMed Article
Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR
Science. 2022 Mar 18;375(6586):1254-1261. doi: 10.1126/science.abf0529. Epub 2022 Mar 17. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 184476 | pXPR_BRD003 FDX1-1 | Lentivirus gRNA targeting human FDX1 gene |
| 184477 | pXPR_BRD003 FDX1-2 | Lentivirus gRNA targeting human FDX1 gene |
| 184478 | pXPR_BRD003 LIAS-1 | Lentivirus gRNA targeting human LIAS gene |
| 184479 | pXPR_BRD003 LIAS-2 | Lentivirus gRNA targeting human LIAS gene |
| 184480 | pXPR_BRD003 LIPT1-1 | Lentivirus gRNA targeting human LIPT1 gene |
| 184481 | pXPR_BRD003 LIPT1-2 | Lentivirus gRNA targeting human LIPT1 gene |
| 184482 | pXPR_BRD003 LIPT2-1 | Lentivirus gRNA targeting human LIPT2 gene |
| 184483 | pXPR_BRD003 LIPT2-2 | Lentivirus gRNA targeting human LIPT2 gene |
| 184484 | pXPR_BRD003 DLAT-1 | Lentivirus gRNA targeting human DLAT gene |
| 184485 | pXPR_BRD003 DLAT-2 | Lentivirus gRNA targeting human DLAT gene |
| 184486 | pXPR_BRD003 Ch2-2 | Lentivirus gRNA targeting Ch2-2 (control) |
| 184487 | plentiCRISPv2_AAVS1 | Lentivirus all in one CRISPR vector targeting human AAVS1 gene |
| 184488 | plentiCRISPv2_FDX1-1 | Lentivirus all in one CRISPR vector targeting human FDX1 gene |
| 184489 | plentiCRISPv2_FDX1-2 | Lentivirus all in one CRISPR vector targeting human FDX1 gene |
| 184490 | plentiCRISPv2_FDX1-3 | Lentivirus all in one CRISPR vector targeting human FDX1 gene |
| 184491 | PLX_307 SLC31A1 | Lentivirus expression for SLC31A1 gene |
| 184492 | PLX_307 GFP | Lentivirus expression for GFP |
| 184493 | PLEX_313 SLC31A1 | Lentivirus expression for SLC31A1 gene |
| 184494 | PLEX_313 GFP | Lentivirus expression for GFP |
| 184495 | PLX_307 FDX1 | Lentivirus expression for FDX1 |