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A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation.
Vides EG, Adhikari A, Chiang CY, Lis P, Purlyte E, Limouse C, Shumate JL, Spinola-Lasso E, Dhekne HS, Alessi DR, Pfeffer SR
Elife. 2022 Sep 23;11:e79771. doi: 10.7554/eLife.79771. PubMed Article

Plasmids from Article

ID Plasmid Purpose
186012pCMV Flag-LRRK2 K17A/K18AFlag-LRRK2 K17A/K18A
186013pCMV Flag-LRRK2 K17A/K18A/R1441GFlag-LRRK2 K17A/K18A/R1441G
186014pET14b His Rab8a Q67LHis Rab8a Q67L
186015pET21b GFP-Rab10 Q68LHisGFP-Rab10 Q68LHis
186016pQE-80L 2xHis-LRRK2 Armadillo 1-1592xHis-LRRK2 Armadillo 1-159
186017pQE-80L 2xHis-LRRK2 Armadillo 1-5522xHis-LRRK2 Armadillo 1-552
186018pQE-80L 2xHis-LRRK2 Armadillo 350-5502xHis-LRRK2 Armadillo 350-550
186019pQE-80L 2xHis-LRRK2 Armadillo-K17A2xHis-LRRK2 Armadillo-K17A
186020pQE-80L 2xHis-LRRK2 Armadillo- K18A2xHis-LRRK2 Armadillo- K18A
186021pQE-80L 2xHis-Rab292xHis-Rab29

Antibodies from Article