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A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons.
Perez-Sanchez J, Middleton SJ, Pattison LA, Hilton H, Ali Awadelkareem M, Zuberi SR, Renke MB, Hu H, Yang X, Clark AJ, St John Smith E, Bennett DL
Sci Transl Med. 2023 Oct 4;15(716):eadh3839. doi: 10.1126/scitranslmed.adh3839. Epub 2023 Oct 4. PubMed Article

Plasmids from Article

ID Plasmid Purpose
208361pAAV-CAG-mCherry-Tandem-PSAM4-GlyRExpression of the inhibitory chemogenetic tool PSAM4-GlyR and mCherry reporter. Application of ultrapotent agonists induces neuronal silencing.

Antibodies from Article