Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate.
Wu YQ, Zhang CS, Xiong J, Cai DQ, Wang CZ, Wang Y, Liu YH, Wang Y, Li Y, Wu J, Wu J, Lan B, Wang X, Chen S, Cao X, Wei X, Hu HH, Guo H, Yu Y, Ghafoor A, Xie C, Wu Y, Xu Z, Zhang C, Zhu M, Huang X, Sun X, Lin SY, Piao HL, Zhou J, Lin SC
Cell Res. 2023 Nov;33(11):835-850. doi: 10.1038/s41422-023-00874-4. Epub 2023 Sep 19. PubMed Article
Wu YQ, Zhang CS, Xiong J, Cai DQ, Wang CZ, Wang Y, Liu YH, Wang Y, Li Y, Wu J, Wu J, Lan B, Wang X, Chen S, Cao X, Wei X, Hu HH, Guo H, Yu Y, Ghafoor A, Xie C, Wu Y, Xu Z, Zhang C, Zhu M, Huang X, Sun X, Lin SY, Piao HL, Zhou J, Lin SC
Cell Res. 2023 Nov;33(11):835-850. doi: 10.1038/s41422-023-00874-4. Epub 2023 Sep 19. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 212994 | pCMV5 n-myc mPirh2 | expresses mouse PIRH2 |
| 212995 | pBOBI C-FLAG PHGDH | expresses human PHGDH |
| 212996 | pBOBI C-FLAG PHGDH T57A | expresses human PHGDH |
| 212997 | pBOBI C-FLAG PHGDH T78A | expresses human PHGDH |
| 212998 | pBOBI C-FLAG PHGDH R135W | expresses human PHGDH |
| 212999 | pBOBI C-FLAG PHGDH V261M | expresses human PHGDH |
| 213000 | pBOBI N-HA AXIN1 | expresses mouse AXIN1 |
| 213001 | pBOBI TP53 S46A | expresses human P53 |
| 213003 | pCDNA3.3 N-MYC TIP60 | expresses human TIP60 |
| 213004 | pBOBI N-FLAG HIPK2 | expresses mouse HIPK2 |
| 213005 | pBOBI N-HA AXIN1 delta PHGDH (delta 321-340) | expresses mouse AXIN1 |