Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors.
Shay TF, Sullivan EE, Ding X, Chen X, Ravindra Kumar S, Goertsen D, Brown D, Crosby A, Vielmetter J, Borsos M, Wolfe DA, Lam AW, Gradinaru V
Sci Adv. 2023 Apr 21;9(16):eadg6618. doi: 10.1126/sciadv.adg6618. Epub 2023 Apr 19. PubMed Article
Shay TF, Sullivan EE, Ding X, Chen X, Ravindra Kumar S, Goertsen D, Brown D, Crosby A, Vielmetter J, Borsos M, Wolfe DA, Lam AW, Gradinaru V
Sci Adv. 2023 Apr 21;9(16):eadg6618. doi: 10.1126/sciadv.adg6618. Epub 2023 Apr 19. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 201903 | pUCmini-iCAP-PHP.eC | non-standard AAV2 rep-AAV-PHP.eC cap plasmid with AAV cap expression controlled by a tTA-TRE amplification system |