Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone.
Stenoien DL, Cummings CJ, Adams HP, Mancini MG, Patel K, DeMartino GN, Marcelli M, Weigel NL, Mancini MA
Hum Mol Genet. 1999 May . 8(5):731-41. PubMed Article
Stenoien DL, Cummings CJ, Adams HP, Mancini MG, Patel K, DeMartino GN, Marcelli M, Weigel NL, Mancini MA
Hum Mol Genet. 1999 May . 8(5):731-41. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 28235 | pEGFP-C1-AR | Mammalian expression of Androgen receptor fused to EGFP |
| 86427 | pEGFP-C1-AR Q0 | Fluorescent human androgen receptor (fused to EGFP) with deleted polyglutamine region |
| 86428 | pEGFP-C1-AR Q48 | Fluorescent human androgen receptor (fused to EGFP) with expanded polyglutamine region |